#Nanotechnology identifies brain tumor types through MRI'virtual biopsy'in animal studies: If results are confirmed in humans,
tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections;
new NIH grant will fund future study Abstract: Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through"virtual biopsies
"and then attack the molecular structure of the disease. If laboratory research with mice is borne out in human studies,
the results could be used to deliver nanoscale drugs that can distinguish and fight tumor cells in the brain without resorting to surgery."
"Our nanodrug can be engineered to carry a variety of drugs, proteins and genetic materials to attack tumors on several fronts from within the brain,"said Julia Ljubimova, MD, Phd,
professor of neurosurgery and biomedical sciences at Cedars-Sinai and a lead author of an article published online in the American Chemical Society's journal ACS Nano.
Ljubimova, director of the Nanomedicine Research center in the Department of Neurosurgery and director of the Nanomedicine Program at the Samuel Oschin Comprehensive Cancer Institute, has received a $2. 5 million grant from the National institutes of health to continue the research.
The drug delivery system and its component parts together called a nanobioconjugate or nanodrug, is in an emerging class of molecular drugs designed to slow
or stop cancers by blocking them in multiple ways within the brain. The drug is about 20 to 30 nanometers in size-a fraction of a human hair,
such as seeking out cancer cells and binding to them, permeating the walls of blood vessels and tumor cells,
or dismantling molecular mechanisms that promote tumor growth, "said Eggehard Holler, Phd, professor of neurosurgery and director of nanodrug synthesis at Cedars-Sinai.
The new delivery system plays two roles: diagnosing brain tumors by identifying cells that have spread to the brain from other organs,
and then fighting the cancer with precise, individualized tumor treatment. Researchers can determine tumor type by attaching a tracer visible on an MRI.
If the tracer accumulates in the tumor, it will be visible on MRI. With the cancer's molecular makeup identified through this virtual biopsy,
researches can load the"delivery system"with cancer-targeting components that specifically attack the molecular structure.
To show that the virtual biopsies could distinguish one cancer cell type from another, the researchers devised what is believed to be a unique method,
implanting different kinds of breast and lung cancers into laboratory mice to represent metastatic disease-with one type of cancer implanted on each side of the brain.
Lung and breast cancers are those that most often spread to the brain. The researchers used the nano delivery system to identify
and attack the cancers. In each instance, animals that received treatment lived significantly longer than those in control groups."
"Several drugs are quite effective in treating different types of breast cancers, lung cancer, lymphoma and other cancers at their original sites,
but they are ineffective against cancers that spread to the brain because they are not able to cross the blood-brain barrier that protects the brain from toxins in the blood,
"said Keith Black, MD, chair of the Department of Neurosurgery, director of the Maxine Dunitz Neurosurgical Institute, director of the Johnnie L. Cochran, Jr.,
Brain tumor Center and the Ruth and Lawrence Harvey Chair in Neuroscience.""The nanodrug is engineered to cross this barrier with its payload intact,
so drugs that are effective outside the brain may be effective inside as well,"Black added.#####Ljubimova, Black and Holler led the study
and contributed equally to the article. Rameshwar Patil, Phd, a project scientist in Ljubimova's laboratory, is first author.
Researchers from Cedars-Sinai's Department of Neurosurgery, Department of Biomedical sciences, Department of Imaging, and the Samuel Oschin Comprehensive Cancer Institute contributed to the study with colleagues from the University of Southern California and Arrogene Inc,
. a biotech company associated with Cedars-Sinai. The study was supported by NIH grants U01 CA151815, R01 CA136841, R01 CA188743,
The new NIH National Cancer Institute grant R01ca188743, will fund ongoing study.#####For more information, please click herecontacts:
"MRI Virtual Biopsy and Treatment of Brain Metastatic tumors with Targeted Nanobioconjugates.""Publication Date (Web: April 23, 2015.
May 27th, 2015fine-tuned molecular orientation is key to more efficient solar cells May 26th, 2015cancer Iranian Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th,
The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists'ability to observe single molecules May 23rd,
The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists'ability to observe single molecules May 23rd, 2015aspen Aerogels to Present at the Cowen and Company Technology,
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015nanostructures Increase Corrosion resistance in Metallic Body Implants May 24th, 2015iranian
Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th, 2015discoveries Who needs water to assemble DNA?
