#ost sensitivetest to detect superbugs Researchers have developed the world's most sensitive test to quickly detect dangerous infectious diseases and deadly superbugs such as C difficile and MRSA.
In essence, the new method can pick up any compound that might signal the presence of infectious diseases,
researchers developed a molecular device made of DNA that can be switched'on'by a specific molecule of their choice-such as a certain type of disease indicator
"This invention will allow us to detect anything we might be interested in, bacterial contamination or perhaps a protein molecule that is a cancer marker.
"says Dr. Barbara Sherman, a clinical professor of behavioral medicine. Much of the technology comes off the shelf
"says Dr. Barbara Sherman, a clinical professor of behavioral medicine. Much of the technology comes off the shelf
#New discovery may generate ways to beat deadly malaria WASHINGTON DC: Scientists have identified new ways which help the malaria parasite survive in the blood stream of its victims,
and the finding could lead to new treatments for the disease. Medical Research Council's (MRC) Toxicology Unit researchers at the University of Leicester and the London School of Hygiene and Tropical Medicine found a key protein,
called a protein kinase (Pfpkg), that plays a central role in various pathways and allow the parasite to survive in the blood.
Understanding the pathways the parasite uses means that future drugs could be designed precisely to kill the parasite but with limited toxicity
Co-lead author of the study professor Andrew Tobin said that the understanding of malaria's survival in the blood stream was a real breakthrough
and could lead to cure that stops malaria in its tracks without causing toxic side-effects.
According to the World health organization malaria currently infects more than 200 million people worldwide and accounts for more than 500,000 deaths per year.
Malaria has been a problem in India for centuries. At present, official figures for malaria in India, available at NVBDCP
indicate 0. 7-1. 6 million confirmed cases and 400-1, 000 deaths annually. Professor Patrick Maxwell, chair of the MRC's Molecular and Cellular Medicine Board,
said tackling malaria was a global challenge, with the parasite continually working to find ways to survive our drug treatments.
This study opened the door on potential new treatments that could find and exploit the disease's weak spots but with limited side-effects for patients s
#New sensor chip to detect prostate cancer early Researchers have developed a smart sensor chip that can detect prostate cancer more accurately
and efficiently than current tests which rely heavily on antibodies. The sensor chip, able to pick up on subtle differences in glycoprotein molecules,
will help improve the process of early stage prostate cancer diagnosis, researchers said. Glycoprotein molecules play an essential role in our immune response, because of
which they are useful clinical biomarkers for detecting prostate cancer and other diseases. The team of chemical engineers and chemists at the University of Birmingham, created a sensor chip with synthetic receptors along a 2d surface to identify specific
targeted glycoprotein molecules that are differentiated by their modified carbohydrate chains.""There are two key benefits here.
so could feasibly be kept on the shelf of doctors'surgery anywhere in the world. It can also be recycled for multiple uses without losing accuracy,
The findings show how the rate of false readings that come with antibody based diagnosis can be reduced by the new technology that focuses on the carbohydrate part of the molecule.
the team wanted to identify the presence of disease by detecting a particular glycoprotein which has specific sugars in a specific location in the molecule."
and so we need technology that can discriminate between these subtle differences-where antibodies are not able to,
#Sugar trail may lead to early cancer detection NEW DELHI: In a breakthrough that could lead to a new protocol for cancer detection and treatment,
scientists have identified a glucose delivery mechanism which helps cancer cells to survive and grow. The discovery can help in early detection of not only pancreatic and prostrate cancer but many others like cancer of the breast and colon.
Announcing the findings, scientists from the University of California, Los angeles (UCLA) also suggested the use of certain antidiabetic drugs to reduce the growth of tumours.
Experts and doctors say the findings can give a new protocol worldwide for cancer detection and treatment.
along with positron emission-tomography tomography (PET) that can enable early detection of these cancers cells. Experts say this is the first promising evidence that PET imaging techniques
and treat pancreatic and prostate cancers. The findings also provide strong evidence that certain type-2 diabetic drugs,
belonging to a new class known as SGLT2 inhibitors which are approved already by the US Food
and reduce tumour growth and increase survival among pancreatic and prostate cancer patients. Pancreatic cancer, estimated as the fourth leading cause of cancer-related deaths in the US behind only lung,
colon and breast cancers, is also increasing significantly in India. In most cases, the tumour is detected at a very late stage,
making it very difficult for doctors to remove it. Prostate cancer, though generally more treatable, is also witnessing a rapid increase in incidence in India as well as globally.
