| Fracture (70) |  |
| Injury (460) | |
| Lesion (145) | |
| Sunburn (9) | |
| Wound (147) | |
highlighting the need for an approved drug that can be taken after radiation exposure to protect against organ injury and death.
which can cause cell death and organ injury due to DNA damage. Although some agents tested by the military can provide some protection against radiation sickness when taken prior to radiation exposure,
It is estimated that between 60 to 75 percent of these patients opt for a lumpectomy the removal of the cancerous lesion,
#The artificial hand that'feels'like a real one As far as medical research has come towards treating illness and injury,
The severity of his injuries only became apparent sometime after the accident. He would get regular blackouts.
Are there any earlier injuries, and what kind of injuries? What kind of drugs have been used for treatments?
Also what does the medical imaging tell us or what does the blood biomarkers (blood samples) tell us The database allows neurologists to compare their patientscases with similar ones.
In the second disease corneal neovascularization corneal injury results in the growth of unwanted blood vessels that impair vision.
and then inserted the coated needles near the point of an injury keeping them in place for approximately one minute until the drug dissolved into the cornea.
bandages that signal when a wound is infected with antibiotic-resistant bacteria; or smart clothing that tells a runner she s getting dehydrated.##
what we thought they were they're not a single strain of bacteria with a single lesion leading to the small colony variant phenotype.
##It appears that injury itself can induce fibroblasts to change into endothelial cells so the heart heals better.
To their surprise almost a third of the fibroblasts in the area of the cardiac injury expressed these endothelial markers.
##or overexpressed in the fibroblasts after heart injury and this seemed to regulate fibroblasts becoming endothelial cells.
and used it to treat mice for a few days after cardiac injury. The drug had dramatic results doubling the number of fibroblasts that turned into endothelial cells.
They had more blood vessels at the site of injury and their heart function was better.##
##By increasing the number of blood vessels in the injury region we were able to greatly reduce the effects of the heart attack.##
whether such an approach could be applied for treating scarring in other organs after injury.####The American Heart Association and the National institutes of health funded the work.
and the human trials weren t large enough for the true risk of liver injury to become apparent says Paul Watkins coauthor of the study and professor of medicine and pharmacy at University of North carolina.
In a simulated population the model successfully predicted that rare patients would develop life-threatening liver injury
The study shows that a computer model could accurately forecast the occurrence of troglitazone-induced liver injury.
Before DILISYM no one had been able to completely explain troglitazone liver injury or suggest improved approaches
It turns out that animals do a poor job predicting human drug-induced liver injury.
Drug-induced liver injury is the most common reason drug-development programs are terminated. It is also the leading cause of regulatory actions that lead to failed
We believe that the development of this model in the mouse is important for making progress in the field of skeletal repair where an acute clinical need is present for ameliorating skeletal injury chronic osteoarthritis
#Cells press down to make wounds heal faster National University of Singapore rightoriginal Studyposted by Karen Loh-NUS on September 12 2014scientists have uncovered more details about how our bodies repair wounds.
Earlier studies identified two processes at play in mending injury in the body. One involves the"purse-string"mechanism where a ring of proteins forms at the edge of a wound
and tightens like the strings of a purse. The second is"cell crawling"where cells move across the gap using armlike projections to close the gap.
At the early stages traction forces point away from the wound which suggests wound closure is driven initially by cell crawling.
At later stages the team observed forces pointing toward the wound. The investigators discovered a new mechanism
The contractions enable the cells to close the wound by cooperatively pressing down on the underlying tissue thus quickening the healing.
and then go specifically to the site of a serious injury they could help decrease the number of deaths associated with serious injuries.##
#Drug combo heals wounds fast with less scarring Johns hopkins university rightoriginal Studyposted by Vanessa Mcmains-Johns Hopkins on August 28 2014doctors have stumbled onto a potential new use for two approved medications.
When used in combination they heal wounds more quickly with less scar tissue. In mice and rats injecting the two drugs in combination speeds the healing of surgical woundsâ#by about one-quarter
If the findings published in the Journal of Investigative Dermatology hold up in future human studies the treatment might also speed skin healing in people with skin ulcers extensive burns and battlefield injuries.##
##The wound healing potential of the two drugs was discovered incidentally while the researchers were working to prevent rejection of liver transplants.
