Malaria Diagnosis to Smartphones Researchers at Texas A&m University have developed a novel point-of-care device for field-based diagnosis of malaria using a smartphone.
which is indicative of malarial infection. Despite advances in diagnostic approaches and treatment, malaria remains one of the leading sources of disease and death in developing nations.
The old standardof detection, evaluation of Giemsa-stained blood smears via bright-field microscopy often requires skilled technicians
and successfully did a small cancer gene study using this technique. The group was able to add a few modified cells with the Rasg12v cancer gene in a printed organoid array
and observed how the few mutated cells were able to induce a response from its surrounding tissue.
Zev Gartner, Phd, the paper senior author, stated that he hopes to use this technology to study how changes in the structure of mammary glands can cause the destruction of tissue structure that is associated with tumors that metastasize.
or spinal cord injury. Electrical signals, acquired through either invasive or noninvasive neural interfaces, are decoded to subsequently control external devices.
#White blood cell Mediated Therapy for Neurons in Patients with Parkinson Disease Scientists at the University of North carolina at Chapel hill have begun researching the delivery of neurotropic factors to the brain as a potential therapeutic for Parkinson disease.
However, one potential therapy is the development of smarter immune cells that deliver neurotropic factors to neurons damaged by the disease.
In the study, GDNF alleviated neuroinflammation and reversed neurodegeneration in Parkinson disease model mice. One suggested mechanism of activity is that these cells,
Delivering the protective proteins through immune cells is a breakthrough in GDFP therapy. This new macrophage mediated protein delivery system could potentially provide a therapy for patients who are afflicted by this debilitating disease e
#New Self-Positioning Transcatheter Mitral valve Developed by National University of Singapore Transcatheter heart valve replacements have become life savers for many frail patients who are unsuitable for open heart surgery.
While many benefit from implantation of the prosthetic valves, the anatomy of many patients doesn lend well to the procedure
#Mobileodt Brings Cervical cancer Diagnostics to Developing Countries Early detection significantly improves the survival rates for cervical cancer patients.
Cervical cancer used to be one of the leading causes of cancer deaths in the US,
but mortality rates have declined significantly in the last 40 years due in part to better compliance with regular cervical cancer screening.
and has leveraged this into a new cervical cancer screening product. Their cervical cancer screening system allows any smartphone to be turned into a colposcope,
making this part of the screening process readily available for most clinics. The hardware is equipped with a light source
and magnifying lens that gives a phone camera lens excellent visualization of any abnormalities in the cervical tissue.
Once visualized, the nurse can make a diagnosis or capture photos of the patient cervix and transmit them securely to a physician for further analysis. Mobileodt smartphone application supports annotation of these images and transmission of final recommendations by the remote physicians s
#Nicotine-eating bacteria joins stop-smoking fight Why do people smoke? There's no denying that smoking is horrible for you,
But when their population booms, they can quickly become a plague, consuming coral reefs--their favorite food--with a frenzied fervor.
as well as a unique pneumatic injection arm, it is an efficient executioner. The only thing missing is an audio track proclaiming"Hasta la vista
These electrical signals the same as those a doctor looks at when running an electroencephalogram (EEG) test were sent to a computer,
who had been paralyzed for five years after a spinal cord injury, was able to walk about 12 feet (3. 66 meters).
"Even after years of paralysis, the brain can still generate robust brain waves that can be harnessed to enable basic walking,
"study co-author Dr. An Do, an assistant professor of neurology at the University of California, Irvine, said in a statement."
"We showed that you can restore intuitive, brain-controlled walking after a complete spinal cord injury."
The researchers say the new study provides proof of concept that a person with complete paralysis of both legs can use a brain-controlled system to stimulate leg muscles
or improve walking in individuals with paraplegia due to spinal cord injury, "the researchers said. Before the man could use the system to walk,
Dr. Elizabeth Tyler-Kabara, an associate professor of neurological surgery and bioengineering at the University of Pittsburgh, who was not involved with the study,
In the future, it may be possible to implant the entire system inside a patient's body using implants to the brain,
but applying these chemicals to the surface of wounds has its limits. To best stem blood loss, those chemicals need to be able to find their way deep into a wound.
