#Scientists Demonstrate Intrinsic Chirality in Ordinary Nanocrystals By Stuart Milnethese findings have opened new possibilities in medicine,
which could be medical benefits, while the other form, which is its antipode, would be useless.
while the other is toxic and does not relieve pain. The optical activity is considered to be an important indicator of chiral environment.
published online in the Journal of Maternal-Fetal & Neonatal Medicine, was conducted by an interdisciplinary team of researchers from the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the University of Pennsylvania, Wayne State university/Detroit Medical center
, Seoul National University and Asan Medical center in South korea.""We believe that this technology may be used to address questions that are difficult to answer with current placenta model systems
and help enable research on pregnancy and its complications,"said Roberto Romero, M d.,chief of the NICHD's Perinatology Research Branch and one of the study authors.
#Polymer Nanobrushes Grab Selected Bacteria for Pathogen Detection A Texas A&m Agrilife Research engineer and a Florida colleague have developed a biosensor that can detect listeria bacterial contamination within two
The same technology can be developed to detect other pathogens such as E coli O157: H7, she said.
But listeria was chosen as the first target pathogen because it can survive even at freezing temperatures.
It is also one of the most common foodborne pathogens in the world and the third-leading cause of death from food poisoning in the U s."It can grow under refrigeration,
but it will grow rapidly when it is warmed up as its optimum growth temperature ranges from 30 to 37 degrees Celsius--86 to 98 degrees Fahrenheit,
000 National Science Foundation grant to continue their work on nanobrushes for pathogen detection n
#Nano-Packaged Drug Can Halt and Reverse Progression of Atherosclerosis in Rodents In what may be a major leap forward in the quest for new treatments of the most common form of cardiovascular disease,
scientists at Johns Hopkins report they have found a way to halt and reverse the progression of atherosclerosis in rodents by loading microscopic nanoparticles with a chemical that restores the animals'ability to properly handle cholesterol.
known as atherosclerotic vessel disease, is the leading cause of heart attacks and strokes that claim some 2. 6 million lives a year worldwide, according to the World health organization.
That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound
and clear out D-PDMP was a major hurdle in efforts to test its therapeutic potential in larger animals and humans.
but not potent enough to stop the disease from advancing. Perhaps, most importantly, the team says,
and pumping dysfunction, the hallmarks of advanced disease.""Our experiments illustrate clearly that while content is important,
"says lead investigator Subroto Chatterjee, Ph d.,a professor of medicine and pediatrics at the Johns hopkins university School of medicine and a metabolism expert at its Heart and Vascular Institute."
and its ability not merely to prevent disease but to mitigate some of its worst manifestations."
D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
#Encapsulated, Nanobody-Targeted Drugs Cold Help Treat Sleeping sickness Sleeping sickness, or African trypanosomiasis, is caused by trypanosome parasites transmitted by tsetse flies
The disease is considered fatal if untreated, but as it affects mostly poor people in low-income countries,
A study published on June 25th in PLOS Pathogens reports a new way to circumvent drug resistance
a high-tech approach with potential applications to other infectious diseases. Current treatment of sleeping sickness relies primarily on four drugs.
Three of these drugs get into the interior of the parasite cells via the trypanosome's transport proteins that normally supply the parasite with nutrients,
The researchers developed a drug carrier that consists of polymeric nanoparticles coated with specialized antibodies that target a small conserved (i e.
which is why the chances of developing an effective vaccine have been deemed low.)They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and,
most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.
minimizing the toxicity and circumventing resistance mechanisms caused by mutations in surface transporters.""The implication of this proof-of-concept study of a novel technology for reversing transporter-related drug resistance,
#Nanotechnology Drug in Droplets for Painless Treatment of Secondary Blindness The Mexican company"Medical and Surgical Center for Retina"created a way to transport drugs,
in order to avoid risks and painful treatments in people with secondary blindness due to chronic degenerative blindness such as diabetic retinopathy and degeneration of the eye.
The innovative formula results eliminates the need to administrate the drug by intraocular injection. It is a nanotechnology product,
or antibody fragments and allow its passage into the eye. Once inside it releases the drugs.
"With this technology hospitals that have no resources can apply the needed drugs, without requiring a a specialist or a particular facility for the administration.
