| Anemia (24) |  |
| Hemophilia (11) | |
| Lymphoma (20) | |
| Anemia (24) | |
| Hemophilia (11) | |
| Lymphoma (20) | |
#At home test diagnoses anemia in 60 seconds A device that uses a single drop of blood can quickly diagnose anemia
The disposable self-testing device uses a chemical reagent that produces visible color changes corresponding to different levels of anemia.
and more convenient monitoring of patients with chronic anemia the device could help patients receive treatment before the disease becomes severe potentially heading off emergency room visits and hospitalizations.
Anemia which affects two billion people worldwide is diagnosed now and monitored using blood tests done with costly test equipment maintained in hospitals clinics or commercial laboratories.
and monitor anemia themselves says Wilbur Lam a physician in the Aflac Cancer and Blood disorders Center at Children's Healthcare of Atlanta and the department of pediatrics at Emory University School of medicine.
what is required by other anemia tests says Erika Tyburski the paper's first author and leader of the undergraduate team that developed the device.
and the patient sees a color ranging from green-blue to red indicating the degree of anemia.
The team also plans to study how the test may be applied to specific diseases such as sickle cell anemia.
Finally safety testing was done on blood from hemophiliac patients. Because that blood lacks the triggers needed to cause fibrin formation the particles had no effect.
of which can point to conditions such as high blood pressure, anemia, or lung disease. Fan is developing the sensor with Zhaohui Zhong
of which can point to conditions such as high blood pressure anemia or lung disease. Fan is developing the sensor with Zhaohui Zhong an associate professor of electrical and computer engineering and Girish Kulkarni a doctoral candidate in electrical engineering.
including leukemia, lymphoma, and bladder, breast, lung, and ovarian tumors. Staggering these drugs proved particularly powerful against a type of breast cancer cell known as triple-negative,
Scientists envision that this kind of genome editing could one day help treat diseases such as hemophilia Huntington s disease
it could also be used to study the dynamics of the malformed blood cells that cause sickle cell anemia.
In severe cases, malaria causes seizures, severe anemia, respiratory distress, and kidney failure. Each year, more than 200 million cases of malaria are reported worldwide.
For example, defects found in the pathway cause anemia in humans.""Dehydrogenase enzymes are particularly important
Through a disease management and doctor communication platform, Microhealth is attempting to crowdsource the management of rare, chronic conditions, starting with hemophilia.
If a patient with hemophilia gets a cut, he won stop bleeding until he intravenously injects enough of this protein.
Currently, 10 percent of hemophilia patients in the U s. nearly 3, 000 people) are using Microhealth,
Doctors can also request pictures and additional information from patients, who often live hundreds of miles from hemophilia treatment centers,
And hemophilia is just the first chronic disease that the company will tackle. The team has started already working with rheumatoid arthritis patients,
It reduced non-Hodgkin's lymphoma tumours to about a quarter of their size, got rid of protstate cancer entirely in two of six mice
#New age of genome editing could lead to cure for sickle cell anemia Australia researchers have shown that changing just a single letter of the DNA of human red blood cells in the laboratory increases their production of oxygen-carrying haemoglobin-a world-first
However more research is needed before it can be tested in people as a possible cure for serious blood diseases."
This work was supported by a National institutes of health grant, the Samuel Waxman Cancer Research Foundation, the Leukemia and Lymphoma Society, the Rally Foundation and the Bear Necessities Foundation e
and lymphoma teams at Texas Children Hospital. Ball said STAT3 has been a target for scientists trying to shut down cancer cells.
which recently changed its name from Leukaemia & Lymphoma Research a
#chillesheelof Sickle cell Disease? Researchers from Dana-Farber/Boston Children Cancer and Blood disorders Center have found that changes to a small stretch of DNA may circumvent the genetic defect behind sickle cell disease.
its oral investigational anaplastic lymphoma kinase (ALK) inhibitor, shrank tumors (overall response rate; ORR: 50.0 percent and 47.8 percent, respectively) in people with advanced ALK-positive non-small cell lung cancer (NSCLC) whose disease had progressed following treatment with crizotinib.
Patients may suffer anemia, uncontrolled bleeding and vulnerability to infections. Parents often see their children struggle with swollen lymph nodes, painful enlarged spleens, fatigue and anxiety.
The resulting decrease in blood cells causes symptoms such as anemia, uncontrolled bleeding, and infection. Few effective and well-tolerated therapies exist to manage these chronic autoimmune issues.
A side effect of ribavirin is that it causes anemia--a condition characterized by a decrease in red blood cell levels--in approximately 8 to 10 percent of patients."
The four human patients all had lymphomas, which are cancers of the lymph system, and had enlarged lymph nodes.
