#New approaches for controlling pesticide exposure in childrennew research on household pesticide contamination emphasizes the need for less reliance on pesticides
Families in Boston public housing developments for instance rank pest infestation pesticide use and pest allergies second only to crime as matters of concern.
#Bitter melon juice prevents pancreatic cancer in mouse modelsa University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose
Three years ago researchers showed the effect of bitter melon extract on breast cancer cells only in a Petri dish.
and kill pancreatic cancer cells says Rajesh Agarwal Phd co-program leader of Cancer Prevention and Control at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical
Diabetes tends to presage pancreatic cancer and bitter melon has been shown to effect TYPE II-DIABETES diabetes and has been used for centuries against diabetes in the folk medicines of China and India.
Following this line of thinking Agarwal and colleagues wondered what would happen if they closed out the middle man of diabetes
and directly explored the link between bitter melon and pancreatic cancer. The result Agarwal says is Alteration in metabolic events in pancreatic cancer cells
and an activation of the AMP-activated protein kinase an enzyme that indicates low energy levels in the cells.
Perhaps not coincidentally bitter melon also regulates insulin secretion by pancreatic beta cells. After studies in cell cultures the group showed that mouse models of pancreatic cancer that were fed bitter melon juice were 60 percent less likely to develop the disease than controls.
It's a very exciting finding Agarwal says. Many researchers are engineering new drugs to target cancer cells'ability to supply themselves with energy
and here we have a naturally-occurring compound that may do just that. The Agarwal Lab is now applying for grants that will allow them to move the study of bitter melon into further chemoprevention trials in mouse models of pancreatic cancer.
Story Source: The above story is provided based on materials by University of Colorado Denver. The original article was written by Garth Sundem.
The all-natural products the creation of which can take less than 5 days have no allergy concerns
and diarrhea and the number of affected cases is growing. Currently there is no cure; sufferers have to let the virus run its course for a few days.
#Fertilizers could help tackle nutritional deficiency in African countryenriching crops by adding a naturally-occurring soil mineral to fertilisers could potentially help to reduce disease
--which plays a vital role in keeping the immune system healthy and fighting illness--is likely to be endemic among the Malawi population.
People with low dietary selenium intakes are increased at risk of suffering from a variety of diseases.
and the wider Southern African region in the context of wider mineral malnutrition (for example iron zinc and iodine deficiencies) often referred to as the'hidden hunger'.
Protein misfolding has been linked with diseases such as Alzheimer's. Caetano-Anoll s said however that this research makes an important contribution to understanding how molecules work.
#Secondhand smoke exposure linked to signs of heart disease: Exposure to tobacco smoke may be more dangerous than previously thoughtnonsmokers beware.
or as an adult at work or at home--the more likely you are to develop early signs of heart disease according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session.
and the earliest detectable signs of heart disease. This research provides additional evidence that secondhand smoke is harmful
We actually found the risk of secondhand smoke exposure to be an equivalent or stronger risk factor for CAC than other well-established ones such as high cholesterol hypertension and diabetes.
and then to heart attacks so this lends more credence to enforcing smoking bans Dr. Hecht said.
We know heart disease is accelerated significantly by secondhand smoke exposure so it should be included as a routine part of medical exams
and discussions about heart disease and try to prevent it as best we can. This study included 3098 healthy people between 40 and 80 years old who had smoked never (defined as having smoked fewer than 100 cigarettes in their lifetime)
and who were enrolled already in the Flight attendant Medical Research Institute (FAMRI)- International Early Lung cancer Action Program CT screening program from 2005-2012.
and more likely to have diabetes high cholesterol and high blood pressure. Although his team did not use the standard Agatston score to assess CAC Dr. Hecht said this study further validates the utility of low-dose non-gated CT scans to measure the amount of plaque in the coronary arteries in nonsmokers exposed to secondhand tobacco smoke.
By using this imaging/approach people who have been exposed to tobacco smoke can be evaluated for lung cancer emphysema
and coronary artery disease in a single low-dose scan he said. As a general rule people should limit secondhand smoke exposure as much as possible.
The team hopes to next extend the system to detect the signs of disease bruising
Trying to control deer without a robust understanding of their true numbers can be like sleepwalking into disaster.
They also carry diseases such as Lymes and if numbers are managed not properly they can cause damage to crops as well as road traffic accidents.