The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists'ability to observe single molecules May 23rd,201 0
foam-like battery material that can withstand shock and stress.""It is possible to make incredible materials from trees
135 K) which caused the"high-Tc fever"in the world 30 years ago, it obviously exceeds the record of other"high-Tc superconductors"such as fullerene (C60) superconductors (Tc 33 K) and Mgb2 (Tc 39k),
"finding a nanothermometer sensitive enough at this scale is a great step forward in the field of nanotechnology, with applications in biology, chemistry, physics and even in the diagnosis and treatment of diseases
Molecular machines, novel sensors, bionic materials, quantum computers, advanced therapies and much more can emerge from this endeavour.
ICN2 researchers led by ICREA Prof Sergio O. Valenzuela have investigated hot carrier propagation across graphene using an electrical nonlocal injection/detection method.
diffuse away from the injection point and are detected electrically in a remote voltage probe by measuring the thermoelectric voltage.
It can also be used in the production of artificial skin or other medical stuff. In this research, nanocomposite scaffold was made of silk fibroin,
2015new sensing tech could help detect diseases, fraudulent art, chemical weapons June 1st, 2015thin coating on condensers could make power plants more efficient:
News and information A step towards a type 1 diabetes vaccine by using nanotherapy June 10th, 2015investigation of Optical Properties of Quantum dots in Presence of Magnetic, Electrical Fields June 10th,
2015discoveries A step towards a type 1 diabetes vaccine by using nanotherapy June 10th, 2015investigation of Optical Properties of Quantum dots in Presence of Magnetic, Electrical Fields June 10th,
2015announcements A step towards a type 1 diabetes vaccine by using nanotherapy June 10th, 2015investigation of Optical Properties of Quantum dots in Presence of Magnetic, Electrical Fields June 10th,
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers A step towards a type 1 diabetes vaccine by using nanotherapy June 10th,
but buckled due to changes of the internal stress in the layer during the etching process.
#New Sensors Measure Blood Anticoagulation Drug Iranian researchers from Isfahan University of Technology produced a highly sensitive and accurate sensor
which can measure a type of blood anticoagulation drug. The sensor was produced through a simple
Protamine is an important drug that is used as an anti-heparin agent to prevent blood coagulation during cardiovascular surgeries.
#Biomedical breakthrough: Carbon nanoparticles you can make at home Abstract: Researchers have found an easy way to produce carbon nanoparticles that are small enough to evade the body's immune system,
"The team tested the therapeutic potential of the nanoparticles by loading them with an anti-melanoma drug
In further experiments, the researchers found they could alter the infusion of the particles into melanoma cells by adjusting the polymer coatings.
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,
so you can do multidrug therapy with the same particles.""""By using defined surface chemistry,
and are affiliated with Carle Foundation Hospital in Urbana, Illinois.##For more information, please click herecontacts:
The paper,"Tunable luminescent carbon nanospheres with well-defined nanoscale chemistry for synchronized imaging and therapy,"is available online:
2015cellulose from wood can be printed in 3-D June 17th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th, 2015discoveries Scientists film shock waves in diamond:
Method could be useful in developing green energy and a better understanding of rust June 18th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th,
Method could be useful in developing green energy and a better understanding of rust June 18th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th,
#Nanowire implants offer remote-controlled drug delivery Abstract: Remote-controlled Eradication of Astrogliosis in Spinal cord Injury via Electromagnetically-induced Dexamethasone Release from"Smart"Nanowireswen Gao and Richard Borgenswe describe a system to deliver drugs to selected tissues continuously,
if required, for weeks. Drugs can be released remotely inside the small animals using pre-implanted,
and deposited onto a spinal cord lesion in Glial fibrillary acidic protein-luc Transgenic mices (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
The corticosteroid DEX, a powerful ameliorator of inflammation, was released from the polymer by external application of an Electromagnetic field for 2 hours/day for a week.
and non-invasively, opening the door to many other known therapies, such as the cases that dexamethasone cannot be applied safely systemically in large concentrations.
and wires required by other implantable devices that can lead to infection and other complications, said team leader Richard Borgens, Purdue University's Mari Hulman George Professor of Applied Neuroscience and director of Purdue's Center for Paralysis Research."
