Veena's team perfected the technique of'polymer injection'for electric arc furnaces. In Australia alone, this technology has resulted so far in over two million used car tyres being converted from waste into a valuable feedstock for steel production.
Researchers writing recently in The british Dental Journal argue dentists shouldn't remove impacted wisdom teeth that are not giving any symptoms.
Dentists often remove impacted wisdom teeth to avoid the risk of problems such as pain, gum inflammation and decay.
they advise dentists keep a close eye on the teeth to see if they develop problems.
surgery itself can lead to complications such as nerve damage, damage to other teeth, infection, swelling,
bleeding, pain or affect a patient's ability to open their mouth fully. Tennant and colleagues, including graduate student Abed Anjrini,
previously found 527 per 100,000 Australians were admitted to hospital for impacted wisdom teeth removal in 2008/09--a rate seven times higher than in the UK
by their dentists, to decide whether they want to take the risk of keeping their impacted wisdom teeth.
when you have your wisdom teeth out the more likely you will suffer complications from the surgery,
and will result in an increasing rate of surgical complications. Although, he adds, we won't know
However he was excited most about the technology's potential in treating diseases such as cancer by delivering drugs more efficiently."
Mazdiyasni says future plans include investigating the technology for other engine components including coated parts and fracture critical parts s
#Spot Glaucoma With Your Smartphone Researchers from the Indian Institute of Science, Bangalore, have developed a method to diagnose glaucoma from smartphone images.
Scientists at the Indian Institute of Science (IISC), Bangalore, have announced the development of a new and simple method to detect glaucoma early enough to prevent blindness.
Glaucoma is usually the result of increased pressure in the eye, resulting in damage to the optic nerve,
which carries information to the brain. Since the symptoms of glaucoma do not show up until very late stages,
early detection by a procedure called fundus imaging is advised. Fundus imaging involves taking photographs of the retina
professor of electrical engineering at the IISC and leader of the team that developed the new method. his pre-screening tool can detect glaucoma with 90 percent accuracy,
This is useful when hospitals, government healthcare units or NGOS conduct healthcare camps, he says. The IISC team has not,
Sudipto Pakrasi, chairman of the ophthalmology division at Medanta, Gurgaon, Haryana, tells Scidev. Net that currently available technologies for detection of glaucoma are expensive
while the new method is not only cheap, but will also help with mass-screening for glaucoma.
About 12 percent of India 1. 2 billion people are estimated to be affected by glaucoma. amage to the optic nerve due to glaucoma is not reversible.
If we detect it early then it is possible to halt the progression of glaucoma by appropriate medications or surgery,
Pakrasi says. ision may be preserved at nearly normal levels if glaucoma is detected and treated early. c
#ab-In-A-Needledetects Liver Toxicity In 30 Minutes The researchers are currently working on a prototype that miniaturizes a test lab into the size of a needle.
This ab-in-a-needledevice will be effective, for example, in quickly detecting liver toxicity, a common side effect of chemotherapy.
Current tests entail multiple steps and results could take several days. Instead, the compact kit can take patient samples,
evaluate toxicity and display the results in one simple process. Dr. Wang Zhiping, Director of research Programs at Agency for Science, Technology and Research's (A*STAR) Singapore Institute of Manufacturing Technology (SIMTECH
It is the brainchild of a joint research team from Singapore Nanyang Technological University (NTU Singapore), SIMTECH and the Houston Methodist Hospital Research Institute.
manpower and costs and yet has the same accurate results as the gold standards of current liver toxicity tests, added Chang,
such as ejector pins for iphones, watch springs for expensive hand-wound watches, trial medical implants,
#Telomeres Implicated In Premature Aging Scientists have established successfully a comprehensive model of rare accelerated aging disorder, Hutchinson-gilford progeria syndrome (HGPS), opening up the possibility of treatment for the rare disease.
HGPS is an extremely rare genetic disease which causes patients to start aging rapidly when they are around one year old.