While globally it is the second leading cause of cancer-related deaths in men in India, the incidence of prostate cancer among men has increased by over 220%between 1900 and 2013.
Researchers at UCLA will next begin a clinical study to further investigate the importance of sodium-dependent glucose transporters in glucose delivery.
They hope that these findings will lead to the potential use of the existing antidiabetic medicines to reduce the viability of pancreatic and prostate cancer cells
and improve the survival rate in patients i
#Why HIV progresses slowly in some people Even in the absence of HIV therapy, some HIV-infected people may not suffer from AIDS for many years due to enhanced cholesterol metabolism in certain immune cells,
which is inherited an trait, shows research. The findings may lead to potential development of new approaches to control HIV infection by regulating cellular cholesterol metabolism."
"We have known for two decades that some people do not have the dramatic loss in their T cells
and progression to AIDS that you would expect without drug therapy, "said lead author Giovanna Rappocciolo, assistant professor at University of Pittsburgh in the US.
T-cells are a type of white blood cells that play a very important role in human immunity by scanning for cellular infections."
"Instead, the disease progresses more slowly and we believe altered cholesterol metabolism in certain immune cells may be a reason,
"These results improve understanding of how nonprogressors control HIV without drug therapy and potentially may contribute to new approaches to manage HIV infection,"Rappocciolo added.
The findings were presented at the eighth INTERNATIONAL AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Vancouver, Canada a
#New laser device spells end for diabetic finger pricking LONDON: A new technology developed by an Indian-origin scientist,
and eliminate the need for daily finger pricking for diabetics. Currently, many people with diabetes need to measure their blood glucose levels by pricking their fingers,
squeezing drops of blood onto test strips, and processing the results with portable glucometers. The new technology, developed by Professor Gin Jose and a team in the Faculty of engineering at the University of Leeds,
This could help improve the lives of millions of people by enabling them to constantly monitor their glucose levels without the need for an implant."
this technology opens up the potential for people with diabetes to receive continuous readings, meaning they are alerted instantly
The results of a pilot clinical study, carried out at the Leeds Institute of Cardiovascular and Metabolic Medicine under the supervision of Professor Peter Grant,
and eliminate the need for daily finger pricking for diabetics. Currently, many people with diabetes need to measure their blood glucose levels by pricking their fingers,
squeezing drops of blood onto test strips, and processing the results with portable glucometers. The new technology, developed by Professor Gin Jose and a team in the Faculty of engineering at the University of Leeds,
This could help improve the lives of millions of people by enabling them to constantly monitor their glucose levels without the need for an implant."
this technology opens up the potential for people with diabetes to receive continuous readings, meaning they are alerted instantly
The results of a pilot clinical study, carried out at the Leeds Institute of Cardiovascular and Metabolic Medicine under the supervision of Professor Peter Grant,
Scientists at the premier Regional Medical Reference Centre (RMRC) at Port Blair have found that the bacterial species that causes leptospirosis is no longer socially aloof,
while posing a greater threat to public health. The study is the first to demonstrate how leptospira mutates to form a biofilm, an extra protective layer of microbial cells,
In July, leptospirosis came out of nowhere to kill 16 people in two weeks. The mutation study, published in a Federation of European Microbiological Studies journal in May, was a wake-up call for public health experts to find better ways to tame the bacteria.
The world over leptospirosis has emerged as a crucial zoonotic disease, with leptospira evolving and thriving in an array of mammal hosts
and routinely causing havoc by sneaking into humans.""The biofilms showed very high resistance to Penicillin g, ampicillin and tetracycline,
some of the leading antibiotics used to treat acute leptospirosis in humans and animals,"said Dr Paluru Vijayachari, director of the Port Blair institute."
raised a need to understand its role in epidemics better. Two rare sergroups of the bacteria, Tarassovi and Djasmin, were found responsible for the recent outbreak.
"Humans can literally catch infection in the blink of an eye. The infection can enter through membranes of the eyes, nose or mouth,
or through cuts and abrasions,"said Dr Jayanti Shastri, head of microbiology at BYL Nair Hospital.
She said its spread in humans could be controlled by treating or vaccinating animals.""Till that happens, early diagnosis
and prompt treatment is the key
#Vaccine success holds hope for end to deadly scourge of Ebola The world is for the first time on the verge of being able to protect humans against Ebola,
the World health organization (WHO) said on Friday, as data from a trial in Guinea showed a vaccine was 100 percent effective.