"This tool allows us to apply drugs as needed directly to the site of injury, which could have broad medical applications,
"Borgens said.""The technology is in the early stages of testing, but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
and avoid the terrible side effects of systemic treatment with steroids or chemotherapy.""The team tested the drug-delivery system in mice with compression injuries to their spinal cords
and administered the corticosteroid dexamethasone. The study measured a molecular marker of inflammation and scar formation in the central nervous system and found that it was reduced after one week of treatment.
A paper detailing the results will be published in an upcoming issue of the Journal of Controlled Release
Wen Gao, a postdoctoral researcher in the Center for Paralysis Research who worked on the project with Borgens
and transported a patch of the nanowire carpet on water droplets that were used used to deliver it to the site of injury.
The nanowire patches adhere to the site of injury through surface tension Gao said. The magnitude and wave form of the electromagnetic field must be tuned to obtain the optimum release of the drug,
Youngnam Cho, a former faculty member at Purdue's Center for Paralysis Research; and Jianming Li, a research assistant professor at the center.
GFAP is expressed in cells called astrocytes that gather in high numbers at central nervous system injuries. Astrocytes are a part of the inflammatory process and form a scar tissue,
A 1-2 millimeter patch of the nanowires doped with dexamethasone was placed onto spinal cord lesions that had been exposed surgically,
The lesions were closed then and an electromagnetic field was applied for two hours a day for one week.
###The research was funded through the general funds of the Center for Paralysis Research and an endowment from Mrs. Mari Hulman George. Borgens has a dual appointment in Purdue's College of Engineering and the College of Veterinary medicine.##
Cancer Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015news and information Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
New technique creates multilayered, self-assembled grids with fully customizable shapes and compositions June 23rd,
2015nanomedicine Nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism in animals with atherosclerosis June 23rd, 2015picosun ALD
breaks through in medical technology June 23rd, 2015nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd,
2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015discoveries Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
New technique creates multilayered, self-assembled grids with fully customizable shapes and compositions June 23rd,
2015announcements Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism
2015nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,201 0
and the Environment June 24th, 2015nanoparticle'wrapper'delivers chemical that stops fatty buildup in rodent arteries Experimental therapy restores normal fat metabolism in animals with atherosclerosis June 23rd,
4-D printing to advance chemistry, materials sciences and defense capabilities June 18th, 2015discoveries Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together
or chemical environment to provide unique functionality in a wide range of applications from energy to medicine.
News and information Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th,
and the Environment June 24th, 2015discoveries Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th,
2015announcements Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th, 2015physicists fine-tune control of agile exotic materials:
and the Environment June 24th, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th,
and medical industries due to their properties, including semi-conductivity, being piezoelectric and pyroelectric and biocompatibility.
and primarily funded by the Office of Science of the U s. Department of energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences,
News and information June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015making new materials with micro-explosions:
A novel microscope for nanosystems June 25th, 2015iranian Researchers Synthesize Nanostructures with Controlled Shape, Structure June 25th, 2015discoveries June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield
New technique combines electron microscopy and synchrotron X-rays to track chemical reactions under real operating conditions June 29th, 2015announcements June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising
its high concentration causes digestive malfunctions and results in the related diseases due to its toxicity.
chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015graphene flexes its electronic muscles: Rice-led researchers calculate electrical properties of carbon cones, other shapes June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
and innovation programm 1 e. Its main objective is to reach a level of international excellence in nanomedicine characterisation for medical indications like cancer, diabetes, inflammatory diseases or infections,
EU-NCL is partnered with the sole international reference facility, the Nanotechnology Characterization Lab of the National Cancer Institute in the U s. US-NCL) 3,
This venture holds great promise for using nanotechnologies to overcome cancer and other major diseases around the world.
EU-NCL is connected also closely to national medicine agencies and the European Medicines Agency to continuously adapt its analytical services to requests of regulators.
EU-NCL is designed, organized and operated according to the highest EU regulatory and quality standards. This project is important for Europe,
To provide a trans-disciplinary testing infrastructure covering a comprehensive set of preclinical characterisation assays (physical, chemical,
in-vitro and in vivo biological testing), allowing researchers to fully comprehend the biodistribution, metabolism, pharmacokinetics, safety profiles and immunological effects of their medicinal nanoproducts.
To foster the use and deployment of standard operating procedures (SOPS), benchmark materials and quality management for the preclinical characterisation of medicinal nanoproducts.