Symptoms include stunted growth and joint abnormalities, and patients often die of heart failure by their teenage years.
One in four million children suffer from HGPS, which currently has no effective treatment. The syndrome is caused by a mutated protein called progerin
which induces DNA damage, triggers premature cellular aging and slows down cell proliferation, resulting in accelerated aging.
Therapies incorporating LAP2ALPHA may be administered to early-diagnosis HGPS patients to minimise telomere damage, while older patients, who have undergone already telomere damage,
and vaccines traditionally given by injection. Cheap, lightweight and portable, the advanced nebulizer delivers precise drug doses to patients with life-threatening
or debilitating lung conditions including cancer, tuberculosis, asthma and cystic fibrosis. But the Respitetm nebulizer also has the potential to be used to administer insulin to people with diabetes
or to painlessly vaccinate infants currently subjected to needles. Professor Leslie Yeo, Director of RMIT University Micronanophysics Research Laboratory, said the Respite technology had the potential to revolutionize how patients were treated with drugs
including people with lung cancer whose poor survival rates have stayed stable despite significant therapeutic advances in recent years. nything we can nebulize,
we can potentially deliver, Yeo said. Yeo commented that conventional puffers only manage to get 30 percent of the drugs into the lungs,
Respitetm allows allows the dose to be adjusted based on a patient's size, age, gender, physiological profile and disease severity.
Recent trials in Melbourne also showed sheep given a DNA flu vaccine via a nebulizer had comparable immune responses to animals injected with the vaccine.
despite the significant therapeutic advances achieved in recent years and currently, there are no personalized delivery devices for inhaled cancer drugs to improve these clinical outcomes,
shift work and, perhaps, seasonal affective disorder. The study also provides a mathematical model that accurately predicts the behavior of the clock under different circumstances.
meaning that they can be left in the body without leaving a toxic residue behind.
to provide transplanted organs or future artificial organ implants with the necessary connections to the rest of the body,
giving us endless possibilities in sensing, diagnosis and therapy. And all of this thanks to tiny structures that are up to 1, 000 times smaller than a human hair."
Perhaps in the future it may be possible for doctors to apply flexible bandages to severely burnt skin to reprogram the cells to heal that injury with functional tissue instead of forming a scar.
Alternatively, we may see surgeons first applying the nanoneedle bandages inside the affected region to promote the healthy integration of these new organs and implants in the body.
#Microbubble Technology for Delivery of Nanoparticles to Tumours Biomedical researchers led by Dr. Gang Zheng at Princess Margaret Cancer Centre have converted successfully microbubble technology already used in diagnostic imaging into nanoparticles that stay
trapped in tumours to potentially deliver targeted, therapeutic payloads. The discovery, published online today in Nature Nanotechnology, details how Dr. Zheng and his research team created a new type of microbubble using a compound called porphyrin-a naturally occurring pigment in nature that harvests light.
In the lab in preclinical experiments, the team used low-frequency ultrasound to burst the porphyrin containing bubbles
potentially overcoming one of the biggest translational challenges of cancer nanotechnology. In addition, we have demonstrated that imaging can be used to validate
"says Dr. Zheng, Senior Scientist at the Princess Margaret and also Professor of Medical Biophysics at the University of Toronto.
and therapeutic properties once they burst, he says, in a blink-of-an-eye process that takes only a minute
organic nanoparticle delivery platforms capable of transporting cancer therapeutics directly to tumours. Source: http://www. uhn. ca a
Yet local ph changes can provide invaluable early signals of many pathologies. For example, the ph around a cancer cell is slightly lower than normal,
the presence of an unseen tumor or show whether an infection has developed around a surgical implant."
which GEMS can be employed for biomedical uses.""That would require, among other things, further miniaturization.
