to prevent serious injury to humans (or worse), these robots are normally shut down when anyone enters their workspace.
"When a patient comes with a lesion in his oral cavity, be it his her tongue
"When a patient comes with a lesion in his oral cavity, be it his her tongue
Cure for untreatable wounds BEIJING: Chinese scientists have claimed successfully growing muscle stem cells in a test tube,
a breakthrough that could potentially save the careers of top athletes besides cure untreatable injuries caused from accidents and surgeries due to cancer."
"It can generate enough stem cells to heal permanent wounds, especially those caused externally,"said Hu Ping, a cell biologist with the Shanghai Institute for Biological science at the Chinese Academy of Sciences."
"Muscle stem cells are the ultimate way to cure muscle-related wounds or diseases, "Hu said,
"This technology could cure (recently retired Chinese hurdler) Liu Xiang's injury, "Hu said, referring to Asia's first Olympic gold medallist in the 110-metre hurdles at the 2004 Athens Olympics who also ranks as the continent's first world champion hurdler.
A nagging tendon injury caused the Shanghai native to limp off the track when Beijing hosted the Summer Games in 2008.
blaming his longstanding injury. Now scientists from his hometown believe they have found a way to restore him to full health,
along with millions of other patients bearing muscle-related injuries. By transplanting the stem cells from the test tube back into the patient's body
large wounds require large numbers to be dragged over from healthy parts of the patient's body,
The professor said a similar method could be used to grow tendon stem cells to treat injuries like Liu's. She added that
"Most people in China don't care about muscle injuries until they find they cannot walk,
just as much of an impact on internal injuries including broken bones; rather than having a traditional cast on for months,
The team has developed a new 3d bioprinting technique that allows them to 3d print a thick paste filled with protein-releasing microspheres that can be used to greatly speed up bone regeneration after fractures.
This makes it quite easy to imagine complicated applications like filling bone fractures with this doughy material to not only make bones stronger during recovery from fractures
whether as result of accidents, injuries or illnesses, observes Huber. Under the motto he New Future of Old age the German Federal Ministry of Education and Research (BMBF) is sponsoring research projects for technical solutions such as akrobatik@home that help
Concerned about these alarming statistics, experts at the Johns Hopkins Bloomberg School of Public health Center for Injury Research and Policy challenged a team of Johns Hopkins undergraduate mechanical engineers to design
Andrea Gielen, director of the Johns Hopkins Center for Injury Research and Policy at the Bloomberg School of Public health and one of the team mentors, said she
Evaluating this drug-induced liver injury is a critical part of pharmaceutical drug discovery and must be carried out on human liver cells.
meaning they accumulate injuries over time, which can be severe. For example, they might frequently bite their tongues and the insides of their mouths,
which causes rashes, lesions and arthritis, and creates an increased risk for cancer and diabetes.
and looked at the longstanding theory that pain is transmitted from the site of injury or inflammation through the nervous system using an immune system cell called microglia.
and wakes up cells in wounds helping to stimulate and accelerate the healing process. More than 200,000 patients in the UK suffer with chronic wounds every year at a cost of over £3. 1 billion to the NHS.
The ultrasound treatment, which also reduces the chance of wounds getting infected, is particularly effective
when treating diabetics and the elderly. There are 11 million over-65s, three million diabetics and 10 million smokers in the UK all of whom are likely to suffer problems with healing wounds.
A quarter of diabetics suffer from skin ulcers, particularly foot ulcers, due to the loss of sensation and circulation in the legs.
was carried out in collaboration with the School of Biochemistry at the University of Bristol, the Wound Biology Group at the Cardiff Institute of Tissue Engineering and Repair,
symptoms of infection may include large skin lesions, fever, swelling of the spleen and liver,
The varied approaches were effective in"recruiting"protective monocytes to"lesion sites"in the brain,
Koronyo added that the study gives unprecedented details about monocyte numbers migrating into brain lesion sites
and brings the risk of needle-related diseases and injuries. It also induces crippling fear in many people,
or disorders particularly individuals who have become paralysed following spinal cord injury. EPFL The flexible silicon implant is covered in cracked gold conduction tracks that stretch with the silicon
Pioneering device tracks changes in pressure caused by injury and infection Doctors have developed a brain pressure test using a special set of headphones that can detect life-threatening head injuries and infections.