A team led by Rice physicist Ching-Hwa Kiang found that shear forces like those found in small arteries of patients with atherosclerosis cause snippets of nonclotting VWF to change into a clot-forming shape for hours at a time.
and it's stored there until the cells get signals that the vessels are in danger of injury Moake said.
which prevents people from bleeding to death when blood vessels are damaged by cuts and wounds. The body recognizes
when clotting must stop --when there are too many strings too much sticking too many platelet clumps
Sometimes as in SD flies there are no apparent ill effects but when the selfish genes come in the form of viruses
and governance as was witnessed during the 2003 SARS threat. Similar action focused on curbing ivory demand is key
not only health but the harm tobacco places on their economy by passing laws to reduce use;
Avoidable and unnecessary tobacco-linked illnesses strike people in their prime hit the poorest hardest inhibit country productivity burden already weak healthcare systems
Cancer Society and the Institute of Global Tobacco Control at Johns hopkins university. Meeting attendees were warned by speaker after speaker that
unless there is a concerted international effort now the plague of tobacco smoking that has claimed 100 million lives in the Developed Nations will claim a billion in the Developing Nations where smoking has yet to take hold as it did during the last century in the U s. and other Developed nations.
mysterious disease syndrome as key factors in bee colony deathsa new long-term study of honey bee health has found that a little-understood disease study authors are calling idiopathic
brood disease syndrome (IBDS) which kills off bee larvae is the largest risk factor for predicting the death of a bee colony.
Hopefully this will give us insights into other health problems including colony collapse disorder. The paper Idiopathic brood disease syndrome and queen events as precursors of colony mortality in migratory beekeeping operations in the eastern United states is published in the February issue of Preventive Veterinary medicine.
Co-authors of the study include Dr. Eugene Lengerich of Penn State and Dr. Jeffery Pettis of USDA.
The global poaching crisis for elephants is at epidemic proportions said WCS Executive vice president for Conservation and Science John Robinson.
A weapon in the fight against kidney disease caused by high-fat dietsnew insight into grape seed extract as a therapeutic and preventative measure to fight obesity-induced kidney damage is presented in a new study.
and Metabolism is the first to make a link between GSSES and high-fat-diet-induced renal disease.
In our research obesity-induced leaky kidney and proteinuria are shown to be prevented by GSSE which suggests the use of GSSE as a preventive nutriceutical for high-risk patients said co-author Kamel Charradi a researcher with the Laboratory of Bioactive Substance at the Center of Biotechnology of Borj-Cedria (CBBC) in Tunisia.
This research group has published previously work showing the benefits of GSSE in combating obesity heart dysfunction brain lipotoxicity and kidney cancer.
and produce intestinal cells suggesting their potential to restore healthy tissue in patients with inflammatory bowel disease (IBD).
which is characterized by frequent diarrhea and abdominal pain. IBD actually refers to two conditions--ulcerative colitis and Crohn's disease--in
which the intestines become red and swollen and develop ulcers probably as the result of the body having an immune response to its own tissue.
While there is currently no cure for IBD there are drug therapies aimed at reducing inflammation and preventing the immune response.
While maize is grown in the area today they were able to rule out modern day contamination
and others to study how livestock diet affected the transport of pathogens in field runoff from manure-amended soils.
Results from these studies have been published in Foodborne Pathogens and Disease Applied and Environmental Microbiology and Transactions of the ASABE.
#Modifying infants diet may reduce celiac disease risk, Swedish study suggestsceliac disease is much more common in Sweden than in the rest of Europe
and the U s. but may be prevented with gradually introducing gluten-containing foods to breast-feeding infants according to a comprehensive study led by researchers at Ume㥠University.
Celiac disease also known as gluten intolerance is a chronic disease whose only treatment is a lifelong strict gluten-free diet
Until the 1970s celiac disease was unusual and was diagnosed in only 0. 001%of all children.
Between 1984 and 1996 however Sweden was hit by an epidemic of celiac disease in children under 2 years of age.
A fourfold increase in incidence of clinically detected disease followed by a comparable decrease decade later was conï rmed through the National Swedish Childhood Celiac disease Register.
Through further investigation of the epidemic researchers have shown now that celiac disease currently affects up to 3%of all young people.
