#Bacteria research opens way for new antibiotics University of Adelaide researchers have discovered a target for the development of completely new antibiotics against disease-causing bacteria.
The building block, called the Passenger-associated Transport Repeat (PATR), has been found in virulence factors of many major harmful bacteria including Salmonella, Shigella,
The PATR was shown to be integral in the transport of the virulence factors to the surface of the bacterial cell,
It may shift the way research in this field is conducted. e
#New method detects more breast cancer in screening Tomosynthesis detects 40%more breast cancers than traditional mammography does, according to a major screening study from Lund University, Sweden.
and pave the way for personalized treatment approaches that could optimize clinical outcomes in cancer patients."
This discovery could help find new ways to stop the spread of malaria in a population.
and I know they will be extremely proud that they have contributed directly to research progress in ways that go beyond traditional financial support
"We are still a long way from printing a brain but the ability to arrange cells
"This paves the way for the use of more sophisticated printers to create structures with much finer resolution."
researchers have discovered a new way to switch the polarization of nanomagnets, paving the way for high-density storage to move from hard disks onto integrated circuits.
The advance, to be reported in the Proceedings of the National Academy of Sciences, could lead to computers that turn on in an instant
It is conceivable that this diamond resonator could be applied to sensors--potentially in a highly sensitive way
Now a team of researchers at MIT and Tsinghua University in China has found a novel way around that problem:
The team didn't originally plan it that way, says Li, the Battelle Energy Alliance Professor in Nuclear Science and Engineering,
"She added that a systematic way of recording facial expressions would have a wide range of uses."
"Electrons behave similarly to X-rays in the way they explore speedy phenomena in nature. Electrons scatter off both electrons and atomic nuclei in materials.
saving any additional work of finding a way to attach metal leads. This new fabrication technique is a hyper-efficient way of utilizing the available Mote2 without any wasted or extraneous parts.
When asked about its potential for future use, Professor Heejun Yang of SKKU said, "There are many candidates for 2d semiconductors,
Synthesis of graphene via chemical vapour deposition (CVD) of methane gas onto a copper substrate is the most common way of producing the quantity
but graphene produced in this way is prone to contamination from chemical agents used to remove the growth substrate.
Raman spectroscopy and transport measurements on the graphene/boron nitride heterostructures reveals high electron mobilities comparable with those observed in similar assemblies based on exfoliated graphene.
The key is to transfer CVD graphene from its growth substrate in such a way that chemical contamination is avoided The high mobility of pristine graphene is preserved
"We have a way of choosing the light rays we want to capture and only those rays,"said Srinivasa Narasimhan, CMU associate professor of robotics."
this is accomplished by synchronizing the projector so that as the laser scans a particular plane, the camera accepts light only from that plane.
Alternatively if other camera hardware is used, the mathematical framework developed by the team can compute energy-efficient codes that optimize the amount of energy that reaches the camera.
This new discovery could open the way to incorporating sulfur into other natural products, potentially advancing new therapies for indications beyond cancer."
Hubbard has developed a way to reduce the off-target DNA binding of a class of gene editing proteins known as transcription activator-like effector nucleases (TALENS).
advanced diagnostic techniques and new ways to prevent, or dampen, epidemics.""According to the World health organization, GAS causes more than 600 million cases of human disease every year.
Arraytheir medical diagnostics device is designed to harness centrifugal force--akin to the circular swing of A chair-o-Plane"carnival ride
"Raman spectroscopy uses the way light interacts with matter to produce'unique scattering,'the equivalent of a molecular fingerprint,
"Our pilot study brings us a step closer toward realizing this vision, "said Neugebauer. The team will continue toward its goal of developing an easy-to-use spectroscopy-based point-of-care medical device for fast and reliable diagnostics."
"This method is probably an easy and original way to make a plasma, "said Cedric Poulain, a physicist at The french Alternative energies and Atomic energy commission.