The technique involves a patient wearing the headphones with an ear plug linked to a computer.
when the brain swells as a result of an injury or infection and prevents blood flow, depriving the brain of the oxygen it needs to function.
The headphones are set to be used in the diagnosis and treatment of conditions such as meningitis and head trauma injuries
And doctors said they believe it could be used to distinguish between head injuries and post traumatic stress disorder in soldiers returning from combat zones.'
'We know that high pressure inside the skull resulting from injuries and infections can be fatal,
The study looked at 301 acute and chronic diseases and injuries in 188 countries, finding that developing nations like India and China are now mimicking a trend that had began earlier in Western nations.
Skin cells could grow over a wound more effectively if they moved in accordance with structured cellulose.
for patients who experience trauma to a joint that was otherwise healthy before the injury,
Inflammation is a normal way for the body to respond to injury or infection. The swelling, heat,
and hopefully move toward solving injuries,"said Dr. Hilliard. In the future, neurosurgery may be combined with molecular biology to deliver positive clinical outcomes
and perhaps treat conditions like spinal cord or nerve injuries, he said. During programmed cell death,
These people accumulate numerous self-inflicted injuries, often leading to reduced lifespan. Using detailed genome mapping
The scientists believe that the inhibition of this enzyme could accelerate tissue recovery from injury, disease,
SW033291 or related compounds may merit clinical investigation as a strategy to accelerate recovery after bone marrow transplantation and other tissue injuries. e
or knee osteoarthritis or the severe injuries caused by major trauma, for example in road traffic accidents or war injuries."
or knee osteoarthritis or the severe injuries caused by major trauma, for example in road traffic accidents or war injuries."
#Scientists Smell Success for Treatment of Spinal cord Injuries Three years after they treated patients with spinal cord injury in a randomized clinical trial with transplanted cells from the patients'olfactory mucosa to build a bridge
and daily life activities, wrote the investigators in an article (utologous Olfactory Lamina Propria Transplantation for Chronic Spinal cord Injury:
randomized 12 patients with complete spinal cord injury (SCI) to receive OLP transplants and followed them for three years after transplantation,
Eight of the 12 patients were without bladder sensation at the preoperative evaluation. ptimal outcomes may be related to age, severity and level of injury
and brings the risk of needle-related diseases and injuries. The new microneedle patch is made of dissolvable material,
when EL panels made from plastic are bent too sharply, fractures and a severely diminished output usually result.
A pulse generator inserted under the skin below the collarbone provides electrical signals that create a lesion,
sticking to the tissue at the site of injury and creating a barrier over a wound."
something that could allow better protection of a wound and stop bleeding with a single treatment.
#Ultrasound cuts healing time of chronic wounds by 30 percent Further to the mental anguish, a lot of time in a hospital bed can bring about some agonizing physical discomfort.
and other chronic wounds by around a third, using simple low-intensity ultrasounds. Wound healing presents a serious problem for two demographics in particular
When a young and healthy person incurs an injury to the skin, connective tissue cells called fibroblasts migrate to the site of the wound and kickoff the healing process.
But skin defects that are typical of above groups prevent the migration of fibroblasts and make healing problematic, sometimes leading to amputation.
indicating that it could be applicable to other chronic human wounds. And because it is modelled on
#Mussel-inspired surgical glue shuts down bleeding wounds in 60 seconds The ability of mussels to stubbornly bind themselves to underwater surfaces has intrigued scientists for years.
the scientist say it was able to close bleeding wounds in less than 60 seconds and healed them without inflammation
which therapeutics are incorporated custom into the bandage to match a specific injury. Additionally, although the researcher's tests only involved the use of one ink cartridge,
and it is known to induce walking motions in mice with spinal cord injuries. All five men had been paralyzed for more than two years prior to receiving the treatment,
Much of the worst quake damage and injuries in recent years result from older buildings collapsinghat because modern buildings in earthquake zones are designed with devices called dampers or isolation units,
If the rods and cones that make up the photoreceptors of the eye fail because of injury or illness,
after fractures. While this 3d-bioprintable paste is yet to reach clinical trials, this study could be the first step to a revolutionary treatment method.
Potentially complicated applications such as filling bone fractures with this doughy material could make bones stronger during recovery from fractures.
#Exoskeleton Helps Spinal cord Injury Patient Walk LAS VEGAS Bionic exoskeletons are helping spinal cord injury and stroke patients walk again.