That would open up many additional biomedical applications. One of the most significant features of GEMS is that they can be tuned"in fabrication to respond to different biochemical states
to better differentiate between different pathologies, "Zabow says.""We think that these sensors can potentially be adapted to measure a variety of different biomarkers,
New materials for energy application, new concepts for medical surfaces, new surface materials for tribological systems and nano safety and nano bio.
which can be a complication of cataract surgery. The company envisions a wide application of this immunodepletion strategy in other fibrotic diseases and cancer,
and has completed recently in-licensing intellectual property and additional assets for targeting Myo/Nog cells for therapeutic purposes from LIMR Development Inc. LDI),
a for-profit subsidiary of the Lankenau Institute for Medical Research where an early stage of the technology was developed.
Myo/Nog cells were discovered in the laboratory of Dr. Mindy George-Weinstein, and named for their ability to form muscle (Myo) and their production of Noggin,
a disease that typically occurs in approximately 30%of adults and greater than 70%of children after cataract surgery.
The targeted 3dna approach is similar to that of an antibody drug conjugate (ADC), but delivers 100 times more of the drug to the targeted cells than an ADC
and has observed no toxicity. Additional studies testing this formulation in rabbits undergoing cataract surgery are ongoing with Drs.
Liliana Werner and Nick Mamalis, Co-Directors of the Intermountain Ocular Research center at the University of Utah.
"Dr. Mindy George-Weinstein, Professor of Biomedical sciences at the Cooper Medical school of Rowan University, stated,"Myo/Nog cells have also been found in a variety of tumors,
where we predict they contribute to tumor growth. This targeted 3dna immunodepletion strategy may be useful as an adjuvant therapy to reduce tumor expansion and recurrence."
"Dr. Robert Getts, Chief Science Officer of Genisphere, said, "Since the antibody has broad utility
and 3dna nanocarriers can deliver a variety of drug cargoes, we can easily generate targeted drugs for many of these indications."
doctors and researchers use stains or dyes that stick to the particular structure or molecule they are looking for.
Doctors also have to choose which things to test for, because it not always possible to obtain multiple samples for multiple stains from one biopsy.
The new, advanced infrared imaging technique uses no chemical stains, instead scanning the sample with infrared light to directly measure the chemical composition of the cells.
and now is a professor at the University of Houston. ne of the bottlenecks in automated pathology is the extensive processing that must be applied to stained images to correct for staining artifacts and inconsistencies.
which can then be used for other tests. his approach promises to have immediate and long-term impact in changing pathology to a multiplexed molecular science in both research and clinical practice,
The Carle Foundation Hospital in Urbana, Illinois, and the University of Illinois Cancer Center at the University of Illinois at Chicago were partners in this work e
#Ingenious Microfluidic Device to Detect and Extract Biomolecules from Fluid Mixtures Employing an ingenious microfluidic design that combines chemical and mechanical properties,
and could lead to better technologies for medical diagnostics and chemical purification. A team of Harvard scientists has demonstrated a new way of detecting
Aizenberg said. his new approach holds promise for the next-generation, energy-efficient separation and purification technologies and medical diagnostics.
and produces planetariums, eyeglass lenses, camera and cine lenses and binoculars as well as solutions for biomedical research, medical technology and the semiconductor, automotive and mechanical engineering industries.
thus having the capacity of becoming a standard method of quality control of stem or pluripotent cells before their use in cell therapy or research in biomedicine.
March 9) in the journal Scientific Reports, represents a major step forward in the development of accurate, faster methods of testing for drug toxicity.
so these differences often result in inefficient and costly experiments that do not provide accurate answers about the toxicity of a drug in humans,
who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical school and Boston Children's Hospital and Professor of Bioengineering at Harvard SEAS."
"This advance offers an entirely new approach with which to confront a broad range of problems in fields ranging from energy to medicine."
#Researchers Determine Molecular Structure of Nanobody-P Domain Complex for Norovirus Infection with highly contagious noroviruses,
while not usually fatal, can lead to a slew of unpleasant symptoms such as excessive vomiting and diarrhea.
