or chemical environment to provide unique functionality in a wide range of applications from energy to medicine.
what may be a major leap forward in the quest for new treatments of the most common form of cardiovascular disease,
known as atherosclerotic vessel disease, is the leading cause of heart attacks and strokes that claim some 2. 6 million lives a year worldwide, according to the World health organization.
and cardiac hypertrophy through biodegradable polymer-encapsulated delivery of glycosphingolipid inhibitor), "builds on recent research by the same team that previously identified a fat-and-sugar molecule called GSL as the chief culprit behind a range of biological glitches that affect the body's ability to properly use, transport
That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound, D-PDMP,
and clear out D-PDMP was a major hurdle in efforts to test its therapeutic potential in larger animals and humans.
but not potent enough to stop the disease from advancing. Perhaps, most importantly, the team says,
and pumping dysfunction, the hallmarks of advanced disease.""Our experiments illustrate clearly that while content is important,
"says lead investigator Subroto Chatterjee, Ph d.,a professor of medicine and pediatrics at the Johns hopkins university School of medicine and a metabolism expert at its Heart and Vascular Institute."
and its ability not merely to prevent disease but to mitigate some of its worst manifestations."
D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
if a poor state of health is caused by disease or a lack of water anyway,
They contribute to the early detection of diseases that affect grapevines, such as flavescence dore and black wood, declares Stefano Sgrelli, Ceo of Salt&lemon.
#New device tracks chemical signals within cells Biomedical engineers at the University of Toronto have invented a new device that more quickly
and could identify new targets for cancer medications. Throughout the human body, certain signalling chemicals--known as hormones--tell various cells
leading to cancer. To look into the responses of different cells, the U of T team harnessed the emerging power of digital microfluidics,
or proteins that could be targeted by drugs, eventually leading to new medicines to fight cancer r
It also helps improve our understanding of the development of some diseases that involve a defective transportation to the nuclear pores-such as intestinal ovarian and thyroid cancer r
are being developed by mechanical engineers at Drexel University as a part of a surgical toolkit being assembled by the Daegu Gyeongbuk Institute of Science and Technology (DGIST) in South korea.
and very much in its infancy when it comes to medical applications, Kim said. project like this,
is an opportunity to push both medicine and microrobotics into a new and exciting place.
Borrelia burgdorferi, the bacteria that causes Lyme disease, is classified by its spiral shape, which enables both its movement and the resultant cellular destruction.
is being designed by Bradley Nelson from ETH Zurich, a pioneer in the field of microrobotic surgery.
stenting and angioplasty. Stenting is a way of creating a bypass for blood to flow around the block by inserting a series of tubes into the artery,
while angioplasty pushes out the blockage by expanding the artery with help from an inflatable probe. urrent treatments for chronic total occlusion are only about 60 percent successful,
#University spinout signs deal to commercialize microchips that release therapeutics inside the body (Nanowerk News) An implantable,
microchip-based device may soon replace the injections and pills now needed to treat chronic diseases:
Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
each capped with a metal membrane, that store tiny doses of therapeutics or chemicals. An electric current delivered by the device removes the membrane,
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Michael Cima (left) and Robert Langer Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the worlds largest producer of generic drugs,
to treat specific diseases, with licensing potential for other products. Teva paid $35 million up front, with additional milestone payments as the device goes through clinical trials before it hits the shelves.
Obviously, this is a huge validation of the technology, Cima says. A major pharmaceutical company sees how this technology can further their efforts to help patients.
to $289 billion annually in unnecessary health care costs from additional hospital visits and other issues.
Failure to follow prescriptions, the study also found, causes around 125,000 deaths annually and up to 10 percent of all hospitalizations.
While its first partnership is for treating chronic diseases, Microchips Biotech will continue work on its flagship product, a birth-control microchip, backed by the Bill and Melinda Gates Foundation,
A lot of the therapies are trying to chemically trick the endocrine systems, Cima says. We are doing that with this artificial organ we created.
a single dose of therapeutics is released into the body. Wild ideas Inspiration for the microchips came in the late 1990s,
and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents.
and researchers from Microchips, conducted the microchips first human trials to treat osteoporosis this time with wireless capabilities.