One man with a partial spinal cord injury, Shane Mosko, demonstrated here today (Jan 8) at the 2015 CES how the new bionic legs operate,
More than 3, 500 patients with either spinal cord or stroke injuries have walked more than 15 million steps with the device,
The new exoskeleton can also help people with spinal cord injuries, like Mosko, who uses a wheelchair
either as a direct result of the tissue injury from stroke or through lack of use of the weaker side of the body.
#Injectable Hydrogel Material Serves as Scaffold to Heal Wounds At UCLA researchers have designed an injectable hydrogel scaffold that promotes wound healing by serving as a 3d platform within which new tissue can grow.
as well as the overall chemical composition, allowing the material to be tailored to specific wounds. This is achieved using microfluidic methods methods that the researchers developed to produce the scaffolds.
Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blockssource:
#Light Used to Control Larynx Muscle (VIDEO) In a world first, researchers at the University of Bonn in Germany made a skeletal muscle of a mouse contract in response to light.
Since there no need to swap tools, the procedure can move along faster without the potential risk of unnecessary injury to the esophagus.
Because of its high flexibility, the stent has shown to be positioned easily across different lesions while and maintaining its strength over considerable time periods.
or equal 2. 4). 88.6%freedom from target lesion revascularization, as measured at one-year using Kaplan-Meier analysis s
The team tested the technology on mice with compression injuries, demonstrating that the drug reduced inflammation in the areas where the EM field was applied.
and deposited onto a spinal cord lesion in glial fibrillary acidic protein-luc transgenic mice (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
The corticosteroid DEX, a powerful ameliorator of inflammation, was released from the polymer by external application of an electromagnetic field for 2 h/day for a week.
which in the past has demonstrated considerable benefits for mice with spinal cord injuries. Toward the end of the study, amazingly the patients were able to move their legs on their own without the neurostimulators doing anything at all.
#A stretchy mesh heater for sore muscles If you suffer from chronic muscle pain a doctor will likely recommend for you to apply heat to the injury.
or bedsores, are injuries that can result after prolonged pressure cuts off adequate blood supply to the skin.
"This bandage could provide an easy early warning-system system that would allow intervention before the injury is permanent.
To mimic a pressure wound, the researchers gently squeezed the bare skin of rats between two magnets.
The smart bandage was used to collect data once a day for at least three days to track the progress of the wounds.
reversible tissue damage while three hours of pressure produced more serious, permanent injury. Promising future"One of the things that makes this work novel is that we took a comprehensive approach to understanding how the technique could be used to observe developing wounds in complex tissue,
"said Swisher.""In the past, people have used impedance spectroscopy for cell cultures or relatively simple measurements in tissue.
and extract useful information from wounds developing in the body. That's a big leap."
and as we learn more and more about the responses the body has to disease and injury,
Remote-controlled Eradication of Astrogliosis in Spinal cord Injury via Electromagnetically-induced Dexamethasone Release from"Smart"Nanowireswen Gao and Richard Borgenswe describe a system to deliver drugs to selected tissues continuously,
and deposited onto a spinal cord lesion in Glial fibrillary acidic protein-luc Transgenic mices (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
The corticosteroid DEX, a powerful ameliorator of inflammation, was released from the polymer by external application of an Electromagnetic field for 2 hours/day for a week.
"This tool allows us to apply drugs as needed directly to the site of injury, which could have broad medical applications,
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
"The team tested the drug-delivery system in mice with compression injuries to their spinal cords
and transported a patch of the nanowire carpet on water droplets that were used used to deliver it to the site of injury.
The nanowire patches adhere to the site of injury through surface tension Gao said. The magnitude and wave form of the electromagnetic field must be tuned to obtain the optimum release of the drug,
GFAP is expressed in cells called astrocytes that gather in high numbers at central nervous system injuries. Astrocytes are a part of the inflammatory process and form a scar tissue,
A 1-2 millimeter patch of the nanowires doped with dexamethasone was placed onto spinal cord lesions that had been exposed surgically,
The lesions were closed then and an electromagnetic field was applied for two hours a day for one week.
and record the complex 3-D magnetization in wound magnetic layers. This technique could be important in the development of devices that are highly sensitive to magnetic fields,
which could help patients suffering from muscular dystrophy, amyotrophic lateral sclerosis (ALS), incomplete spinal cord injury, or other hand impairments to regain some daily independence and control of their environment.
and incomplete spinal cord injury, the soft robotic glove could allow them to regain some of their daily independence through robotic gloveassisted hand functions.
and a favorable fracture behavior including self-healing ability. Key to the success are the supramolecular bonds within the soft polymer matrix.
and provide fracture energy dissipation by stick/slip interactions and frictional sliding of the platelets against each other."
