#Research finds combo of plant nutrients kills breast cancer cellsa study led by Madhwa Raj Phd Research Professor in Obstetrics
and Gynecology at LSU Health Sciences Center New orleans and its Stanley S. Scott Cancer Center has found that a super cocktail of six natural compounds in vegetables fruits spices
and plant roots killed 100%of sample breast cancer cells without toxic side effects on normal cells.
The results which also revealed potential treatment target genes are published in the November 2013 issue of The Journal of Cancer.
One of the primary causes of both the recurrence of breast cancer and deaths is a small group of cancer stem cells that evade therapy notes Dr. Raj.
These often multi-drug-resistant cells have the ability to generate new tumors so it is critically important to develop new approaches to more effective and safer treatment or prevention of breast cancer.
The research team tested ten known protective chemical nutrients found in foods like broccoli grapes apples tofu
The researchers administered these six at bioavailable levels to both breast cancer and control cells. They tested the compounds individually and in combination.
When combined though the super cocktail suppressed breast cancer cell growth by more than 80%inhibited migration
and triggered the process leading to cell death resulting in the death of 100%of the breast cancer cells in the sample.
According to the National Cancer Institute's SEER Program which includes data from LSU Health Sciences Center New orleans breast cancer is the second most common cancer with 232340 new cases estimated this year
There are an estimated 2829041 women currently living with breast cancer in the United states. Story Source: The above story is provided based on materials by Louisiana State university Health Sciences Center.
study suggestsin the largest study of its kind people who ate a daily handful of nuts were 20 percent less likely to die from any cause over a 30-year period than were those who didn't consume nuts say scientists from Dana-Farber Cancer
The most obvious benefit was a reduction of 29 percent in deaths from heart disease--the major killer of people in America said Charles S. Fuchs MD MPH director of the Gastrointestinal Cancer Center
But we also saw a significant reduction--11 percent--in the risk of dying from cancer added Fuchs who is affiliated also with the Channing Division of Network Medicine at Brigham
and a lower risk of diseases such as heart disease type 2 diabetes colon cancer gallstones and diverticulitis.
nonetheless the findings are strongly consistent with a wealth of existing observational and clinical trial data to support health benefits of nut consumption on many chronic diseases.
In fact based on previous studies the US Food and Drug Administration concluded in 2003 that eating 1. 5 ounces per day of most nuts may reduce the risk of heart disease.
The above story is provided based on materials by Dana-Farber Cancer Institute. Note: Materials may be edited for content and length.
or ph and pollination syndromes said lead author Yelenik who earned her doctorate from UCSB's Department of Ecology Evolution and Marine Biology and now works for the U s. Geological Survey's Pacific Island Ecosystems
Exposure to arsenic has been linked to a variety of health problems including cancer vascular diseases and low birth weight.
performed differently in people who suffer from autism spectrum disorder than in those who do not.
Autism spectrum disorder and autism are general terms for a group of complex disorders of brain development that affect social interactions communication skills and behaviors.
A subpopulation of neurons in these patients with autism spectrum disorder showed abnormal sensitivity to the mouth region.
Do the cell abnormalities originate in the amygdala or are they the result of processing abnormalities elsewhere in the brain?
There are many questions yet to be answered but this study points us in a specific direction that we believe will help understand autism he said.
because no animal model exists for the highly complex human disorder. The autism study was made possible by patients being treated for epilepsy who underwent surgery to have implanted depth electrodes in their brains to monitor seizure-related electrical activity.
Two of the patients also suffered from a high-functioning form of autism spectrum disorder. The amygdala is a routine target for depth electrodes to localize epileptic seizures.
This provides a unique opportunity to record activity from the amygdala a brain structure that is important for the processing of emotions
and suspected to be abnormal in autism. However until our recent discovery it was unknown
#New vaccine against lung diseases in goats and sheepan intranasal spray was developed using local isolated bacterium in Malaysia
and it was found to provide better protection against infections by Mannheimia haemolytica bacterium than imported vaccines.
or pneumonic diseases in goats and sheep that was developed and patented by its scientists. The soft launch of STVAC7 the first intranasal spray vaccine for goats
or respiratory diseases of goats and sheep caused by bacteria. It was developed and produced using sophisticated recombinant technology
which unlike the imported vaccines has been demonstrated to provide protection against bacterium infection in the small ruminants like goats and sheep.
The current available vaccines against this disease are imported vaccines prepared using foreign strains. They are given via intramuscular injections.