"The doctor Juan carlos Altamirano Vallejo, medical director of the Medical and Surgical Center for Retina, mentions that the conditions that originate in the retina are caused mostly by chronic degenerative diseases such as diabetes (diabetic retinopathy
Patients with this conditions usually require one injection per month which comes at a very high cost
and Innovation and plans to conclude the Clinical Research regulated by the Federal Commission for Protection Against Health risks (COFEPRIS) next year.
The idea is for the medicine to be distributed in state and private health institutions. So far
the achieved results are the same as the ones obtained with intraocular injection, but without the inherent risks of this procedure, such as infection or retinal detachment.
Current talks are being held with COFEPRIS to conduct a study within several diseases and increase its use for different conditions.
In the United states, patients who have followed the treatment have had positive results. The Medical and Surgical Center for Retina provides medical care
and a specialized retina Ophthalmology Clinic provides consultation, which also has an area of`Biotechnology and Drug Research of Biomedical engineering, Diagnosis and Treatment Equipment.
Altamirano Vallejo says that receiving the award opens the doors to reach more people and prevent blindness."
"It is the most important prize delivered by the Presidency of the Republic in the area of`technology and innovation.
For us, to have an entity such as the award foundation to guide us and allows us to learn,
and prevent blindness. Source: http://www. invdes. com. mx
#MEMS Innovations Enable Commercialization of Implantable Microchips for Drug-Delivery An implantable, microchip-based device may soon replace the injections
and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
microchip-based devices that store and release drugs inside the body over many years. Invented by Microchips Biotech cofounders Michael Cima, the David H. Koch Professor of Engineering,
each capped with a metal membrane, that store tiny doses of therapeutics or chemicals. An electric current delivered by the device removes the membrane,
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world largest producer of generic drugs,
to treat specific diseases, with licensing potential for other products. Teva paid $35 million up front, with additional milestone payments as the device goes through clinical trials before it hits the shelves. bviously,
this is a huge validation of the technology, Cima says. major pharmaceutical company sees how this technology can further their efforts to help patients.
to $289 billion annually in unnecessary health care costs from additional hospital visits and other issues.
Failure to follow prescriptions, the study also found, causes around 125,000 deaths annually and up to 10 percent of all hospitalizations.
While its first partnership is for treating chronic diseases, Microchips Biotech will continue work on its flagship product, a birth-control microchip, backed by the Bill and Melinda Gates Foundation,
sees this hormone-releasing microchip as one of the first implantable rtificial organsbecause it acts as a gland. lot of the therapies are trying to chemically trick the endocrine systems Cima says. e are doing that with this artificial organ we created.
and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents. e were trying to find the killer application.
and researchers from Microchips, conducted the microchipsfirst human trials to treat osteoporosis this time with wireless capabilities.
In that study, published in a 2012 issue of Science Translational Medicine, microchips were implanted into seven elderly women,
Results indicated that the chips delivered doses comparable to injections and did so more consistently with no adverse side effects.
of life-a cellular recycling unit with a role in many diseases. The proteasome complex is present in all multicellular organisms,
and plays a critical role in cancer by allowing cancer cells to divide rapidly. Researchers used a technique called electron cryo-microscopy,
Scientists from The Institute of Cancer Research, London, and the Medical Research Council (MRC) Laboratory of Molecular biology in Cambridge were able to visualise the proteasome complex down to a resolution of around 3. 5 Angstroms,
and was funded by Cancer Research UK and the MRC. The research could help other scientists to use CRYO EM in structure-based drug design studies-in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.
Blocking the proteasome prevents this regulated recycling of amino acids and triggers controlled cell death, particularly in fast-dividing cells typical of cancer.
Senior study author Dr Edward Morris, Team Leader in Structural Electron microscopy at The Institute of Cancer Research, London, said:"
"Dr Emma Smith, senior science communications officer at Cancer Research UK, said:""Revealing the molecule's detailed shape could be the first step towards designing more precise drugs to block it.
This molecule plays an important role in some cancers and drugs that block it are already available to patients
unsafe drinking water and the inadequate supply of water for hygiene purposes contribute to almost 90%of all deaths from diarrheal diseases
#Smart Sensor Chip with Nanocavities for Early Prostate Cancer Diagnosis Researchers at the University of Birmingham believe that the novel technology will help improve the process of early stage diagnosis. Glycoprotein molecules,
Because of their essential role in our immune response, they are useful clinical biomarkers for detecting prostate cancer and other diseases.