However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
as there is a greater risk for fracture if a device is too large or too complex.
Since the realignment of the atoms causes stress and eventually fractures in the material, the atomic lattice of a substance cannot be rearranged infinitely often.
certain skills and gear helped people avoid injury or death: Owning a reliable, waterproof tactical flashlight was absolutely essential,
as many people suffered injuries from being hit by debris in flood waters. The ability to navigate on foot,
and teeth Heal wounds Form scar tissue Helps the absorption of iron Helps thyroid hormone production Helps metabolize folic acid, tyrosine,
and minor injuries could begin this century. MRSA has spread from hospitals into the community
Paralyzed from the neck down after suffering a gunshot wound when he was 21, Erik G. Sorto now can move a robotic arm just by thinking about it
neurons in the hippocampal region of the brain contain a large number of DNA lesions, known as double strand breaks.
even though conventional wisdom dictates that DNA lesions are very bad as this amagecan be mutagenic
mechanisms where neuronal injury engages immune responses to influence disease progression. Here we show that the expression of mutant proteins causative for ALS in Caenorhabditis elegans motor neurons induces an innate immune response via TIR-1/Sarm1.
and looked at the longstanding theory that pain is transmitted from the site of injury or inflammation through the nervous system using an immune system cell called microglia.
People with similar injuries have controlled previously prosthetic limbs using implants placed in their motor cortex an area of the brain responsible for the mechanics of movement.
but this is not possible for people with a spinal injury because the messages from the nerves cannot reach the brain.
and shell enter a wound. They can also self-amputate if they get too hot,
Shining red light on skin or cells in a dish gives an instant energy boost that could help heal wounds,
The curious healing effect has been known for decades researchers have been investigating its use in eye injuries
"Other research groups are investigating this phenomenon as a way to speed up the healing of skin wounds
and it fractures under the pressure. Regardless, cracked concrete is never something you want to see in a building, bridge, or street.
cracking and quickly sealing its wounds. Jonkers hopes that eventually more buildings will be built with the biological concrete,
scabbing over small breaks like blood in a wound. It works like this. Tiny spheres of liquid are embedded in the airplane wing.
and the liquid inside (a carbon-based substance) spills out to fill the'wound'.'Then, other chemical catalysts in the wing harden the liquid,
and UV-B, with shorter wavelengths that cause sunburns. But there are concerns about some of the chemicals in commercial sunscreens,
the researchers now think patients with severe spinal cord injuries may be able to recover multiple body functions,
and the almost 1. 3 million who have spinal cord injuries. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
which had been found to induce leg movement in mice with spinal cord injuries, during the final four weeks of the study.
and Sunburn With This Smart Bikini Spinali Design brings wearable technologies to the beach (where skin cancer runs rampant) The french are credited with creating the modern bikini,
and improve survival outcomes after surgery and injury.""We are excited very,"lead researcher Sanford Markowitz,
and eye injuries,"said Ho. We can't wait t
#Paralysed people have learnt to control robots remotely with their thoughts Scientists have developed technology that's given paralysed people the ability control a robot remotely using just their thoughts,
and develop new treatments for neurological disorders, such as spinal cord injuries and Parkinson disease.""Our artificial neuron is made of conductive polymers
"These encouraging results provide continued evidence that spinal cord injury may no longer mean a lifelong sentence of paralysis and support the need for more research,"Roderic Pettigrew,
and has been shown to help mice with spinal cord injuries move again. At the start of the study the men's legs only moved
that those individuals with partial injuries have even more room for improvement.""""All patients are going to need something slightly different,
#Novel eye-tracking technology detects concussions head injury severity Neuroscientists and concussion experts from NYU Langone and elsewhere in a study publishing online January 29 in Journal of Neurotrauma present a unique simple and objective diagnostic tool for concussion that can be utilized in the emergency room or one day
when a patient can safely return to work following a head injury. The eyes have served as a window into the brain with disconjugate eye movements--eyes rotating in opposite directions--considered a principal marker for head trauma as early as 3500 years ago.