In that study, published in a 2012 issue of Science Translational Medicine, microchips were implanted into seven elderly women,
Results indicated that the chips delivered doses comparable to injections and did so more consistently with no adverse side effects.
said Robert L. Geahlen, Distinguished Professor of Medicinal Chemistry at Purdue. We were able to show the turn off of this kinase very rapidly alters the physical properties of the cell.
The paper was authored by former doctoral student Alexander X. Cartagena-Rivera, now a postdoctoral fellow at the National institutes of health's National Institute on Deafness and Other Communication Disorders (NIDCD;
who is affiliated with the Purdue Center for Cancer Research. And thats one of the reasons we were looking at this particular type of cancer cell with this particular form of Syk in it.
One goal of the research is to correlate physical properties of cells with tumor suppression and the action of the kinase on the cell.
#Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells (Nanowerk News) Nanoparticles packed with a clinically used chemotherapy drug
and kill cancer stem-like cells, according to a recent study led by researchers at The Ohio State university Comprehensive Cancer Center-Arthur G. James Cancer Hospital
and Richard J. Solove Research Institute (OSUCCC-James). Cancer stem-like cells have characteristics of stem cells
and are present in very low numbers in tumors. They are highly resistant to chemotherapy
and radiation and are believed to play an important role in tumor recurrence. This laboratory and animal study showed that nanoparticles coated with the oligosaccharide called chitosan
and encapsulating the chemotherapy drug doxorubicin can target and kill cancer stem-like cells six times more effectively than free doxorubicin.
The study is reported in the journal ACS Nano("Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells").
""Our findings indicate that this nanoparticle delivery system increases the cytotoxicity of doxorubicin with no evidence of systemic toxic side effects in our animal model,
"says principal investigator Xiaoming (Shawn) He, Phd, associate professor of Biomedical engineering and a member of the OSUCCC-James Translational Therapeutics Program."
and be used to treat many types of cancer.""This study showed that chitosan binds with a receptor on cancer stem-like cells called CD44,
enabling the nanoparticles to target the malignant stem-like cells in a tumor. The nanoparticles were engineered to shrink,
break open, and release the anticancer drug under the acidic conditions of the tumor microenvironment and in tumor-cell endosomes and lysosomes,
which cells use to digest nutrients acquired from their microenvironment. He and his colleagues conducted the study using models called 3d mammary tumor spheroids (i e.,
, mammospheres) and an animal model of human breast cancer. The study also found that although the drug-carrying nanoparticles could bind to the variant CD44 receptors on cancerous mammosphere cells,
researchers at University of Michigan Life sciences Institute and University of Texas Southwestern Medical center have discovered. The findings,
The phenomenon of RNAI is expected to find applications in medical treatments. RNAI is mediated by RNA-induced silencing complex (RISC),
for example as gene therapy to suppress the production of a disease-causing protein n
#Photonic crystal fibre: a multipurpose sensor Glass fibres can do more than transport data. A special type of glass fibre can also be used as a high-precision multipurpose sensor,
a co-author of the study, doctor of physical and mathematical sciences, and lecturer at the MIPT Section of the Physics and Chemistry of Nanostructures (DMCP).
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
"the study identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer,
Guo holds a joint appointment at the UK Markey Cancer Center and in the UK College of Pharmacy."
or die and thus, no longer able to cause disease. ne of the vexing problems in the development of drugs is drug resistance,
former Dean of the UK College of Pharmacy and current UK provost. r. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism,
Guo focuses much of his work on the use of ribonucleic acid (RNA) nanoparticles and a viral nanomotor to fight cancer
viral infections and genetic diseases. He is well-known for his pioneering work of constructing RNA nanoparticles as drug carriers u
where they create clothing that kills bacteria, conducts electricity, wards off malaria, captures harmful gas and weaves transistors into shirts and dresses.
which could help in warding colds, flu and other diseases. Two of Hinestrozas students created a hooded bodysuit embedded with insecticides using metal organic framework molecules,
Malaria kills more than 600,000 people annually in Africa. While insecticide-treated nets are common in African homes
This means that when we want to stimulate genes to work harder to fight a genetic disease
This condition is the basis of some syndromes and neurological diseases.""If we can stimulate the remaining gene to work harder,
we can reduce the symptoms of the disease in some cases, "says Fimiani.""Hopefully our study will encourage others to repeat our research
Dr. Zhang and his Phd student Daniel Padmos examined gold and silver nanoparticles two very important materials, particularly in the future of biomedicine.