This makes the development of an effective vaccine to protect against infection, as well as antiviral therapy to combat already-existing infections,
particularly challenging",says Dr. Grant Hansman, a virologist who leads the CHS Research Group on Noroviruses at the German Cancer Research center (Deutsches Krebsforschungszentrum, DKFZ) and Heidelberg University.
Hansman's research team recently discovered that a"nanobody"called Nano-85 was able to bind to intact norovirus-like particles (VLPS) in culture.
Nanobodies are very similar to antibodies, which recognize and bind to antigens.""However, nanobodies are much smaller, more stable, easier to produce,
and cost-effective than traditional monoclonal antibodies, "says Hansman. Interestingly, Nano-85 was able to recognize the VLPS from a variety of different norovirus strains.
this could be a very promising lead in developing norovirus antiviral therapy. This could be especially beneficial to immunosuppressed individuals such as cancer patients.
Administering a vaccine to protect against infection would overwhelm the patient's immune system. However, if he or she has the option of receiving an antiviral to eliminate the infection,
the norovirus becomes much less dangerous.""Source: http://www. dkfz. d d
#Canatu Announce Multitouch, Button-Free Automotive Panels with Carbon nanobud Films Canatu, a leading manufacturer of transparent conductive films, has in partnership with Schuster Group
and Display Solution AG, showcased a pioneering 3d encapsulated touch sensor for the automotive industry. The partnership is delivering the first ever,
then back-molded by injection molding, resulting in a unique 3d shape with multitouch functionality.
as they are attached to the skin with a biocompatible, medical-grade adhesive. Users can therefore decide where they want to position the sensor patch
#Lab on a Chip Acoustofluidic Sputum Liquefaction Device for Safe Asthma and Tuberculosis Diagnostics A device to mix liquids utilizing ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis
of sputum from patients with pulmonary diseases such as tuberculosis and asthma. The device, developed by engineers at Penn State in collaboration with researchers at the National Heart, Lung,
or around 19 million people, have asthma, and in undeveloped regions where TB is still a widespread
and often deadly contagion. o develop more accurate diagnosis and treatment approaches for patients with pulmonary diseases,
we have to analyze sample cells directly from the lungs rather than by drawing blood,
different drugs are used to treat different types of asthma patients. If you know what a person immunophenotype is
you can provide personalized medicine for their particular disease. There are several issues with the current standard method for sputum analysis. The first is that human specimens can be contagious,
With the lab on a chip system a nurse can operate the device with a touch of a few buttons
Stewart J. Levine, a Senior Investigator and Chief of the Laboratory of Asthma and Lung Inflammation in the Division of Intramural Research at NHLBI, said his on-chip sputum liquefier is a significant advance regarding our goal
This will allow health care providers to individualize asthma treatments for each patient and advance the goal of bringing precision medicine into clinical practice.
This research was supported by the American Asthma Foundation Scholar Award the National Science Foundation, and the NHLBI Division of Intramural Research.
or diagnose substances at a molecular level. ur system can do chemistry, biology, biochemistry, molecular biology, clinical diagnosis,
and chemical analysis, said company president and cofounder Fanqing Frank Chen. nd our system can be implemented very cheaply,
or an advanced nanophotonic automated system, with sensitivity to the level of a single molecule, far superior to sensors on the market today. oday detection and diagnosis methods are far from perfectetection limits are in PPM (parts
including food safety, environmental monitoring (of both liquids and gases), medical diagnosis, and chemical analysis. Optokey customers include a major European company interested in food safety,
and a German company interested in point-of-care diagnosis. think wee at the cusp of a really major transition in the field,
and it can go into schools, restaurants, factories, hospitals, ambulances, airports, and even battlefields. he next market Chen is targeting is the smart home,
Trained at Los alamos National Laboratory and Mount sinai Hospital at NYU, Chen started out as a biochemist working on biomedical devices.
