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With recent advances in technology such as Bluetooth, we are now able to build medical devices that weren't possible just a decade ago#.
"For people who live far from hospitals, in places like Africa, this could be life changing.#
#Award-winning innovation revolutionises vaccine production A European union (EU)- funded research project has opened up a radical new era in the world of vaccine discovery and production.
Focused on veterinary vaccines, the project's work has made possible a dramatically faster and more effective route to the creation of vaccines to combat some of the most devastating diseases affecting farm livestock.
The same accelerated route can be used to uncover a vast new range of urgently-needed vaccines for humans as well.
Named PLAPROVA (Plant Production of Vaccines), the project was the successful result of an unprecedented co-funding initiative between the EU and Russia
with Russia matching the#2 million of funding provided by the EU under its 7th Framework Programme.
the PLAPROVA consortium focused on the use of plants proteins to produce vaccines against diseases such as avian flu, bluetongue, foot and mouth disease,
which has revolutionary implications for future vaccine production. It also helped win a major innovation award for the lead researcher.
This triggers the production of proteins which are of potential pharmaceutical interest as the basis for new vaccines.
thus opening up much wider possibilities for genuinely novel vaccines. Previously, the timescale required before results were known for just a single protein meant researchers naturally played safe and tended to produce'biosimilars'
i e. vaccines which replicated already existing ones. It was a situation which discouraged the search for new products.
when dealing with seasonal outbreaks when a vaccine needs to be created urgently, usually in a matter of months from the time the strain of disease is first indentified.
Discussions are in progress with vaccine manufacturers in South africa about production of a bluetongue vaccine. And a Canadian firm, Medicago Inc, has applied successfully the technique to the discovery and production of pandemic flu vaccines for humans, on
which it has completed recently a Phase II clinical trial. The revolutionary impact of the new PLAPROVA technique
with the possibilities it opens up for future work in vaccine discovery, was recognised with the naming of Professor Lomonossoff as Innovator of the Year 2012 by the Biotechnology and Biological sciences Research Council (BBSRC), U s
but also for public health budgets and for the European biotechnology industry n
#FLEXPAKRENEW#Green materials for flexible packaging Over 16 million tonnes of flexible packaging are used each year across Europe.
##The technology can be embedded in any porous material such as cloth potentially opening the door for wider applications says Collins. He envisions smart scrubs for health care workers that can sense exposure to a virus;
and efficacy requirements for using this wireless charging system in commercial medical devices. But it has the potential to eliminate bulky batteries
Either way, far-field electromagnetic waves have been ignored as a potential wireless power source for medical devices. Near-field waves can be used safely in wireless power systems.
Some current medical devices like hearing implants use near-field technology. But their limitation is implied by the name:
just as mass, anonymised patient records could improve health care. But its success depends on service providers persuading users (farmers
#Synthetic vaccine could prevent future outbreaks of foot-and-mouth disease Virologists have devised a way to create an entirely synthetic vaccine for foot-and-mouth disease.
The vaccine could prevent future outbreaks of the disease, and potentially lead to new treatments for polio and other human diseases.
and spurred a decision to protect against future outbreaks with vaccination rather than mass slaughter.
however a vaccine made from inactivated virus caused another UK outbreak. The authors say that there is absolutely no chance that their new vaccine could revert into an infectious virus
because it contains no viral genes. Also being entirely synthetic, it cannot be contaminated with live virus during manufacturing.
It will be 6-8 years before the vaccine is available to farmers, they estimate. But if the method used to create the vaccine proves successful when scaled to commercial production,
it could also be used to create vaccines for human diseases that are caused by viruses of the same family, such as hand, foot and mouth disease,
which is ubiquitous in Southeast asia, and polio, which still blights the lives of millions of people in the developing world."
But if we could use this to move away from inactivated polio viruses in the vaccines,
Earlier attempts to produce a synthetic vaccine for foot and mouth disease were thwarted often by peculiarities of viral geometry.
