| Fracture (70) |  |
| Injury (460) | |
| Lesion (145) | |
| Sunburn (9) | |
| Wound (147) | |
It is estimated that between 60 to 75 percent of these patients opt for a lumpectomy the removal of the cancerous lesion,
what we thought they were they're not a single strain of bacteria with a single lesion leading to the small colony variant phenotype.
This same gene mutation has been associated with the formation of plaque-like lesions in the brains of people with Alzheimer disease,
or lipids leading to the development of lesions and hastening the onset of atherosclerosis. This exposure may be especially chronic for those employed in research laboratories
simulate lesion dynamics or implement network analysis functions from a library of graph theoretic measures. Within the immersive mixed/virtual reality space of Brainx3 users can explore and analysis dynamical activity patterns of brain networks
whom also had called lesions Hunner lesions, which affect about 10 to 15 percent of IC sufferers.
Usually, doctors cauterize these lesions (which don disappear on their own) while patients are under anesthesia in an operating room.
in our trials, the lesions in those using Liris disappeared after two weeksin five out of six patients,
Last year, Taris began an ongoing focus study specifically on patients with Hunner lesions. ain is a subjective outcome,
ut the disappearance of the Hunner lesions was a purely objective outcome. That objective result,
the MIT team can measure how well cells repair the most common DNA lesions, including single-strand breaks,
of which carry a specific type of DNA damage, also called DNA lesions. Each of these CIRCULAR DNA strands,
the DNA lesions prevent those genes from being expressed, so when the DNA is repaired successfully, the cell begins to produce the fluorescent protein.
In others, repairing the DNA lesion turns the fluorescent gene off. By introducing these plasmids into cells and reading the fluorescent output,
scientists can determine how efficiently each kind of lesion has been repaired. In theory, more than five plasmids could go into each cell,
which type of lesion the plasmid carries, as well as information about which patient cells are being tested.
and have significant adverse effects on macrophages a type of white blood cell that take up lipids leading to atherosclerotic lesion development and its consequent cardiovascular events such as heart attack or stroke.
or ultraviolet light did the DNA form base lesions, a form of DNA damage associated with attack by radicals.
#Building Better Knees For The NBA The stress of repetitive jumping makes NBA players#particularly prone to painful even career-ending cartilage lesions.
#The Substitute that Deliversto fix a lesion doctors use osteochondral autograft transplant#surgery#(OATS)# to transfer cartilage from a non-load-bearing section of the patient s knee.#
and James Fox all professors of biological engineering at MIT had identified the presence of a lesion,
This lesion, a damaged form of the normal DNA base cytosine, is caused by the reactive molecule hypochlorous acid the main ingredient in household bleach
The lesion 5clc, was present in remarkably high levels within the tissue, says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
who led the current research. hey found the lesions were very persistent in DNA, meaning we don have a repair system to take them out,
Essigmann says. n our field lesions that are persistent, if they are also mutagenic, are the kind of lesions that would initiate cancer,
he adds. DNA sequencing of a developing gastrointestinal tumor revealed two types of mutation: cytosine (C) bases changing to thymine (T) bases,
the researchers decided to investigate the lesion further, in a bid to uncover if it is indeed mutagenic.
the researchers first placed the 5clc lesion at a specific site within the genome of a bacterial virus. They then replicated the virus within the cell.
the researchers replicated the genome containing the lesion with a variety of different types of polymerase,
the researchers predict that accumulation of the lesions would increase the mutation rate of a cell up to 30-fold,
Lesions in DNA can occur as often as 100,000 times per cell per day. They can be the result of normal metabolic activities, like free radicals,
Improper repair of DNA lesions can lead to mutations, abnormal chromosome structures, or loss of genetic information that in turn can cause premature aging, cancer, and genetic abnormalities.
If the cell's replication machinery collides with the lesion, a strand break can occur."
"Or, a serious lesion may be tolerated and the cell will continue to replicate. This may or may not be a good decision,
It is the degree of genomic instability caused by the lesion that will determine whether the cell will survive."