"Once developed fully, SNAS will lay the foundation for developing an entire new pipeline of drugs to treat a range of diseases, from psoriasis, lupus and rheumatoid arthritis to lymphoma, bladder cancer and prostate cancer."
targeting lymphoma and a form of autoimmune hepatitis.""The spherical nucleic acids always win from potency and speed standpoints,
In a study of mice, the researchers tested SNAS against lymphoma. For the animals treated with SNAS,
and destroy lymphoma cells. Next, focusing on nonalcoholic steatohepatitis (NASH), the researchers found eightfold increases in potency when animals were treated with SNAS and a 30 percent greater reduction in the animals'fibrosis score.
This gives you a catalytic effect that grows into a systemic search for cells that look for example, like lymphoma cells."
Examples include diseases such as hemophilia sickle cell anemia, muscular dystrophy and cystic fibrosis. While the field is still in its relative infancy,
Hubbard says human clinical trials involving sequence-specific DNA-editing agents are already underway. If successful, he expects the first clinical applications could be seen in the next decade.
which has been linked to the development of lymphoma, leukaemia, and brain tumours, plus a number of congenital diseases that affect a person growth."
researchers are looking at the potential of such drugs as a treatment for several types of lymphoma."
whose lymphoma diagnosis was confirmed by conventional pathology from another four with benign lymph node enlargement. Along with protein analyses, the system was enhanced to successfully detect DNA--in this instance from human papilloma virus--with great sensitivity.
We are following the same approach for other rare and less rare blood diseases.""Frdric Revah, CEO of Genethon, the laboratory of the AFM-Telethon and the trial sponsor, said"These first results of our clinical trial for the treatment of Wiskott Aldrich syndrome are very encouraging.
Lymphatic filariasis, spread by mosquitoes, leads to elephantiasis, a condition marked by painful, disfiguring swelling in parts of the body.
representing a major setback in the efforts to eradicate river blindness and elephantiasis. Next generation Cellscope uses video, automationfor this latest generation of the mobile phone microscope, named Cellscope Loa, the researchers paired a smartphone with a 3d printed plastic base where the sample of blood
Examples include diseases such as hemophilia, sickle cell anemia, muscular dystrophy and cystic fibrosis. While the field is still in its relative infancy,
drugs that are approved currently for treatment of other hematologic cancers such as polycythemia vera and myelofibrosis."
"The Penn team, in collaboration with Alain Rook, MD, director of the Cutaneous T-cell Lymphoma Program and a professor of Dermatology, aims to develop a molecular taxonomy for mutations in SS patients.
Lymphatic filariasis, spread by mosquitoes, leads to elephantiasis, a condition marked by painful, disfiguring swelling.
representing a major setback in the efforts to eradicate river blindness and elephantiasis. Next generation Cellscope uses video, automation For this latest generation of the mobile phone microscope, named Cellscope Loa, the researchers paired a smartphone with a 3d printed plastic base where the sample of blood
Examples include diseases such as hemophilia sickle-cell anemia, muscular dystrophy and cystic fibrosis. Though the field is still in its relative infancy,
Next, they collected saliva from a patient who suffers from hyperuricemia, a condition characterized by an excess of uric acid in the blood.
This unique medication could mean a dramatic reduction of the difficult side-effects of traditional cancer treatments like hair loss, nausea, anemia and neuropathy.
Alnylam has more than 11 drugs including ones for hemophilia Hepatitis b and even high cholesterol in its development pipeline and has three in human trials progress that led the pharmaceutical company Sanofi to make a $700 million investment in the company last winter.
It can also be applied to blood diseases, like sickle cell anemia, or be used to look at contamination, for example in food or milk.
The approach has been used to treat leukemia as well as lymphoma, according to Dr. Rapoport, who is the Director of the Blood and Marrow Transplant Program at the University of Maryland Marlene and Stewart Greenebaum Cancer Center.
The technique has had positive clinical results recently in conditions ranging from blood diseases to blindness.''We are somewhat late in the auditory field but
"Several drugs are quite effective in treating different types of breast cancers, lung cancer, lymphoma and other cancers at their original sites,
Scurvy Anemia Infertility Arteriosclerosis Artherosclerosis Cataracts Glaucoma Nosebleeds Fatigue Infection Gingivitis Gastrointestinal problems Gallstones Dermatitis Impaired hormones Low insulin production
As model genes the researchers used JAK2 a gene that when mutated causes a bone marrow disorder known as polycythemia vera;
"High-dosage oral vitamin D3 supplementation attenuated HIV-1 replication, increased circulating white blood cells and reversed winter-associated anemia,"the researchers reported."
and lymphoma patients with a first generation of experimental T cell therapies developed by its academic partners.
In an earlier CAR-T trial at Sloan Kettering, to treat non-Hodgkin lymphoma, two patients suffered a cytokine storm
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