Initial results from the trial, which tested Merck and Newlink Genetics'VSV-ZEBOV vaccine on some 4, 000 people who had been in close contact with a confirmed Ebola case,
showed 100 percent protection after 10 days. The results were described as"remarkable"and"game changing"by global health specialists."
"We believe that the world is on the verge of an efficacious Ebola vaccine, "WHO vaccine expert Marie Paule Kieny told reporters in a briefing from Geneva.
The vaccine could now be used to help end the worst recorded outbreak of Ebola, which has killed more than 11,200 people in West Africa
since it began in December 2013. WHO Director-General Margaret Chan said the results, published online in the medical journal The Lancet,
were an"extremely promising development"."""This is going to be a game changer, "she told reporters.""It will change the management of the current Ebola outbreak and future outbreaks."
"This and other vaccine trials were tracked fast with enormous international effort as researchers raced to be able to test potential therapies
and vaccines while the virus was still circulating.""We knew it was a race against time
and that the trial had to be implemented under the most challenging circumstances, "says John-Arne Rottingen, head of infectious disease control at the Norwegian Institute of Public health and chair of the trial's steering group."
"Ring vaccination"The Guinea trial began on March 23 to evaluate the effectiveness and safety of a single dose of VSV-ZEBOV using a so-called"ring vaccination"strategy,
where close contacts of a person diagnosed with Ebola are immunised-either immediately, or at a later date.
As data began to emerge showing the very high protection rates in those vaccinated immediately,
however, researchers decided on July 26 that they would no longer use the"delayed"strategy, since it was becoming clear that making people wait involved unethical and unnecessary risk.
with all participants receiving the vaccine immediately, and will be extended to include 13-to 17-year-olds and possibly also 6-to 12-year-old children,
Jeremy Farrar, a leading infectious disease specialist and director of the Wellcome Trust, said the trial"dared to use a highly innovative and pragmatic design,
which allowed the team in Guinea to assess this vaccine in the middle of an epidemic"."""Our hope is that this vaccine will now help bring this epidemic to an end
and be available for the inevitable future Ebola epidemics, "his statement said. The medical charity Doctors without Borders (MSF),
which has led the fight against Ebola in West Africa, is now calling for VSV-ZEBOV to be rolled out to the other centres of the outbreak, Liberia and Sierra leone,
where it says it could break chains of transmission and protect front-line health workers. The success of the Guinea trial is a huge relief for researchers, many of
whom had feared that a sharp decline in cases this year would scupper hopes of proving that a vaccine could work.
as the only real hope for demonstrating the efficacy of a vaccine e
#China plans to enforce real names on Social media Chinese government has issued new regulations to eliminate fake social media accounts.
In the study published in The New england Journal of Medicine, researchers from Sweden employed a mobile phone app on a sample of 30,000 patients from Stockholm, Sweden.
The researchers found that the notification system brought about a 30 percent increase in the number of volunteers providing emergency CPR for victims of heart attack.
they said that the 30-day survival rate after heart attack, was 10 percent when onlookers provided CPR,
there was a 30 percent increase in CPR administration by onlookers before medical responders reached the spot.
but not part of the health care system formally, came forward. Later, another 4, 000 joined and these were usually volunteers within the distance of about one-third of a mile from the patient.
#Japan to invest $21 million in developing 3d printed human organs Could 3d printable human organ transplants become a reality in the coming years?
And just a few weeks ago in early December we learned of a collaboration between 3d printing company Organovo and the Yale School of medicine that aims to pioneer 3d bioprinted surgical tissues themselves.
This Japanese announcement thus follows a current trend in medical science but they are reportedly doing it on a hitherto unseen scale.
which is expected to revolutionize medical help. And as an estimated 100000 people are on the waiting list for organ transplantation in the US alone it#s no wonder that the medical field is turning its focus towards 3d printing r
#Design Lab Workshop merges 3d printing with solar energy for glowing architecture As more architects look into ways of using additive manufacturing as a way of constructing their buildings,
3d models is becoming more and more commonplace, especially in the fields of medicine, CGI and graphic design.
#Doctors use 3d printing to aid successful open-heart surgery on four-year old Jan 15, 2015 By Simon Born with a heart condition that resulted in her having two open heart surgeries before the time she was even four years old, Adaenelie Gonzalez, a four-year old from Miami, Florida in the United states,
recently underwent her third heart surgery last week. However unlike her previous open heart surgeries, the use of 3d printing enabled doctors to perform a third open heart surgery last week that may just be her last.
