This makes it much easier to home in on potential drug targets for therapy. Scientists also no longer have to solely rely on mouse models of human disorders.
Using the invention on carboplatin a common cancer treatment drug, used against ovarian and lung cancers has boosted the potency by almost five times.
"The tool can be used to take away the wastage in a drug, meaning that you need less of it to do the same work.
and could mean that the drugs treat tumours much more effectively. As well as helping with treatment, the tool could cut down the wastage created during the process of making drugs.
That could make the pharmaceutical much more sustainable and reduce their impact on the environment.
More of the devices are being made, reports ABC News, and will be sent to other researchers in Australia and elsewhere.
as well as how certain drugs affect babies before they are born. The team present their findings in a paper,
of which were told they had been given a"dumbing pill "which prevented them from talking before all three were asked which one was still able to speak.
#Researchers Develop 3d printing Method to Produce Shell Capsules That Can Be loaded with Therapeutic Drugs Researchers at the University of Minnesota have introduced a novel 3d printing based method to produce highly monodisperse core/shell capsules that can
be loaded with biomolecules such as therapeutic drugs. They expect that this platform of 3d printed programmable release capsules will be useful in applications such as dynamic tissue engineering, 3d printed drug delivery systems, synthetic/artificial tissues, programmable matter,
and bionic nanosystems. Another important application area could be combinatorial screening of biomolecular gradients drugs, toxins, pollutants,
etc. against cell types. ur method provides us with robust control over particle properties, passive release kinetics,
and Drug Administration approval next year to expand its use to men. n the U s,
and requests from nontransportation companies will be evaluated on a case-by-case basis, he said. The announcement applies only to patents wholly owned by Toyota.
As a Phase III clinical trial, this technology is in the last phase of testing needed to obtain U s. Food and Drug Administration (FDA) approval for use in clinical settings.
But tweaking the type of medication they are taking, or the dose, can be very effective at preventing a frightening attack."
a name brand injection device that delivers the medication epinephrine to treat the life-threatening allergic response called anaphylaxis.
#Shaping Implantable Medical devices to Avoid Immune system Tiny medical implants that can ferry drugs, cells, or other therapies safely to sites of disease are already seeing the light of day.
Study in journal Restorative Neurology and Neuroscience: A new technique for modeling neuronal connectivity using human pluripotent stem cellsource:
So far the device has been able to identify drugs and certain metabolites in animal tissue, hopefully soon moving on to trials with human samples.
Food and Drug Administration
#Optical Probe to Help Remove Only Cancerous Tissues in Brain Surgeries Neurosurgeons removing a tumor have to be obsessive about resecting just enough
the fact that tumors tend to be denser was the basis for many designed devices,
#Electromagnetic field Activated Drug Loadded Nanowires Drug releasing implants can be of great benefit for conditions requiring long term treatment in a targeted area of the body.
Researchers at Purdue University have come up with a new way of releasing drugs into the body in a controlled manner using tiny injectable nanowire implants.
Applying an electromagnetic field over the wires caused them to release the drug. Turning off the EM field immediately stopped the drug release process.
The team tested the technology on mice with compression injuries, demonstrating that the drug reduced inflammation in the areas where the EM field was applied.
This worked over a period of weeks, pointing to this approach being applicable in long-term clinical applications.
Implantable Drug Releasing Microchips Over the past few years wee covered Microchips Biotech, an MIT spin out company that developed an implantable technology to release drugs inside the body in a controlled manner.
The company has partnered now with Teva Pharmaceutical to produce the initial product and put it through clinical trials.
each containing one dose of a particular medication. The tops of these reservoirs are capped by a metal membrane
allowing for administration at the exact times and even with multiple medications. The company microchips have gone already through a successful clinical trial on patients with osteoporosis,
Wireless Implantable Microchips Deliver Drugs When Needed Continuous Microchips Glucose Monitoring Shows Promiseompany homepage: Microchips Biotechource:
#Tiny Remote Controlled Implant Releases Drugs Into Brain The blood-brain barrier is a picky bouncer, preventing most therapeutic compounds from crossing its barricades.
researchers from Washington Universityin St louis and the University of Illinois at Urbana-Champaign have developed a wireless implant that can be controlled remotely to release drugs right into the brain.
and contains four tiny drug chambers. It also HAS LED a tiny built-in that can deliver light to the implantation site
The drug delivery component is particularly interesting for clinical research, since optogenetics is only practical for researchers studying biological processes.
