The findings have been accepted by the international journal'Biological Psychiatry'for publication.""A total 130 people0 Alzheimer's patient, 41 patients suffering from mild cognitive impairment and 49 healthy individualsarticipated in the study.
and this has got applications in chemistry, engineering, biology, medicine, so there's a lot of potential there and that's just for research purposes,
and this has got applications in chemistry, engineering, biology, medicine, so there's a lot of potential there and that's just for research purposes,
At the same time, other genetic modifications to the virus mean it stimulates the body's own immune response to attack
which is manufactured by the American pharmaceutical company Amgen, have already been submitted to drugs regulators in Europe and the USA.
Kevin Harrington, UK trial leader and professor of biological cancer therapies at the ICR and an honorary consultant at the Royal Marsden, said he hoped the treatment could be available for routine use within a year in many countries
At the same time, other genetic modifications to the virus mean it stimulates the body's own immune response to attack
which is manufactured by the American pharmaceutical company Amgen, have already been submitted to drugs regulators in Europe and the USA.
Kevin Harrington, UK trial leader and professor of biological cancer therapies at the ICR and an honorary consultant at the Royal Marsden, said he hoped the treatment could be available for routine use within a year in many countries
Blaine A Pfeifer, an associate professor of chemical and biological engineering in the University at Buffalo School of engineering and Applied sciences, has been studying how to engineer Escherichia coli (E coli) to generate new varieties of erythromycin, a popular antibiotic.
Blaine A Pfeifer, an associate professor of chemical and biological engineering in the University at Buffalo School of engineering and Applied sciences, has been studying how to engineer Escherichia coli (E coli) to generate new varieties of erythromycin, a popular antibiotic.
#Gene mutation that leads to colour blindness identified Researchers have identified a previously unknown gene mutation that causes sufferers to be
Researchers at the University of California, San diego School of medicine and Shiley Eye Institute at UC San diego Health System identified the gene mutation that underlies achromatopsia, an inherited eye disorder.
"We're very excited to have discovered a mutation in the ATF6 gene which plays a major role in this disorder,
Five other genetic mutations have previously been identified by research groups as pivotal in achromatopsia.""But we still had families that didn't have any of those gene mutations.
We knew this meant there must be other genes and proteins involved, "Lin said. The new study found that a mutation in the ATF6 gene damaged proteins necessary for proper function of the eye's cone photoreceptors.
In the study, the scientists looked at 18 achromatopsia patients from 10 different families who had been identified as lacking the five previously known gene mutations.
The families received testing in the lab of Susanne Kohl, the study's first author from Centre for Ophthalmology at University of Tuebingen in Germany.
All 18 were found to have the ATF6 gene mutation. Lin said the ATF6 gene, when working properly, is a key regulator of the unfolded protein response (UPR).
since proteins carry out many biological functions.""In this particular disease, we think a mutation in the ATF6 gene disrupts the UPR process
and causes the production of bad proteins which keep cone photoreceptors from functioning properly, "said Lin.
Lin noted that the UPR is a different molecular mechanism than those affected by the other five gene mutations."
The study was published online in Applied and Environmental microbiology, a journal of the American Society for Microbiology."
Specifically, the copper surfaces destroyed both the virus'genome, and its capsid, or protein shell."
hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.
hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.
hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.
especially those caused externally,"said Hu Ping, a cell biologist with the Shanghai Institute for Biological science at the Chinese Academy of Sciences."
such as mutations that could lead to tumours. Such trials are crucial as safety is of paramount importance.
Dr William R Wilcox, a human genetics professor at Emory University, called the results"promising.""But he expressed caution, given that only 10 children were getting the high dose
or DNA molecule representing a genome of a virus-an action that leads to a massive,
"said Yingfu Li, a professor in the Departments of Biochemistry and Biomedical sciences, Chemistry and Chemical Biology."