The team got around the problem by engineering the vaccine to have disulphide bonds cross-linking the protein triangles together.
says John Oxford, a virologist at St bartholomew s and the Royal London Hospital.""This really is an ace paper#they've truly given the entire issue a whole new dimension,
and Charleston that the new vaccine is unable to cause an infection or outbreak. Marvin Grubman, an animal-disease researcher at the US Department of agriculture in Orient Point, New york, says that the new vaccine"is a good piece of work,
but certainly not very novel, pointing to a foot-and-mouth vaccine his team devised that uses adenovirus to deliver empty viral shells.
That vaccine, he says, has been approved for use in the United states for cases of emergency. The authors however point out that their vaccine does not require the injection of live viruses
and that it would be suitable for preventive vaccination as well as in cases of severe outbreaks o
#Gene-analysis firms reach for the cloud For Chaim Jalas at the Center for Rare Jewish Genetic disorders in New york,
DNA sequencing is the easy part. It costs less than US$1, 500 per person to have the important parts of his clients genomes sequenced.
as ever more affordable sequencing moves from academia into the clinic (see Nature 494,290-291; 2013).
and hospitals to analyse data. But one of the biggest questions will be how deeply analysis companies can reach into medical settings,
Hospitals can be fined if patient privacy is compromised, and clinical geneticists may be uneasy about uploading data to the cloud."
That is a large part of why many hospitals have chosen so far to build their own analysis infrastructure,
"says Dmitry Oleynikov at the University of Nebraska Medical center.""That difficulty increases logarithmically when you're trying to do complex procedures such as an operation."
who are demonstrating delivery of vaccines in Africa. Delta Drone in France is using the platform for open-air mining operations,
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
An atomically thin two-dimensional ultrasensitive semiconductor material for biosensing developed by researchers at UC Santa barbara promises to push the boundaries of biosensing technology in many fields from health care to environmental protection to forensic industries.
Medical devices designed to reside in the stomach have a variety of applications, including prolonged drug delivery, electronic monitoring,
Now, researchers at MIT Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern
medical devices and Internet of things devices anything that doesn require massive amounts of electricity. It will be launching on Kickstarter in one month for $99,
and will diagnose diseases without requiring specialized laboratories particularly useful in regions with limited access to doctors and hospitals.
He envisioned a mog Free Towerthat would operate using the same air purifying technology hospitals do.
While noting that the work will need still refinement before it becomes a public health threat, he marveled at how quickly developments had been unfolding in bioengineering--for morphine synthesis
Paramedics equipped with these fizzy bandages could prolong the lives of patients during transit to the hospital, for instance
Dr James Fildes, from the University's Collaborative Centre for Inflammation Research and the Transplant Centre at the University Hospital of South Manchester NHS Foundation Trust, led the study.
#Ebola Vaccine Demonstrates 100%Protection in Latest African Trial According to an unusual new study, published last week in the world most prestigious medical journal Lancet, the deadly outbreak
might finally come to an end a vaccine, developed by the Public health Agency of Canada and manufactured by the American pharmaceutical company Merck Sharp & Dome, was shown just to confer 100%protection against the disease,
starting mere 10 days after receiving a single shot. One of the two currently-tested Ebola vaccines has been shown in a recent trial to provide 100%protection against the disease
starting just 10 days after receiving a single shot. Image credit: Julien Harneis via flickr. com, CC BY-SA 2. 0. his will go down in history as one of those hallmark public health efforts,
said Michael Osterholm, Director of the Center for Infectious disease Research and Policy in Twin cities, Minnesota,
who wasn involved in the study. e will teach about this in public health schools. he vaccine,
the researchers opted for a design called ring vaccination, whereby only the contacts, and the contactscontacts, of new Ebola patients were vaccinated.