"Sometimes, these forks run into obstacles-like the lesions described above-that block their progress. When they do,
"Fork reversal is a central mechanism that our replication machinery uses to deal with DNA lesions,
and collision with the lesion is prevented.""In this study, Vindigni and team have identified new enzymes that enable cells to resume replication once the DNA lesion has been repaired.
Vindigni found that DNA2, an enzyme that works both as a nuclease (an enzyme that degrades DNA)
and James Fox all professors of biological engineering at MIT had identified the presence of a lesion,
This lesion, a damaged form of the normal DNA base cytosine, is caused by the reactive molecule hypochlorous acid the main ingredient in household bleach
The lesion 5clc, was present in remarkably high levels within the tissue, says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
who led the current research. hey found the lesions were very persistent in DNA, meaning we don have a repair system to take them out,
Essigmann says. n our field lesions that are persistent, if they are also mutagenic, are the kind of lesions that would initiate cancer,
he adds. DNA sequencing of a developing gastrointestinal tumor revealed two types of mutation: cytosine (C) bases changing to thymine (T) bases,
the researchers decided to investigate the lesion further, in a bid to uncover if it is indeed mutagenic.
the researchers first placed the 5clc lesion at a specific site within the genome of a bacterial virus. They then replicated the virus within the cell.
the researchers replicated the genome containing the lesion with a variety of different types of polymerase,
the researchers predict that accumulation of the lesions would increase the mutation rate of a cell up to 30-fold,
and performing the repair. think having this will also reduce the incidence of residual lesions imperfections in repair by allowing us to simulate
which can require large and specialized equipment. hese bandages can be tailored individually for easy application on tumor lesions of all shapes and sizes,
because youe not going to recover function below the lesion,?he said. hey have been told that for decades,
The vaccine eradicated high-grade precancerous cervical lesions in nearly half of women who received it, scientists report.
The goal of the trial was to find nonsurgical ways to treat precancerous lesions caused by human papillomavirus (HPV),
according to the US Centers for Disease Control and Infection. very standard therapeutic option for women with these lesions destroys part of the cervix,
and pathology at Johns hopkins university School of medicine. vaccine able to cure precancerous lesions could eventually be one way women can avoid surgery that is invasive
High-grade cervical lesions occur most often in women 40 or younger. Because the lesions can progress to cancer,
they are removed today usually by surgery, freezing, or laser treatment. The procedures remove the precancerous areas in about 80 percent of women.
Less troublesome low-grade lesions usually are monitored just. They pose less of a cancer risk and usually regress on their own.
with newly diagnosed, high-grade precancerous cervical lesions. The women were assigned randomly to receive either three doses of the vaccine over a 12-week period or saline injections.
55 (48.2 percent) had regression of their precancerous lesions, meaning they disappeared or converted to low-grade lesions,
compared with 12 of 40 (30 percent) who received saline. The regression rate was closer to 50 percent in 107 women who received all three vaccine doses. n many of these women,
the vaccine not only made their lesions disappear, but it also cleared the virus from their cervix,
Trimble says. n most unvaccinated patients whose lesions went away, the virus was still present,
and many still had low-grade lesions. Clearance of the virus is a ignificant bonus she says,
because lingering HPV is a major risk factor for recurrence of cervical lesions. In biopsy samples, patients whose lesions completely regressed after vaccination had more immune T cells in the tissue. t important that T cells capable of recognizing HPV stay in the cervix
and fight off any recurrence of the infection, Trimble says. She is also studying other types of vaccines to prevent high-grade cervical lesions from developing into cancer.
The injection vaccine is made by Inovio Pharmaceuticals Inc, . which funded the clinical trial and whose employees coauthored the report with Trimble.
Historically, treatment for these metastatic lesions has been surgical excision with or without radiation therapy, but disease recurrences can still be very high.
TWO YEARS LATER The data indicate that all patients achieved complete clinical response to the treated lesions within one to three months of starting the intralesional IL-2-based therapy.
Eventually, the buildup of misfolded proteins can cause lesions to form in the brain, leading to disease."
