#Enzyme responsible for obesity-related high blood pressure identified"Hypertension is a condition in which arterial blood vessels are exposed to persistently elevated blood pressure,
"Hypertension can lead to severe health issues such as heart attacks, kidney failure, organ damage, and weakened or ruptured blood vessels.
Although both approaches restored nitric oxide production and reversed hypertension in obese rats, the use of arginase-inhibiting drugs may be a better solution."
"Blocking arginase activity offers a more specific approach in treating hypertension, because you are directly targeting the underlying biochemical defect in obesity,
However, Durante feels that identifying the role of arginase in the development of obesity-related hypertension will ultimately benefit obese patients."
"The key to reversing the effects of obesity-related hypertension will be to effectively block arginase activity.
But group A strep is also the major cause of preventable childhood heart disease caused by rheumatic fever and rheumatic heart disease.
"By comparison, the heart diseases are more challenging just because there are so many genes to sequence, "said Wilson."
That could be the moment for doctors to break out the complementary long padlock probes for inherited heart disease.
A preliminary test of the assay on blood samples and some skin samples from 29 participants from families with inherited heart disease validated the clpp approach
The heart disease clpp assay was cheaper, faster and more accurate than whole-genome assays. The Stanford team next plans to test the technique on a group of 200-300 patients.
"The assay will shorten the time it takes to diagnose difficult or unusual heart disease cases,
"Suppose you have a 60-year-old patient who comes in with heart failure, "he said."
and we find he has no history of heart attack or other issues, and yet the heart is not performing well.
such as dilated cardiomyopathy, we now have both a cause and a diagnosis, and we can initiate treatment right away."
which lowers glucose levels, triglycerides and hypertension. He also states that the benefits of the pomegranate are better than those of fruits like the cranberry, grapefruit, grape or black and green tea,
Symptoms include fatigue, dizziness, chest pain/pressure, heart murmurs, shortness of breath during activity, heart palpitations and fainting.
Aortic stenosis can lead to heart failure and death. About 100,000 people in the United states have aortic stenosis a
as muscle wasting is associated also with other serious illnesses such as HIV/AIDS, heart failure, rheumatoid arthritis and chronic obstructive pulmonary disease and is also a prominent feature of aging."
ranging from 5 to 15 per cent in chronic heart failure and COPD, and from 60 to 80 per cent in advanced cancer.
increasing the risk of blindness, nerve damage, stroke, heart disease and several other serious health conditions.
and this may lead to congestive heart failure or it may worsen an existing heart failure. Pioneered by Associate professor Leo Hwa Liang from the Department of Biomedical engineering at NUS'Faculty of engineering
#New test predicts teens'future risk of heart disease Risk for cardiovascular disease, currently running rampant in the United states,
Risk Factors for Cardiovascular disease Approximately 610,000 people die from heart disease every year in the United states--that's one of every four deaths.
Cardiovascular disease has predominantly modifiable risk factors meaning that the disease is entirely preventable. These modifiable risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
and abnormal cholesterol levels that together increase the risk of cardiovascular disease. It takes into account variables specific both to race and gender."
and yet they are at very high risk for developing type 2 diabetes and CVD cardiovascular disease,
and we found that there was a high correlation between the metabolic severity score for those children and for their later development of cardiovascular disease and diabetes,
the result is a potentially fatal arrhythmia. Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves--using light.
Cardiac experts find novel approach to treat heart failure A teenage girl faced with sudden rapid heart deterioration,
a man in the prime years of his life suffering from debilitating heart failure and a former NFL athlete crippled by end-stage heart failure were treated all successfully with a surgical approach pioneered by cardiac experts at University of California, San diego School of medicine.
The work, recently published in The Annals of Thoracic Surgery, demonstrated significant benefits of implanting a left ventricular assist device (LVAD) in the right atrium to provide better blood flow through the lungs,
and death for a person waiting for a transplant or suffering from advanced heart failure.""An LVAD relieves symptoms,
or short of breath in patients with advanced heart disease,"said Victor Pretorius, MBCHB, lead author of the report and surgical director of cardiac transplant and mechanical circulatory support at UC San diego Health."
cardiovascular disease or neurodegenerative conditions, have a much more complex genetic component. Many different variations in the genome sequence can affect your risk of disease
According to the American Heart Association, African americans are at a higher risk than whites to die of heart disease.
and blood pressure. didn expect that discrimination would have such a strong relationship with these particular markers of cardiovascular disease risk in kids this young,
The research team primary focus is on how the heart grows normally as well as abnormally in disease. fter hypertension or a heart attack
Professor Thomas said. ut a common end result of this compensatory growth is eventual heart failure, a major cause of death in Australia. uring laboratory tests,
#Artificial blood vessels become resistant to thrombosis Scientists from ITMO University developed artificial blood vessels that are not susceptible to blood clot formation.