Focusing on just the wound healing##side effect##the scientists launched the rodent study to determine what the mechanism behind its therapeutic effects might be.
Additionally they found that the wounds in animals that received the drug combination healed with less scar tissue and regrew skinâ##s hair follicles.
Though the study tested the drug combination only on surgical excisions the researchers say the beneficial effects also apply to burn injuries
This same gene mutation has been associated with the formation of plaque-like lesions in the brains of people with Alzheimer disease,
many examiners are prone to assess normal variations as injuries from trauma. n the other hand,
Studies of stroke injury in rodents have noted SVZ cells apparently migrating into the neighboring striatum.
however, there is already too much damage to the blood-brain barrier and the drug causes bleeding in the brain, severe injury,
which can run for years without needing to be wound manually. The new system works like this:
and caused some severe sunburns. The team estimated that about three-quarters of the meteoroid evaporated at that point.
and found the arthquakesonly within a narrow temperature range that simulates conditions where the real earthquakes occur in Earth. sing synchrotron X-rays to aid our observations we found that fractures nucleate at the onset of the olivine to spinel transitiongreen says. urther these fractures propagate dynamically
or lipids leading to the development of lesions and hastening the onset of atherosclerosis. This exposure may be especially chronic for those employed in research laboratories
possibly even including damaged nerve cells and spinal chord injuries. Via Dvice Share Thissubscribedel. icio. usfacebookredditstumbleupontechnorat t
because it requires placing ultrasound leads on the skin directly over the bone injury. That impossible with an old-school plaster castut not with a 3d printed cast of the future.
and strengthen muscles in aged mice People become less able to bounce back from injuries as they age.
healthy tissue to recover from illness or injury. But because stem cell therapies remain cutting edge,
The lab most recent findings suggest that stem cell therapy could be used to help older patients recover from muscular injuries, for example from falls,
or an injury. his really opens a whole new avenue to enhance the repair of specific muscles in the elderly, especially after an injury.
Key scientific and technological advances in the CYPHER 2. 0 service include modelling the interaction of the reservoir's natural fracture networks with the fractures induced by the hydraulic fracturing process.
This results in a more accurate fracture network model with which to simulate the production performance of the completion design.
Critical operational factors can then be adjusted in real time between stages during the fracture treatment to further optimize well performance.
and also aid in the stimulation design to help improve their fracture efficiency and effectiveness.
and sensors into a desirable geometry with 5d data reconstruction Enhancing fracture determination from seismic data with improved full azimuth imaging
using full-azimuth fracture orientation and intensity analysis Wojciech Kobusinski, head of Depth Imaging Group at Geofizyka Torun,
when common infections and minor injuries which have been treatable for decades can once again kill. Honey is a natural antibacterial
Its viscosity acidity and sugar content make it good at sealing wounds and it even contains small amounts of hydrogen peroxide.
but they did work wonders for 10 horses with persistent wounds. The bacteria were mixed with honey
and applied directly to the horses'wounds which had resisted other attempted remedies. The mixture healed all 10.
Thus it is not surprising to observe dramatic cellular plasticity after exposure to significant external stresses such as an injury.
phase I safety study of a stem cellerived therapy for spinal cord injury. The publicly traded company has an extensive patent portfolio relating to embryonic stem cell research,
In the trial, eight to ten paralyzed individuals within 7 to 14 days of their injury will be injected at the point of injury with stem cellerived precursors to oligodendrocytes,
and regenerate after an injury.)""This is a very sophisticated mechanism#it seems that the bacterium knows the mechanistic interaction of the Schwann cell better than we do,
which precursors of neural support cells grown from human ES cells were injected into people with spinal-cord injuries.
simulate lesion dynamics or implement network analysis functions from a library of graph theoretic measures. Within the immersive mixed/virtual reality space of Brainx3 users can explore and analysis dynamical activity patterns of brain networks
even if the neural pathways from the brain are interrupted physically as the result of a spinal cord injury.
