In short, it could be the perfect filament for various technological and medical applications. And while some graphene successes have been achieved previously,
also makes the ink flexible and safe to use in medical situations. Led by Ramille Shah,
entitled hree-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications. 3d printed graphene appeared on the cover.
And so far, biomedical experiments have been quite successful. As a test, her team populated a graphene scaffold with stem cells,
They are also already envisioning sensors, implants and other structures. ells conduct electricity inherently especially neurons.
it is hardly surprising that we hear about exciting new (bioprinted) medical innovations almost every week.
The team has developed a new 3d bioprinting technique that allows them to 3d print a thick paste filled with protein-releasing microspheres that can be used to greatly speed up bone regeneration after fractures.
hese harsh conditions may prevent the incorporation of cells and therapeutic proteins in the fabrication processes,
This makes it quite easy to imagine complicated applications like filling bone fractures with this doughy material to not only make bones stronger during recovery from fractures
#MEDPRIN 3d prints world first biological meningioma Redura for use in brain surgery While 3d bioprinting innovations sound lifesaving and revolutionary, most are still years away from impacting ordinary
people in regular hospitals. However, one Chinese company is already implementing a bioprinted product on a large scale across the world.
Called MEDPRIN, they have developed the world first 3d printed biological meningioma called Redura a replica of tissue covering the brain
and are already applying it in surgical rooms across the world. MEDPRIN is based in Guangzhou,
China and was founded by a team of biomedical scientists in 2008 as a developer of regenerative medical materials and devices.
they have grown out to become a global leader in the field of implantable medical devices, and the Redura is just one of the many products they have released.
and has received already a number of medical certificates, including from CE and CFDA. It has also reportedly been applied on tens of thousands of cases across the world
Usually, when patients undergo brain surgery, doctor first need to cut through a layer of protective tissue between the skull and the brain.
When patching everything up, they'paste'an artificial Meningioma layer on the area in question and sew everything together.
While these have already been widely and successfully used in brain surgeries everywhere, they are not biological
and have a tendency to disrupt a patient life-as most artificial meningioma layers contain metal parts
and will often case security alarms to beep. Fortunately this 3d printed biological Redura doesn suffer from these problems,
but when wet it begins to resemble a thin rubber surface perfect for use in surgical rooms.
Over a course of up to three months, a completely new Meningioma beings to grow, while the artificial structure naturally degrades.
and has been used in world renowned hospitals such as Cambridge university Hospital. So far, no reports of adverse reactions have been made
he said. he core membrane adopts the most advanced 3d printing based bio-regenerative medical platform,
According to the company, doctors could just use Redura on the defect areas and sow it together. edura is hydrophobic with a more than 90 contact angle that acts as a watertight barrier for the prevention of cerebrospinal fluid (CSF) leakage,
and non-toxicity. uan Yuyu further stated that the Redura is absorbed eventually into the body. imply put Redura provides the bracket in
the Redura begins to slowly degrade into toxic-free carbon dioxide and water, 'he says. edura is degraded fully
a tensionless urethral sling, a hernia repair piece, and artificial skin, blood vessels and ligament, many of which rely on the exact same 3d printing technique.
According to Xu Tao, the availability of 3d printed medical tissues could widely change over the coming years. issue repair is a complex human organ regeneration process,
he said. he plan is to develop more than 10 kinds of implantable medical devices products within the next 5 years.
we are leading the establishment of Guangzhou Research Institute of regenerative medical industry, seeking to integrate global and domestic regenerative medical technology
Whether its for medical use or for other scientific purposes, the ability to create custom objects using additive manufacturing methods at the nanoscale is allowing experts to manipulate objects at even the smallest levels.
The new results will help pave the way for DNA NANOTECHNOLOGY in medicine over the next 10 years.
Unfortunately, many common diagnostic tools, such as enzyme-linked immunosorbant assay (ELISA), require large and expensive readout instruments that can only be found in well-equipped hospital labs. Now,
Image via UCLATO conduct a traditional ELISA test, doctors place antigen samples from the patient onto a surface,
normally a small transparent plate resembling a honeycomb with 96 tiny wells. Specific antibodies are placed then into each well,
which can be analyzed by doctors to determine whether particular viruses are present. While that process may seem a bit complicated to us non-medical experts
and dramatically reduce diagnosis costs per patient compared to nonbatched or nonstandard tests. A traditional ELISA 96-well platewith the UCLA researcher new invention, the same steps are taken,
comparing 571 patient samples to FDA-approved samples of mumps, measles, and herpes simplex viruses 1 and 2. The platform achieved an accuracy of 99.6 percent in diagnosing mumps, 98.6 percent for measles,
and 99.4 percent each for herpes simplex 1 and 2. Schematic overview and different perpsectives of the colorimetric readeraccording to the research paper,
hand-held platform could assist healthcare professionals perform disease screening and vaccination tracking campaigns in resource-poor and field settings.