It is shown also that the risk of developing the disease can be reduced when the child is breastfed
and in the United states. We now have proven this way of introducing gluten reduces the risk of getting celiac disease says Dr. Anneli Ivarsson.
which is part of the Preventcd European project ETICS is a screening study conducted in 2005-2011 among 12-year-olds born during the epidemic (1993) and after (1997).
The blood samples were analysed for celiac disease and the children who had elevated levels were called to the nearest pediatric clinic for a small intestinal biopsy to check for disease suspicion.
In summary for a twelve year period starting in 1984 Sweden experienced a unique epidemic of celiac disease in the youngest children.
It was developed by a decade of adverse infant nutrition and Sweden has by far the highest incidence of celiac disease in Europe
and the United states. It is estimated that there are upwards of 150000 people with celiac disease in Sweden
of which about 100000 have not yet received proper diagnosis and treatment. Increased attention is needed at all for so many victims as possible to get the proper diagnosis
and treatmentceliac disease is much more common in Sweden than in the rest of Europe
Celiac disease also known as gluten intolerance is a chronic disease whose only treatment is a lifelong strict gluten-free diet
Until the 1970s celiac disease was unusual and was diagnosed in only 0. 001%of all children.
Between 1984 and 1996 however Sweden was hit by an epidemic of celiac disease in children under 2 years of age.
A fourfold increase in incidence of clinically detected disease followed by a comparable decrease decade later was conï rmed through the National Swedish Childhood Celiac disease Register.
Through further investigation of the epidemic researchers have shown now that celiac disease currently affects up to 3%of all young people.
It is shown also that the risk of developing the disease can be reduced when the child is breastfed
and in the United states. The researcher team led Dr. Anneli Ivarsson at the Department of public health and Clinical Medicine speculate that there may be a window of opportunity in which an infanwe now have proven this way of introducing gluten reduces the risk of getting celiac disease says Dr
which is part of the Preventcd European project ETICS is a screening study conducted in 2005-2011 among 12-year-olds born during the epidemic (1993) and after (1997).
The blood samples were analysed for celiac disease and the children who had elevated levels were called to the nearest pediatric clinic for a small intestinal biopsy to check for disease suspicion.
In summary for a twelve year period starting in 1984 Sweden experienced a unique epidemic of celiac disease in the youngest children.
It was developed by a decade of adverse infant nutrition and Sweden has by far the highest incidence of celiac disease in Europe
and the United states. It is estimated that there are upwards of 150000 people with celiac disease in Sweden
of which about 100000 have not yet received proper diagnosis and treatment. Increased attention is needed at all for so many victims as possible to get the proper diagnosis and treatmentstory Source:
A University of Colorado Cancer Center review published in this month's issue of the journal Current Opinion in Gastroenterology shows that resistant starch also helps the body resist colorectal cancer through mechanisms including killing pre-cancerous cells
and reducing inflammation that can otherwise promote cancer. Resistant starch is found in peas beans
But consumed correctly it appears to kill pre-cancerous cells in the bowel says Janine Higgins Phd CU Cancer Center investigator and associate professor of Pediatrics at the University of Colorado School of medicine.
and sizes of lesions due to colorectal cancer and an increased number of cells that express the protein IL-10 which acts to regulate the body's inflammatory response Resistant starch may also have implications for the prevention
of breast cancer Higgins says. For example if you let rats get obese get them to lose the weight
This effect on obesity may help to reduce breast cancer risk as well as having implications for the treatment of colorectal cancer.
There are a lot of things that feed into the same model of resistant starch as a cancer-protective agent Higgins says.
which benefits exactly will pan out as mechanisms of cancer prevention one thing is clear: resistant starch should be on the menu.
and were successful in doing So long-term smokeless tobacco use is associated with cardiovascular disease and cancer.
The study was funded by the National Cancer Institute (R01 CA121165. Story Source: The above story is provided based on materials by Mayo Clinic.
Advantages of using plants to produce therapeutic proteins include the ability to produce large quantities quickly and cheaply the absence of human pathogens the stability of the proteins and the ease with
Instead the scientists say they should be grown under clearly defined and enforced conditions to keep the food and animal feed chain'contamination free'.
They chose the first plant-derived anti-HIV monoclonal antibody to be tested in humans. It was isolated purified
#Phosphorus starvation linked to symptoms of citrus disease Huanglongbing in new studythe citrus disease Huanglongbing (HLB) meaning yellow shoot disease in Chinese
and also called citrus greening in English-speaking countries is the most destructive disease threatening the citrus industry worldwide.