Joint Research Centre-European commission (IT) European Research Services Gmbh (DE), Leidos Biomedical Research, Inc. U s.)Trinity college Dublin (IE) Stiftelsen SINTEF (NO) University of Liverpool
#New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment Iranian researchers designed a biosensor with application in assessment of effectiveness of drugs on the stability of the four-strand structure of DNA to prevent the growth
The four-strand structure of DNA plays an important role in the process of creation of cancerous cells and in the prohibition of a type of active enzyme in cancers.
The studies can be used in the diagnosis, designing and production of anticancer drugs. The research team presented an effective method to detect the four-strand structure of DNA by using biosensors.
Winner of the 2015 Lindros Award for translational medicine, Kjeld Janssen is pushing the boundaries of the emerging lab-on-a-chip technology The postage stamp-sized square of fused silica Kjeld Janssen is holding
but inside the clear chip lies the potential to improve how medicine and medical research is done. f you can integrate
and automate an analysis technique into a chip, it opens doors to great applications, said Janssen, a postdoctoral researcher in the Sumita Pennathur Lab at UC Santa barbara. With only a minimal amount of human plasma,
the Omnisense nanofluidic chip he is developing is the heart of a device that can assist in the swift and accurate diagnosis of bacterial
or viral infection in less time than it would take conventional tests and it would cost less as well.
particularly in remote areas where people don have access to a full medical lab, as well as data gathering for clinical trials or epidemiological studies.
For the impact his project will have in the field of translational medicine the postdoctoral scholar has been awarded the 2015 Lindros Award from the UCSB Translational Medical Research Laboratory (TMRL.
t very awesome, Janssen, a recent transplant from The netherlands, said of the award. It feels like a recognition of his effort,
including late-night and after-hours work, and of his students which is especially gratifying and motivating,
and methodologies in all of medicine, said Dr. Scott Hammond, executive director of TMRL. orking with the Pennathur Lab, Kjeld Janssen research is intended to bring real-time detection to the world of medicine.
This technology, said Hammond, allows for the identification of specific DNA markers in an advanced microfluidic device. urther,
where the local health care infrastructure might not be able to support the level of research
or medicine necessary to monitor or treat patients. Efforts to study and combat highly infectious diseases,
including Hepatitis C, SARS or MERS, could also benefit from the user friendly chip and its rapid results. is award is truly helping our lab become translational,
said UCSB mechanical engineering professor Sumita Pennathur. t a big step forward in terms of bringing out nanofluidic technology to real biomedical applications of disease diagnosis
. I'm so excited for him!
#Crystal structure and magnetism--new insight into the fundamentals of solid state physics: HZB team decodes relationship between magnetic interactions and the distortions in crystal structure within a geometrically'frustrated'spinel system Abstract:
A team at HZB has carried out the first detailed study of how magnetic and geometric ordering mutually influence one another in crystalline samples of spinel.
and record the complex 3-D magnetization in wound magnetic layers. This technique could be important in the development of devices that are highly sensitive to magnetic fields,
such as in medical diagnostics for example. Their results are published now in Nature Communications. 3d structures in materials
#Sensor technology can improve accuracy of prostate cancer diagnosis, research shows Abstract: New research has shown how a smart sensor chip,
and efficiency of prostate cancer diagnosis. Researchers at the University of Birmingham believe that the novel technology will help improve the process of early stage diagnosis. Glycoprotein molecules,
Because of their essential role in our immune response, they are useful clinical biomarkers for detecting prostate cancer and other diseases.
In doing so, they developed a more accurate and efficient way of diagnosing prostate cancer than the current tests
so could feasibly be kept on the shelf of a doctors'surgery anywhere in the world.
Problematically for diagnosis, the protein part of glycoproteins does not always change if the body is diseased.
The findings, published in the journal Chemical science, show how the rate of false readings that come with antibody based diagnosis can be reduced by the smart technology that focuses on the carbohydrate part of the molecule.
the team wanted to identify the presence of disease by detecting a particular glycoprotein which has specific sugars in a specific location in the molecule.
the sugar part of the prostate cancer glycoprotein is reacted with a custom-designed molecule that contains a boron group at one end (the boron linkage forms a reversible bond to the sugar).
and the only key that will fit is the specific prostate cancer glycoprotein that we're looking for.
"Dr John Fossey added,"It's estimated that one in eight men will suffer from prostate cancer at some point in their life,
so there's a clear need for more accurate diagnosis. By focussing on the sugar, we appear to have hit the'sweet spot'for doing just that.
and collaboration with commercial partners, will open the door to adapting the current technology for other diseases.