In addition to serving low-resource or remote areas, the researchers noted that intrinsic wireless connectivity can serve epidemic-related studies,
generating real-time, spatiotemporal maps of disease prevalence and immunity. e are always looking toward the next innovation,
and are looking to adapt the basic design of this ELISA cellphone reader to create smartphone-based quantified readers for other important medical tests,
said Dino Di Carlo, professor of bioengineering and one of the researchers on the team. t is quite important to have these kinds of mobile devices,
especially for administering medical tests that are done usually in a hospital or clinical laboratory, added lead researcher Aydogan Ozcan. t fantastic for an undergraduate to be first author on the publication,
physics and astronomy, to bioengineering, pathology and laboratory medicine. The Californa Nanosystems Institute and the Johnsson Comprehensive Cancer Center also contributed, with support from the National Science Foundation and the Howard hughes medical institute.
Since 3d printing technology is acknowledged already for being affordable and easily transportable to low-resource areas,
it is easy to imagine this kind of groundbreaking medical technology being used in remote, rural or developing countries, many
of which are at high risk for virus-related epidemics. And, given the incredibly high success rates of the clinical trials so far, it can only be hoped that this lifesaving device is put to good use as soon as humanly possible. a
#Surgeons turn to 3d printing to help perform world first pediatric bilateral hand transplant in USA Although wee previously heard about the many remarkable instances where 3d printing has helped improve the quality of life for an individual thanks to its increased usage and acceptance in the medical industry,
none of the scenarios involved a surgical procedure as complicated as a hand transplant. Yet, thanks to a team of surgeons in Philadelphia, an 8-year-old boy can now throw the football thanks to a recent hand transplant that was made possible thanks to the aide of 3d printing.
The 8-year-old Zion Harvey, sadly lost his hands and feet to an infection several years ago and has learned
since how to live without them. In order for doctors to perform the rare procedure, a total of four simultaneous operating teams were required;
while two were focused on the donor limbs, two were focused on Zion. In order to prepare for the procedure,
the team practiced for nearly a year and a half. Among other reasons, speed was of the utmost importance due to the ability to only have about five hours from the time they received the hands to the time they had to ensure that blood was flowing again.
Of course, finding the right hands to even transplant in the first place wasn without its challenges, too. In order to determine whether a set of donor hands would be the right size for Zion
Dr. L. Scott Levin and another member of Zion surgical team created sample hands on a 3d printer that were based on CT SCANS of Zion forearms.
This week, it was announced by the Children's Hospital of Philadelphia that the surgery, which occurred in early July,
and that Zion is both the first pediatric hand transplant patient in the U s as well as the world's first pediatric bilateral hand transplant patient.
the surgery took 10 hours and involved a team of 40 doctors and nurses from the Children's Hospital, Penn Medicine,
and Shriners Hospital for Children in Philadelphia. According to Dr. Benjamin Chang, a surgeon who was on Zion hand transplant team, the complicated surgery involved uniting 2 bones, 2 deep arteries, 4 veins, 10 nerves, and 22 tendons."(
"The challenge involved) bringing everything together so that they not only looked like hands, but also functioned as hands,
"explained Dr. Chang. Thanks to the thorough preparations performed by the surgical team in advance of the actual surgery,
Zion recovery was limited to just a week in the hospital intensive care unit. Currently, he is undergoing intensive hand therapy several times a day
in order to improve his hand function. As for throwing a football, Zion has a few months before football season gets underway in the US-but there no rush, of course. s
The ubiquitous and democratizing nature of 3d printing continues to obo Turtle Receives Species1st 3d printed Jaw Implant 3d printing has had its fair share of heartwarming stories
people with disabilities will be able to feel the relative temperature level of an object. The higher the temperature of the objects, the stronger the cautionary electrical impulse sent from the micro control panel is.
and authenticity of experience for persons with disabilities using a prosthetic. It will help them live better independently
s far as people with disabilities are concerned, they have a great wish to be able to live as normal healthy people.
safer future for those with disabilities. he design is currently undergoing commissioning and testing, according to Siyi.