#Paving the way for a faster quantum computer Since its conception, quantum mechanics has defied our natural way of thinking,
and it has forced physicists to come to grips with peculiar ideas. Although they may be difficult to digest,
The Way Forward This is the first time that a superposition of quantum gates has been implemented in the lab. At the same time
exciting way to connect theoretical research on the foundations of physics to experimental quantum computing g
paving the way for invasive predators to wreak havoc with native mammals, worsening Australia's extinction crisis and igniting discussions about bringing the devil back to the mainland.
an airplane or a farming tool and appreciate the durable layers protecting its parts. But depositing this covering is an essential manufacturing step that allows machines to function with repeated use."
Erdemir plans to continue exploring ways to improve surface hardening. For now, he said he's thrilled that the ultra-fast boriding technique is close to its first real-world applications n
a better way to test cardiac patients for any genes that might be causing their problems.
and help clinicians make real-time decisions about the best way to care for patients s
#New life of old molecules: Calcium carbide Remarkably, despite the above mentioned trend of mega-molecules,
"The researchers suggest that ants may be capable of responding not just to the presence or absence of particular hydrocarbons but also to the particular way in
of ways. It's a major step forward in creating a quantum computer to solve problems such as designing new drugs
#Better way to engineer therapeutic proteins into antibodies Some proteins exist so fleetingly in the bloodstream that they can't be given effectively as therapies.
"The major challenge for Lerner, Peng and their colleagues was to design leptin into an antibody in such a way that it would fold up into a functional structure
that can sandwich 2-D sheets of elements that otherwise couldn't be combined in a stable way.
is significant because it represents a new way of combining elemental materials to form the building blocks of energy storage technology--such as batteries, capacitors and supercapacitors,
Mastering Materials Combining two-dimensional sheets of elements in an organized way to produce new materials has been the goal of Drexel nanomaterials researchers for more than a decade.
"But Drexel researchers came up with a clever way to circumvent this chemistry challenge. It starts with a material called a MAX phase,
An Elemental Impasse Four years later, the researchers have worked their way through the section of the Periodic table with elements called"transition metals"
Specialists are still working in the proper way to administer it.""We analyze what is best:
and flaws in structures where safety is critical. he reason transducers are made still this way is mostly historical;
The best way to access the memories in this system is to return the brain to the same state of consciousness as
they changed the way the stressful event was encoded. In the drug-induced state, the brain used completely different molecular pathways
"That's useful because it means we had a way to do multicolor imaging within a very narrow emission window,
researchers in Brunger's laboratory at the Stanford School of medicine found a way to grow crystals of the complex.
This allowed transport into the nucleus of a protein called Smad2, which is essential for TGF-beta to exert its effects on astrocytes.
In other experiments, the scientists showed that eliminating p75ntr from astrocytes blocked the transport of Smad2 into the nucleus."Nuclear pores are gatekeepers
"Similar to the balloons, in our research we connect fluidic segments in such a way that an interplay between their nonlinear response results in unexpected behavior.
But first Bertoldi's team had to find a way to control something that, by definition, is uncontrollable.
"It's remarkable that instability itself has provided a way to improve and push the field of soft actuators forward."
better drugs for autoimmune conditions and new ways to expedite recovery from sepsis. The research
"This device could transform the way people with severe muscular weakness or other speech disorders communicate.
This could prove useful for developing ways to replace wires between chips with optical connectors,
opening the way to plasmonic counterparts of electronic components.""Potentially, we hope to achieve logic gates, which underpin all processing circuits,
and frosting on aircraft wings.""This represents a fundamentally new concept in engineered surfaces, "said Tak-Sing Wong, assistant professor of mechanical engineering and a faculty member in the Penn State Materials Research Institute."
in such a way that these surfaces possess both high surface area and a slippery interface to enhance droplet collection and mobility.
After years of trying to find an efficient and affordable way to extract uranyl, researchers at the University of Chicago, Peking University,
without altering the enzyme itself--establishing a new route for enzyme engineering and demonstrating the versatility of these synthetic proteins.
The way these cells organize themselves structurally in different organ systems helps them coordinate their amazingly diverse behaviors and functions,
#Magnetic fields provide a new way to communicate wirelessly Electrical engineers at the University of California, San diego demonstrated a new wireless communication technique that works by sending magnetic signals through the human body.
and more secure way to communicate information between wearable electronic devices, providing an improved alternative to existing wireless communication systems,
We're trying to find new ways to communicate information around the human body that use much less power,
The gene defect causes the absence of a protein variant involved in the transport of essential enzymes into structures in the cell called peroxisomes.
