Transporter

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Synopsis: Domenii: Transport: Transport generale: Transport: Transporter:

& Microbe Amarasinghe and Daisy Leung assistant professor of pathology and immunology show that VP24 tightly binds to a nuclear transporter a protein that takes molecules into

and out of the cell nucleus. Among the molecules these transporters take into the nucleus is STAT1 an important component of the interferon signaling pathway.##

##But when VP24 is attached to some of these transporters STAT1 can t get into the nucleus.##The study shows that VP24 s action specifically prevents STAT1 transport.

but the researchers were able to do it by way of a transporter, a protein that moves materials across cell membranes.

one of a class known as multidrug and toxic compound extrusion transporters (MATES) that are found in cell membranes.

Previous efforts to identify compounds that block MATE transporters have been unsuccessful partly because researchers had a poor understanding of how these proteins work.

But in the past three years scientists have made some progress mapping the transporters detailed architecture. Two different labs have revealed already the structures of two bacterial MATE proteins,

But he is working to identify blocking peptides for MATE transporters found in human cells and in V. cholerae."

the researchers took advantage of albumin function as a transporter of molecules called fatty acids. Albumin has binding pockets that can capture fatty, hydrophobic molecules,

The researchers stress that their experiment is fundamentally different than Star trek's transporter. The transporter teleports matter by converting matter into a signal for transport,

and then converting the signal back to matter at some other location. But earlier this month, a renowned theoretical physicist said technology such as this could pave the way for a Star trek-style teleporter.

#Japanese engineer develops world's first'car in a bag'Pocket-sized personal transporters could soon be seen on the streets of Tokyo.

A Japanese engineer has developed a portable transporter small enough to be carried in a backpack that he says is the world's first'car in a bag'.

'Twenty-six-year-old Kuniako Sato and his team at Cocoa Motors recently unveiled the lithium battery-powered"Walkcar"transporter,

Sato expects to see many other uses for his transporter, as he says it has enough power to help people push wheelchairs with ease.

In its cellular membrane, the bacterium had a previously unknown type of ion transporter. The protein,

Integrating these ion transporters into the neuronal membrane makes it possible to alter their state of charge using light impulses

The modeling of these arrangements could inform the cluster's use as a transporter of pharmaceutical drugs

#Computer-Designed Rocker Protein Worlds First To Biomimic Ion Transport For the first time, scientists recreated the biological function of substrate transportation across the cell membranes by computationally designing a transporter protein.

mechanisms and interactions of known transporters to overcome several barriers in protein engineering, including membrane protein folding.

making sure that the transporter that youe made ends up in the right place at the right time.

Frommer and his lab have worked extensively on the family of SWEET sugar transporters, which play several key roles in plants,

which encodes a sugar transporter protein in maize, was shown to be expressed specifically in the maize seed by the group of Prem Chourey at University of Florida,

passive glucose transporters membrane proteins known as GLUTS were known to be the primary method used by the body to deliver glucose to tumours.

Researchers at UCLA will next begin a clinical study to further investigate the importance of sodium-dependent glucose transporters in glucose delivery.

and drug resistance is caused by mutations that cripple these transporters. Jose Garcia-Salcedo, from the Instituto de Investigacion Biosanitaria in Granada, Spain,

most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

and circumventing resistance mechanisms caused by mutations in surface transporters.""The implication of this proof-of-concept study of a novel technology for reversing transporter-related drug resistance,

they say, "is limited not to a single nanobody used to demonstrate the technology, nor to a single drug, nor indeed to trypanosomiasis.""

'Glucose transporter type 1, called GLUT1, transports glucose across the cell membrane of most cells in the body and is especially important in the uptake of glucose by the brain and blood vessels,

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