Yet, in laboratory studies, the combination of the two factors can help identify which compounds are promising neurological drug candidates.
The device reacts to infrared light to open up its drug chambers. Since such frequencies of light are able to penetrate a patient skull
the infrared light source can be used as a simple remote control to open up the drug chambers as necessary s
The patients also received the drug buspirone that acts like serotonin and which in the past has demonstrated considerable benefits for mice with spinal cord injuries.
enabling researchers to test drugs and cosmetics without using animals. The organs-on-chips tand to significantly reduce the need for animal testing by providing a faster
whether new drug compounds will be successful in human clinical trials, the university said in a news release.
and often it because the animal models being used to develop these drugs are not predictive of the human situation,
the basis for battery-making, changing the electrolytes to a nontoxic, saline solution--making the entire process safe and harmless,"according to SALT Corp.,at their website.
showed applying small quantities of antibiotic to the surface of medical devices, from small dental implants to hip replacements, could protect patients from serious infection.
the risk of deep bone infection is reduced substantially. ur research shows that applying small quantities of antibiotic to a surface between the polymer layers
chemicals and drugs any substance that someone wants to track closely and then detected using an optical readout device.
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
"People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores.""The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning;
says that the particles could be the basis for reduced risk pesticide products with reduced cost and minimized environmental impact."
"We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
"People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores.""The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning;
says that the particles could be the basis for reduced risk pesticide products with reduced cost and minimized environmental impact."
"We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
minimally invasive device for controlling brain cells with drugs and lighta study showed that scientists can wirelessly determine the path a mouse walks with a press of a button.
Typically, scientists who study these circuits have to choose between injecting drugs through bulky metal tubes
and can simultaneously deliver drugs and lights.""We used powerful nanomanufacturing strategies to fabricate an implant that lets us penetrate deep inside the brain with minimal damage,
or cannulas, scientists typically use to inject drugs. When the scientists compared the implant with a typical cannula they found that the implant damaged
The scientists tested the device's drug delivery potential by surgically placing it into the brains of mice.
they made mice walk in circles by injecting a drug that mimics morphine into the ventral tegmental area (VTA), a region that controls motivation and addiction.
when the scientists directed the device to simultaneously inject a drug that blocks neuronal communication.
It has room for up to four drugs and has four microscale inorganic light-emitting diodes. They installed an expandable material at the bottom of the drug reservoirs to control delivery.
When the temperature on an electric heater beneath the reservoir rose then the bottom rapidly expanded
and pushed the drug out into the brain.""We tried at least 30 different prototypes before one finally worked,
Scientists used soft materials to create a brain implant a tenth the width of a human hair that can wirelessly control neurons with lights and drugs.
and could form the basis of optical computing. At its most basic level, your smart phone's battery is powering billions of transistors using electrons to flip on and off billions of times per second.
and could form the basis of optical computing. At its most basic level, your smart phone's battery is powering billions of transistors using electrons to flip on and off billions of times per second.
Nanotechnology shows promise for more accurate prostate cancer screening and prognosis March 17th, 2015'Additive manufacturing'could greatly improve diabetes management March 17th, 2015nanotechnology Drug Delivery Market in the US 2012-2016:
One of the newest methods of synthesis in modern chemistry, click chemistry, works on a similar basis. Here, molecules are combined to form new chemical compounds by means of chemical'snaps'.
Sensors constructed on the basis of such substrates can be used, for example, to detect the presence of preservatives in foodstuffs.
2015nanomedicine'Additive manufacturing'could greatly improve diabetes management March 17th, 2015nanotechnology Drug Delivery Market in the US 2012-2016:
NC State Industrial & Systems Engineering Research Team Arms Implants With Battery-Activated Nanotechnology March 14th, 2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th,
Distinguished professor in Drexel's Department of Materials science & Engineering, has been used as the basis for much of Drexel's materials research intended to find better materials for batteries.
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015discovery demystifies origin of life phenomenon:
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015is US immigration policy'STEMMING'innovation?