There may now be a solution, however, and it comes in the unlikely form of fizz, reports Wired.
propelling them deep into a wound as they pop. The new concoction is composed of powdered marble, tranexamic acid
Water from the blood is the catalysis that sets it fizzing. f you can get the particles in the general area of the wound,
a biomedical engineer at the University of British columbia. t similar to when a grenade goes off
all the way to the damaged internal blood vessels feeding the wound. By clotting so deep into the lesion, the clot was shown to be more stable.
Right now the fizzing agent is a bit messy. While chemicals do get deeper into the wound,
they pop off in every other direction too. Eventually researchers hope to make the delivery process more efficient,
Paramedics equipped with these fizzy bandages could prolong the lives of patients during transit to the hospital, for instance
For example, people with arthritis may be able to get pain relieving drugs during walks in doses that are proportional to how many steps are taken.
and a member of MIT Koch Institute for Integrative Cancer Research, is the paper senior author.
The finding demonstrates that the stress of crystal deformation can impart a newfound degree of control over magnetic and electrical behavior in spintronic devices and sensors.
however, apply stress in all directions equally. he biggest challenge we faced was accurately controlling uniaxial stress at temperatures as low as 3 kelvin,
The team constructed a unique cell that clamps a multiferroic barium cobalt germanium oxide (Ba2coge2o7) crystal between a pair of zirconium oxide pistons (Fig. 1). They then investigated how the sample electric polarization changed under uniaxial stress.
In contrast, by deforming the Ba2coge2o7 crystal with varying levels of uniaxial stress, the researchers could tune the polarization output in unprecedented ways, from fully on to fully off,
because they show we can control the spin-driven ferroelectricity in this compound by applying uniaxial stress at the low megapascal level,
particularly for crystals with high levels of symmetry. any multiferroic materials have the potential to show stress-induced effects,
#Nanotechnology developed to help treat heart attack and stroke Australian researchers funded by the National Heart Foundation are a step closer to a safer
and more effective way to treat heart attack and stroke via nanotechnology. The research jointly lead by Professor Christoph Hagemeyer, Head of the Vascular Biotechnology Laboratory at Baker IDI Heart and Diabetes Institute and Professor Frank Caruso,
an ARC Australian Laureate Fellow in the Department of Chemical and Biomolecular engineering at the University of Melbourne, was published today in the leading journal Advanced Materials.
Professor Frank Caruso from the Melbourne School of engineering said the targeted drug with its novel delivery method can potentially offer a safer alternative with fewer side effects for people suffering a heart attack
or stroke. p to 55,000 Australians experience a heart attack or suffer a stroke every year. bout half of the people who need a clot-busting drug can use the current treatments
because the risk of serious bleeding is too high, he said i
#Aluminium could give a big boost to capacity and power of lithium-ion batteries One big problem faced by electrodes in rechargeable batteries,
This expansion and contraction of aluminum particles generates great mechanical stress, which can cause electrical contacts to disconnect.
but hopefully it will lead to medical applications. This gives us new opportunities to look at cell structures
and whether there any degradation of those structures in diseases. any diseases are caused either by an invading pathogen or degradation of a cell internal structure.
including medical diagnostics, industry, and the military. The research, published in the highly respected scientific journal, Nature Communications on September 1st, describes how the composition of gases in different environments can be detected by measuring small colour changes of the innovative bio-inspired sensor.
One of the most critical biological and medical tools available today, it lies at the core of genome analysis. Reading the exact make-up of genes,
sequencing technology will definitely shift from research to clinics, says Aleksandra Radenovic. or that, we need rapid and affordable DNA sequencing
and cancer drugs Longing to find a cure for cancer, HIV and other yet incurable diseases,
each requiring preclinical and clinical testing with live subjects. How many chemical agents more to try? Moving at such rate, will we find the cure during our lifetime?
This approach will eventually provide more effective preclinical selection of drug candidates for the subsequent long-term and expensive clinical trial.
and vaccines against many dangerous diseases including HIV, hepatitis and cancer. The research, led by Yury Stebunov,
a scientist at the MIPT, was published in the ACS Applied materials & Interfaces. The paper is titled"Highly sensitive and selective sensor chips with graphene oxide linking layer".
Owing to the above-mentioned merits, SPR biosensing is an outstanding platform to boost technological progress in the areas of medicine and biotechnology.
Widespread introduction of this method into preclinical trials will completely change the pharmaceutical industry. With SPR sensors we just need to estimate the interaction between the drug and targets on the sensing surface,
and low-cost fabrication compared to sensor chips that are already commercially available. ur invention will help in drug development against viral and cancer diseases.
