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This could be used to create an array of nanoneedles for use in drug delivery or other applications says Xu Zhang a Ph d. student in Chang's lab
#Tiny'Nanoneedles'Prompt Parts of the Body to Generate New Blood vessels The researchers, from Imperial College London and Houston Methodist Research Institute in the USA, hope their nanoneedle technique could ultimately help damaged organs
and nerves to repair themselves and help transplanted organs to thrive. The nanoneedles work by delivering nucleic acids to a specific area.
Nucleic acids are the building blocks of all living organisms and they encode, transmit and express genetic information.
The nanoneedles are tiny porous structures that act as a sponge to load significantly more nucleic acids than solid structures.
The nanoneedles are made from biodegradable silicon, meaning that they can be left in the body without leaving a toxic residue behind.
and sirna into human cells in the lab, using the nanoneedles. They also showed they could deliver nucleic acids into the back muscles in mice.
using nanoneedles, to provide transplanted organs or future artificial organ implants with the necessary connections to the rest of the body,
but we are pleased that the nanoneedles have been successful in this trial in mice. There are a number of hurdles to overcome
and we haven't yet trialled the nanoneedles in humans, but we think they have enormous potential for helping the body to repair itself."
"The researchers are now aiming to develop a material like a flexible bandage that can incorporate the nanoneedles.
Alternatively, we may see surgeons first applying the nanoneedle bandages inside the affected region to promote the healthy integration of these new organs and implants in the body.
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