Therefore STVAC7 was developed using local isolated bacterium that was found to be able to provide protection against infections by Mannheimia haemolytica bacterium A2 A7 and A9.
If used according to the suggested protocol it can reduce mortality due to this disease by more than 90%he added.
Prof Zamri said the pneumonic diseases brought about by the bacterium usually caused a mortality rate of 30%during the rainy season
and technology could be modified to produce vaccines against other diseases of animals and humans. In fact the technology can be modified further to produce test kits for various diseases he said.
Story Source: The above story is provided based on materials by Universiti Putra Malaysia (UPM. The original article was written by Noor Eszereen Juferi.
The Heart of New Ulm Project reinforce the positive influence of lifestyle factors in mitigating risks that potentially increase the likelihood of heart disease and other health problems.
and nutrition specifically eating more fruits and vegetables in addressing metabolic syndrome (MS) a common precursor to cardiovascular disease (CVD).
and demonstration project with a goal of reducing heart attacks in New Ulm Minn. over a ten year period.
Our data suggests that there is a clear connection between increased body weight or the decrease in the consumption of fruits and vegetables and the development of metabolic syndrome a clustering of CVD risk factors.
and high blood pressure reinforcing the importance of modifying nutrition and physical activity behaviors to improve health
and prevent disease. Story Source: The above story is provided based on materials by Minneapolis Heart Institute Foundation.
and sugar and starch synthesis. Apple one of the world's most popular fruits tends to be highly susceptible to zinc deficiency.
Although the apple trees showed no zinc deficiency symptoms and the leaf zinc nutrition was at a low level continuing zinc sprays on these trees was required to increase fruit quality the researchers said.
but the cultivars have suffered historically from several deficiencies including low yields late maturity disease and pest susceptibility and lack of uniformity.
'Observations of a number of'Carotex-312'plantings in Texas and the results of prior research with the parental lines used to develop'Carotex-312'also suggested that the new cultivar has several potentially useful disease-resistance attributes.
#Drinking more milk as a teenager does not lower risk of hip fracture laterdrinking more milk as a teenager apparently does not lower the risk of hip fracture as an older adult
While drinking milk during adolescence is recommended to achieve peak bone mass milk's role in hip fractures later in life has not been established.
which is a risk factor for hip fracture according to the study background. Diane Feskanich Sc.
D. of Brigham and Women's Hospital and Harvard university Boston and colleagues examined the association between remembered teenage milk consumption and risk of hip fracture at older ages in a study of more than 96000 men
During the follow-up 1226 hip fractures were reported by women and 490 by men. Study findings indicate teenage milk consumption (between the ages of 13-18 years) was associated with an increased risk of hip fractures in men with each additional glass of milk per day as a teenager
associated with a 9 percent higher risk. Teenage milk consumption was associated not with hip fractures in women.
The association between drinking milk and hip fractures in men was influenced partially by height according to the studywe did not see an increased risk of hip fracture with teenage milk consumption in women as we did in men.
One explanation may be the competing benefit of an increase in bone mass with an adverse effect of greater height.
Women are at higher risk for osteoporosis than men hence the benefit of greater bone mass balanced the increased risk related to height the authors comment.
Cheese intake during teenage years was associated not with the risk of hip fracture in either men or women.
and height in preventing hip fractures in older adults. Dietary Guidelines for Americans 2010 recommends the consumption of three cups of milk
In this investigation higher milk consumption at this age did not translate into a lower risk of hip fracture for older adults
Lactobacillus johnsonii has previously been shown to exclude Clostridium perfringens from the guts of poultry opening the door to it being developed as a way of reducing necrotic enteritis in poultry and food poisoning in humans.
This strain of Lactobacillus johnsonii is now being taken through farm-scale trials to assess its potential use to combat pathogenic infections of poultry by bacteria such as C. perfringens.
and future work will focus on unpicking how the EPS molecules in the coat contribute to colonization and pathogen exclusion.
and neck cancer a Saint louis University researcher has found. Preliminary findings of the research were published in the Public library of Science One Journal by Ratna Ray Ph d. associate professor of pathology at Saint louis University.
Ray found that bitter melon extract a vegetable commonly used in Indian and Chinese diets reduces the head and neck cancer cell growth in the animal model.