However, the developed chip should go through a clinical trial for medical applications
#Crucial hurdle overcome in quantum computing: quantum logic gate in silicon built for the first time A team of Australian engineers has built a quantum logic gate in silicon for the first time,
and development of new medicines by greatly accelerating the computer-aided design of pharmaceutical compounds (and minimising lengthy trial and error testing);
sensitive and low-cost diagnosis of many diseases, including HIVNEW research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases such as rheumatoid arthritis and HIV.
An international team of researchers have designed and synthetized a nanometer scale DNA"machine "whose customized modifications enable it to recognize a specific target antibody.
this makes our platform adaptable for many different diseases"."""Our modular platform provides significant advantages over existing methods for the detection of antibodies,"added Prof.
Such sensors could also be used to monitor the effectiveness of stem cell therapies, Jasanoff says. s stem cell therapies are developed,
it going to be necessary to have noninvasive tools that enable you to measure them, he says.
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015discoveries First theoretical proof: Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015announcements First theoretical proof: Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers First theoretical proof:
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015artificial Intelligence Making robots more human April 29th, 2015lifeboat Foundation launches Interactive Friendly AI April 6th,
#Gold-diamond nanodevice for hyperlocalised cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells,
which can potentially be applied to thermal cancer therapy. Pei-Chang Tsai from the Institute of Atomic and Molecular Sciences, at the Academia Sinica, Taipei,
therefore act as switchable nanoheaters for therapies based on delivering intense and precise heat to cancerous cells,
#Artificial blood vessels become resistant to thrombosis Abstract: Scientists from ITMO University developed artificial blood vessels that are not susceptible to blood clot formation.
The results of the study were published in the Journal of Medicinal Chemistry. Surgery, associated with cardiovascular diseases, such as ischemia,
often require the implantation of vascular grafts-artificial blood vessels, aimed at restoring the blood flow in a problematic part of the circulatory system.
which results in compulsory and lifelong intake of anticoagulants among patients and sometimes may even require an additional surgical intervention.
they actively release medicine into the blood. The lifetime of such grafts is determined often by the amount of drug stored within the graft,
but to any kind of implants. You just need to take the right kind of drug. For example, after the implantation of an artificial ureter, urease crystals often start to grow inside
and doctors do not know how to deal with this problem. It is possible to apply a similar drug-containing coating that dissolves urease.
The same approach may be used for kidney or liver surgery, but these are plans for the future,
#Advance in photodynamic therapy offers new approach to ovarian cancer The findings were published just in the journal Nanomedicine:
Nanotechnology, Biology and Medicine, and after further research may offer a novel mechanism to address this aggressive and often fatal cancer that kills 14,000 women in the United states each year.
Ovarian cancer has a high mortality rate because it often has metastasized into the abdominal cavity before it's discovered.
Toxicity and cancer-cell resistance can also compromise the effectiveness of radiation and chemotherapy that's often used as a follow-up to surgery.
The new approach being developed by researchers from the OSU College of Pharmacy and the University of Nebraska takes existing approaches to photodynamic therapy
and makes them significantly more effective by adding compounds that make cancer cells vulnerable to reactive oxygen species,
"Surgery and chemotherapy are the traditional approaches to ovarian cancer, but it's very difficult to identify all of the places where a tumor has spread,
and in some cases almost impossible to remove all of them, "said Oleh Taratula, an assistant professor in the Oregon State university/Oregon Health & Science University college of Pharmacy."
"Photodynamic therapy is a different approach that can be used as an adjunct to surgery right during the operation,
and genetic therapy, composed of"small, interfering RNA,"are attached to what researchers call"dendrimer-based nanoplatforms,
Compared to existing photodynamic therapies, this approach allows the near-infrared light to penetrate much deeper into abdominal tissues,
Using photodynamic therapy alone, some tumors in laboratory animals began to regrow after two weeks. But with the addition of the combinatorial genetic therapy to weaken the cancer cell defenses,
there was no evidence of cancer recurrence. During the procedures, mice receiving the gene therapy also continued to grow
and gain weight, indicating a lack of side effects.""Cancer cells are very smart, "Taratula said.""They overexpress certain proteins, including one called DJ1,
that help them survive attack by reactive oxygen species that otherwise might kill them. We believe a key to the success of this therapy is that it takes away those defensive mechanisms."