In doing so, they developed a more accurate and efficient way of diagnosing prostate cancer than the current tests
which rely heavily on antibodies. These antibodies are expensive to produce, subject to degeneration when exposed to environmental changes (such as high temperatures
or UV LIGHT) and more importantly, have a high rate of false-positive readings. Professor Paula Mendes said,
so could feasibly be kept on the shelf of a doctors'surgery anywhere in the world.
Problematically for diagnosis, the protein part of glycoproteins does not always change if the body is diseased.
The findings, published in the journal Chemical science, show how the rate of false readings that come with antibody based diagnosis can be reduced by the smart technology that focuses on the carbohydrate part of the molecule.
the team wanted to identify the presence of disease by detecting a particular glycoprotein which has specific sugars in a specific location in the molecule.
and so we need technology that can discriminate between these subtle differences-where antibodies are not able to."
the sugar part of the prostate cancer glycoprotein is reacted with a custom-designed molecule that contains a boron group at one end (the boron linkage forms a reversible bond to the sugar).
and the only key that will fit is the specific prostate cancer glycoprotein that we're looking for.
"Dr John Fossey added,"It's estimated that one in eight men will suffer from prostate cancer at some point in their life,
so there's a clear need for more accurate diagnosis. By focussing on the sugar, we appear to have hit the'sweet spot'for doing just that.
and collaboration with commercial partners, will open the door to adapting the current technology for other diseases.
Lots of diseases produce specific glycoproteins, so there are a number of possible avenues to improve the accuracy of our diagnoses."
where they create clothing that kills bacteria, conducts electricity, wards off malaria, captures harmful gas and weaves transistors into shirts and dresses. otton is one of the most fascinating and misunderstood materials,
which could help in warding colds, flu and other diseases. Two of Hinestroza students created a hooded bodysuit embedded with insecticides using metal organic framework molecules,
Malaria kills more than 600,000 people annually in Africa. While insecticide-treated nets are common in African homes
Other students have used MOFS to create a mask and hood capable of trapping toxic gases in a selective manner.
#Discovery of Mesh Cell Structure Could Help Understand Development of Cancer For the first time a structure called he meshhas been identified
which is found to change in certain cancers, such as those of the breast and bladder.
The finding was made by a team led by Dr Stephen Royle, associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school.
and support from Cancer Research UK and North West Cancer Research. Dr Royle said: e had been looking in 2d
TACC3, is overproduced in certain cancers. When this situation was mimicked in the lab, the mesh and microtubules were altered
Dr Emma Smith, senior science communications officer at Cancer Research UK, said: roblems in cell division are common in cancer cells frequently end up with the wrong number of chromosomes.
and it might be a crucial insight into why this process becomes faulty in cancer
and whether drugs could be developed to stop it from happening. orth West Cancer Research (NWCR) has funded the research as part of a collaborative project between the University of Warwick and the University of Liverpool,
which could potentially better inform future cancer therapies. s a charity we fund only the highest standard of research,
award-winning scientists and pioneering professionals. arwick Medical school division of biomedical cell biology carries out fundamental molecular and cellular research into biomedical problems.
Major human diseases such as cancer inflammation, neurodegeneration and bacterial/viral infection are primarily diseases of cells.
Without a molecular understanding of the underlying cell biology, intelligent directed therapeutic intervention is impossible. The division research focuses on fundamental cell biology processes such as cell division and intracellular communication.
Source: http://www2. warwick. ac. uk m
#Scientists Discover New Chemical reaction Pathway on Titanium dioxide The reaction mechanism, reported in ACS Nano, involves the application of an electric field that narrows the width of the reaction barrier,
Technology areas of interest include cloud applications, analytics, social media, mobile, materials, medical devices, digital health, healthcare IT, instruments and cloud software infrastructure.
The nanoparticles infused with silver ions were utilized to attack Pseudomonas aeruginosa, disease-causing bacteria; E coli, a bacterial species that cause food poisoning;
Staphylococcus epidermis, bacteria that form toxic biofilms on plastics such as catheters in the human body; and Ralstonia, a genus of bacteria that contains various soil-borne pathogens.
All these bacteria were destroyed by the newly developed nanoparticles. Using this latest technique, researchers can easily modify the nanoparticle recipe to target certain microbes.