Surgery, associated with cardiovascular diseases, such as ischemia, often require the implantation of vascular grafts artificial blood vessels,
could let you see how hypoxia was changing in the tumor, so you could adjust the radiation accordingly.
and thrombosis will impair fracture healing, Schoenecker said. It follows that if fibrin is removed not efficiently,
so that the diagnosis of heart conditions such as coronary heart disease or arrhythmia can be improved greatly. In the future, a special shield room for detecting the bio-magnetic field would be unnecessary
and we know that diabetics are more likely to suffer from cardiovascular disease such as heart attacks, stroke and heart failure. igh blood pressure affects even more people at least 4. 6 million Australians. onfirming this connection reliably provides new hope for those people
and new avenues for research. e can say for certain that one causes the other, but this study helps to connect the dots,
Professor Rahimi said that the link between hypertension and fatal heart issues had been documented well, but the connection to diabetes had been less clear. revious smaller studies have varied significantly
looked at the health records of 4. 1 million adults in the UK who were initially free of diabetes and cardiovascular disease and found:
such as those targeting cardiovascular disease, in which the platelet membrane could help us target relevant sites in the body
#New Test Predicts Teensfuture Risk of Heart disease Risk for cardiovascular disease, currently running rampant in the United states,
Approximately 610,000 people die from heart disease every year in the United states oughly one of every four deaths
Cardiovascular disease has predominantly modifiable risk factors, meaning that the disease is entirely preventable. These risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
and abnormal cholesterol levels that together increase the risk of cardiovascular disease. It takes into account variables specific both to race
and yet they are at very high risk for developing type 2 diabetes and cardiovascular disease,
if it correlated with their risk on developing cardiovascular disease and type 2 diabetes later in life,
and we found that there was a high correlation between the metabolic severity score for those children and for their later development of cardiovascular disease and diabetes,
the result is a potentially fatal arrhythmia. Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves using light.
the result is a potentially fatal arrhythmia. Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves using light.
It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.
cardiovascular disease, neurodegenerative conditions and diabetes, which can be driven by mutations in control regions of the genome.
and can lead to heart attack and stroke. The disease affects more than four million Americans and causes over 750,000 hospitalizations and 130,000 deaths per year in the United states alone.
The team, led by Jérôme Kalifa, M d.,Ph d.,a cardiologist and U-M Medical school assistant professor at the Center for Arrhythmia Research,
One of her daughters has a usually fatal lung condition called pulmonary arterial hypertension. In addition to GM pigs
saving the lives of people who would otherwise die from heart failure. In the U s. about 2, 400 heart transplant occur each year,
The operation leaves a scar on the neck and can lead to heart attack short-term facial paralysis from nerve damage and bleeding
The procedure is less invasive causing only minor bruising in the groin no risk of nerve damage and a lower heart attack risk than endarterectomy.
A transient ischaemic attack also known as a mini-stroke can be a warning sign that someone has carotid artery stenosis
Preventative procedures to treat such carotid artery stenosis are therefore crucial. Carotid endarterectomy is a common yet invasive surgery used to treat carotid artery stenosis
and is used widely throughout the UK. Previously far less was known about the long-term effectiveness of stenting as an alternative procedure.
and evaluate a person's risk for developing diabetes and cardiovascular disease. But determining the body's metabolic response to fructose has been much more difficult
All of these increase the risk of developing diabetes and cardiovascular disease. Fructose is a pervasive presence throughout our foods:
These modifications ease concerns of patients like Kim Doran of New Albany OH who have a family history of heart disease.
Both my parents passed away from heart attacks. So having that history of heart disease my main concern was the radiation affecting my heart said Doran It made
me feel a hundred percent better to know that that's the procedure I needed to have.
#Scientists create mimic of good cholesterol to fight heart disease, stroke Scientists at The Scripps Research Institute (TSRI) have created a synthetic molecule that mimics oodcholesterol
a condition where plaque buildup in the arteries can cause heart attacks and strokes. therosclerosis is the number one killer in the developed world,
#New device for heart failure safely improves heart function, quality of life, study shows A new implantable device to control heart failure is showing promising results in the first trial to determine safety and effectiveness in patients according to lead researcher Dr. William Abraham of The Ohio State university Wexner
Medical center. Results of the study are published in the Journal of American College of Cardiology Heart failure.