A new study'Small RNA profiling reveals phosphorus deficiency as a contributing factor in symptom expression for citrus Huanglongbing disease'published online February 19 in the journal Molecular Plant profiled small
Symptoms of the disease include blotchy mottled leaves sections of yellow and underdeveloped vegetative growth premature fruit drop
These high costs are largely due to the need for more additional treatments to mitigate the disease's effects
of which regulate plant responses to microbial infections. To study the expression of citrus srnas in response to HLB we grafted 19 greenhouse-grown healthy sweet orange plants with HLB-positive bark or leaf pieces.
Both donor and receptor trees tested negative for other graft-transmissible pathogens of citrus. As controls five plants were mock-inoculated with pathogen-free healthy tissue.
Samples were collected at 10-and 14-week post inoculation/grafting for small RNA profiling. Leaves were collected also continuously at later points to ensure that the tissue used for srna libraries was from the diseased trees. srnas ranging from 18 to 28 nucleotides were isolated cloned
which means that they can potentially be developed into early diagnosis markers for the disease. This is important because
In particular mir399 which is induced by P starvation in other plant species was discovered to be induced by HLB infection in the diseased citrus trees.
and in older adults slower walking speed is a predictor of disability nursing home admission and even death.
As the burden of disability becomes increasingly common and expensive identification of modifiable contributors to functional decline in older adults is emerging as a significant priority of public health research Beavers said.
A leafy plant related to a common weed known as lamb's quarter was infected also with a virus that caused a local infection.
The infection was enough to boost the plant's drought tolerance and may mean that the virus does not have to actively replicate in the cells where the resistance to drought occurs according to Roossinck.
and grow them better and more tolerant of environmental stress like heat and drought or pathogens?
#Links between ozone levels and cardiac arrest analyzedresearchers at Rice university in Houston have found a direct correlation between out-of-hospital cardiac arrests and levels of air pollution and ozone.
if there is a link between ambient ozone levels and cardiac arrest. Ensor is a professor and chair of Rice's Department of Statistics and Raun is a research professor in Rice's Department of Statistics.
and more than 11000 concurrent out-of-hospital cardiac arrests (OHCA) logged by Houston Emergency Medical Services (EMS).
Early intervention is seen as critical as the chance of survival for a person suffering cardiac arrest drops 10 percent for every minute he
The beetles don't carry disease but their larvae feed on the ash trees'sap effectively killing the trees by depriving trees of their nourishment.
In the last 15 years disease ecology has really come to the fore as a basic science. Most of what is known about plant viruses comes from studies of crops.
and still thriveresearchers have studied viruses as agents of disease in humans domestic animals and plants but a study of plant viruses in the wild may point to a more cooperative benevolent role of the microbe according to a Penn State virologist.
When most people think of viruses they think of serious diseases and death such as the AIDS virus Roossinck said.
However on a research trip in Costa rica a biodiversity hot spot in Central america she noticed that unmanaged wild plants looked healthier than managed agricultural fields.
In the melons it was causing severe disease while in the wild plants there were no symptoms.
Roossinck said she is curious about how the wild plants avoid disease and if there is a way this can be used in agriculture.
#Researchers find potential new therapeutic target for treating non-small cell lung cancerresearchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer.
IKBKE overexpression has been associated with breast and prostate cancers. However it had not been linked to environmental carcinogen such as tobacco smoke until now.
Tobacco smoke is documented the strongest initiator and promoter of lung cancer. The traditional model holds that tobacco components promote carcinogenesis through a process that leads to DNA damage.
Recent studies have shown that tobacco smoke can also promote lung cancer through changes in the pathways that regulate cell proliferation and survival.
in order to find potential drug targets to treat non-small cell lung cancer. In this study IKBKE was found to be induced by two tobacco carcinogens:
Their findings suggest that IKBKE is a key molecule related to tobacco-induced lung cancer. Since IKBKE kinase is induced by tobacco small molecular inhibitors of IKBKE could have a therapeutic drug potential for lung cancer explained lead author Jin Q. Cheng Ph d. M d. senior member
of the Molecular Oncology Department at Moffitt. Current treatments for non-small cell lung cancer include surgery radiotherapy and chemotherapy.
However patients eventually develop resistance to treatment. There is a great need to better understand the molecular mechanism of resistance
According to the researchers STAT3 is activated frequently in various types of human cancers and when activated STAT3 increases IKBKE overexpression and protein levels.
