#Clinical trial studies vaccine targeting cancer stem cells in brain cancersan early-phase clinical trial of an experimental vaccine that targets cancer stem cells in patients with recurrent glioblastoma multiforme
the most common and aggressive malignant brain tumor has been launched by researchers at Cedars-Sinai's Department of Neurosurgery Johnnie L. Cochran Jr.
Brain tumor Center and Department of Neurology. Like normal stem cells cancer stem cells have the ability to self-renew
The drug targets a protein CD133 found on cancer stem cells of some brain tumors and other cancers.
and grown in the laboratory before being injected under the skin as a vaccine weekly for four weeks and then once every two months according to Jeremy Rudnick MD neuro-oncologist in the Cedars-Sinai Department of Neurosurgery
and Department of Neurology the study's principal investigator. Dendritic cells are the immune system's most powerful antigen-presenting cells--those responsible for helping the immune system recognize invaders.
Cedars-Sinai's brain cancer stem cell study is open to patients whose glioblastoma multiforme has returned following surgical removal.
The human sense of smell is far better at guiding us through our everyday lives than we give it credit for said senior author Johan Lundstrã m Phd a cognitive neuroscientist at Monell.
Fat molecules typically are not airborne meaning that they are unlikely to be sensed by sniffing food samples said lead author Sanne Boesveldt Phd a sensory neuroscientist.
which in turn sends a nerve signal to the brain. In response the brain triggers a range of protective effects against diabetes and obesity:
the sensation of hunger fades energy expenditure at rest is enhanced and last but not least the liver produces less glucose.
and Swidbert Ott from the Champalimaud Neuroscience Programme the Instituto Gulbenkian de Ciã ncia in Portugal and the University of Cambridge as they reveal that the locust'solitarious
To Simå es and colleagues'surprise it was found that this was due to an incapacity by newly gregarious locusts to acquire negative/aversive memories that made them on encountering toxic plants see these as appetitive.
--while solitarious and gregarious locusts had no problem gaining negative memories (so being conditioned to link vanilla to the unpalatable diet)
In contrast all 3 stages gained without problems the positive/appetitive memories (to link the lemon odour to nutritious food.
On the other hand if the animals were trained first then crowded and only after tested crowding had no effect on (old) memories
This showed that during the locusts'initial period of gregarization/crowding (transiens form) the animals can not acquire new negative memories.
Since crowding blocks new negative memories could the old negative memory be replaced simply by a positive one?
even if crowding cannot eliminate a previous memory by temporarily blocking new aversive memories it permits an update of it
This capacity to override previous memories which only occurs during the initial stages of gregarization/crowding is crucial for survival in the swarm because with increasing numbers of individuals also raises not only competition for food but also exposure to predators.
despite being able to gain aversive memories lies in their learning mechanism. In fact while solitarious locusts acquire aversive memories in about 4 hours most probably through a taste-controlled mechanism gregarious animals take 24 hours to show a reaction
(and transiens never do). This suggest that the gregarious'learning mechanism is post-ingestive and most probably dependent on food toxicity instead of taste.
since they simply do not acquire new negative memories suggesting that they are even more resilient to toxicity than gregarious.
and the fatty acids that would have been particularly important for the hominin brain. Her finding is grounded in existing data that details the diet of year-old baboons in Amboseli National park in Kenya--a similar environment to that once inhabited by Paranthropus boisei.
They also provided a good source of nourishment for a medium-sized hominin with a large brain.
and brain) while some are detrimental to your health (trans fat increases heart disease risk factors).
#Researchers target cancer stem cells in malignant brain tumorsresearchers at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute and Department of Neurosurgery identified immune system targets on cancer
stem cells--cells from which malignant brain tumors are believed to originate and regenerate--and created an experimental vaccine to attack them.
A Phase I safety study in human volunteers with recurrent glioblastoma multiforme the most common and aggressive brain tumor in adults is underway.
The researchers identified certain fragments of a protein--CD133--that is found on cancer stem cells of some brain tumors and other cancers.
but we now have a human clinical trial underway to assess safety for further study said John Yu MD vice chair of the Department of Neurosurgery director of surgical neuro-oncology medical director
of the Brain tumor Center and neurosurgical director of the Gamma Knife Program at Cedars-Sinai.