This is the first time throughout the world that the spinal-cord activation patterns for walking have been decoded Paraplegics still have neural connections (so-called locomotion centers) below the site of the injury
Exactly how the neural networks need to be stimulated depends upon the patient individual injury profile and is the subject of further studies.
which involves attaching electrodes to the surface of the skin. his method allows easy access to the neural connections in the spinal cord below a spinal injury
inflammation (a reaction to injury or infection) and autophagy (a cellular process involved in the removal of damaged cellular components.
and helps us to understand better how brain cell respond to disease and injury. There are estimated to be 100 million cells in a mouse brain
while scar-forming cells migrate to the site of a wound. But finding ways of guiding artificial materials within the body has proven more difficult.
whom also had called lesions Hunner lesions, which affect about 10 to 15 percent of IC sufferers.
Usually, doctors cauterize these lesions (which don disappear on their own) while patients are under anesthesia in an operating room.
in our trials, the lesions in those using Liris disappeared after two weeksin five out of six patients,
Last year, Taris began an ongoing focus study specifically on patients with Hunner lesions. ain is a subjective outcome,
ut the disappearance of the Hunner lesions was a purely objective outcome. That objective result,
then the cable can get taut and fracture, which is really bad news . So we wanted to understand what was underlying those patterns.
which, when wound on a spool, retains a certain amount of curve as it unwound.
To train the material Holschuh first wound raw SMA fiber into extremely tight millimeter-diameter coils then heated the coils to 450 degrees Celsius to set them into an original or trained shape.
If your suit happens to have sensors it could tourniquet you in the event of injury without you even having to think about it.
the MIT team can measure how well cells repair the most common DNA lesions, including single-strand breaks,
of which carry a specific type of DNA damage, also called DNA lesions. Each of these CIRCULAR DNA strands,
the DNA lesions prevent those genes from being expressed, so when the DNA is repaired successfully, the cell begins to produce the fluorescent protein.
In others, repairing the DNA lesion turns the fluorescent gene off. By introducing these plasmids into cells and reading the fluorescent output,
scientists can determine how efficiently each kind of lesion has been repaired. In theory, more than five plasmids could go into each cell,
which type of lesion the plasmid carries, as well as information about which patient cells are being tested.
or people who have suffered traumatic injuries. The researchers also anticipate that it could help scientists learn more about tumor biology.
or over edge of a wall, going that fast could mean crashes and injuries. So for some customers that operate in dangerous terrain,
the ankle was least stiff a finding that suggests this direction of movement is most vulnerable to injury.
hich are highly relevant to many ankle injuries including the common ankle sprain. n intriguing extension of this work is that it may be possible to train individuals to activate their ankle musculature in a way that helps reduce the chance of injury,
Sensing thrombinblood clotting is produced by a complex cascade of protein interactions culminating in the formation of fibrin a fibrous protein that seals wounds.
Between 1979 and 2013, there were over 40,000 reported injuries and nearly 20,000 fatalities due to unexploded land mines.
"Making graphene-based nano devices by mechanical fracture sounds attractive, but it wouldn't make sense until we know how to get the right types of edgesnd now we do said
and have significant adverse effects on macrophages a type of white blood cell that take up lipids leading to atherosclerotic lesion development and its consequent cardiovascular events such as heart attack or stroke.
Possibly as a result of the swelling or for other unknown reasons the silicon fractures and breaks down.
or ultraviolet light did the DNA form base lesions, a form of DNA damage associated with attack by radicals.
and the Massachusetts institute of technology could buy wounded soldiers the time they need to survive by preventing blood loss from serious internal injuries.
Once injected, the material locks into place at the site of the injury and rapidly decreases the time it takes for blood to clot in some instances by a whopping 77 percent,
incompressible injury one where it is difficult if not impossible to apply the pressure needed to stop the bleeding he
"Our material's combination of injectability, rapid mechanical recovery, physiological stability and the ability to promote coagulation result in a hemostat for treating incompressible wounds in out-of-hospital, emergency situations,
and his colleagues solidifies at the site of the wound and begins promoting coagulation in the targeted area.
"Most of these penetrating injuries, which today are the result of explosive devices, rupture blood vessels and create internal hemorrhages through
Researchers synthesize platelet-like nanoparticles that can do more than clot blood (Phys. org) Stanching the free flow of blood from an injury remains a holy grail of clinical medicine.