In non-small cell lung cancer nicotine-induced IKBKE depends on STAT3. The authors noted that the activation stage of STAT3 represents an attractive therapeutic potential
and IKBKE levels increase in response to nicotine and nicotine-derived nitrosamine ketone this evidence can be used potentially to develop a non-small cell lung cancer intervention strategy that targets IKBKE concluded Cheng.
The work was supported by National Cancer Institute Grants CA137041 and P50 CA119997 and James & Esther King Biomedical Research Program 1kg02 1kd04 and 1kn08.
The above story is provided based on materials by H. Lee Moffitt Cancer Center & Research Institute.
The first project was launched in 2009 by the Department of energy at a corn ethanol production facility in Decatur Ill. operated by the Archer daniel midlands Company.
and disease resistance as a way to eliminate unpromising lines early in the process. To do this the K-State team including graduate students Nan An Brent Christenson
Every year an estimated 443000 people in the United states die from smoking or exposure to secondhand smoke according to the federal Centers for Disease Control and Prevention (CDC.
Another 8. 6 million people suffer from a serious smoking-related illness. Annually costs associated with smoking-related illness account billions in medical expenses
and lost productivity and 5. 1 million years of potential life lost in the United states the CDC reports.
The voter-funded state program centers on changing social norms around smoking to reduce smoking and tobacco-induced diseases.
The research was supported by TRDRP Grant 18st-0201 and National Cancer Institute Grant CA-61021.
The new study focused on two of the most widespread mycotoxin contaminants of grain crops--deoxynivalenol (DON) and zearalenone (ZEN.
and Mexico according to a University of Michigan ecologist who studies the disease. The current outbreak of coffee rust is seen the worst in Central america
and Mexico since the fungal disease arrived in the region more than 40 years ago. Guatemala recently joined Honduras and Costa rica in declaring national emergencies over the disease.
The Guatemalan president said the outbreak could cut coffee production by 40 percent in his country for the 2013-2014 growing season.
They all say that it's the worst explosion of this disease they've ever seen said Vandermeer a professor in the Department of Ecology and Evolutionary Biology and at SNRE.
And this year it seems to have hit a tipping point where the various things that are antagonistic to the roya in a complex ecosystem have declined to the point where the disease can escape from them
It could be that this disease is just going to run itself out this year and will then return to previous levels he said.
The path this disease takes will have huge implications for the region's coffee producers. Coffee rust is the most important disease of coffee worldwide.
It was discovered first in the vicinity of Lake victoria in East Africa in 1861 and was identified later
The disease soon spread to much of Southeast asia and eventually throughout the southern central and western coffee-growing regions of Africa.
Since 1970 the disease has spread to every coffee-growing country in the world according to the Coffee Research Institute.
Coffee rust spores are spread by the wind and the rain from lesions on the underside of leaves.
Long-term exposure can lead to the development of different types of cancer as well as serious cardiovascular neurological and other health problems.
Although the yield of aromatic rice is lower the farmers will not need to spend much money on applying chemicals that could pollute the environment and harm their own health.#
It could also benefit people suffering from celiac disease who consume rice-based foods on a regular basis. Therefore it is essential that further research on aromatic rice from different parts of Bangladesh
and Technology are the latest in a long effort to understand the environmental aspects of antibiotic resistance which threatens decades of progress in fighting disease.
Alvarez contended that confined animal feeding operations (CAFOS) are potential sources of environmental contamination by antibiotics
which can cause allergic reactions in some humans. Asian needle ants also appear to be driving out native ant populations in forests--including native species that play important roles in ecosystem processes such as dispersing seeds.
when cholera had been ravaging the capital Dr Wickstead explained. A garden on a site like this might tell us more about the people who lived
and vegetables to the diet may help protect the kidneys of patients with chronic kidney disease (CKD) with too much acid build up according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).
#¢Urine measurements of kidney injury were lower after one year in both groups.#¢#¢Although fruits and vegetables are rich in potassium
and vegetables patients had a favorable response by reduction of urinary kidney injury markers said Dr. Wesson.
Our study suggests that these interventions will help maintain kidney health in those with kidney disease added Dr. Goraya.
and without dietary intervention in patients with chronic kidney disease is needed urgently. Study co-authors include Jan Simoni Phd and Chan-Hee Jo Phd.
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