After he joined Berkeley Lab around 2000, he learned about quantum dots, which are nanocrystals with peculiar properties,
and accurately detect a biomarker for prostate cancer, which has a high rate of false positives using conventional diagnostic tools.
#Packaging Cancer drug into Nanoparticles Double Tumor Destroying Efficacy Researchers have packaged a widely used cancer drug into nanoparticles,
more than doubling its effectiveness at destroying tumors. The drug paclitaxel has been used for decades to fight breast, ovarian, lung and other cancers.
But its effectiveness has been limited by its small molecular size and insolubility in water--properties that allow the body to clear the drug too quickly,
reducing its accumulation in tumors. Many molecular packaging systems have been developed to deliver the drug while counteracting these effects, with a protein-bound version of the drug called Abraxane currently the leading therapy.
But Ashutosh Chilkoti professor and chair of the Department of Biomedical engineering at Duke university, thought his team could do better.
the Duke team doubled tumor exposure to the drug compared to Abraxane while simultaneously reducing its effects on healthy tissue.
This kept mice with tumors alive significantly longer and, in some cases, completely eradicated the tumors.
and accumulate in tumors where they take advantage of a tumor's acidic environment.""The chemical bonds holding the polypeptide cage together are stable in blood,
but dissolve in a tumor's lower ph levels,"said Jayanta Bhattacharyya, senior researcher in Chilkoti's lab and first author on the paper."
"This delivers the drug directly to the tumor and helps prevent it from randomly absorbing into healthy tissue, reducing side effects."
A second group of mice had human prostate tumors growing under their skin. Similarly, while they did not survive past 60 days
with some experiencing a complete cure. As the mortality rates suggest the Duke technology showed a higher concentration of paclitaxel in the tumors with more staying power than Abraxane,
while simultaneously showing much lower levels throughout the rest of the mice's bodies.""Clearly in the animal model there is a night and day difference,
"said Neil Spector, an oncologist at Duke Medicine familiar with the work.""But it's not just the increase in clinical efficacy
it's also the improvement in targeting and reduction in toxicity, which is just icing on the cake.
it could be a game-changer for cancer therapy.""In future work, Chilkoti and coworkers will begin applying the packaging system to other cancer drugs with the goal of developing a"one size fits all"technology to improve the effectiveness of many other cancer drugs s
when releasing lithium. his expansion and contraction of aluminum particles generates great mechanical stress, which can cause electrical contacts to disconnect.
Researchers in professor Margaret Frey lab create fibers hundreds of times thinner than a human hair that can capture toxic chemicals and pathogens.
and to capture toxic substances in liquids. Tiny, complex devices traditionally are made in high-tech clean rooms using expensive equipment and costly material, like gold.
processes done in a medical testing lab for example, purifying samples, mixing ingredients, capturing bacteria can be done with material about the size of a deck of cards.
and will diagnose diseases without requiring specialized laboratories particularly useful in regions with limited access to doctors and hospitals.
and allows it to time-release. y allowing rapid detection of disease and preventing agricultural chemical release into the environment,
Understanding how cells release those signals in less than one-thousandth of a second could help launch a new wave of research on drugs for treating brain disorders.
Many mental disorders, including depression, schizophrenia and anxiety, affect neurotransmitter systems,"said Axel Brunger, the study's principal investigator.
and shared the 2013 Nobel prize in Physiology or Medicine. Thomas C. Südhof, a professor at the Stanford School of medicine and Howard hughes medical institute investigator who shared that 2013 Nobel prize with Rothman,
Samples taken from a single individual could be analyzed this way, opening applications for disease diagnostics and research.
or not could be used to better understand the progression of disease. any researchers, Saven said,
ave observed these long tangles of aggregated peptides and proteins in diseases like Alzheimer and Parkinson,
since the 1980s to take detailed images inside the body-helping doctors to make a medical diagnosis
and investigate the staging of a disease. An international team of researchers, led by Dr Munitta Muthana from the University of Sheffield's Department of Oncology,
have now found MRI SCANNERS can non-invasively steer cells, which have been injected with tiny super-paramagnetic iron oxide nanoparticles (SPIOS), to both primary and secondary tumour sites within the body.