Gonzalez condition, which prevented blood from properly flowing into the heart from the lungs (also known as anomalous pulmonary venous connection),
caused her to experience erratic and severe breathing problems. Sadly, the four-year old has spent much of her young childhood dealing with the condition
and going in and out of the hospital for efforts to control it. At one point, the doctor even said that they were out of options. seriously,
I kind of lost hope. I didn think there was anything that was going to be able to help her,
Thankfully, a team of pediatric medicine professionals from Miami Children Hospital were able to scan Gonzalez heart and produce a 3d printed model
which was used for surgeons to study the condition. Creating an anatomically-correct 3d print of a patient heart is far from your run-of-the-mill 3d printing project, however.
the surgeons were able to practice manipulating the blood vessels and exploring all of the possible repairs without having to operate.
the surgeons were then able to create a map of every nerve and artery before attempting their third open heart surgery on the four-year old.
The use of the 3d printed model was critical for the surgery success in part because the team had done never the surgical procedure before.
Without properly training themselves the doctor ran the possibility of tragically killing the young girl if any steps in the surgery went awry.
Even though the doctors were previously able to study Gonzalez condition using traditional two-dimensional scans, the data proved to be not as informative as they needed for operating. wasn going to operate on her based on the data that we already had said
Burke. He even compared the use of a two-dimensional image to a 3d printed model to teaching somebody how to throw a football,
adding: t be like saying, K, I going to teach you how to throw a football by handing you a picture of a football.
Thankfully, the ability to study the 3d printed model of Gonzalez heart proved to be an invaluable tool before heading into the surgery last week.
Already, Gonzalez is out of the bed and moving whereas before the surgery she could barely move
Thanks to the surgery, Gonzalez is expected at least to live through her teenage years. o me,
Thanks to the success of Gonzalez surgery, Miami Children Hospital plans on using 3d printing in the future for other surgical procedures."
"The fourth day after surgery I envisioned her still being on a breathing machine in the ICU getting massive amounts of medication,
medical professionals and others that regularly make use of additive manufacturing technologies to get excited about.
Recently, additive manufacturing played a significant role in the development of a revolutionary new medical device that,
whether he had a headache, was hungry or he simply wanted to say love you
and technologies that can handle a range of people with different disabilities that make communication difficult.
Among others, these include people with nonverbal autism, people with nonverbal learning disorders, people with ALS, people with Rett Syndrome,
people who have suffered traumatic brain injury, stroke victims and anyone else with limited mobility. ur goal is to create an affordable, customizable,
#Chinese doctor removes kidney tumor with the aid of a 3d printed replica May 23, 2015 By Simonwhile wee seen how developments to additive manufacturing technologies have helped both bring down the cost of getting something 3d printing as well as delivering results faster,
one of the more significant contributions wee seen the technology make hase been in the health and medical sector.
More recently, doctors at the Xiangya Hospital of Urology at Central South University in China were able to leverage 3d printing technology in an effort to help successfully remove a tumor from a 60-year-old woman kidney.
Thanks to the use of a 3d printed model in advance of the surgical procedure, the doctors were not only able to remove the tumor-but also save the kidney itself;
Because the left renal tumor was located directly next to the renal hilum-an area of the kidney that features many vital arteries
and veins-the surgery would have called for a removal of the entire kidney in most cases to avoid the risk of causing further damage to a patient.
Dr. Qi Lin, chose to use 3d printing to assist in the process of planning the surgery. To create the accurate replica of the patient kidney
Dr. Qi Lin took a series of CT SCANS of the patient kidney, tumor and surrounding area
the doctors were able to pinpoint necessary locations for incisions and other details that would ultimately lead the surgery to success. On May 11th,
Dr. Qi Lin-along with his medical team-performed the 90-minute surgery and were successfully able to remove the tumor while keeping the kidney intact with patient.
In addition to helping reduce the amount of blood loss to just 50 ml during the procedure
the use of the 3d printed replica also dramatically reduced the length of the surgery; what used to take hours only took a mere hour and a half. ith this new 3d technology,
when aided by the surgeon, it creates a situation where eeing is believingadded Dr. Qi Lin. his is true from multiple dimensions,
and allowed us to pinpoint the tumor, the arteries and the surrounding kidney tissue before surgery,
practice the surgery and then decide on the correct path and operation to perform. Posted in 3d printer Applications (adsbygoogle=window. adsbygoogle.