Heart failure is one of the fastest growing forms of heart disease and it's one of the most common reasons people are hospitalized said Abraham director of the Division of Cardiovascular Medicine at Ohio State's Wexner Medical center.
The optimal drug therapies we have today often aren't enough to manage this disease for some patients
In the pilot study 20 patients with New york Heart Association (NYHA) functional class III or ambulatory functional class IV heart failure were implanted with the device.
At the one year mark three of the patients had mild or no symptoms of heart failure.
I effectively reversing their heart failure Abraham said. Additionally patients were able to walk an average 100 feet farther during standardized measures
Drug and device therapies that are currently available for heart failure improve that same quality of life score by only five or 10 points.
There were no hospitalizations among the participants for stroke thrombosis sepsis or bleeding which often occurs in patients using left ventricular assist devices (LVADS).
They help people participate in tests for Parkinson, diabetes, cardiovascular disease, asthma, and breast cancer. Apple Jeff Williams came out on stage today at the Apple Watch event to show off Researchkit.
In the United states alone Tighe notes almost 20 percent of Americans will be older than 65 by 2030 making them more vulnerable to Alzheimer s cardiovascular disease and other age-associated conditions.
In the United states alone Tighe notes almost 20 percent of Americans will be older than 65 by 2030 making them more vulnerable to Alzheimer s cardiovascular disease and other age-associated conditions.
what her genes said about her chance of developing Alzheimer and heart disease. The report only delved into her genetic genealogy, possible relatives,
As science links these variants to disease risk, the idea has been that genotypes could predict your chance of getting cancer or heart disease
if I had a high risk or genetic predisposition toward heart disease, diabetes, or Alzheimer. I don,
but it can become essential for the millions living with chronic conditions like diabetes, heart disease, and depression.
#Nerve-Stimulating Implant Could Lower Blood pressure An implantable device that reduces blood pressure by stimulating a nerve in the neck could someday be an alternative to drugs for controlling hypertension.
Such implants might offer new hope to those with extreme hypertension. Up to 30 percent of people with high blood pressure cannot be treated fully with medication
The president-elect of the American Society of Hypertension John Bisognano says the work is an impressive and promising application of recent advances in miniaturized electronics and microsurgery.
Bisognano a cardiologist who runs a resistant-hypertension clinic at the University of Rochester Medical center in New york knows well the need for more treatment options.
which means they are at high risk for stroke heart failure and kidney failure he says. Implanted electrical devices that control bodily functions have been used for many years.
Whereas drugs cannot adapt to patient activities an intelligent implant can he says which could offer a way to treat hypertension on demand d
The researchers found that the notification system brought about a 30 percent increase in the number of volunteers providing emergency CPR for victims of heart attack.
they said that the 30-day survival rate after heart attack, was 10 percent when onlookers provided CPR,
what may be a major leap forward in the quest for new treatments of the most common form of cardiovascular disease,
known as atherosclerotic vessel disease, is the leading cause of heart attacks and strokes that claim some 2. 6 million lives a year worldwide, according to the World health organization.
That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound
D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
Wireless Monitoring Sensor to Help Manage Heart failure Scott & White Memorial is one of six hospitals in Texas
click New Tech Helping Heart failure Patientse are always looking for new and innovative ways to treat our patient disease process
and improve outcomes for heart failure patients, said Robert Scott III, MD, Director for Advanced Heart failure at Scott & White Memorial. his device will give us the ability to anticipate problems with our patients before they occur,
decreasing their chance of being readmitted to the hospital, and improving their quality of life. emorial implemented the Cardiomems HF System
which is the first and only FDA-approved heart failure monitoring device proven to significantly reduce hospital admissions.
which are used traditionally as indirect measures of worsening heart failure. The new system allows patients to transmit daily sensor readings from their homes to their health care providers allowing for personalized
According to the Centers for Disease Control and Prevention, more than 5. 1 million Americans have heart failure
Patients with heart failure are hospitalized frequently, have reduced a quality of life and face a higher risk of death.
US researchers have found that peat fires in the southern states during the summer of 2008 caused a spike in emergency room visits for heart failure and asthma-related respiratory complications.
who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco."
including nine types of heart disease, the leading cause of death in the United states. The researchers performed statistical tests to check that the 55 diseases for
The researchers also found a relationship between birth month and nine types of heart disease, with people born in March facing the highest risk for atrial fibrillation, congestive heart failure,
A previous study using Austrian and Danish patient records found that those born in months with higher heart disease ratesarch through Junead shorter life spans. aster computers
a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco. his technology could help us quickly screen for drugs likely to generate cardiac birth defects,
who's using an app to study heart disease.""It's one thing that people have with them every day."