We wanted to see the effect of the bitter melon extract treatment on different types of cancer using different model systems said Ray who first tested the extract in breast and prostate cancer cells.
and neck cancer cell growth in the mouse model reducing the growth of the tumor. In a controlled lab setting Ray found that bitter melon extract regulated several pathways that helped reduce the head and neck cancer cell growth in the animal model.
and volume of the tumor had reduced. Bitter melon is a tropical vegetable that is commonly used in Indian and Chinese cooking.
but a combination of things--existing drug therapy along with bitter melon--may help the efficacy of the overall cancer treatment Ray said.
Head and neck cancers which account for 6 percent of all cancer cases start in the mouth nose sinuses voicebox and throat.
They frequently are aggressive and often spread from one part of the head or neck to another.
and neck cancer patients Ray said she and her team would need to validate their results with other preclinical models.
and climate change has allowed the current epidemic to spread from lodgepole pine to jack pine a tree species that was thought to be unsuitable for beetle survival in Alberta.
and disease outbreaks in trees and forests across the world has been increasing. The review The consequences of Tree Pests and Diseases for Ecosystem Services by scientists from the universities of Southampton Cambridge Oxford and St andrews is published today (15 november) in the journal Science.
The research shows that the experience of widespread death of trees similar to that seen from Dutch elm disease
and with the arrival last year of the new fungal disease of ash--Chalara fraxinea--has not been unique to the UK.
Furthermore there is growing concern that aspects of globalisation--in particular high volumes and new forms of trade--may increase the risk of disease spreading
and provide opportunities for genetic reassortment which can enhance pathogenicity (the ability of an organism to cause disease).
Trees and forests provide a wide variety of ecosystem*services in addition to timber food and other provisioning services such as carbon sequester
and disease management are needed that take into account these multiple services and the different stakeholders they benefit as well as the likelihood of greater threats in the future resulting from globalisation and climate change.
and researchers stress the importance of risk management at pathways of introduction especially where modern trade practices provide potential new routes of entry for pests and pathogens.
and practice can prevent the introduction of new diseases and improve recovery and ongoing management this includes the breeding of resistant trees and development of effective bio-control systems.
Modern pest and disease management for plants and the natural environment needs to be based on an extensive science base.
and herbivores as well as why some species reach epidemic prevalence and abundance. Researchers also examined the difficulties of maintaining tree health
and diseases for the full range of ecosystem services provided by trees. The term pest and disease was used to describe all pathogens
and small-to medium-size insect herbivores that--by causing tree damage and death--disrupt the ecosystem services provided by trees.
If the vc system is switched on'during early infection of ash leaves then the spores (ascospores) responsible for infection might antagonise one other
Alternatively if the vc system is switched off'the germinating spores might cooperate during ash leaf infection leading to a greater spread of the fungus.
Later as larger lesions form in ash tissues the vc system might define the'territory'defended by each pathogen individual.
The fact that most isolates of Chalara fraxinea are incompatible with each other could mean that it might be difficult to deploy damaging fungal viruses against the pathogen as a disease control method
#Combating key viral livestock diseases in Ethiopiagelagay Ayelet Melesse's doctoral research reveals that there are several serotypes of the virus causing foot-and-mouth disease (FMD) and the African horse sickness virus (AHSV
His study also highlights the economic repercussions of these viruses and other viral diseases in domestic livestock.
and combating the spread of such diseases and to increased self-sufficiency in food. Livestock play an important role in Ethiopia as a livelihood both for nomads
However due to a number of diseases affecting domestic animals this resource is not reaching its full potential.
Typical diseases in this respect are foot-and-mouth disease (FMD) African horse sickness (AHS) lumpy skin disease (LSD) and camel pox.
Up until now we have had limited only knowledge about the real economic consequences of these diseases their distribution types of virus
and also the ecological and operational factors that may have a bearing on the prevalence of the diseases.
Research on lumpy skin disease and African horse sickness shows that outbreaks of these diseases occur at the end of the rainy season (in November and December.
Melesse's doctoral research has provided us with valuable information about virus types disease distribution in relation to season and geographical region and the economic significance and risk factors for FMD LSD AHS and camel
These bioactive compounds respectively help to prevent cardiovascular diseases and cancer. This is contained in a study carried out by the University of Barcelona and the CIBEROBN network Spain
The study PREVENTION with a MEDITERRANEAN Diet (PREDIMED) has shown recently the link between the Mediterranean diet and low levels of cardiovascular disease.
which we eat are reduced related to cardiovascular diseases Rosa Marã a Lamuela researcher at the UB and the person responsible for the project told SINC.