"The overexpression of DJ1, researchers said in their study, is associated with invasion, metastasis, resistance to cancer therapies,
and overall cancer cell survival. That excess of DJ1 is silenced by the genetic therapy composed of sirna.
The findings of this research, Taratula said, could also build upon some other recent advances in photodynamic therapy, in
which a different compound called naphthalocyanine could be administered prior to surgery, causing the cancer cells to"glow
"and fluoresce when exposed to near-infrared light. This provides a literal road map for surgeons to follow,
showing which tissue is cancerous and which is not. There's no reason that approach couldn't be combined with the newest advance
providing multiple mechanisms to improve surgical success and, with minimal side effects, help eradicate any remaining cancer cells that were removed not completely."
"Our study established a prospective therapeutic approach against ovarian cancer, "the researchers wrote in their conclusion."
"The tumors exposed to a single dose of a combinatorial therapy were eradicated completely from the mice
He also points to medical applications, such as physical feedback for athletes as they exercise and real-time hospital monitoring for caregivers concerned about changes in a patient's vital signs.
and wiring that normally are associated with close medical surveillance.""Overall, the military has the advantage of being able to move ahead with potentially higher risk research,
and study diseases Abstract: Using physical chemistry methods to look at biology at the nanoscale, a Lawrence Berkeley National Laboratory (Berkeley Lab) researcher has invented a new technology to image single molecules with unprecedented spectral and spatial resolution,
and study diseases Ke Xu, a faculty scientist in Berkeley Lab's Life sciences Division, has dubbed his innovation SR-STORM,
but hopefully it will lead to medical applications. This gives us new opportunities to look at cell structures,
and whether there's any degradation of those structures in diseases.""Many diseases are caused either by an invading pathogen or degradation of a cell's internal structure.
Alzheimer's, for example, may be related to degradation of the cytoskeleton inside neurons.""The cytoskeleton system is comprised of a host of interacting subcellular structures and proteins,
The detection process is exactly opposite to the spin wave injection: a spin wave collides at the interface between YIG and platinum,
such as ejector pins for iphones, watch springs for expensive hand-wound watches, trial medical implants,
#Targeted drug delivery with these nanoparticles can make medicines more effective: Nanoparticles wrapped inside human platelet membranes serve as new vehicles for targeted drug delivery The research,
and technology to achieve"precision medicine, "said Shu Chien, a professor of bioengineering and medicine, director of the Institute of Engineering in Medicine at UC San diego,
and a corresponding author on the study.""While this proof of principle study demonstrates specific delivery of therapeutic agents to treat cardiovascular disease and bacterial infections,
it also has broad implications for targeted therapy for other diseases such as cancer and neurological disorders,"said Chien.
The ins and outs of the platelet copycats On the outside, platelet-mimicking nanoparticles are cloaked with human platelet membranes,
and certain pathogens such as MRSA bacteria, allowing the nanoparticles to deliver and release their drug payloads specifically to these sites in the body.
platelet-mimicking nanoparticles can also greatly minimize bacterial infections that have entered the bloodstream and spread to various organs in the body.
"Our platelet-mimicking nanoparticles can increase the therapeutic efficacy of antibiotics because they can focus treatment on the bacteria locally without spreading drugs to healthy tissues
"We hope to develop platelet-mimicking nanoparticles into new treatments for systemic bacterial infections and cardiovascular disease."
The collaborative effort also includes Kang Zhang, a professor of ophthalmology and chief of Ophthalmic Genetics at UC San diego and a corresponding author on this study y
#Portable Nanosensors Help Early Diagnosis of Breast cancer Tumors The nanosensor will be able to help the early diagnosis of breast cancer tumors even at very tiny dimensions after the completion of tests
The aim of the research was to facilitate the diagnosis of cancer tumors, including breast cancer, without the need for advanced clinical devices.
and simulated in this research for the early and easy diagnosis of breast tumors. The nanosensor consists of plasmonic nanoparticles that are placed at regular distance from each other.
the sensor is very sensitive to changes in electromagnetic fields that are dispersed with different tissues (normal and tumor.
The throughputs of waves are different through natural and tumor tissues. Therefore, the interaction of tissues with electromagnetic waves created by a similar electrical field ends in different results.
It means a non-consistency happens in the profile received from the interaction of emitted light and various healthy and cancer tissues.