Apple launched its Researchkit program in March with five apps to investigate Parkinson's, asthma, heart disease, diabetes and breast cancer.
Smartphone Medicine Dr. Michael Mcconnell, a cardiologist who's using an app to study heart disease,
who's using an app to study heart disease.""It's one thing that people have with them every day."
Apple launched its Researchkit program in March with five apps to investigate Parkinson's, asthma, heart disease, diabetes and breast cancer.
#Flawed science triggers U-turn on cholesterol fears For decades they have been blacklisted as foods to avoid, the cause of deadly thickening of the arteries, heart disease and strokes.
'London-based cardiologist Dr Aseem Malhotra, science director of campaign Group action On Sugar, wrote in The british Medical Journal that it was time to'bust the myth of the role of saturated fat in heart disease'.
'He added that the food industry had contributed effectively to heart disease by lowering saturated fat levels in food and replacing it with sugar.
and saturated fat in food to heart disease were tinged with scandal'.
#NSA testing smartphones that can tell who you are by the way you write: Handwriting recongition system The NSA is set to begin using smartphone software that can recognise a person by the way they write.
who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco.'
am I at risk of heart disease? One day soon your mirror might actually be able to give you the answer.
like heart disease or diabetes. revention is the most viable approach to reduce the socioeconomic burden of chronic and widespread diseases,
For example, the damage from a major heart attack could cost you around five billion heart cells. Future stem cell treatments will require this number
what may be a major leap forward in the quest for new treatments of the most common form of cardiovascular disease,
known as atherosclerotic vessel disease, is the leading cause of heart attacks and strokes that claim some 2. 6 million lives a year worldwide, according to the World health organization.
That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound, D-PDMP,
D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
Furthermore, white blood cell count can be used to predict a person risk of developing conditions such as diabetes and heart disease.
'If you experience a major heart attack the damage could cost you around five billion heart cells.
Scurvy Anemia Infertility Arteriosclerosis Artherosclerosis Cataracts Glaucoma Nosebleeds Fatigue Infection Gingivitis Gastrointestinal problems Gallstones Dermatitis Impaired hormones Low insulin production
#Smart mirror monitors your face for telltale signs of disease Mirror mirror on the wall, am I at risk of heart disease?
like heart disease or diabetes. Need for prevention revention is the most viable approach to reduce the socioeconomic burden of chronic and widespread diseases,
Dr. Deepak Srivastava, a director at the Gladstone Institute of Cardiovascular disease in San francisco.""When cardiovascular surgeons go in to repair a defect in the heart,
such as exploring triggers that cause heart attacks. Dassault hopes that medical device makers will also use the Living Heart Project's technology for research and development.
Results of the study showed that increased lactate production was detected by hyperpolarized MRI in areas of hypoxia
than develop diabetes or heart disease. Kidney stones cause severe pain, obstruction of the urinary tract, and loss of worker productivity.
and is already in use in human gene therapy trials for blindness, heart disease, muscular dystrophy and other conditions.
and heart disease and there is no cure. People with type 2 diabetes have reduced sensitivity to insulin a hormone that normally triggers uptake of glucose by cells
minimally invasive approach appears safe for treating life-threatening aneurysms that occur in the deepest part of the aorta,
An aneurysm occurs when the wall of the vessel weakens, and if an aneurysm in the aorta bursts, it can lead to death in a matter of minutes."
"Currently, thoracic aortic aneurysms that reach into the aortic arch are very difficult to treat with minimally invasive endovascular methods
While our study only addressed aneurysms, the results have implications for cardiothoracic surgeons who perform procedures to repair tears in the ascending aorta (type A dissection),
whether this treatment will be safe and effective in aneurysms that extend a little closer to the heart within the aorta,
and health conditions like diabetes and heart disease. Identifying the changes that occur at a cellular level due to these psychosocial factors allows us to understand the causes of these poor health conditions
including diabetes, heart disease, and cancer. According to Carrie Partch a professor of chemistry and biochemistry at UC Santa cruz and corresponding author of the paper, the connection between clock disruption and cancer is still unclear."
