Tropes

ScienceDaily_2014 00499.txt

#Tobacco use associated with increased risk of oral HPV-16 infectionstudy participants who reported tobacco use or had higher levels of biomarkers of tobacco exposure had a higher prevalence of the sexually transmitted infection oral human papillomavirus type 16 (HPV-16) according to a study in the October 8 JAMA a theme issue on infectious disease. Oral HPV-16 is believed to be responsible for the increase in incidence of oropharyngeal squamous cell cancers in the United states. An association between self-reported number of cigarettes currently smoked per day and oral HPV prevalence has been observed according to background information in the article. Carole Fakhry M d. M p h. of the Johns hopkins university School of medicine Baltimore and colleagues investigated associations between objective biomarkers reflective of all current tobacco exposures (environmental smoking and use of smokeâ less tobacco ) and oral HPV-16 prevalence. The researchers used data from the National Health and Nutrition Examination Survey (NHANES) a probability sample of the U s. population. Mobile examination center participants ages 14 to 69 years were eligible for oral HPV DNA testing. Computer-assisted self-interviews were used to ascertain self-reported tobacco use and sexual behaviors. Selfâ reported tobacco use for the past 5 days included any nicotineâ containing product. Biomarkers of recent tobacco use included serum cotinine a major nicotine metabolite and urinary 4-(methylnitrosamino)- 1-(3-pyridyl)- 1-butanol (NNAL) a tobaccoâ specific carcinogenic metabolite. This analysis included 6887 NHANES participants of whom 2012 (28.6 percent) were current tobacco users and 63 (1. 0 percent) had oral HPV-16 detected. Current tobacco users were more likely than nonusers to be male younger less educated and to have a higher number of lifetime oral sexual partners. Self-reported and biological measures of tobacco exposure as well as oral sexual behavior were associated significantly with prevalent oral HPV-16 infection. Oral HPV-16 prevalence was greater in current tobacco users (2. 0 percent) compared with never or former tobacco users (0. 6 percent. Average cotinine and NNAL levels were higher in individuals with vs without oral HPV-16 infection. These findings highlight the need to evaluate the role of tobacco in the natural history of oral HPV-16 infection and progression to malignancy the authors write. Story Source: The above story is provided based on materials by JAMA-Journal of the American Medical Association. Note: Materials may be edited for content and length. Journal Reference R

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