"This discovery was made possible by using 30 years of data and biologic specimens. Rappocciolo and her colleagues searched for patterns in gene expression,
or the degree to which specific genes are turned on or off.""These results improve understanding of how nonprogressors control HIV without drug therapy
Understanding leptospira's mutation, when in contact with aquatic organisms, is of greater significance for Mumbai,
The mutation study, published in a Federation of European Microbiological Studies journal in May, was a wake-up call for public health experts to find better ways to tame the bacteria.
or through cuts and abrasions,"said Dr Jayanti Shastri, head of microbiology at BYL Nair Hospital.
which tested Merck and Newlink Genetics'VSV-ZEBOV vaccine on some 4, 000 people who had been in close contact with a confirmed Ebola case,
and schools with a focus on bioengineering applications that utilize living organs and other human tissues.
both have an extensive background in biotechnology. At age 18, Erik Gatenholm started his first medical device company, manufacturing meniscus implants and other implants, such surgical meshes for ventral hernia repairs and wound dressings.
and are compared often to the biological structure of cartilage. While the development of the 3d printable hydrogels is certainly a breakthrough for Zhao and the rest of the team,
added David Mooney, a professor of bioengineering at Harvard university. his builds off earlier work using other polymer systems,
but also pave the way for more complex optical fiber structures that are able to host a variety of applications for industries ranging from telecommunications and aerospace to biotechnologies and more."
#MEDPRIN 3d prints world first biological meningioma Redura for use in brain surgery While 3d bioprinting innovations sound lifesaving and revolutionary, most are still years away from impacting ordinary
Called MEDPRIN, they have developed the world first 3d printed biological meningioma called Redura a replica of tissue covering the brain
It full name is the Redura Biomimetic-Synthetic-Absorbable Dural Substitute, and has received already a number of medical certificates,
they are not biological and have a tendency to disrupt a patient life-as most artificial meningioma layers contain metal parts
this 3d printed biological Redura doesn suffer from these problems, but instead closely resembles the existing membrane and a patient autologous cells.
the machine sprays out a fiber-like ink onto biological paper that simulates the collagen structures found in body.
and clinical resources to push 3d printing from biological tissue reconstruction all the way up to 3d printing of organ regeneration.
The mobile platform has been tested successfully in a clinical microbiology laboratory, comparing 571 patient samples to FDA-approved samples of mumps, measles,
professor of bioengineering and one of the researchers on the team. t is quite important to have these kinds of mobile devices,
physics and astronomy, to bioengineering, pathology and laboratory medicine. The Californa Nanosystems Institute and the Johnsson Comprehensive Cancer Center also contributed, with support from the National Science Foundation and the Howard hughes medical institute.
The research spearheaded by Aydogan Ozcan, associate director of the California Nanosystems Institute, Dino Di Carlo, professor of bioengineering,
and Omai Garner, associate director of clinical microbiology for the UCLA Health System, and written by UCLA undergraduate Brandon Berg (the study first author) manages to shrink this work down to the size
The FDA-approved well-plate readers used in clinical labs today were compared with the team handheld smartphone diagnostic in a UCLA clinical microbiology laboratory.
tissue engineering an assembling biomaterials and many more. Even in military 4d printing will play a huge role in self repairing the parts. 3d printing is the best technology that has been widespread all over the world with the 4d printing around the corner will boost the market for 3d printers further,
thus inducing greater biological damage. In this study, the authors analysed the spectra of secondary electrons emitted from a carbon nanoparticle composed of fullerite,
has spent his Ph d. studies researching molecules that mimic nature biochemical machinery. He first designed an artificial pump two years ago,
Some of the examples comprise materials that deliver biomolecules, rotate light, or control the flow of energy.
The team employed cryo-electron microscopy, also known as CRYO EM, to observe the particles and origami frames. This work was headed by Huilin Li, Brookhaven Lab and Stony Brook University biologist,
and Tong Wang, the other lead co-author of the paper and who also works with Li in the Biosciences department of Brookhaven.
In order to view the varied density components individually, the researchers need to subtract the data from the images
CRYO EM preserves samples in their near-native states and provides close to nanometer resolution. We show that CRYO EM can be applied successfully to probe the 3d structure of DNA NANOPARTICLE clusters,
Wang said. The DOE Office of Science supported the study. DOE Office of Science supports the Brookhaven National Laboratory.
said Nicholas Hud, a professor in Georgia Tech School of Chemistry and Biochemistry. ith this work,
which also included Martha Grover from Georgia Tech School of Chemical & Biomolecular engineering, has used so far the solvent to assemble three structures,
who is also director of the NSF-NASA Center for Chemical Evolution and associate director of the Parker H. Petit Institute of Bioengineering and Bioscience,
The project goal is to develop new tools to elucidate the mechanism of action of a threat agent, drug, biologic or chemical on living cells within 30 days from exposure.
96 spot, target plate, suitable for simple and complex biological mixtures, and compatible with most standard MALDI-MS instrument systems.