Revolutionary cell-based therapies, which exploit modified human cells to treat diseases such as cancer, have advanced greatly over recent years.
However, targeted application of cell-based therapy in specific tissues, such as those lying deep in the body where injection is not possible,
has remained problematic. The new research suggests MRI SCANNERS are the key to administering treatments directly to both primary
and secondary tumours wherever they are located in the body. The study, published today (date) in Nature Communications shows that cancer mouse models injected with immune cells carrying SPIOS and armed with the cancer killing oncolytic virus (OV)
which infects and kills cancer cells, showed an 800 per cent increase in the effects of the therapy.
Dr Munitta Muthana, from the University of Sheffield, said:""Our results suggest that it is possible to use a standard MRI SCANNER to naturally deliver cell-based therapies to both primary and secondary tumours
which would normally be impossible to reach by injection.""This not only increases the therapeutic efficacy but also decreases the risk of unwanted side effects."
"The beauty of using the MRI SCANNER to administer the therapy is that you can also use it for its original purpose providing a real-time image-guide to ensure the treatment has gone where it is needed
#Universitat Jaume I Patents Graphene-Based Catalysts for Energy conversion and Storage Researchers at the Universitat Jaume I have developed materials based on graphene that can catalyse reactions for the conversion and storage of energy.
The technology patented by the UJI combines graphene and organometallic compounds in a single material without altering the most interesting properties of graphene,
This new technology may contribute to medical cost reduction while maintaining the quality of medical treatment.
This study was published in the online version of the academic journal Biomaterials on June 9, 2015.
This new technology may contribute to medical cost reduction while maintaining the quality of medical treatment without using growth factors that are expensive and prone to deactivation.
To promote angiogenesis in body parts where blood flow is poor due to diabetes, research has been conducted to develop materials that absorb growth factors
and gradually release them. Studies also have been carried out to combine stem cells that produce growth factors and materials.
to target legs of diabetes patients with poor blood flow and to effectively regenerate blood vessels.
This technology also may contribute to cost reduction in certain medical treatments. Based on these positive results
the research group intends to engage in collaborative studies with medical and industrial sectors, and aims to expand its activities in the field of regenerative medicine and developing medical devices s
#Harvard Researchers Develop New System for Producing Stable, Amorphous Nanoparticles from Wide Material Range Before Ibuprofen can relieve your headache,
it has to dissolve in your bloodstream. The problem is Ibuprofen, in its native form, isn particularly soluble.
For one, the particles do not seem to degrade over time a problem that plagues the coated nanoparticles. e ran one hundred cycles of writing
#Nanoporous Gold Sponge Detects Pathogens Faster This novel technique enables sensitive DNA detection in compound biological samples e g.,
According to UC Davis researchers, these sponge-like nanoporous gold hold the potential for enabling new devices to detect agents responsible for causing disease in both plants
It almost like a natural sieve. arly identification of disease biomarkers and pathogenic microbes is possible with the swift and sensitive detection of nucleic acids.
Going forward, the team anticipates that their research will be useful in the progress of mini point-of-care diagnostic systems for clinical and agricultural applications. he applications of the sensor are quite broad ranging from detection of plant pathogens to disease biomarkers,
For instance, in human sepsis cases, the illness can be detected early on, thereby preventing any needless treatments as doctors can now establish bacterial contamination much more rapidly than ever before.
Similarly in agriculture, without the occurrence of any symptoms researchers can still detect if pathogens are present.
Pallavi Daggumati, Zimple Matharu, and Ling Wang in the Department of Electrical and Computer engineering at UC Davis were the other authors of the papers.
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