however, promises to benefit a high number of patients with heart failure or rhythm abnormalities that complicate sepsis.
and is already in use in human gene therapy trials for blindness, heart disease, muscular dystrophy and other conditions.
a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco. his technology could help us quickly screen for drugs likely to generate cardiac birth defects,
#Xenotransplantation of MSC Sheets Attenuates Left Ventricular Remodeling Xenotransplantation of Bone marrow-Derived Human Mesenchymal Stem Cell Sheets Attenuates Left Ventricular Remodeling in a Porcine Ischemic Cardiomyopathy Model.
Bone marrow-derived autologous human mesenchymal stem cells (MSCS) are one of the most promising cell sources for cell therapy to treat heart failure.
and effective treatment for ischemic cardiomyopathy (ICM). METHODS AND RESULTS: Human MSCS acquired from bone marrow were positive for CD73, CD90,
These were transplanted successfully over the infarct myocardium of porcine ICM models induced by placing an ameroid constrictor on the left anterior descending coronary artery without any procedural-related complications (MSC group=6:
Immunohistochemistry of the von Willebrand factor showed that the vascular density in the infarct border area was significantly greater in the MSC group than the sham group.
Expression of angiogenesis-related factors in the infarct border area of the MSC group was significantly greater than that of the sham group,
#New receptor for controlling blood pressure discovered High blood pressure is a primary risk factor in the development of many cardiovascular diseases.
which could be a factor in the development of hypertension: the physical forces of the flowing blood activate a receptor on the surface of the inner vascular wall.
or if it does not function correctly, this can cause hypertension. Under the leadership of the Max Planck researchers, a new study has now been shed able to some light on key elements of the mechanism that leads to the release of nitrogen monoxide
are of major clinical interest. e want to examine the extent to which malfunctions in this key blood pressure regulation principle are responsible for the development of vascular diseases such as hypertension
Knowledge about this principle could in future be used for the prevention and treatment of hypertension t
The innovative approach may lead to more effective therapies with fewer side effects, particularly for diseases such as cancer, heart disease and neurodegenerative disorders.
In the future, the researchers hope to study the signaling protein arrestin with other GPCRS that are involved in heart disease
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