Emiliana De Santis, who is developing the standard in NPL's Biotechnology Group, said:""Our ability to exploit self-assembly processes allows us to enable
"A new reliable biological standard is particularly attractive to the electron microscopy community as it has the potential to offer a cost effective solution for high-resolution imaging."
and when as a result of instructions contained in an organism's DNA genome.""From the features of the proposed method, it's easy to expect that we can obtain the same accuracy in a liquid environment,
In their setup, a sphere was placed on one of the prongs--in a biological system
"Future work for Yabuno and his colleagues involves using the cantilevers to obtain high-accuracy quantitative measurements of biological samples such as human cells and DNA in liquid media d
and other biological parts. n the biological domain, there are various molecules and atoms in contact with one another, sliding along like biomolecular motors,
as a result of friction or lack of friction, Gangloff says. o this intuition for how to arrange atoms so as to minimize
and related impact of their novel method propels a huge variety of research fields investigating effects relevant from raft tectonics down to biological systems
which is still the gold standard in the health care industry for making a definitive diagnosis. Also routinely used today is a newer method for rapidly identifying bacteria based on a DNA-analysis technique called quantitative polymerase chain reaction (qpcr),
"This opens up a completely new frontier where we can explore the interface between electronic structures and biology.
but no one has addressed this issue-the electronics/cellular interface-at the level at which biology works."
"The idea of merging the biological with the electronic is not a new one for Lieber.
a process common to delivery of many species in biology and medicine-you could go to the doctor
"The ability to precisely control droplets using fluidic computation could have a number of applications in high-throughput biology and chemistry,
Dmitry Fedyanin and Yury Stebunov, have developed an ultracompact highly sensitive nanomechanical sensor for analyzing the chemical composition of substances and detecting biological objects,
researchers make it react with specific substances or even biological objects. If you place antibodies to certain viruses on the cantilever,
and its mission is to seek nanotechnology solutions to challenges in the fields of biology, energy or technology.
Researchers in Sykes'lab are now assessing precisely how the low energy electrons travel through biological fluids.
biotechnology and nanobiotechnology for applications including targeted drug delivery. Chirality of an object is its property that allows it to be non-superimposable with its mirror image.
The human body is composed of chiral biomolecules. Many other biological objects are composed also of these chiral biomolecules.
In these compounds, the'left'form may be significantly different from the'right'form. Among these forms, usually one form is beneficial,
"said Dr. Carmen Gomes, Agrilife Research engineer with the Texas A&m University department of biological and agricultural engineering, College Station.
"I do the biological and polymer engineering; he does the electrochemistry and nanostructures, "she said.
As for the biological component, Gomes said she is using"nanobrushes"specially designed to grab particular bacteria.
A report on the work, published online in the journal Biomaterials, builds on recent research by the same team that previously identified a fat-and-sugar molecule called GSL as the chief culprit behind a range of biological glitches that affect the body's ability to properly use, transport
and purge itself of vessel-clogging cholesterol. That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound
and drug resistance is caused by mutations that cripple these transporters. Jose Garcia-Salcedo, from the Instituto de Investigacion Biosanitaria in Granada, Spain,
most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.
and circumventing resistance mechanisms caused by mutations in surface transporters.""The implication of this proof-of-concept study of a novel technology for reversing transporter-related drug resistance,
which also has an area of`Biotechnology and Drug Research of Biomedical engineering, Diagnosis and Treatment Equipment.
Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
Invented by Microchips Biotech cofounders Michael Cima, the David H. Koch Professor of Engineering, and Robert Langer, the David H. Koch Institute Professor, the microchips consist of hundreds of pinhead-sized reservoirs,
and osteoporosis. Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world largest producer of generic drugs,
Apart from providing convenience, Microchips Biotech says these microchips could also improve medication-prescription adherence a surprisingly costly issue in the United states. A 2012 report published in the Annals of Internal medicine estimated that Americans who don stick to prescriptions rack up $100 billion
Microchips Biotech will continue work on its flagship product, a birth-control microchip, backed by the Bill and Melinda Gates Foundation,
Cima, who now serves on the Microchips Biotech board of directors with Langer, sees this hormone-releasing microchip as one of the first implantable rtificial organsbecause it acts as a gland. lot of the therapies are trying to chemically trick the endocrine systems Cima says. e are doing that with this artificial organ we created.
For years, the technology underwent rigorous research and development at Microchips Biotech. But in 2011, Langer and Cima,
MEMS innovations Microchips Biotech made several innovations in the microelectromechanical systems (MEMS) manufacturing process to ensure the microchips could be commercialized.