By clotting so deep into the lesion, the clot was shown to be more stable. Right now the fizzing agent is a bit messy.
"A better understanding of the mechanisms involved in axon guidance will offer new possibilities for developing techniques to treat lesions resulting from spinal cord injuries,
as the single strand moves over other portions of the structure, some"surveillance"protein components check for lesions or mistakes in the nucleotide sequence before it gets copieda sort of molecular quality control.
lesions to other parts of the brain, including the prefrontal cortex, known to be involved in certain aspects of decision-making,
and James Fox all professors of biological engineering at MIT had identified the presence of a lesion,
This lesion, a damaged form of the normal DNA base cytosine, is caused by the reactive molecule hypochlorous acid the main ingredient in household bleach
The lesion 5clc, was present in remarkably high levels within the tissue, says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
who led the current research. hey found the lesions were very persistent in DNA, meaning we don have a repair system to take them out,
Essigmann says. n our field lesions that are persistent, if they are also mutagenic, are the kind of lesions that would initiate cancer,
he adds. DNA sequencing of a developing gastrointestinal tumor revealed two types of mutation: cytosine (C) bases changing to thymine (T) bases,
the researchers decided to investigate the lesion further, in a bid to uncover if it is indeed mutagenic.
the researchers replicated the genome containing the lesion with a variety of different types of polymerase,
the researchers predict that accumulation of the lesions would increase the mutation rate of a cell up to 30-fold,
such as for analysing the development of neurodegenerative processes, the impact of a lesion from a trauma or tumour, response to treatment, etc.
which had caused lesions in patientsskin or lymph nodes. When the drug was injected into the cancerous sites over the course of six months,
more than 16 percent of patients saw their lesions shrink. So far, virology treatments haven worked as well in cancers in tissues deeper in the bodyhe drug has to be injected directly into the tumor site
with symptoms ranging from severe diarrhea to intestinal lesions to death. Bogyo's team has developed ways of conducting high-throughput screens of small molecules to speedily test their ability to inhibit
When a dental lesion appears, the dormant stem cells in the pulp awaken and try to repair the tooth by an unknown process.
two neurotransmitters that are essential to the body (see schema on page 2). The presence of these receptors on the surface of these stem cells indicated that they had the ability to respond to the presence of dopamine and serotonin in the event of a lesion.
activated by the dental lesion, are responsible for releasing a large quantity of serotonin and dopamine. Once released, these neurotransmitters then recruit the stem cells to repair the tooth by binding to their receptors (see schema on page 2). The research team was able to confirm this result by observing that dental repair was absent in rats with modified platelets that do not produce serotonin or dopamine,
and tricalcium phosphate-based biomaterials to repair the tooth and fill lesions. Our results lead us to imagine unprecedented therapeutic strategies aimed at mobilising the resident pulpal stem cells
meaning more healthy women with benign lesions were recalled for further testing. This is a drawback in screening,
Importantly, lesions to other parts of the brain, including the prefrontal cortex, known to be involved in certain aspects of decision-making,
such as for analysing the development of neurodegenerative processes, the impact of a lesion from a trauma or tumour, response to treatment, etc e
and James Fox all professors of biological engineering at MIT had identified the presence of a lesion,
This lesion, a damaged form of the normal DNA base cytosine, is caused by the reactive molecule hypochlorous acid the main ingredient in household bleach
The lesion 5clc, was present in remarkably high levels within the tissue, says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
who led the current research. hey found the lesions were very persistent in DNA, meaning we don have a repair system to take them out,
Essigmann says. n our field lesions that are persistent, if they are also mutagenic, are the kind of lesions that would initiate cancer,
he adds. DNA sequencing of a developing gastrointestinal tumor revealed two types of mutation: cytosine (C) bases changing to thymine (T) bases,
the researchers decided to investigate the lesion further, in a bid to uncover if it is indeed mutagenic.
the researchers first placed the 5clc lesion at a specific site within the genome of a bacterial virus. They then replicated the virus within the cell.