According to Alexander Richter, first author of the paper and a Ph d. candidate at NC State who received the 2015 Lemelson-MIT prize,
The method released the stress in the laminate layer and avoided stress to build up between the two stacked layers.
Yet, more traditional approaches to thermocompression bonding come with long cycle times(>1 minute per die),
rapid, data-rich biomedical imaging. By merging data simultaneously collected by thousands of microlenses optical elements each smaller than the width of a human hair this new multispectral microscope is able to produce a continuous series of datasets that essentially reveal how much of multiple colors
Multispectral Imaging Color and Data Combinemultispectral imaging is used for a variety of scientific and medical research applications.
Medical researchers are able to study these frequencies to learn about the composition and chemical processes that are taking place within a biological sample.
This is essential for pharmaceutical research particularly cancer research--to observe how cells and tissues respond to specific chemicals and experimental drugs.
which find application in cancer treatment, pollution reduction, renewable energy collection. Scientists from Harvard, Boston, and Princeton universities have played also a role in the development of this innovative technique, called D Structure Identification of Nanoparticles by Graphene Liquid Cell EM (SINGLE),
and observe and study the biological and medical significance of RNA misregulation. Details will be published the week of July 20 in the journal Proceedings of the National Academy of Sciences (PNAS.
"Mirkin is the George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences and professor of medicine, chemical and biological engineering, biomedical engineering and materials science and engineering.
which was the first genetic-based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood.
a start-up company, has developed a proprietary nano-polymer additive that protects against any microbial infection
or implant-associated infection, improve clinical outcomes and increase device longevity. The nano-polymer additive's unique features are that they are activated only upon contact,
Antimicrobial resistance (AMR) is considered to be the most urgent and important challenge of all medical fields.
"Unless we take significant actions to improve efforts to prevent infections. the implications will be devastating."
"1 NIH (National institutes of health) estimates that"Infectious diseases are the second cause of death worldwide, more than13 millions deaths per year (mostly due to bacteria.
More than 60%of microbial infections proceed with involvement of biofilms.""Prof. Ervin Weiss inventor and one of the developers of the nano-polymer additive technology adds,
and heavy metals, will revolutionize medical device industry. s
#Novel Method Utilizes Nanoparticles and UV LIGHT to Isolate, Extract Contaminants In a new paper published this week in Nature Communications,
for Integrative Cancer Research. Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.
Brandl says. hen we came up with the idea to use our particles to remove toxic chemicals, pollutants,
minimizing the risks of leaving toxic secondary products to persist in, say, a body of water. nce they switch to this macro situation where theye big clumps,
from environmental remediation to medical analysis. The polymers are synthesized at room temperature, and don need to be prepared specially to target specific compounds;
offering the example of a cheap testing kit for urine analysis of medical patients. The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
#Coral-Like Nanoplates Help Remove Toxic Heavy metals from Water A new material that mimics coral could help remove toxic heavy metals like mercury from the ocean,
Toxic heavy metal ions like mercury, lead and arsenic are released into the water through human activity, including manufacturing and industrial processes.
One major source of toxic metal contamination is the ocean. When mercury pollutes the water
The mercury builds up in the food chain, ultimately resulting in toxic fish. According to THE WHO, between 1. 5 and 17 in every thousand children living in selected subsistence fishing populations showed cognitive impacts caused by the consumption of fish containing mercury.
Heavy metals are also toxic to corals: even at low concentrations, small amounts of heavy metal pollution can kill corals.
This heightened toxicity is due to coral being very efficient at collecting, or adsorbing, heavy metals. The researchers behind the new study have taken inspiration from this
including medicine, electronics and energy. Discovered only 11 years ago, graphene is one of the strongest materials in the world,
However, current methods for production currently require toxic chemicals and lengthy and cumbersome processes that result in low yield that is not scalable for commercial applications.
The process is relatively faster, safer and green devoid of any toxic substances (just graphite plus concentrated light.
and someone with schizophrenia would be a leap in our understanding of how our brains shape who we are (or vice versa).
whether as result of accidents, injuries or illnesses, observes Huber. Under the motto he New Future of Old age the German Federal Ministry of Education and Research (BMBF) is sponsoring research projects for technical solutions such as akrobatik@home that help
while others suffer from hearing impairments. hese specific disabilities led to concrete ideas, explains Mizera. Three ideas were implemented by the researchers together with the thalidomide victims, Heidelberg University,
whether rotational, vertical or horizontal. hile users play, they unconsciously do recommended the exercises by therapists.
and stress would be too great. In a project funded by The swiss National Science Foundation (SNSF) Empa
and the University Hospital Zurich thus teamed up to develop the sensor Glucolight which gages the blood sugar level through the skin without taking any blood.