To do so, Microchips Biotech modified a cold-welding ongue and grooveprocess. This meant depositing a soft,
or'CRYO EM'-imaging samples frozen to-180oc-to show the proteasome complex in such extraordinary detail that they could view a prototype drug bound to its active sites.
The research could help other scientists to use CRYO EM in structure-based drug design studies-in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.
CRYO EM offers the opportunity to study protein complexes in conditions closer to those in the human body.
The finding was made by a team led by Dr Stephen Royle, associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school.
s a cell biologist you dream of finding a new structure in cells but it so unlikely.
when they divide each new cell has a complete genome. Mitotic spindles are made of microtubules
A cell needs to share chromosomes accurately when it divides otherwise the two new cells can end up with the wrong number of chromosomes.
This is called aneuploidy and this has been linked to a range of tumours in different body organs.
The mitotic spindle is responsible for sharing the chromosomes and the researchers at the University believe that the mesh is needed to give structural support.
and cells had trouble sharing chromosomes during division. Dr Emma Smith, senior science communications officer at Cancer Research UK, said:
roblems in cell division are common in cancer cells frequently end up with the wrong number of chromosomes.
This early research provides the first glimpse of a structure that helps share out a cell chromosomes correctly
award-winning scientists and pioneering professionals. arwick Medical school division of biomedical cell biology carries out fundamental molecular and cellular research into biomedical problems.
Without a molecular understanding of the underlying cell biology, intelligent directed therapeutic intervention is impossible. The division research focuses on fundamental cell biology processes such as cell division and intracellular communication.
Source: http://www2. warwick. ac. uk m
#Scientists Discover New Chemical reaction Pathway on Titanium dioxide The reaction mechanism, reported in ACS Nano, involves the application of an electric field that narrows the width of the reaction barrier,
Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State. The nanoparticles infused with silver ions were utilized to attack Pseudomonas aeruginosa, disease-causing bacteria;
and Ralstonia, a genus of bacteria that contains various soil-borne pathogens. All these bacteria were destroyed by the newly developed nanoparticles.
which was led by which Louis Bouchard, assistant professor of chemistry and biochemistry, and Dimitrios Koumoulis, a UCLA postdoctoral scholar,
Co-authors of the PNAS research were Danny King, formerly a UCLA graduate student in chemistry and biochemistry;
#New Multispectral Microscope for Studying Impact of Experimental Drugs on Biological Samples This is the largest such microscopic image ever created.
This level of multicolor detail is essential for studying the impact of experimental drugs on biological samples
are present at each point in a single biological sample. harmaceutical research is awash with cutting-edge equipment that tries to image
and chemical processes that are taking place within a biological sample. This is essential for pharmaceutical research particularly cancer research--to observe how cells
and observe and study the biological and medical significance of RNA misregulation. Details will be published the week of July 20 in the journal Proceedings of the National Academy of Sciences (PNAS.
"Mirkin is the George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences and professor of medicine, chemical and biological engineering, biomedical engineering and materials science and engineering.
Nanoflares have been very useful for researchers that operate in the arena of quantifying gene expression. Aurasense, Inc.,a biotechnology company that licensed the Nanoflare technology from Northwestern University,
and EMD-Millipore, another biotech company, have commercialized Nanoflares. There are now more than 1, 700 commercial forms of Nanoflares sold under the Smartflare?
name in more than 230 countries. The Sticky-flare is designed to address limitations of Smartflares? most notably their inability to track RNA location and enter the nucleus. The Northwestern team believes Sticky-flares are poised to become a valuable tool for researchers who desire to understand the function of RNA in live cells l
In particular, materials that mimic biological adsorbents like coral have potentially huge applications.""The researchers tested the coral-like nanoplates on removing mercury from water.
"We hope our work provides inspiration for more research into the development of materials that mimic biological organisms
said Younan Xia, a professor in the Wallace H. Coulter Department of Biomedical engineering at Georgia Tech and Emory University.
and Biochemistry and the School of Chemical and Biomolecular engineering at Georgia Tech. e have made hollow nanocages of platinum with walls as thin as a few atomic layers
but the researchers expect expenses to drop over time (as has been the case with genome sequencing).
biotechnology and instrumentation expertise to develop a portable, autonomous device that analyzes trace elements. The highly miniaturized microbial analysis machine,
and quantify nucleic acid sequences. Source: http://www. asu. edu
#Researcher Integrates"Motherboard"in Textiles for Determining Sleep Cycles The specialist in infrared physics found a way for the technology to reach the majority of the population,
The future potential of the device is highlighted by co-senior author Zhen Gu, Phd, a professor in the Joint UNC/NC State department of Biomedical engineering:"
which will allow sensors to be incorporated into electronic apparel for measuring biological data, including heart rate and muscle contraction.
environmental monitoring, and chemical, biological, radiological, nuclear, and explosives (CBRNE) detection. For more information, go to FLIR web site at www. FLIR. com o
#Novel Synthetic Biosensor Glows in Response to Conditions that Mimic TB Infection Robert Abramovitch, an MSU microbiologist,
The findings, published in Nature Chemical Biology, raise promise for medicine but also concerns about"home-brewed"illegal drugs.