the researchers replicated the genome containing the lesion with a variety of different types of polymerase,
the researchers predict that accumulation of the lesions would increase the mutation rate of a cell up to 30-fold,
such as for analysing the development of neurodegenerative processes, the impact of a lesion from a trauma or tumour, response to treatment, etc e
it can be difficult to determine precisely where lesions and growths are, because of mismatches between imaging speed and peristalsis,
and a 50 percent reduction in the size of plaque lesions in their hearts. e were surprised definitely at the results in the oral feeding studies,
This panel of genes can now be used in precision medicine to diagnose malignant lesions and can be applied to personalized cancer treatment.
and they sometimes fail to detect cancer lesions behind normal tissue. In tomosynthesis approved by the FDA in 2011, a series of x-ray images are taken in an arc across the breast,
"When a patient comes with a lesion in his oral cavity, be it his her tongue
"When a patient comes with a lesion in his oral cavity, be it his her tongue
which causes rashes, lesions and arthritis, and creates an increased risk for cancer and diabetes.
symptoms of infection may include large skin lesions, fever, swelling of the spleen and liver,
The varied approaches were effective in"recruiting"protective monocytes to"lesion sites"in the brain,
Koronyo added that the study gives unprecedented details about monocyte numbers migrating into brain lesion sites
A pulse generator inserted under the skin below the collarbone provides electrical signals that create a lesion,
Because of its high flexibility, the stent has shown to be positioned easily across different lesions while and maintaining its strength over considerable time periods.
or equal 2. 4). 88.6%freedom from target lesion revascularization, as measured at one-year using Kaplan-Meier analysis s
and deposited onto a spinal cord lesion in glial fibrillary acidic protein-luc transgenic mice (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
and deposited onto a spinal cord lesion in Glial fibrillary acidic protein-luc Transgenic mices (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
A 1-2 millimeter patch of the nanowires doped with dexamethasone was placed onto spinal cord lesions that had been exposed surgically,
The lesions were closed then and an electromagnetic field was applied for two hours a day for one week.
neurons in the hippocampal region of the brain contain a large number of DNA lesions, known as double strand breaks.
even though conventional wisdom dictates that DNA lesions are very bad as this amagecan be mutagenic
Sox9 begins to be expressed in pre-cancerous lesions and is maintained in invasive tumors. Deletion of Sox9 prevents skin cancer formation demonstrating the essential role of Sox9 during tumorigenesis
"Eighty-two percent of the smooth muscle cells within advanced atherosclerotic lesions cannot be identified using the typical methodology
since the lesion cells down-regulate smooth muscle cell markers. As such, we have underestimated grossly how many smooth muscle cells are in the lesion."
"Suddenly, the role of smooth muscle cells is much more complex, much less black-and-white. Are they good or bad?
which cell is which within the lesion."("The research also shows other subsets of smooth muscle cells were transitioning to cells resembling stem cells and myofibroblasts.
Of major interest, loss of Klf4 in smooth muscle cells did not reduce the number of these cells in lesions
Shankman's findings raise many critical questions about previous studies built on techniques that failed to assess the composition of the lesions accurately.
Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.
painful lesions associated with inflammatory acne.""Our understanding of acne has changed dramatically in the last 15-20 years,
"Applying IL-6/Stat3 blockers to clinical practice might be dangerous for patients with cancerous lesions,
but replicates when injected into lesions or tumors, and then stimulates the body immune system to fight the cancer. he results from this study are said amazing,
and a half years to receive injections in each of the more than 60 lesions on her leg.
The lesions eventually began to fade and finally disappeared. She has been in remission for almost three years. want everyone to know they should never give up hope.
which causes rashes, lesions and arthritis, and creates an increased risk for cancer and diabetes.
A 1-2 millimeter patch of the nanowires doped with dexamethasone was placed onto spinal cord lesions that had been exposed surgically,
The lesions were closed then and an electromagnetic field was applied for two hours a day for one week.
The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed.
but also viruses. And so adenovirus increases the size of the lesion in the membrane, and can leave the endosome before the endosome becomes a lysosome
because youe not going to recover function below the lesion, 'he said. hey have been told that for decades,
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