This project is named ynthdawleyafter the Sprague Dawley rat the most commonly used rat in biomedical research.
as well as for specific pathological abnormalities and diseases. Perhaps eventually, they could extend their work to plant dissection as well.
#joimax Receives FDA Approval for 3d printed Spinal Implants 3d printing has begun already to disrupt the medical space,
with low-cost prosthetics acting as a clear example of just how personal and affordable medical devices can be.
And, as stories are reported daily as to the ability to create patient-tailored implants with 3d printing,
the FDA is continuing to approve these devices for implant. The latest is a spinal implant from a German company called joimax,
which just received 510 (k) clearance from the US governmental body. The Endoscopic Lumbar Interbody Fusion,
or Endolif On-Cage implant, is a titanium alloy implant manufactured with Electron Beam Melt (EBM) technology.
Due to its 3d printed nature, the implant can both be customized to the patient, by converting patient CT or MRI scans to 3d models,
so that doctors can fuse the device with an endoscope. According to the company, 600 Endolif procedures have already been performed throughout Europe.
the Endolif is part of a larger trend of implementing 3d printing in medical procedures. This trend, which also includes such companies as Materialise
and Conformis, will ultimately be one that becomes mainstream medical practice i
#UCLA Researchers Design Low-cost Smartphone Blood Tester The smartphone is probably the most exciting computing tool human beings have at their disposal.
It is designed to detect antigens in samples of blood with an ELISA test used to detect a number of bacteria,
it is used in many hospitals all over the world. Among other applications, ELISA tests can be used to determine
Blood samples are tested after specific antibodies that bind to antigens meet the blood in the embedded well portion of the plate.
The introduced antibodies contain enzymes whose substrates react chemically and cause a distinct change in color.
Any antigens that may be present can be detected from analyzing the color changes. So how does the handheld ELISA diagnostic tool work?
especially for administering medical tests that are done usually in a hospital or clinical laboratory, remarked Ozcan. his mobile platform can be used for point-of-care testing,
screening populations for particular diseases, or tracking vaccination campaigns in most resource-poor settings. It fantastic for an undergrad to be first author on the publication.
The FDA-approved well-plate readers used in clinical labs today were compared with the team handheld smartphone diagnostic in a UCLA clinical microbiology laboratory.
measles, and herpes simplex viruses 1 and 2 were all part of the dual ELISA tests. From 571 patient samples, the mobile platform was 99.6 percent accurate at diagnosing mumps, 98.6 percent for measles,
and 99.4 percent for both herpes simplex 1 and 2. ur team is focused on developing biomedical technologies that work with mobile platforms to assist with on-site testing
and health-care in disadvantaged or rural areas, Berg said. e are always looking toward the next innovation,
and are looking to adapt the basic design of this ELISA cellphone reader to create smartphone-based quantified readers for other important medical tests,
According to them 4d printing will make a huge impact on the applications from home appliances to medical implants.
In the medical field 4d printing objects could be crucial for making nanorobots for chemotherapy, tissue engineering an assembling biomaterials and many more.
send a virtual cure to a poisoned co-player, or find out a key with which you can unlock a virtual treasure.
#Plasmons Influence Carbon-Based Nanoparticles for Sensitizing Cancerous Tumors In a study published in EPJ D,
#CAP-XX Introduces Thinline Supercapacitors with Unique Nanotechnology Construction Examples include wearables (medical, fitness and health monitors, smart watches, drug delivery systems), portables (active
and injection or inhalation system delivery. The Thinline idea was born while working with a customer designing a disposable insulin pump."
which can be used with the conventional confocal laser microscopes that are found in many biomedical research institutes.
"Pantazis hopes the technique will be used more broadly in biomedical research in the future and is in talks with microscope manufacturers to implement this technology.
Fluorescent proteins Fluorescent proteins play a key role in biomedical research. It is these proteins that researchers use to colour a cell structure or specific molecule,
Each drop in the mesoscale atom could contain various therapeutic substances which would be released under different conditions.
This sort of'smart'container for medicines could carry out carefully planned drug therapy in a selected organ in the human body.
which represent a major milestone for designing materials with customized functions and structures for applications in medicine, optics, and energy.