Dr John Dueber, a bioengineer at the university, said:""What you really want to do from a fermentation perspective is to be feed able to the yeast glucose,
Prof Paul Freemont, one of the directors of the Centre for Synthetic biology and Innovation at Imperial College London, said:"
"Researchers have been working out the genetic sequence-the blueprint-of all human viruses for many years. The team used this information to generate a pool of bacteriophage-viruses that grow easily in the laboratory-with each bacteriophage expressing a tiny fragment of this human-virus blueprint on its surface.
#L'oreal to start 3d printing skin French cosmetics firm L'oreal is teaming up with bioengineering start-up Organovo to 3d-print human skin.
a bioengineering research scientist at Heriot Watt university. Printing skin could be a different proposition,
Chuyang Cheng, a fourth-year graduate student in Stoddart's laboratory and first author of the paper, has spent his Ph d. studies researching molecules that mimic nature's biochemical machinery.
A team of chemists and biologists at the Institute of Transformative Biomolecules (ITBM), Nagoya University have succeeded in finding new molecules that change the circadian rhythm in mammals by applying synthetic chemistry methods,
Disruption of the circadian rhythm by genetic mutations and environmental factors such as jet lag, may lead to sleep disorders,
The mechanism of the circadian clock works by circadian clock proteins CLOCK and BMAL1 heterodimers binding to a genetic sequence called E-box (CACGTG),
and worked closely with the biologists at ITBM to synthesize molecules for studying structure-activity relationships (SARS)."Through SAR studies on the molecular derivatives of KL001,
"says Takashi Yoshimura, an animal biologist and professor at ITBM, who also led this research from a biological perspective."
"It was found that the carbazole moiety was critical for rhythm-changing activity and that the substituents on the heteroaromatic ring are responsible for tuning the rhythm lengthening/shortening activities,
This is my first research outcome from the center's interdisciplinary collaboration between chemists and biologists,
and animal/plant biologists from different research groups work in the same lab space.""We hope we can make further use of synthetic chemistry to make bioactive molecules that can control the circadian rhythm of animals and gain further insight into the circadian clock mechanism,
#Complex, large-scale genome analysis made easier The mset algorithm by Oliver Stegle at EMBL-EBI makes large-scale,
complex genome analyses easier. Researchers at EMBL-EBI have developed a new approach to studying the effect of multiple genetic variations on different traits.
The new algorithm, published in Nature Methods, makes it possible to perform genetic analysis of up to 500,000 individuals-and many traits-at the same time.
The relationship between genes and specific traits is complicated more than simple one-to-one relationships between genes and diseases.
Genome-wide association studies (GWAS) show that many genetic factors are at play for any given trait
but scientists are just beginning to explore how, specifically, genetic variations affect health and disease. Two major statistical challenges to finding these connections involve analysing associations between many different genetic variants and multiple traits,
and can explain a larger proportion of these traits in terms of the genetics that drive them."
These methods will help researchers determine which specific aspects of our biology are inherited, and uncover new insights into the genetics behind our countless biological processes."
"Source: European Molecular biology Laborator r
#A microtubule'roadway'in the retina helps provide energy for vision Fluorescently labeled microtubules extend from the tips of the dendrites (top) into the axon and down into the giant synaptic terminal (bottom) of a single isolated goldfish retinal
Peter Facchini, professor in biological sciences, Jill Hagel, research associate, and Scott Farrow, Phd student. Many people who live in developing countries do not have access to the pain relief that comes from morphine or other analgesics.
"The findings were published July 1 in Nature Chemical Biology, and detail the missing step to morphine biosynthesis. Next steps Facchini says the isolation of this gene,
among many other things, is a key step toward the reassembly of the pathway to morphine in microorganisms such as yeast."
codeine and oxycodone,"says Facchini, professor of biological sciences in the Faculty of science and an internationally recognized expert on the opium poppy."
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