| Glomerulonephritis (8) |  |
| Urinary tract infection (13) | |
polycystic kidney disease and glomerulonephritis. The organoids developed characteristics of these diseases. Those with mutations in polycystic kidney disease genes formed balloon-like, fluid-filled sacks, called cysts, from kidney tubules.
The organoids with mutations in podocalyxin, a gene linked to glomerulonephritis, lost connections between filtering cells. utation of a single gene results in changes kidney structures associated with human disease,
polycystic kidney disease and glomerulonephritis. The organoids developed characteristics of these diseases. Those with mutations in polycystic kidney disease genes formed balloon-like, fluid-filled sacks, called cysts, from kidney tubules.
The organoids with mutations in podocalyxin, a gene linked to glomerulonephritis, lost connections between filtering cells. utation of a single gene results in changes kidney structures associated with human disease,
They engineered mini-kidneys with genetic changes linked to two common kidney diseases, polycystic kidney disease and glomerulonephritis.
The organoids with mutations in podocalyxin, a gene linked to glomerulonephritis, lost connections between filtering cells. utation of a single gene results in changes kidney structures associated with human disease,
or those associated with glomerulonephritis. The scientists then coaxed the stem cells to differentiate into mature kidney cells that self-assembled into functional organoids with the physical complications related to their genetic mutations;
while organoids with changes in a protein that is implicated in glomerulonephritis displayed altered cell to cell interactions,
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