This type of approach has never been used in a formal vaccine study ever before. The rings, also called clusters, were randomized such that 48 of them received the vaccine right after a new Ebola case sprung up in their community,
while the other 42 received a shot only three weeks afterwards. Of the 2, 380 people who were assigned to the latter group,
16 got infected. In the second group consisting of 2 014 people the count of new Ebola cases was zero,
The Director-General of THE WHO Margaret Chan called for further studies to clear up any lingering doubts about the vaccine efficacy,
#Researchers Smash Records with Pig-to-Primate Organ transplants With the financial aid of a biotechnology executive whose daughter may need a lung transplant,
or between-species organ transplants. The researchers say they have kept a pig heart alive in a baboon for 945 days
achieved by Massachusetts General Hospital. Also this summer, transplant experts at the University of Pittsburgh said they kept a baboon alive with one of Revivicor pig kidneys for more than four months.
surgeons at St vincent Hospital in New south wales described three cases in which they waited as little as two minutes after a person heart stopped before they began removing it.
says Stephen Large, a surgeon at Papworth Hospital in the United kingdom, which has used the system as part of eight heart transplants.
a transplant surgeon at the Massachusetts General Hospital. arm is the way to go with metabolically active tissue. everal small companies are working on warm perfusion machines,
Donors at the Papworth hospital have included victims of car accidents and failed suicide attempts by hanging.
and I would say they are not. arge hospital, in a rural area a half hour drive from Cambridge, has taken some new and even more radical steps,
returning to the hospital the following day for the clinician to retrieve images from the pad. uture works include optimising the system model
For this purpose the KIT scientists established a pilot plant at the hospital of Wonosari There bacteria in the water are reduced among others by UV radiation
and hence are suited mainly for urban facilities such as schools and hospitals. In the villages where power is need lacking we much simpler technologies Obst says.
By a pipeline system fecal sludge of the hospital enters a two-stage unaerobic reactor where it is mixed with biowaste.
It is used then for the gas stoves in the kitchen of the hospital. The remaining solid is applied as a fertilizer on the fields in the vicinity.
#Bioinspired coating for medical devices repels blood, bacteria From joint replacements to cardiac implants and dialysis machines medical devices enhance
or save lives on a daily basis . However any device implanted in the body or in contact with flowing blood faces two critical challenges that can threaten the life of the patient the device is meant to help:
They developed a new surface coating for medical devices using materials already approved by the Food and Drug Administration (FDA.
Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical school and Boston Children's Hospital as well as professor of bioengineering at Harvard School of engineering and Applied sciences (SEAS.
--so we further adapted our approach by capitalizing on the natural roughness of chemically modified surfaces of medical devices said Aizenberg who leads the Wyss Institute's Adaptive Materials platform.
The Wyss team developed a super-repellent coating that can be adhered to existing approved medical devices.
While most of the team's demonstrations were performed on medical devices such as catheters and perfusion tubing using relatively simple setups they say there is a lot more on the horizon.
We feel this is just the beginning of how we might test this for use in the clinic said co-lead author Daniel Leslie Ph d. a Wyss Institute Staff Scientist who aims to test it on more complex systems such as dialysis machines
Reflecting the strong collaborative model of the Wyss Institute the cross-disciplinary team included researchers representing the Wyss Institute SEAS Harvard Medical school and Boston Children's Hospital
What emerged could become a new paradigm for implantable medical devices extracorporeal circuits and more. Story Source:
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
Essentially, doctors at the Columbia University Medical center have been able to print a knee meniscus using a degradable plastic scaffold and a protein growth system.
Unfortunately, many common diagnostic tools, such as enzyme-linked immunosorbant assay (ELISA), require large and expensive readout instruments that can only be found in well-equipped hospital labs. Now,
and vaccination tracking campaigns in resource-poor and field settings. In addition to serving low-resource or remote areas, the researchers noted that intrinsic wireless connectivity can serve epidemic-related studies,
it is used in many hospitals all over the world. Among other applications, ELISA tests can be used to determine
or tracking vaccination campaigns in most resource-poor settings. It fantastic for an undergrad to be first author on the publication.
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
"Morphine plays a vital role in pain relief in many hospitals, but it requires a poppy harvest to manufacture.