Current estimates by optometrists suggest that up to 90 percent of patients with concussions or blast injuries exhibit dysfunction in their eye movements.
or extremity injuries but did not require head CT SCANS had similar abilities to coordinate eye movements as normal uninjured controls.
and had normal CT SCANS most were slightly worse at 1-2 weeks after the injury
and subsequently recovered about one month after the injury. Among all trauma patients the severity of concussive symptoms correlated with severity of disconjugacy.
or swelling in the brain as a potential biomarker for assessing brain function and monitoring recovery in people with head injuries.
Dr. Samadani's future work aims to replicate eye-tracking's diagnostic potential for head injuries on a larger scale in Iraq
Two patients who suffer a head injury and present with virtually-identical CT SCANS might have completely different symptoms Dr. Samadani points out.
particularly individuals who have become paralyzed following spinal cord injury, "explains Lacour, co-author of the paper,
it nonetheless includes electronic elements that stimulate the spinal cord at the point of injury. The silicon substrate is covered with cracked gold electric conducting tracks that can be pulled and stretched.
"For the time being, the e-Dura implant has been tested primarily in cases of spinal cord injury in paralyzed rats.
However, for patients who experience trauma to a joint that was otherwise healthy before the injury,
They showed that NDP1 bioactivity governs key gene interactions decisive in cell survival when threatened by disease or injury.
Tracheal damage can be caused by tumor endotracheal intubation blunt trauma and other injuries. Narrowing and weakness of the trachea can occur
such as to treat fractures and other pathologies that cause this kind of deviations in the bones of adult people.
and wound healing and is activated when a delta or jagged ligand of one cell interacts with the notch receptor on an adjacent one.
in order to cope with unpredictable episodes of infection injury and tumor formation. The immune system has to think on its feet said Davis senior author of the new study which will be published Jan 15 in Cell.
Almost 20 years ago, Heber-Katz noticed that the MRL mouse can spontaneously regenerate cartilage and other tissues after injury
of which is increased markedly before and after injury in the MRL mouse. Under normal oxygen conditions, HIF-1a is degraded by prolyl hydroxylases (PHDS.
Next, they selected a non-regenerating strain of mice to see what would happen when they experimentally up-regulated (stabilized) HIF-1a levels after an ear hole punch injury.
the drug-treated mice showed a pattern of molecular changes indistinguishable from that observed in MRL mice during regeneration in response to injury, confirming HIF-1a as a central driver of healthy regeneration of lost
In the body, inflammation is normally a natural healing response to infection or injury.""You get a recruitment of white blood cells that fight off the infection
or work to heal the injury, "explained first author Emma Borgeson, Phd, a postdoctoral fellow at UC San diego and UCD."
and injury and have an amazing ability to change what they do to suit the situation in which they find themselves.
It has always been assumed that the programming takes place once the cells arrive at the point of injury
or injury itself but this data suggests that it's the signals that are being sent out from the gut that are impacting the whole immune system.
or even prevent many of the blunt-force injuries we see today.""Seepersad led the work along with UT Austin research scientist Michael Haberman.
and delivered to match a complex injury. The published research was restricted to one ink cartridge, but the scientists believe it could extend to multi-cartridge printing combining complex functions.
Sox9 begins to be expressed in pre-cancerous lesions and is maintained in invasive tumors. Deletion of Sox9 prevents skin cancer formation demonstrating the essential role of Sox9 during tumorigenesis
including treatment for other diseases and eye injuries
#UVA fertilization discovery may lead to male contraceptive Groundbreaking new reproductive research has identified key molecular events that could be playing a critical role as sperm
#Stretchy mesh heater for sore muscles If you suffer from chronic muscle pain a doctor will likely recommend for you to apply heat to the injury.
"Eighty-two percent of the smooth muscle cells within advanced atherosclerotic lesions cannot be identified using the typical methodology
since the lesion cells down-regulate smooth muscle cell markers. As such, we have underestimated grossly how many smooth muscle cells are in the lesion."
"Suddenly, the role of smooth muscle cells is much more complex, much less black-and-white. Are they good or bad?
which cell is which within the lesion."("The research also shows other subsets of smooth muscle cells were transitioning to cells resembling stem cells and myofibroblasts.
Of major interest, loss of Klf4 in smooth muscle cells did not reduce the number of these cells in lesions
Shankman's findings raise many critical questions about previous studies built on techniques that failed to assess the composition of the lesions accurately.
Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.
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