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2015 has been a reakthroughyear that has shown significantly more promise for bio printing technologies-including the announcement of an upcoming surgery that will see a 3d printed thyroid gland be implanted for testing-a first of its kind.
More recently, researchers at Bucktown Polymers have developed a new type of 3d printing material that cures rapidly
While lives are already being saved by high-level 3d printing in academic hospitals all over the world, most of these cases involve 3d printed implants
and replicas used to prepare for unusual surgeries. Doubtlessly, the real 3d printing revolution in the medical world is yet to come:
bio 3d printing. Involving special bio-inks made from biocompatible polymers and cells, these could be used for 3d printing just about everything in the human body, from cartilage, to bone structures and theoretically even entire new organs.
And now a Swedish start-up called CELLINK has developed a bioink that could make this medical revolution happen as soon as possible.
For the current problem is this: scientific progress with these bioprinted materials is agonizingly slow.
Various institutes and hospitals all over the world are experimenting with new materials and applications, but most won result in practical solutions for years.
as an estimated 21 people waiting for organ transplants are dying every single day. And this is exactly where CELLINK comes In this Swedish company lead by Erik Gatenholm
At age 18, Erik Gatenholm started his first medical device company, manufacturing meniscus implants and other implants, such surgical meshes for ventral hernia repairs and wound dressings.
but even in bone disease, changing toe forms and other complications over time, chief advisor of Jiaodukeji, Xu Chaoyi, explained. his is
#The 3d printed Peek smartphone adapter helps diagnose eye disease in developing countries While we come across so many interesting 3d printed applications,
the ones with the greatest impact are surely those that help doctors, save lives and improve the quality of life of the poor and underprivileged.
And in that respect, the 3d printed Peek short for the Portable Eye Examination Kit developed by a team of British ophthalmologists,
Perfect for use in third world countries and remote locations far from medical help, this kit essentially consists of a 3d printed add-on for smart phones that can be used to treat preventable blindness.
Thanks to this successful backing, the Peek can now also be ordered pre by doctors. This project has been devised by Andrew Bastawrous, Stewart Jordan, Kate Tarling and Mario Giardini,
it has the potential to help more than 39 million people around the world who lack access to basic optical healthcare. 0%of this blindness is avoidable,
Think about eye diseases like cataracts, glaucoma and others. While equipment for diagnosing such diseases already exist
they are heavy, expensive, fragile and require extensive training not at all suitable for use in remote regions without proper electricity.
This helps us to diagnose eye diseases, ready for treatment. Peek Retina combines both a traditional ophthalmoscope and a retinal camera in a mobile phone, providing a portable,
While the ability to 3d bioprint an entire functional organ-such as a liver or even skin implants-is still a few years off,
Previously, wee seen how medical researchers have been experimenting with something similar to create 3d bioprinted scaffolding for slowly introducing cells for a diabetic treatment process.
but the demonstration that one can achieve similar mechanical performance with a common biomedical polymer is a substantial advance iit is also quite exciting that these new tough gels can be used for 3d printing,
2015 By Simonalthough wee been seeing many recent applications for 3d printing being used effectively in the medical industry,
and ock-operatedon in an effort to let the surgeons better understand their patient condition before committing to the final surgical procedure.
not only more effective surgeries that have taken also considerably less time, but also less invasive surgeries that cost less.
But for all of the advantages of using 3d printing before a surgery what about using 3d printing as a tool for repairing an injured area or for after a surgery, too?
This is what Exovite, a new Spanish company consisting of professionals from different areas including medicine, electronics, computers,
mechanics and additive manufacturing technologies are currently looking at and they just might be able to make the healing process faster thanks to 3d printing.
Currently, the company is developing a system of immobilization and rehabilitation that will create a revolution in the field of orthopedics and musculoskeletal treatments.
Among other features of the system include savings in both time costs for both the medical professionals and the patients themselves.
Among other goals that the company hopes that users of their technology will achieve include optimized medical treatments as well as a more seamless user experience throughout the procedure due to an improved quality of the procedures themselves.
In other words, similar to how 3d printing has helped revolutionize how prosthetic devices are made both and fabricated, Exovite research and resulting technologies could have
just as much of an impact on internal injuries including broken bones; rather than having a traditional cast on for months,
users could receive the company unique method of therapy and be healed in a matter of weeks.
users will even be able to share the healing progress with medical professionals online as well as receive advice based on the rate of healing.
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