Controlling blood flow is a primary concern and first line of defense for patients and medical staff in many situations from traumatic injury to illness to surgery.
The process of coagulation is familiar to anyone who has suffered even the most minor of injuries such as a scrape or paper cut.
Blood rushes to the site of the injury and within minutes the flow stops as a plug forms at the site.
and a viscous substance that brings healing factors to the injury. Coagulation is actually a choreography of various substances among the most important
of which are platelets the blood component that accumulates at the site of the wound to form the initial plug.
As soon as an injury occurs however the platelets because of the physics of their shape and their response to chemical stimuli move from the main flow to the side of the blood vessel wall
and congregate binding to the site of the injury and to each other. As they do so the platelets release chemicals that call other platelets to the site eventually plugging the wound.
But what happens when the injury is too severe or the patient is on anticoagulation medication
or is impaired otherwise in his or her ability to form a clot even for a modest or minor injury?
That's where platelet-like nanoparticles (PLNS) come in. These tiny platelet-shaped particles that behave just like their human counterparts can be added to the blood flow to supply
Emergency situations can be brought under control faster injuries can heal more quickly and patients can recover with fewer complications.
and flexibility of natural platelets PLNS can also flow to the injury site and congregate there.
yielding insights into treatment for degenerative neurological conditions or restoring nerve connections after injury. Researchers at the University of Illinois at Urbana-Champaign and the University of Wisconsin-Madison created the microtube platform to study neuron growth.
They posit that the microtubes could one day be implanted like stents to promote neuron regrowth at injury sites
-and time is crucial for restoring severed connections in the case of spinal cord injury or limb reattachment.
or are perturbed by injury or disease. The new device uses graphene a recently discovered form of carbon on a flexible plastic backing that conforms to the shape of tissue.
Like cling wrap new biomaterial can coat tricky burn wounds and block out infection More information:
that's why when bone density decreases, fractures become more likely. But using the right mathematically determined structures to distribute
#Building Better Knees For The NBA The stress of repetitive jumping makes NBA players#particularly prone to painful even career-ending cartilage lesions.
#The Substitute that Deliversto fix a lesion doctors use osteochondral autograft transplant#surgery#(OATS)# to transfer cartilage from a non-load-bearing section of the patient s knee.#
The New Last Resortused to treat large injuries autologous chondrocyte implantation (ACI) involves harvesting cartilage from the patient
Paralyzed Rats Walk Again, Now Farther Than Ever Like a severed telephone line (from back in the days when phones had wires) a spinal cord injury can cut off communication between the brain
one above the injury and one below. Then the top array reads the electrical commands from the brain and beams them to the lower array.
Essentially the EES is a bridge that bypasses the spinal cord injury. The technology has given already paralyzed rats
if a blow was powerful enough to potentially cause a head injury. At a time when the sport has been hammered with bad news this#might be a game changer.
No casualties or even small injuries were reported although the area is being contained and treated with caution.
and supports assistive communication technologies for individuals who are unable to effectively communicate due to neurological injury and disease.
Says Bacher#if we develop a piece of technology for someone with a spinal cord injury who is moving their head to control a computer there s no reason that can#t help someone
For people who have become paralyzed due to a spinal injury the normal flow of brain signals through the spine
which will promote efficient rehabilitation. e would like to see these robots used for rehabilitation training in hospitals nursing homes and private homes after an injury or for use as a preventive measure prior to injury. i
For example if a person has a cervical injury and can only move from the neck up you can put a switch next to their head.
Previous work by the team have enabled animals paralysed by spinal cord injury (SCI) to voluntarily walk again using both chemical and electrical stimulation.
E-dura is implanted over the lumbosacral segments below the site of injury and engages with the#dormant#lumbar locomotor circuits.
and helps heal wounds. However in cancer, fibroblasts are coopted into re-sculpting and stiffening the surrounding matrix.
#US ARMY Turns to Computer Software for Medic Training Technology already has pushed medical and emergency responder training well beyond the days of mock wounds and static mannequins.