The failed transport of these enzymes affects the levels of two specific fat variants in the cell, plasmalogenes and phytanic acid.
This way the researchers obtain data for each type of mutation as well as precise mutation frequencies at any position of the RNA.
"The combination of muscle activation detection with motion sensors is a new and exciting way of understanding human intent with other applications in addition to enhanced SLR systems,
maybe one way to delay or reduce your risk for Alzheimer's is by genetically holding in check the normal increase in eotaxin that occurs in most of the population,"
and provides a simple way to visualize patterns in copy number mutations across populations of cells.
Today, scientists at Cold Spring Harbor Laboratory (CSHL) publish a new interactive analysis program called Gingko that reduces the uncertainty of single-cell analysis
and provides a simple way to visualize patterns in copy number mutations across populations of cells.
referring to the graphical way that CNV changes are represented by analysts. Right now, CNV is not a commonly used diagnostic measurement in the clinic."
"We're looking into the best way of collecting samples, analyzing them, and informing clinicians about the results,
"Cold Spring Harbor has established itself as the world leader in single-cell analysis, "says Schatz."
#A humanoid robot to liaise between space station crews A team of French researchers from the Institut cellule souche et cerveau (Inserm/Université Claude Bernard Lyon 1),
would liaise between the different crews that change every six months in order to pass on information. These results will be presented at the 24th International Symposium on Robot and Human Interactive Communication
since crews change every six months. In this scenario, an electronic card is damaged. Nao plays the role of the scientist's assistant by following his directions
the memory of this event will enable the robot to use a video system to show the repair that was made to a new member of the crew.
and then transferring them to the scientists in the next crew. These results demonstrate the feasibility of this system
"We are putting two tubes together in a strange way. What we want is a structure that is flexible and stiff at the same time.
what is called potassium transport. A follow-up experiment showed that new intestinal cells treated with E. histolytica showed potassium efflux--the flow of potassium from inside a cell out through the cell wall--directly before cell death."
and used drugs to block their ability to transport potassium. Blocking potassium efflux created cells that were resistant to E. histolytica."
"Looking for a way to get past this problem, scientists have developed another therapeutic agent, which proved much more effective,
Now, by borrowing from kirigami, the ancient Japanese art of paper cutting, researchers at the University of Michigan have developed solar cells that can have it both ways."
"Our study shows that genome mining is not only a viable route to new natural products, but that there are a tremendous number of new compounds awaiting discovery from the genomes of microbial strains,
"Because the lung is a potential entry route for infection into the body, its immune response is developed highly.
but this is the first time it has been used in this way. The researchers are hopeful that EVLP will be used in patients to reduce high rates of rejection and wastage of scarce donor lungs.
"This development seems to offer a route which means others won't have to suffer in this way and from a personal perspective
called Scales, is a real and practical way to see through brain and body tissue.""In recent years, generating see-through tissue--a process called optical clearing--has become a goal for many researchers in life sciences because of its potential to reveal complex structural details of our bodies, organs,
cleaner with waste-recycling catalyst Researchers at Cardiff University have devised a way of increasing the yield of biodiesel by using the waste left over from its production process.
It is believed this new process will have significant environmental benefits by improving the yield of biodiesel in a sustainable way that doesn't require the use of additional fossil fuels
By 2020, the EU aims to have 10 per cent of the transport fuel of every EU country come from renewable sources such as biofuels.
In their study, the researchers, from the Cardiff Catalysis Institute, developed a way of turning the crude glycerol back into methanol,
and potentially cheaper, way, by converting an undesired by-product into a valuable chemical that can be reused in the process."
"We set out to establish ways in which the waste product glycerol could be used to form other useful compounds,
"This research has the potential to transform the way in which waste is dealt with, and seriously improve the quality of life by reducing carbon emissions from fossil fuels
In this study, identifying a specific gene behind more aggressive forms of acute myeloid leukemia could give clues for new ways to personalise treatments for select patients.
the sooner we can find new ways to stop it
#Microbiologists describe new insights into human neurodegenerative disease Microbiology researchers at the University of Georgia studying a soil bacterium have identified a potential mechanism for neurodegenerative diseases.