and these properties can be used in many different biomedical applications, explains Dr. Zhang, lead author of the study.
biomedical scientists have developed drugs with nanogold to target malignant tumours. The nanogold attracts light emitted from laser therapies
On the other hand, nanosilver could have potential applications in fighting bacterial diseases. Uncovering shape The shape of the surface of nanoparticles is key,
and designing the building blocks for groundbreaking discoveries in biomedical applications. This experience invigorates my interest in this type of research,
In the future, he plans to build upon this research to develop new functional nanomaterial systems and test their biomedical potential l
a bacterium that causes food poisoning; Pseudomonas aeruginosa, a common disease-causing bacterium; Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species;
and Staphylococcus epidermis, a bacterium that can cause harmful biofilms on plastics like catheters in the human body.
The nanoparticles were effective against all the bacteria. The method allows researchers the flexibility to change the nanoparticle recipe in order to target specific microbes.
It was observed by a team of researchers including Gilles Hickson, an assistant professor at the University of Montreals Department of Pathology and Cell biology and researcher at the CHU Sainte-Justine Research Centre, his assistant Silvana Jananji, in collaboration with Nelio
it can be a source for triggering cancer, for example, said Hickson. It is well known that microscopic cable-like structures,
and to certain diseases, said Hickson, who has devoted the last 15 years of his research life to cell biology.
In fact, all cancers are unchecked characterised by cell division, and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset and spread.
But before we get there, we must continue to expand our knowledge about the basic processes
Ultimately, this could help the rational design of more specific therapies to inhibit the division of cancer cells,
"The simple, low-cost and compact nature of this method makes it particularly attractive for point-of-care applications in settings that lack sophisticated medical resources.
Too many white blood cells may indicate a bacterial infection, tissue damage or inflammatory diseases such as arthritis or allergies,
whereas too few could denote a viral infection or bone marrow deficiency. Furthermore, white blood cell count can be used to predict a person risk of developing conditions such as diabetes and heart disease.
Currently, white blood cell counts are performed at large central laboratories equipped with large and expensive analysis systems that are operated by experienced medical technicians.
But many parts of the world lack such facilitates or expertise. To address this problem, Yi Zhang, Jianhao Bai,
Hong Wu and Jackie Y. Ying from the Institute of Bioengineering and Nanotechnology in Singapore have developed a compact,
The work opens the door for scientists to manipulate such organisms to produce compounds useful as fuels or medicines."
such as mental disability, autism and cancer. A new technology--called"Sticky-flares"--developed by nanomedicine experts at Northwestern University offers the first real-time method to track
and observe and study the biological and medical significance of RNA misregulation. Details will be published the week of July 20 in the journal Proceedings of the National Academy of Sciences("Quantification
"Mirkin is the George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences and professor of medicine, chemical and biological engineering, biomedical engineering and materials science and engineering.
which was the first genetic-based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood.
and transparent material perfect for everything from water bottles to medical devices. But recently, that soaring success has soured:
a substance that can derail the body's hormone balance and potentially cause cancer or birth defects.
for Integrative Cancer Research. Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.
from environmental remediation to medical analysis. The polymers are synthesized at room temperature, and don need to be prepared specially to target specific compounds;
offering the example of a cheap testing kit for urine analysis of medical patients. The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
'If you experience a major heart attack the damage could cost you around five billion heart cells.
Professor of Biomedical Surfaces in the School of Pharmacy and Chris Denning, Professor of Stem Cell biology in the School of medicine and funded by the Engineering and Physical sciences Research Council (EPSRC).
when those therapies are proved to be safe and effective. Billions of stem cells are needed as trials move into second phase Using a high throughput materials discovery approach the research team has found this man-made material,
#A'nanomachine'for surgery with no incision (Nanowerk News) A surgical operation has long been considered one of the first options in cancer treatment;
extended hospitalization, sometimes for as long as one month; and the economic costs. Against such a background, recently neutron capture therapy (1) has been drawing attention.