Combat Medic, developed for the service by Applied Research Associates, places trainees in a 3-D collaborative world where they learn to treat the three injuries most associated with preventable battlefield deaths hemorrhage, blocked
"However), in situations where people have spinal cord injury, so they are quadriplegic...you probably couldn't give them sensation back through the nerves,
The big benefit of Sanchez's approach is being able to use prostheses for people with spinal cord injuries,
The 28-year-old man in the current demonstration has been paralyzed for more than a decade because of a spinal cord injury.
and said only that he had suffered a spinal cord injury.""By wiring a sense of touch from a mechanical hand directly into the brain,
and James Fox all professors of biological engineering at MIT had identified the presence of a lesion,
This lesion, a damaged form of the normal DNA base cytosine, is caused by the reactive molecule hypochlorous acid the main ingredient in household bleach
The lesion 5clc, was present in remarkably high levels within the tissue, says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
who led the current research. hey found the lesions were very persistent in DNA, meaning we don have a repair system to take them out,
Essigmann says. n our field lesions that are persistent, if they are also mutagenic, are the kind of lesions that would initiate cancer,
he adds. DNA sequencing of a developing gastrointestinal tumor revealed two types of mutation: cytosine (C) bases changing to thymine (T) bases,
the researchers decided to investigate the lesion further, in a bid to uncover if it is indeed mutagenic.
the researchers first placed the 5clc lesion at a specific site within the genome of a bacterial virus. They then replicated the virus within the cell.
the researchers replicated the genome containing the lesion with a variety of different types of polymerase,
the researchers predict that accumulation of the lesions would increase the mutation rate of a cell up to 30-fold,
Lesions in DNA can occur as often as 100,000 times per cell per day. They can be the result of normal metabolic activities, like free radicals,
Improper repair of DNA lesions can lead to mutations, abnormal chromosome structures, or loss of genetic information that in turn can cause premature aging, cancer, and genetic abnormalities.
If the cell's replication machinery collides with the lesion, a strand break can occur."
"Or, a serious lesion may be tolerated and the cell will continue to replicate. This may or may not be a good decision,
It is the degree of genomic instability caused by the lesion that will determine whether the cell will survive."
"Sometimes, these forks run into obstacles-like the lesions described above-that block their progress. When they do,
"Fork reversal is a central mechanism that our replication machinery uses to deal with DNA lesions,
and collision with the lesion is prevented.""In this study, Vindigni and team have identified new enzymes that enable cells to resume replication once the DNA lesion has been repaired.
Vindigni found that DNA2, an enzyme that works both as a nuclease (an enzyme that degrades DNA)
and pursued postdoctoral research in multiphysics, fracture mechanics, and applied mathematics at Lehigh University. When he tells how he came to be at NRL in 1986,
However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
as there is a greater risk for fracture if a device is too large or too complex.
and James Fox all professors of biological engineering at MIT had identified the presence of a lesion,
This lesion, a damaged form of the normal DNA base cytosine, is caused by the reactive molecule hypochlorous acid the main ingredient in household bleach
The lesion 5clc, was present in remarkably high levels within the tissue, says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
who led the current research. hey found the lesions were very persistent in DNA, meaning we don have a repair system to take them out,
Essigmann says. n our field lesions that are persistent, if they are also mutagenic, are the kind of lesions that would initiate cancer,
he adds. DNA sequencing of a developing gastrointestinal tumor revealed two types of mutation: cytosine (C) bases changing to thymine (T) bases,
the researchers decided to investigate the lesion further, in a bid to uncover if it is indeed mutagenic.
the researchers first placed the 5clc lesion at a specific site within the genome of a bacterial virus. They then replicated the virus within the cell.
the researchers replicated the genome containing the lesion with a variety of different types of polymerase,
the researchers predict that accumulation of the lesions would increase the mutation rate of a cell up to 30-fold,
When the material did fracture, the researchers found it far more likely for this to happen at the eight-member rings,
Most commercial sunblocks are good at preventing sunburn, but they can go below the skin surface
the researchers tested their sunblock against direct ultraviolet rays and their ability to cause sunburn.
the researchersformulation protected equally well against sunburn. They also looked at an indirect and much less studied effect of UV LIGHT.
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