The meaningful signal is a tool for the detection of tumor tissue e
#Pushing the limits of lensless imaging: At the Frontiers in Optics conference researchers will describe a custom-built ultrafast laser that could help image everything from semiconductor chips to cells in real time Using ultrafast beams of extreme ultraviolet light streaming at a 100,000 times a second, researchers
Material moves foldable electronics, new implantable medical devices a step closer Abstract: Researchers have discovered a new stretchable,
This is a crucial step in creating a new generation of foldable electronics-think a flat-screen television that can be rolled up for easy portability-and implantable medical devices.
indicating it is a good material for implantable medical devices. Fatigue is a common problem for researchers trying to develop a flexible, transparent conductor,
That means the materials aren't durable enough for consumer electronics or biomedical devices.""Metallic materials often exhibit high cycle fatigue,
and fatigue has been a deadly disease for metals, "the researchers wrote.""We weaken the constraint of the substrate by making the interface between the Au (gold) nanomesh and PDMS slippery,
One of the most critical biological and medical tools available today, it lies at the core of genome analysis. Reading the exact make-up of genes,
sequencing technology will definitely shift from research to clinics, "says Aleksandra Radenovic.""For that, we need rapid and affordable DNA sequencing
leading to inexpensive devices that could detect dozens of disease markers in less than 5 minutes Chemists used DNA molecules to developed rapid,
may aid efforts to build point-of-care devices for quick medical diagnosis of various diseases ranging from cancer, allergies, autoimmune diseases, sexually transmitted diseases (STDS),
when atoms are brought too close together-to detect a wide array of protein markers that are linked to various diseases.
and the results sent back to the doctor's office. If we can move testing to the point of care,
which would enhance the effectiveness of medical interventions. The key breakthrough underlying this new technology came by chance."
explains that this novel signaling mechanism produces sufficient change in current to be measured using inexpensive electronics similar to those in the home glucose test meter used by diabetics to check their blood sugar.
allowing us to build inexpensive devices that could detect dozens of disease markers in less than five minutes in the doctor's office
including pathogen detection in food or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments a
#Efforts to Improve Properties of Body Implants Using Nanocoatings Yield Positive Results Despite the high performance of metallic implants, including titanium and its alloys, in human body,
the relatively weak corrosion resistance of the implants in the body and their inappropriate compatibility has resulted in a great challenge in the application of metallic alloys.
Therefore, Iranian researchers studied a type of composite nanocoating to obtain modified properties of biomaterials to be used in human body.
The nanocoating has high resistance to abrasion and corrosion. A nanocomposite coating has been produced in this research by combining hydroxyapatite nanoparticles as the base material and diopside ceramic.
and help design new drug therapies against pathogens by targeting enzymes that interact with DNA."
These fine details may also help scientists understand how mutations in proteins can lead to disease
or find protein properties that would be ideal targets for drug therapies.""For example, viral genes code for their own proteins that process their DNA,
and charge to some part of another molecule--such as the binding site of a human protein involved in some physiological process that goes awry in a given disease.
including medicine, building, textile and military after being mass-produced. Among textile products, woolen fabrics are used in various industries due to their unique properties such as insulation and flexibility.
In each test, the researchers'newly fabricated patches picked up body signals that were stronger than those taken by existing medical devices,
Lu is cofounder and scientific adviser for Stretch Med Inc.,a medical device company in which she has an equity partnership.
and cancer cells to help us unravel disease mechanisms, and for characterizing cells from diseased tissue of patients.""
#Scientists pave way for diamonds to trace early cancers Physicists from the University of Sydney have devised a way to use diamonds to identify cancerous tumours before they become life threatening.
synthetic version of the precious gem can light up early-stage cancers in nontoxic, noninvasive Magnetic resonance imaging (MRI) scans.
Targeting cancers with tailored chemicals is not new but scientists struggle to detect where these chemicals go since,
short of a biopsy, there are few ways to see if a treatment has been taken up by a cancer.
Led by Professor David Reilly from the School of Physics researchers from the University investigated how nanoscale diamonds could help identify cancers in their earliest stages."
"We knew nano diamonds were of interest for delivering drugs during chemotherapy because they are largely nontoxic and non-reactive,
"By attaching hyperpolarised diamonds to molecules targeting cancers the technique can allow tracking of the molecules'movement in the body,
and target cancers long before they become life-threatening, "says Professor Reilly. The next stage of the team's work involves working with medical researchers to test the new technology on animals.
Also on the horizon is research using scorpion venom to target brain tumours with MRI scanning g
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