By irradiating the affected area with a pinpoint light beam, ultrasonic waves, and thermal neutrons, which can be administered safely to living organisms,
This therapy has a lower burden on patients. However, the technological development to deliver the neutron sensitizer molecules to cancer cells has been a great challenge.
or magnevist) broadly used as an MRI contrast agent to the affected area("Hybrid Calcium phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron capture Tumor Therapy").
and is delivered to cancer tissues. The research team has clarified that selective accumulation of the developed nanomachine in a cancer tumor enables contrast imaging of a solid cancer.
Moreover, when the Team applied the nanomachine to cancer neutron capture therapy, they confirmed a remarkable curative effect.
This nanomachine therapy enables an imaging-guided thermal neutron irradiation treatment; thus it can be expected to lead to a reliable cancer treatment with no missed cancer cells.
The realization of surgery with no incision (chemical surgery) by nanomachine allows us to anticipate outpatient treatment with no need of hospitalization n
#3d'printouts'at the nanoscale using self-assembling DNA structures A novel way of making 3d nanostructures from DNA is described in a study published in the renowned journal Nature("DNA rendering of polyhedral meshes
at the nanoscale"."The study was led by researchers at Karolinska Institutet who collaborated with a group at Finland's Aalto University.
says study leader Bjrn Hgberg from the Department of Medical Biochemistry and Biophysics at Karolinska Institutet.
foldable and lightweight energy storage device that provides the building blocks for next-generation batteries needed to power wearable electronics and implantable medical devices (ACS Central Science,"Self-Assembled Multifunctional Hybrids:
which the desired rate of molecule delivery could be tuned dynamically over time to achieve the optimal therapeutic outcome.
or the induction of mechanical stress-all of which can change the properties of a particular hydrogel designed to be responsive to those triggers."
In particular, biomedical applications, an area where the use of biocompatible polycarbonates is established well, have been left out.
for example, could provide many more possibilities for biomedical applications n
#New material opens possibilities for super-long-acting pills (Nanowerk News) Medical devices designed to reside in the stomach have a variety of applications,
including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
As such, they are designed usually to remain in the stomach for a limited time. Now, researchers at MITS Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern
and could allow for the development of long-acting devices that reside in the stomach, including orally delivered capsules that can release drugs over a number of days, weeks,
which is a medical emergency potentially requiring surgical intervention, says Koch Institute research affiliate Giovanni Traverso,
as there is a greater risk for fracture if a device is too large or too complex.
a professor of medical science and engineering at Brown University who was not involved with this study.
patients adherence to long-term therapies for chronic illnesses is only 50 percent in developed countries, with lower rates of adherence in developing nations.
Medication nonadherence costs the U s. an estimated $100 billion every year, the bulk of which comes in the form of unnecessary hospitalizations.
The researchers also say that single-administration delivery systems for the radical treatment of malaria
and other infections could significantly benefit from these technologies. In a March 2015 commentary piece in Nature("Perspective:
Special delivery for the gut"),Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.
they envision an emerging field of orally delivered devices that can maximize adherence and therapeutic efficacy y
#Technology helps personalized medicine, enabling epigenomic analysis with a mere 100 cells A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation,
inflammation and cancer, is reported on today in the research journal Nature Methods("A microfluidic device for epigenomic profiling using 100 cells").
"The examination of epigenomes requires mapping DNA interactions with a certain protein in the entire genome.
This epigenomic characterization potentially allows medical doctors to create personalized treatment of diseases, by understanding the state of a patient,
Chang Lu, a professor of chemical engineering at Virginia Tech, has worked on the development of tools to effectively analyze living cells with the long-term goal of gaining a better understanding of a range of diseases.
the team plans to use this technology to study other epigenomic changes involved in inflammation and cancer in the near future e
or producing designer therapeutics and perhaps one day even non-biological polymers. No one has developed ever something of this nature. e felt like there was a small very small chance Ribo-T could work,
Since the realignment of the atoms causes stress and eventually fractures in the material, the atomic lattice of a substance cannot be rearranged infinitely often.
and someone with schizophrenia would be a leap in our understanding of how our brains shape who we are (or vice versa).
certain skills and gear helped people avoid injury or death: Owning a reliable, waterproof tactical flashlight was absolutely essential,
Possessing emergency first aid and medical skills was also extremely important, as many people suffered injuries from being hit by debris in flood waters.
The ability to navigate on foot, possibly with a compass, was also extremely valuable. Many people had to abandon their vehicles in areas unfamiliar to them.