Researchers develop a faster way to treat the heart after a heart attack Stem cell have been the main focus of healing therapy research
For healing after a heart attack, the ideal time to administer these therapies is when reopening the clogged blood vessel
While stem cells show promise for heart attack treatment, the process of harvesting and reintroducing the cells
Heart attacks occur when the heart's blood vessel is blocked and blood flow stops, cutting off oxygen to the heart.
and tested the microspheres'effectiveness in pigs with induced heart attacks. The researchers observed that the microspheres were not toxic
It also did not decrease the size of the area damaged by the heart attack or the composition of the scar.
the study shows that microsphere therapy can potentially be an"off-the-shelf and immediate alternative to stem cell therapy"for treating heart attacks and potentially other diseases s
Some bone marrow stem cells reside in low oxygen (hypoxia) zones. These specialized zones are secured as immune cells
Hypoxia-activated cell signaling pathways may also protect the stem cells from dying or aging.
Experiments also confirmed that these stem cells express a hypoxia activated gene, the hypoxia inducible factor 1 alpha (HIF-1 alpha.
Most cardiomyocytes don't replenish themselves after a heart attack or other significant heart muscle damage. The UT Southwestern researchers were able to devise a new cell-tracing technique,
who holds the James T. Willerson, M d. Distinguished Chair in Cardiovascular diseases and the Frank M. Ryburn, Jr.
Instead, the researchers developed a sophisticated protein-tracking technique based on the presence of a hypoxia-responsive protein called Hif-1alpha.
"This fate-mapping approach, based on protein stabilization rather than gene expression, is an important tool for studying hypoxia in the whole organism.
This is what causes most heart attacks. The clot can also dislodge and cause a stroke if it lodges in a blood vessel in the brain.
#Two biomarkers linked to severe heart disease found Arrayarrayinterestingly, Nichols and his colleagues did not set out to pinpoint the two key biomarkers.
They wanted to create an insulin resistant animal model that mimicked human heart disease. They chose pigs,
Sure enough, all the pigs with severe heart disease had elevated levels of fructosamine and oxidized LDL.""Also, this correlation was more common in females,
"Clemmons found a study from Finland published in 2005 showing that elevated glycated protein levels were associated strongly with advanced heart disease and increased mortality in women but not in men."
Clemmons added,"We could also study what's different about these female pigs that make them much more susceptible to severe heart disease,
and is already in use in human gene therapy trials for blindness, heart disease, muscular dystrophy and other conditions.
a huge deal,"said George Bakris, MD, professor of medicine and director of the Comprehensive Hypertension Center at the University of Chicago Medicine."
Patients most at risk are those with chronic kidney disease combined with diabetes and hypertension or heart failure.
patients with hyperkalemia, hypertension, type 2 diabetes and chronic kidney disease. All patients were taking RAAS inhibitors to treat their CKD prior to and during study treatment.
Thirty-five percent of patients also suffered from heart failure. Depending on the severity of their hyperkalemia
The combination of chronic kidney disease, type 2 diabetes, high blood pressure, hyperkalemia and, in about one-third of cases, heart failure, can be deadly.
and worsening of hypertension, plus constipation and diarrhea. Events related to patiromer primarily involved low magnesium, mild to moderate constipation and diarrhea.
and evaluate aldosterone blockade in heart failure patients.""Previous research demonstrated the short-term benefits of patiromer,
Confronted with a rare and particularly difficult case of congenital heart failure, Richard Kim, MD, from the Children Hospital of Los angeles (CHLA) took a step forward
#Noninvasive test predicts death risk from heart disease A noninvasive scan that determines the extent of plaque buildup in the heart accurately predicts the likelihood of heart attack or death over a 15-year period,
if a patient is shown to be at risk for heart disease but not yet showing symptoms. ll high-risk individuals irrespective of their symptom status should be considered for this study.
and more aggressively and hopefully prevent patients from ever having a heart attack. Heart disease is the No. 1 cause of death in the United states, killing 40 percent more people than all types of cancer combined.
But while there are routine screens for many types of cancer, there isn a universally adopted test used to check for heart attack risk in people who are not exhibiting symptoms associated with heart disease.
The researchers say their findings demonstrate that the coronary artery calcification test, a 5-minute procedure that examines the total amount of calcified plaque buildup in the heart arteries,
should fill that void. his test predicts the risk of heart attacks better than any other diagnostic heart test that we have, especially in asymptomatic patients,
or do not have disease that places them at heightened risk of heart attacks. While previous studies have connected coronary artery calcification test results and long-term patient prognosis
including history of diabetes, elevated cholesterol levels, documented high blood pressure or family history of coronary heart disease.
investigators calculated the risk that participants would die for any reason, not just because of a heart attack,
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