Csga was found to degrade the phospholipid cardiolipin into fragments that were used as energy sources during sporulation much the same way humans produce
To help, Furis and a team of UVM materials scientists have invented a new way to create
the UVM team was able to observe nanoscale defects and boundaries in the crystal grains in the thin films of phthalocyanine--roadblocks in the electron highway."
"Think of these as easy-on ramps onto a highway--instead of an awkward stop sign at the top of a hill--that allow excitons to move far and fast.
the new research provides a powerful way to explore many other types of organic materials, too--with particular promise for improved solar cells.
This allows organic thin films to carry energy along this molecular highway with relative ease,
The scientists blocked glycolysis, another way that cells make ATP, so that the cells had to rely solely on their mitochondria for energy.
an Associate professor of Medicine at Mcgill University, says by way of explaining the importance of the discovery."
We have found that different coatings does change the way that they interact with the tooth surface.""
whilst at the same time exploring ways to commercialise it. Commercialisation is vital: if we cannot build a business that can sell thousands of these to health providers at a price they find attractive,
#Coordinating traffic down the neuronal highway An international team of researchers, led by scientists at the National University of Singapore (NUS),
and choline acetyltransferase (Chat) find their way to the right region of the neuron is largely unknown.
and the University of Michigan (U-M). They identified and characterised a protein that transports the enzyme ACL to the tips of neurons,
marking ACL for transport by the enzyme kinesin-1 to the neuron terminals. Once there
The researchers showed that a BNIP-H mutant associated with Cayman ataxia caused defects in the transport of the ACL enzyme.
scientists may be able to develop ways to better control NKTS to attack tumors. The new study also suggests there may be a way to intervene in the pathway to block inflammation.
When the researchers deleted the gene for RIPK3 or inhibited other parts of the pathway,
possibly paving the way for new therapies that can either hone the pathway's cancer-killing role or reduce its role in inflammation.
The tiny cargo-filled sacs then attach to the sperm like decorations on a Christmas tree before the sperm fuses with the egg.
"Discovery of these oviductosomes provides us with a window into the cargo being delivered by the female to the sperm,
"Currently, Deleon and her team are analyzing the protein-rich contents of this cargo to find out exactly what gives the sperm
#Coordinating traffic down the neuronal highway An international team of researchers, led by scientists at the National University of Singapore (NUS),
and choline acetyltransferase (Chat) find their way to the right region of the neuron is largely unknown.
and the University of Michigan (U-M). They identified and characterised a protein that transports the enzyme ACL to the tips of neurons,
marking ACL for transport by the enzyme kinesin-1 to the neuron terminals. Once there
The researchers showed that a BNIP-H mutant associated with Cayman ataxia caused defects in the transport of the ACL enzyme.
a gas station, and a university coffee shop. During the experiments, they used a bank application, cell phone application,
"This is used in many ways, but not so much for detection. We felt that there was a lot of potential in harnessing this designable DNA-binding technology for detection."
Learning more about such viruses could help scientists find ways to permanently eliminate them.""Latent HIV provirus is pretty much the final barrier to curing AIDS,
and there aren't any ways to eradicate it, "Slomovic says. While treating diseases using this system is likely many years away,
whether two genes located far from each other on a chromosome fold in such a way that they end up next to each other,
Vaginal rings with multiple reservoirs present a promising way for preventing sexually transmitted infections (STIS) and notably HIV infection in young women with high risk of exposure.
and could pave the way for entirely 3d printed wearable devices, soft robots, and electronics. The research was led by Jennifer A. Lewis, the Hansjörg Wyss Professor of Biologically Inspired Engineering at the Harvard John A. Paulson School of engineering and Applied sciences (SEAS) and a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering
which will guide how scientists and engineers build aircraft components, for example. The research, led by Jianwei (John) Miao,
because different arrangements of atoms cause electrons to interact in different ways. However, scanning transmission electron microscopes only produce two-dimensional images.
producing the material in a different way to allow it to remain fatigue-free through thousands of cycles s
"A cool way to improve solar efficiency In 2014, the same trio of inventors developed an ultrathin material that radiated infrared heat directly back toward space without warming the atmosphere.