Initial tests reveal that BMARS delivers superior oxides of nitrogen (NOX) reduction on modern turbo-charged gasoline direct injection (GDI) engines compared to OEM catalysts,
and silver--one of the most widely used coating materials in medical applications. As a result of this damage the researchers believe the drug may not deliver the desired therapeutic effect in patients
and that chemotherapy treatment may be compromised. Furthermore, the research indicates that a by-product of the reaction between 5-Fu
Graphene is a biocompatible material with low toxicity that has already been suggested as an external coating for biomedical applications.
Together with our collaborators and students, we are increasing our understanding of the critical interactions between drugs and medical coatings,
one atom may move down a peak providing a little stress for another atom to move up a trough,
may change the way doctors approach treatment for patients who develop potentially deadly infections and may also help the food industry screen against contamination with harmful pathogens, according to researchers at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, South korea.
Described this week in The Optical Society (OSA) journal, Optics Express, the new approach involves bouncing laser light off individual bacteria under the microscope,
which is still the gold standard in the health care industry for making a definitive diagnosis. Also routinely used today is a newer method for rapidly identifying bacteria based on a DNA-analysis technique called quantitative polymerase chain reaction (qpcr),
"This means the present method can be utilized as a prescreening test for point-of-care bacterial diagnosis for various applications including medicine and food hygiene.""
"Why Speed Matters in Infection Control In hospitals and clinics worldwide, bacterial infections are a major source of illness,
In the most severe cases, bacterial poisoning causes severe disease and syndromes like sepsis, meningitis, pneumonia,
and gastroenteritis all of which can be deadly unless the patient is given immediate and appropriate treatment.
The true challenge of fighting those infections is time. In order to best treat their patients, doctors would like to know exactly which bacteria they are infected with,
but the lost hours or days spent identifying the exact pathogen can make the road to recovery that much steeper.
Sepsis, for instance, can develop so rapidly that mortality has been seen to increase by 9 percent per hour until treatment is given.
Waiting two days may kill the patient, Park added. For that reason, many hospital-acquired infections are treated presumptively,
before they are identified definitively, using broad-spectrum antibiotics. These powerful combinations of potent drugs are often effective,
allowing doctors to prescribe the best drugs available to treat an infection and improving outcomes for people with hospital-acquired infections though the effectiveness of the approach remains to be proven in future clinical trials.
In their initial experiments, Park and his colleagues showed as a proof of principle that they could identify bacteria with high accuracy.
The first three are known all pathogens to infect humans through the food chain or via hospital-acquired infections.
which is the base for Anthrax. Under a microscope, all four of these rodlike bacteria look nearly identical.
In addition to helping in the clinic the new method may be useful in the food industry or for homeland security applications.
would it be possible to deliver the mesh electronics by syringe needle injection, a process common to delivery of many species in biology and medicine-you could go to the doctor
and you inject this and you're wired up.'"'"Though not the first attempts at implanting electronics into the brain-deep brain stimulation has been used to treat a variety of disorders for decades-the nano-fabricated scaffolds operate on a completely different scale."
and administered like any other injection. After injection, the input/output of the mesh can be connected to standard measurement electronics
so that the integrated devices can be addressed and used to stimulate or record neural activity.""These type of things have never been done before, from both a fundamental neuroscience and medical perspective,
"Lieber said.""It's really exciting-there are a lot of potential applications.""Going forward, Lieber said, researchers hope to better understand how the brain
#Innovative Hand-held Tool and App to Monitor for Signs of Skin cancer Unveiled at World Dermatology Conference Sadeghi,
#Once people take high-quality, high-resolution images of suspicious moles or skin abnormalities, they can archive images
Molescope#is expected to provide healthcare benefits in communities without access to medical specialists and in those with long waitlists,
and a more expensive professional version to be presented at the World Congress of Dermatology meeting.
and is registered FDA as a Class 1 medical device in the U s a CE mark in the EU
The company is initiating an early adopter program with qualified dermatologists and receiving strong interest from potential distributors and channel partners throughout the world.
Hugh Macnaught, is now chair of the company board of directors. t was obvious from the outset that Maryam had identified an unmet medical need
It was released in June 2011 and donated to the BC Cancer Agency at Vancouver General Hospital.
Sadeghi Phd research on skin cancer prevention and analyzing dermoscopic images for early skin cancer diagnosis using intelligent computer technologies was recognized with a 2012 Innovation Challenge Award from the Natural sciences and Engineering Research Council
and Toxic Gases RMIT University researchers have created wearable sensor patches that detect harmful UV radiation and dangerous, toxic gases such as hydrogen and nitrogen dioxide.
stretchy electronic sensors are also capable of detecting harmful levels of UV radiation known to trigger melanoma.