There are so many hare-brain environmental schemes out there and in the whisky industry that just don't work
Argentine greenhouse robot brings automation to the massesbuenos AIRES--The new Trakã Â r agricultural robot does not have the brains, firepower or complexity of one of the Transformers,
resource control and competition Bioengineering e coli to turn seaweed into fuel Fatty foods cause brain scarring, study shows
computing leadsif you could measure 2010 in terms of brainpower, it was a banner year. That's because innovation levels--as measured by patent volume--are higher than ever, with activity across the majority of 12 key industries,
and memories, film and hybrid circuits. On the other hand, materials and processes showed gains, thanks to Korea's Samsung and Hynix Semiconductor and Japan s Toshiba.
But the tiny brain in this little thing could take you places you've never been before,
The honey bee has a puny brain. But man is that miniscule mound of gray matter finely tuned as the winged pollinator's mission control center.
They're building a computer model that unlike other AI projects does not mimic the brains of human, monkeys or mice.
Because the honey bee brain is smaller and more accessible than any vertebrate brain, we hope to eventually be able to produce an accurate and complete model that we can test within a flying robot.
Step aside pea brain. Hello bee brain. Warranty void after one sting. Photo: Mouagip via Wikimeda.
More natural navigation on Smartplanet: Save a bird: Turn off a light
To cut fire risk, San francisco airport hires 400 goatsshrubs and small trees around airports could become fire hazards for nearby homes
But the commercial production of large amounts of synthetic pheromones requires the use of harmful chemicals (such as neurotoxins hexane
Bosco Verticale is the brainchild of Stefano Boeri, whose firm Stefano Boeri Architetti is focused on contemporary architecture and urbanism.
Brain scans? Robots doing autopsies? Probably not. Even before more human lead autopsies are done, researchers will need a better understanding of female sexuality.
As chief structural engineer at Skidmore, Owings & Merrill, the famed Chicago architecture firm, Baker is the brains behind dozens of landmarks:
People who have this inherited disease endure progressive damage to the heart, brain, and other organs,
Human brains do in fact weigh about three pounds(#55. Some are simply unverifiable: grapes are the most popular fruit in the world(#371)
and then these other forms that have larger brains, that have stone-tool technology and,
. I don't have any memories from my childhood of zoos. For me, when my older daughter was old enough to drag me to the Buffalo Zoo,
Johns hopkins university in Baltimore  observed that people who took a caffeine pill scored higher on memory tests than did swallowed those who a dummy tablet, the BBC reportsâ in a summary of an article in Nature Neuroscience.
Bionic beesengineers from the universities of Sheffield and Sussex are planning on scanning the brains of bees
It's important to note that this won't be an entirely comprehensive model of a bee's brain--it's only going to be associated the parts with its sense of smell and vision.
what the team call a"Green Brain, "one that can react to new situations and improvise rapidly just like a"real"animal or insect brain.
The project has been funded by the Engineering and Physical sciences Research Council with a £1m grant, with Nvidia providing some of its top-end graphics processors for the development team to work with.
but we also believe the computer modelling techniques we will be using will be widely useful to other brain modelling and computational neuroscience projects".
have personalities like vertebrates--let's hope they upload a relatively laid-back bee's brain, lest it go rogue
I wanted an herbal compound that provided neural protection in the brain. L-theanine (also known as gamma-glutamylethylamide,
and glutamate and can cross the blood-brain barrier to directly affect the brain. Among its psychoactive properties, theanine is reported to reduce mental stress and improved cognition and mood via its binding to the GABA brain receptors in the parasympathetic nervous system.
Thus, theanine appears to increase the overall level of the brain inhibitory transmitter GABA and is reported to promote alpha wave production in the brain.
Theanine also increases brain dopamine concentrations and has significant affinities for the AMPA and NMDA receptors.
The NMDA receptors help control memory and synaptic plasticity. Theanine may also have positive effects on serotonin levels to promote restful Sleep in rats,
theanine is neuroprotective. All of these neuroprotective properties of L-theanine make it a strong complementary addition to the three essential core herbs of the herbal mix.
< Back - Next >
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011