It's astonishingly easy to lose your sense of direction inside a thunderstorm. Those who could keep their senses
#Hospitals encouraging new mothers to breastfeed by scrapping free formula programs (Naturalnews) A major shift seems to be taking place in how the conventional medical system views appropriate feeding protocols for newborns.
A recent study found that many hospitals across the country are now ditching free infant formula handouts in an attempt to encourage new mothers to exclusively breastfeed their babies rather than pump them up with soy protein, corn syrup solids,
Published in the peer-reviewed journal Pediatrics, the paper looked at the prevalence of hospitals
and birth centers distributing infant formula discharge packs to breastfeeding mothers in the U s. between 2007 and 2013.
hospitals are implementing new no-formula protocols to promote breastfeeding over infant formula. Epidemiologist Dr. Jennifer Nelson, M d,
. and her colleagues evaluated data from the Maternity Practices in Infant Nutrition and Care survey,
which is administered every two years to all hospitals with registered maternity beds. The survey includes questions about how many infant formula discharge packs are distributed to new mothers before these women are discharged from the hospital.
With a nearly 98 percent response rate, the survey is considered a highly credible indicator of infant formula distribution trends among hospitals and birth centers.
Based on the responses gathered the team calculated that infant formula distribution rates dropped by an astounding 41 percent between 2007 and 2013, falling from 72.6 percent to 31.6 percent.
Similarly, teaching hospitals have abandoned almost completely the practice, with only 5. 5 percent of them giving out free formula in 2013.
Six years prior in 2007,63 percent of teaching hospitals handed out free infant formula. The most dramatic decline occurred at hospitals with the highest numbers of babies delivered.
In 2013, less than 12 percent of high-volume delivery hospitals handed out free infant formula. In this case"
high volume"refers to hospitals that deliver at least 5, 000 babies annually. Infant formula companies are just like Big Pharma:
they give free samples to hospitals to gain customers A major issue with handing out free infant formula to new mothers is that it encourages these women to avoid breastfeeding their children,
maintain researchers. Nearly 80 percent of new mothers start out breastfeeding their children, according to the data.
"Hospitals and health care systems are places we look to for guidance on health, "says Dr. Jennifer Nelson,
lead author of the study and a researcher at the U s. Centers for Disease Control and Prevention (CDC),
"When hospitals distribute formula to breastfeeding mothers, it signals that formula feeding is as good as breastfeeding."
"Part of the problem is that infant formula companies actively distribute samples to hospitals as a way to boost sales
The practice is akin to how Big Pharma hands out drug samples to doctors, who then pass these drugs on to their unwitting patients."
and the connection to community support,"adds Dr. Lori Feldman-Winter, a professor of pediatrics at Cooper University Hospital in New jersey,
"Evidence shows that providing new mothers with free formula in hospitals or as part of discharge packs (free gifts) decreases overall and exclusive breastfeeding
#Vitamin c shown to annihilate cancer Vitamin c is a well-known antioxidant and is used commonly to fight off a cold.
Inexpensive possible cancer treatment may never reach patients Conducted in vitro, lab tests were performed by injecting high doses of Vitamin c into human ovarian cells.
This major finding could potentially save millions of lives and at only a fraction of the price of modern cancer treatments.
"Patients are looking for safe and low-cost choices in their management of cancer. Intravenous Vitamin c has that potential based on our basic science research and early clinical data."
These and similar findings have been dismissed by the modern medicine industry because of the lack of patentability.
Additionally, how can they validate years of cutting into patients via invasive surgery and putting patients on the conveyer belt of radiation
and teeth Heal wounds Form scar tissue Helps the absorption of iron Helps thyroid hormone production Helps metabolize folic acid, tyrosine,
and epinephrine (stress hormones) Insulin production Calcium metabolism Fights free radicals The majority of people suffer from Vitamin c deficiency
Low levels of Vitamin c can increase your risk for various cancers and arthritis. Other health issues caused by low levels of Vitamin c include:
Scurvy Anemia Infertility Arteriosclerosis Artherosclerosis Cataracts Glaucoma Nosebleeds Fatigue Infection Gingivitis Gastrointestinal problems Gallstones Dermatitis Impaired hormones Low insulin production
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