#Ultracompact Highly sensitive Nanomechanical Sensor Can Detect Viral Disease Markers Two young researchers working at the MIPT Laboratory of Nanooptics and Plasmonics,
such as viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases,
including HIV, hepatitis, herpes, and many others. The sensor will enable doctors to identify tumor markers,
whose presence in the body signals the emergence and growth of cancerous tumors. The sensitivity of the new device is characterized best by one key feature:
according to its developers, the sensor can track changes of just a few kilodaltons in the mass of a cantilever in real time.
One Dalton is roughly the mass of a proton or neutron, and several thousand Daltons are the mass of individual proteins and DNA molecules.
So the new optical sensor will allow for diagnosing diseases long before they can be detected by any other method,
If you place antibodies to certain viruses on the cantilever, it'll capture the viral particles in the analyzed environment.
#Nanoparticles Arrest Destruction of Beta Cells and Avoid Diabetes Development This work led to more studies with the support of the Spanish Government, Catalan Government and private patrons with a keen interest in it.
Thanks to this, the article published today in PLOS ONE describes a new step towards the creation of a vaccine,
and even curing the disease in humans. Initially the researchers avoided the destruction of the insulin-producing pancreatic cells (beta cells) in the body by modifying the individual's immune cells, known as dendritic cells.
This important step requires the extraction of the subjects'dendritic cells for their subsequent manipulation and re-injection.
and avoid Diabetes development. This technique could be a much better candidate for a human vaccine.
The invention is protected commercially and an international patent has been applied for. Droplets of fat and water which can be produced on a large scaleliposomes have been used in several medical treatments.
They are not cells, but droplets with an external fat membrane, similar to cell membranes. They can be made using a very specialized process,
The Catalan researchers are the first group in the world to use liposomes that imitate naturally dying cells to fight against Diabetes.
Next stepsafter showing that liposomes prevent the onset of Type 1 Diabetes in mice, the next steps are to test it in human cells in vitro,
to start clinical trials on human candidates for preventive vaccination and to cure the disease by combining the vaccine with regenerative therapies.
The Germans Trias Institute plans to carry out these steps with patients at the hospital and to optimize the product by dosage and guideline studies.
It is planned also to optimize the product for personalization. To achieve these objectives more competitive funding will be necessary from public agencies.
Growing incidence and complex consequencestype 1 Diabetes is an illness where the body does not recognize the beta cells of the pancreas as its own
The most serious is that in the long term hyperglycemia provokes retinal damage that can lead to blindness renal insufficiency, destruction of nerve fibers or
what is called"Diabetics Foot"where ulcers form, leading eventually to the need to amputate. The causes of the disease are unknown,
although there are both genetic and environmental factors involved. About 0. 3%of the population is affected
This immunotherapy presents a possible solution for Type 1 Diabetes. Source: http://www. uab. es e
. a professor of chemistry at Tufts and senior author on the paper, worked with iodine-125 radioactive isotope that is routinely used in cancer therapies.
Gold-Plated Cancer Fighters? Then Alex Pronschinske, Ph d.,first author on the paper and a postdoctoral researcher in Sykeslab, suggested that they measure the electrons emitted by the sample without prodding from X-rays in the photoelectron spectrometer.
which have been shown to be very effective in radiation oncology because they break cancer cellsdna into pieces.
Because these electrons can travel only 1 to 2 nanometers human hair is about 60,000 nanometers widehey do not affect healthy tissue and organs nearby.
you get this big flux of low energy electrons coming out. he finding suggests a new avenue for radiation oncology:
then affix the nanoparticles to antibodies targeting malignant tumors and put them in a liquid that cancer patients could take via a single injection.
Theoretically, the nanoparticles would attach to the tumor and emit low energy electrons, destroying the tumor DNA.
The gold-based nanoparticles would be flushed out of the body, Sykes says, unlike free iodine-125,
which can accumulate in the thyroid gland and cause cancer. If proven, this approach could be a potential improvement over current radiation therapy protocols, in
which doctors treat some cancers by putting radioisotopes, including iodine-125, into tiny titanium capsules and implanting them in tumors.
Instead of emitting large amounts of low energy electrons as the gold-bound iodine does, the titanium capsules inhibit radiation,
Sykes says, making such therapies less effective than they could be. He has applied for a patent on the new technique.
Researchers in Sykes'lab are now assessing precisely how the low energy electrons travel through biological fluids.
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