The operation, at Manchester Royal Eye Hospital, is the first time it has been implanted in a patient with age-related macular degeneration (AMD)
and was led by Paulo Stanga, consultant ophthalmologist and vitreo-retinal surgeon at Manchester Royal Eye Hospital and professor of ophthalmology and retinal regeneration at the University of Manchester.
Four more patients with dry AMD will receive the implant at Manchester Royal Eye Hospital,
which aims to bring new drugs and medical devices to patients. Cathy Yelf, of the Macular Society, said:"
Bringing techniques and testing that is normally confined to a laboratory or hospital, out into the field,
unlike traditional techniques that are using instruments that you normally find in a lab or hospital,
and enable telemedicine and mobile health, but there also another angle that makes them attractive,
It can also be used for simple tests that are done normally only at hospitals such as total count of red or white blood cells.
and it is used widely in hospitals. It can also be used to identify potential allergens in food, among other applications.
or tracking vaccination campaigns in most resource-poor settings. It fantastic for an undergrad to be first author on the publication.
Surgeons at Manchester Royal Eye Hospital implanted a chip at the back of Mr Flynn eye in a four-hour procedure last month.
Professor Paulo Stanga, consultant ophthalmologist at the Manchester Royal Eye Hospital, said: r Flynn progress is truly remarkable.
#World First Malaria Vaccine Approved and it Will be Not-for-Profit The world first malaria vaccine has been given approval by a European medical agency for future use in Sub-saharan africa, where more than a quarter million children under the age of five die every year from the disease.
European regulators examined phase III clinical trial results involving more than 16,000 young children conducted by research centers in eight African countries (Burkina faso, Gabon, Ghana, Kenya, Malawi, Mozambique, Nigeria
Glaxosmithkline Vice president for Africa told CNN. t is the first time anyone ever has been able to make a vaccine against a parasite.
Perhaps most impressive, Glaxosmithkline, the pharmaceutical company that worked on this vaccine for 30 years, and received $200 million from the Gates Foundation, is making RTS, S available as a nonprofit drug.
with all that money going back into further research for a malaria vaccine that could be even more effective.
and expects to invest a further $200 to $250 million until the vaccine is ready for market.
With this approval from the European Medicines Agency Friday, the vaccine next will be considered by the World health organizations,
and if they will use the vaccine, along with current Malaria prevention techniques, like bed nets. 80%of the children involved in the clinical trials were protected also by insecticide treated bed nets.
malaria cases were reduced by almost half in children aged 5-17 months at the time of first vaccination and by 27%in infants aged 6-12 weeks.
000 clinical malaria cases were prevented over the study period for every 1, 000 children vaccinated
and nanotechnology as well as the completion of a device that may improve quality of life in indoor settings, from hospitals to underground parking garages.
and are affiliated with Carle Foundation Hospital in Urbana, Illinois.##For more information, please click herecontacts:
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
#New material opens possibilities for super-long-acting pills (Nanowerk News) Medical devices designed to reside in the stomach have a variety of applications,
Now, researchers at MITS Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern
and proof of principle,"says Harald Ott of Massachusetts General Hospital in Boston, who grew the limb."
as a result of an infection and those triggered by a vaccine. Instead the technique might be useful in outbreaks of new viruses. Understanding how our immune system responds to other viral fragments might reveal clues as to
according to local public health officials. Over a one-year period, the researchers released the modified males into the local environment
With this information health care workers can then personalize the baby's nutritional supplements to help with appropriate weight gain.
health care workers have performed hundreds of analyses of breast milk. Simmons, the Ruth and Harry Roman Chair in Neonatology in honor of Larry Baum said the information from both analyses should ultimately lead to healthier weight gain, better neurological outcomes and shorter hospital stays
researchers from Erasmus Medical center in The netherlands used a biodegradable material called Polyactive, which keeps proteins intact,
as well as public health in the case of diseases that can move from animals to humans, the paper authors wrote.
#New material opens possibilities for super-long-acting pills Medical devices designed to reside in the stomach have a variety of applications,
Now, researchers at MIT Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern
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