Various studies have shown that the intake of carotenoids such as lycopene prevents prostate cancer and the consumption of foods rich in beta-carotene help to reduce the incidence of lung cancer.
Eating a daily amount of 120 grams of sofrito added to pasta for example the total intake of polyphenols is 16 to 24 milligrams per portion
This mapping database which will be updated annually quantifies all forest stand-replacement disturbances whether due to logging fire disease or storms.
whether probiotics could substitute for antibiotics by reducing pathogen populations in the intestines says first author Carmen Bednorz of Freie Universitat Berlin Germany.
because without them the rationale goes in such close quarters a surfeit of pathogens would slow growth.
but reduced infections by Chlamydia spp. and pathogenic E coli according to the report. In the study Bednorz and her collaborators compared piglets fed with E. faecium to those in a control group.
and disease-resistant stocks of honey bees Niã o said. Story Source: The above story is provided based on materials by Penn State.
These lipids may be a new culprit that we can target in the small intestine in fighting atherosclerosis said senior author Dr. Alan Fogelman executive chair of the department of medicine
and director of the atherosclerosis research unit at the David Geffen School of medicine at UCLA. Big effect of small amount of LPAPREVIOUSLY it was thought that the role of the small intestine in response to a high-fat high-cholesterol diet was simply to package the fat
because they are found in far smaller amounts in the small intestine than other lipids like cholesterol may play a more direct role in contributing to the factors that cause atherosclerosis.
The findings suggest that some of the factors leading to atherosclerosis occur in the small intestine and not just the liver.
and prevent abnormalities in blood levels of'good'and'bad'cholesterol that contribute to heart attack
and lead to new treatments said Judith Gasson a professor of medicine and biological chemistry director of UCLA's Jonsson Comprehensive Cancer Center and senior associate dean for research at the Geffen
#Researcher finds potential new use for old drugsa class of drugs used to treat parasitic infections such as malaria may also be useful in treating cancers
and immune-related diseases a new WSU-led study has found. Researchers discovered that simple modifications to the drug furamidine have a major impact on its ability to affect specific human proteins involved in the on-off switches of certain genes.
The drug has a long history of use in serious parasitic diseases such as malaria African sleeping sickness and PCP a common infection in HIV/AIDS.
and function of the human immune system and it plays important roles in diseases such as some leukemias multiple sclerosis and diabetes.
PU. 1 is also a member of a large family of related transcription factors known as ETS that is involved in a broader range of cancers and other diseases.
This gene is especially interesting in Arabidopsis as mutations only cause the semi-dwarfism and have no further negative effects on the performance of the plants
They apparently can compensate for all of the effects of the loss except for the semi-dwarfism.
Koornneef and his colleagues have identified six different genetic causes for the semi-dwarfism. These include mutations that the prevent the growth factor from being formed with the correct size mutations that replace especially important amino acids with useless ones as well as mutations that prevent the proper splicing of MESSENGER RNA prior to the protein biosynthesis
Moreover Koornneef and his colleagues were able to show that Arabidopsis only rarely displays semi-dwarfism in the wild.
Koornneef's investigations also prove that semi-dwarfism has arisen independently in every location. The semi-dwarf Arabidopsis plants always had different genetic backgrounds explains the geneticist
The DNA sequence shows that a few plants attempted to rid themselves of the semi-dwarfism again.
The answer may be found somewhere within the genetics of the sheep and the course of the disease assessment and control of tick populations and biological control of ticks.
Weakens the immune systemtick-bites in sheep may result in the disease tick-borne fever (TBF) induced by the bacterium Anaplasma phagocytophilum (A. ph). TBF causes high fever
However they do not necessarily die from the infection says tick researcher Lise Grã¸va at Bioforsk Organic at Tingvoll in Norway.
The disease itself is not fatal but makes sheep more susceptible to secondary infections. Arthritis is the most common disease that can arise.
Illness normally occurs 10-14 days after grazing starts. Blood tests show that almost all the lambs are infected during the season in tick infested areas.
The direct cause of death due to TBF is often an acute pasteurella infection--a bacterial disease
which can cause acute blood poisoning with inflammation of the heart sac heart lungs or digestive organs.
It is recommended therefore to vaccinate sheep against pastuerella in areas where tick-borne fever is prevalent.