Glucolight spares the premature babies blood samples and enables the blood sugar level to be monitored permanently thanks to the sensor's novel measuring technology which comprises several parts:
A microdialysis measuring head which was developed at the University Hospital Zurich with a smart membrane developed at Empa;
The computer then uses these two different readings to calculate the premature baby's blood sugar level.
and the first clinical studies are scheduled at the University Hospital Zurich for 2015. However it could be years before the use of Glucolight becomes standard.
Empa and the University Hospital Zurich are currently in negotiations with partners for the industrial production of the sensor.
For the future the researchers also envisage the use of Glucolight in other fields such as diabetes s
The Saturas sensor provides accurate information for optimized irrigation to reduce water consumption with no stress to the plants and increases fruit production and quality.
--whose deregulation is associated with diseases ranging from diabetes to cancer to epilepsy--have gradually been brought to light.
No one doubts that this is an important pathway with implications for aging cancer and diabetes and we had figured out the core machinery of the pathway says Sabatini.
But the mystery has been what are the sensors? Now we've found what is likely the first nutrient sensor.
because hyperactivation of the pathway can lead to aberrant growth seen in cancer or metabolic abnormalities associated with diabetes.
Intriguingly because SLC38A9 activates the pathway it may represent a target for clinical situations in
In this case one could think about situations where you would want to increase protein synthesis perhaps to treat muscle atrophy and disease-related weight loss.
and medical care sectors to connect with general public and sub-health population. In particular wearable vital sign monitoring devices is set to revolutionize the healthcare and medical devices industry over the next few years.
In the hospital and home healthcare there are portable pulse oximeters that provide noninvasive continuous monitoring of individual's heart rate
and compared with a medical grade handheld pulse oximter. Human trial testing results shows that the accuracy of the wrist-worn pulse oximetry device closely agreed with the medical grade specifications said Jyh-Chern Chen President of Taiwan Biophotonic Co
. This report has been submitted to the journal of Biomedical Optics Express in Nov. 2014 for publication.
Founded by a team of experts from the Industrial Technology Research Institute (ITRI) the Taiwan Biophotonic Corporation has developed the world-leading noninvasive and wearable sensing technologies for healthcare
and medical devices said Ching-Yen Tsay Chairman of ITRI. This reflective pulse oximetry sensor is just the beginning of a line of wearable solutions that Taiwan Biophotonic Co. will be introducing this year.
and sales of medical and healthcare related products Headquartered from Hsin-chu Taiwan tbpc is dedicated to develop novel noninvasive sensing solutions that measure various physiological parameters for healthcare and medical care.
Danehorn and Holmström formed the company, Neosense Technology, with Lars Åke Brodin, a professor of medical engineering at KTH, with the hope of bringing their technology to market by 2018."
"When with severe inflammation of the stomach and intestines, infection and impaired lung function, bad blood oxygen control can be deadly,
Oxygenation at too high a level can cause damage to the retina, and blindness.""If we can contribute to better monitoring and stabilisation of oxygenation supply,
In the longer term, Neosense Technologies'technology could also be used for adults in intensive care and in cardiac and vascular surgery.
Neosense Technologies collaborates with both KTH, Karolinska University Hospital and Uppsala University Hospital s
#Portable, Autonomous Device Analyzes Trace elements in Water, Air and Upper atmosphere Researchers from Arizona State university School of Earth and Space exploration have combined their sensors,
since it is able to quantify pathogens, he doesn see it as a medical diagnostic tool. t designed for exploration,
he said. eing able to detect trace components, single molecules, autonomously and reliably, without the need for sample return or hardware consumables in a really tiny,
what our machine is all about. lthough there may be limited medical diagnostic applications, Youngbull envisions use of the device in homeland security, mass transit, public spaces, hospitals, schools, food production and combat theater analytics.
Autonomous, digital droplet PCR is useful for many aspects of science. The device might even one day be integrat ed into a rover,
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