Lots of diseases produce specific glycoproteins, so there are a number of possible avenues to improve the accuracy of our diagnoses
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
the study identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer,
Guo holds a joint appointment at the UK Markey Cancer Center and in the UK College of Pharmacy."
or die and thus, no longer able to cause disease.""One of the vexing problems in the development of drugs is drug resistance,
"Dr. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism,
"##Guo focuses much of his work on the use of ribonucleic acid (RNA) nanoparticles and a viral nanomotor to fight cancer, viral infections and genetic diseases.
#Bonelike 3-D silicon synthesized for potential use with medical devices: Semiconducting silicon spicules engage tissue like a bee stinger Abstract:
Researchers have developed a new approach for better integrating medical devices with biological systems. The researchers, led by Bozhi Tian,
"One of the major hurdles in the area of bioelectronics or implants is that the interface between the electronic device
TVOC is known as a carcinogen that can cause disability in the nervous system from skin contact or from inhalation through respiratory organs s
News and information SUNY Poly CNSE to Present Cutting-edge Semiconductor Technology Developments at SEMICON West 2015 Conference July 10th, 2015super graphene can help treat cancer July 10th,
2015super graphene can help treat cancer July 10th, 2015graphene-based film can be used for efficient cooling of electronics July 10th,
2015new Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015discoveries Super graphene can help treat cancer July 10th,
2015graphene-based film can be used for efficient cooling of electronics July 10th, 2015scientists Apply Magnetic nanoparticles to Eliminate Cancerous Cells July 10th,
Replacing silver coating on catheters with graphene increases treatment effect July 9th, 2015materials/Metamaterials Super graphene can help treat cancer July 10th,
2015super graphene can help treat cancer July 10th, 2015graphene-based film can be used for efficient cooling of electronics July 10th,
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Super graphene can help treat cancer July 10th, 2015graphene-based film can be used for efficient cooling of electronics July 10th,
2015bonelike 3-D silicon synthesized for potential use with medical devices: Semiconducting silicon spicules engage tissue like a bee stinger July 8th,
"The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning; Pseudomonas aeruginosa, a common disease-causing bacterium;
Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species; and Staphylococcus epidermis, a bacterium that can cause harmful biofilms on plastics-like catheters-in the human body.
The nanoparticles were effective against all the bacteria. The method allows researchers the flexibility to change the nanoparticle recipe in order to target specific microbes.
#Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize.
so that the very enzymes that make cancers dangerous could instead guide their destruction.""We can start with a small molecule
and build that into a nanoscale carrier that can seek out a tumor and deliver a payload of drug,
The system takes advantage of a class enzymes called matrix metalloproteinases that many cancers make in abundance.
The shell fragments form a ragged mesh that holds the drug molecules near the tumor.
builds on his group's earlier sucess using a similar strategy to mark tumors for both diagnosis and precise surgical removal.
That means the drug was inactivated as it flowed through the circulatory system until it reached the tumor.
The protection allowed the researchers to safely give a dose 16 times higher than they could with the formulation now used in cancer clinics,
in a test in mice with grafted in fibrosarcoma tumors. In additional preliminary tests, Callmann and colleagues were able to halt the growth of the tumors for a least two weeks,
using a single lower dose of the drug. In mice treated with the nanoparticles coated with peptides that are impervious to MMPS or given saline,
the tumors grew to lethal sizes within that time. Gianneschi says they will broaden their approach to create delivery systems for other diagnostic and therapeutic molecules."
"This kind of platform is not specific to paclitaxel. We'll test this in other models-with other classes of drug and in mice with a cancer that mimics metastatic breast cancer, for example."
"They'll also continue to modify the shell, to provide even greater protection and avoid uptake by organs such as liver, spleen and kidneys,
"We want to open up this therapeutic window."#"##Additional authors include Matthew Thompson in Gianneschi's chemistry research group and Christopher Barback, David Hall and Robert Mattrey in UC San diego's Moores Cancer Center.
All animal procedures were approved by UC San diego's institution animal care and use committee. Callmann holds a fellowship through the Cancer Researchers in Nanotechnology Program at UC San diego. The National Institute of Biomedical Imaging
and Bioengineering provided financial support. This novel approach to using enzyme-directed assembly of particle theranostics (EDAPT) is patent pending.
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