"That's not necessarily the only way,"said Raman, a co-first-author of the paper."
But Swartz was so certain his approach would work that he found ways to bootstrap the project over the several years that it took to finish his experiments.
The discovery is a potential game-changer in Type 2 diabetes research, leading to a new way of thinking about the disease and its future treatment."
--and how they can fail--could lead to new ways to treat the disease, delaying or even preventing diabetes,
studying the insulin-producing cells from donors with diabetes is a powerful way to do it."
but finding a way to translate those findings into clinical use could yet take decades.
Despite this, Macdonald believes the findings show an important new way forward.""We don't know enough to stop Type 2 diabetes yet,
Not only would this provide a more accurate way of delivering drugs, but the cages themselves could be used therapeutically."
and deliver their cargo, they could break down into additional therapeutic agents. We can now design two things into one."
François started looking for ways to get it in check. One idea was finding something to make the antitumor drug everolimus more effective."
The way in which amino acids are linked together then determines which proteins are produced eventually, and in turn,
The use of either preferred or non-preferred codons is like having speed signs on the protein production highway:
The findings, published online Sept. 23,2015 in Nature, could change the way researchers think about how cancer spreads
#Viruses join fight against harmful bacteria In the hunt for new ways to kill harmful bacteria,
and 10 control games that were structured the same way. The researchers took steps to ensure participants couldn't use clues other than direct brain communication to complete the game.
"Evolution has spent a colossal amount of time to find ways for us and other animals to take information out of our brains
The newly described Cpf1 system differs in several important ways from the previously described Cas9, with significant implications for research and therapeutics,
In the second of two late-breaking presentations of research that is predicted to change the way kidney cancer patients are treated,
in many cases tumour cells find ways to escape control by these drugs. Cabozantinib is a new drug that targets possible escape mechanisms of tumour cells,
the development of new, lighter and stronger materials spanning consumer electronics to aircraft; and faster information searching through large databases s
"What we see is that there is a lot of diversity in the transport properties of these pores,
and in understanding transport through these really small pores in ultrathin materials,"Karnik says s
"His discovery offers a way to overcome this problem, offering hope that treatments may be developed for currently non-curable degenerative diseases, like Stargardt disease and ARMD."
Even if there's a long way to go before launching clinical trials, this means, in theory, that will be eventually be able to treat countless patients."
and in this way we can measure the resistance at different positions in a skyrmion'says Christian Hanneken, a Phd student in the group of Prof.
Mice with bladder tumours that are treated with M. brumae in the same way as patients survive longer than untreated mice and, what is more, in larger numbers than those treated with the usual mycobacterium:
"The way that we normally diagnose metabolic syndrome appears to have some racial discrepancies where African-american individuals are diagnosed not with metabolic syndrome at a very high rate
This development paves the way toward the production of lightweight, flexible, and high-power electronics, such as wearable devices, portable power supplies and hybrid and electric vehicles."
"Ultimately the goal of this research is to find ways to power current and future technology with efficiency
and in a sustainable way,"says Cranston, whose joint research was published recently in Advanced Materials."
researchers have discovered several ways of using genome sequencing of tumours to predict whether an individual cancer patient will benefit from a specific type of medicine.
and thus also as an effective and easy way of monitoring people who are at risk of developing cancer.
#Scientists pave way for diamonds to trace early cancers Physicists from the University of Sydney have devised a way to use diamonds to identify cancerous tumours before they become life threatening.
short of a biopsy, there are few ways to see if a treatment has been taken up by a cancer.
in this case opening the way for us to image and target cancers long before they become life-threatening,
Obtaining the bacterial consortium opens the way to production and subsequent application in contaminated aquifers, using the strategy of bioaugmentation,
"It's a remarkable new way to manipulate light.""Although this infinitely high velocity sounds like it breaks the rule of relativity,
Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves--using light.
So, the research team set out to find ways to steer the excitation waves, borrowing tools from the developing field of optogenetics,
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