Disinfection of the umbilical cord in lambs immediately after birth has also been effective. It prevents new bacteria from entering the bloodstream.
and cause disease if the immune system is weakened. There are no exact figures as to how many lives ticks take compared to predators.
We know that individuals respond differently to infection. Some lambs experience a shorter period of fever and a shorter period with poor immune system after an infection than others.
We are also looking at whether some individuals have more ticks than others and whether this has an influence on the growth in lambs says Grã¸va. She emphasizes that having robust animals with good immune systems is a prerequisite for sheep husbandry in tick areas.
It is presumed that the infection can cause flu-like conditions. In people with impaired immune systems an infection can cause pneumonia
but as far as we know nobody has died from this says Grã¸va. Sick sheep are slaughtered not.
Tick##ites in sheep can lead to the disease tick-borne fever (TBF) which causes high fever
and weakens the immune system. As a result of TBF animals may become seriously ill from diseases they usually cope with.
Bioforsk is therefore conducting field trials where the aim is to reduce tick populations in sheep grazing areas by using a tick pathogenic fungus called Metarhizium.
#Higher dietary acid load increases risk of diabetes, study saysa study of more than 60 000 women has shown that higher overall acidity of the diet regardless of the individual foods
making up that diet increases the risk of type 2 diabetes. The study the first large prospective study to demonstrate these findings is published in Diabetologia the journal of the European Association for the Study of Diabetes (EASD)
and is by Dr Guy Fagherazzi and Dr Franã§oise Clavel-Chapelon Center for Research in Epidemiology and Population Health INSERM Paris France and colleagues.
whether increased acidosis caused by dietary acid loads increased the risk of type 2 diabetes.
A total of 66485 women from the E3n study (The french Centre of the European Prospective Investigation into Cancer and Nutrition a well-known ongoing epidemiological study) were followed for new diabetes cases over 14 years.
During follow-up 1372 new cases of incident type 2 diabetes occurred. In the overall population those in the top 25%(quartile) for PRAL had increased a 56 risk of developing type 2 diabetes compared with the bottom quartile.
Women of normal weight (BMI of 25 and under) had increased the highest risk (96%for top quartile
In our study the fact that the association between both PRAL and NEAP scores and the risk of incident type 2 diabetes persisted after adjustment for dietary patterns meat consumption
and intake of fruit vegetables coffee and sweetened beverages suggests that dietary acids may play a specific role in promoting the development of type 2 diabetes irrespective of the foods
We have demonstrated for the first time in a large prospective study that dietary acid load was associated positively with type 2 diabetes risk independently of other known risk factors for diabetes.
and may lead to promotion of diets with a low acid load for the prevention of diabetes.
John Middleton a professor in the MU College of Veterinary medicine says these higher levels of fat are often precursors to future health problems in cows.
These higher levels of fat in the liver are tied often to health problems in dairy cows including increased risk for uterus and mammary infections as well as ketosis
While the researchers did not find any direct links to health problems they say correlations with higher levels of fat in the liver call for further research into the health implications of low blood calcium levels.
#Obesity among risk factors for delayed lactation in women with gestational diabetespre-pregnancy obesity and older maternal age are among the risk factors for delayed lactation for women with gestational diabetes mellitus
or diabetes during pregnancy and to determine whether pre-pregnancy weight was an independent risk factor even after the severity of their GDM was taken into account.
and March 2011 in the Study of Women Infant Feeding and Type 2 Diabetes (SWIFT) an ongoing study of Kaiser permanente Northern California members who experienced a diagnosis of gestational diabetes.
(which is indicative of greater severity of gestational diabetes). Given the potential for breastfeeding to mitigate the higher risk that women with GDM face for developing type-2 diabetes skilled lactation support is particularly important for obese women with GDM said lead author Susana L
. Matias Phd a postdoctoral researcher at the Kaiser permanente Division of Research and the University of California Davis Department of Nutrition.
Gestational diabetes mellitus defined as glucose intolerance with first onset during pregnancy occurs in 7 percent of all U s. pregnancies
A history of GDM confers up to a sevenfold higher risk of diabetes and almost 50 percent of women with a GDM pregnancy will be diagnosed with type 2 diabetes within five to eight years after pregnancy.
Identification of risk factors for delayed milk production could help target breastfeeding support services and enable women with GDM to experience the benefits of lactation for their own future health and that of their offspring.
or mostly breastfeeding groups had lower prevalence of pre-diabetes than formula-feeding groups even among obese women.
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