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015nobel Laureate Martin Chalfie to Address International Nanomedicine Conference March 11th,
2015turmeric Extract Applied in Production of Antibacterial Nanodrugs March 12th, 2015silk could be new'green'material for next-generation batteries March 11th,
this could be a very promising lead in developing norovirus antiviral therapy. This could be especially beneficial to immunosuppressed individuals such as cancer patients.
However, if he or she has the option of receiving an antiviral to eliminate the infection,
including live cells and drugs. Many thousands of times thinner than the average human hair, nanofibers are used by medical researchers to create advanced wound dressings--and for tissue regeneration
drug testing, stem cell therapies and the delivery of drugs directly to the site of infection.
Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through"virtual biopsies
"Our nanodrug can be engineered to carry a variety of drugs, proteins and genetic materials to attack tumors on several fronts from within the brain,"said Julia Ljubimova, MD, Phd,
The drug delivery system and its component parts together called a nanobioconjugate or nanodrug, is in an emerging class of molecular drugs designed to slow
or stop cancers by blocking them in multiple ways within the brain. The drug is about 20 to 30 nanometers in size-a fraction of a human hair,
which is 80,000 to 100,000 nanometers wide. Cedars-Sinai scientists began developing the"platform"of the drug delivery system about a decade ago.
The nanodrug can have a variety of chemical and biological"modules"attached.""Each component serves a specialized function,
"Several drugs are quite effective in treating different types of breast cancers, lung cancer, lymphoma and other cancers at their original sites,
May 27th, 2015fine-tuned molecular orientation is key to more efficient solar cells May 26th, 2015cancer Iranian Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th,
Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th, 2015discoveries Who needs water to assemble DNA?
and his work on aerogels is in the basis for the invention of soft electronics. Another partner is leading battery researcher, Professor Yi Cui from Stanford university t
chemicals and drugs-any substance that someone wants to track closely -and then detected using an optical readout device e
We are pleased very that our recently introduced flame transport synthesis method on the basis of zinc oxide now enables the simple synthesis of interconnected 3d networks from tin oxide
The fascinating part is the structure of the single belt-like nanostructures delivered by this synthesis on the basis of tin oxide crystal structure.
scientists assemble promising antimicrobial compounds June 1st, 2015govt. -Legislation/Regulation/Funding/Policy Next-generation illumination using silicon quantum dot-based white-blue LED June 7th,
2015laboratories NIST's'nano-raspberries'could bear fruit in fuel cells June 9th, 2015mesoporous Particles for the Development of Drug Delivery System Safe to Human bodies June 9th,
Advanced method opens up new opportunities for investigation of dynamic processes June 9th, 2015mesoporous Particles for the Development of Drug Delivery System Safe to Human bodies June 9th, 2015mems MEMS Industry
2015stable Perovskite Solar cells Developed through Structural Simplification June 9th, 2015materials/Metamaterials Mesoporous Particles for the Development of Drug Delivery System Safe to Human bodies June 9th,
Transistors, which form the basis of today's computing, are tiny devices that stop the flow of electric current (off and on,
#New Sensors Measure Blood Anticoagulation Drug Iranian researchers from Isfahan University of Technology produced a highly sensitive and accurate sensor
which can measure a type of blood anticoagulation drug. The sensor was produced through a simple
Protamine is an important drug that is used as an anti-heparin agent to prevent blood coagulation during cardiovascular surgeries.
a simple but very sensitive sensor based on fluorescence spectroscopy was presented by using cadmium telluride quantum dots to quickly measure protamine drug.
it is able to prevent excess consumption of the drug without wasting time. Therefore, the required medical actions can be taken before it gets too late.
-Legislation/Regulation/Funding/Policy Toward nanorobots that swim through blood to deliver drugs (video) June 17th,
2015discoveries Toward nanorobots that swim through blood to deliver drugs (video) June 17th, 2015high-tech nanofibres could help nutrients in food hit the spot June 17th,
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Toward nanorobots that swim through blood to deliver drugs (video) June 17th,
and carry payloads of pharmaceutical drugs to targeted tissues. Unlike other methods of making carbon nanoparticles-which require expensive equipment
We use spectroscopy to confirm the formulation as well as visualize the delivery of the particles and drug molecules."
"The team found that the nanoparticles did not release the drug payload at room temperature, but at body temperature began to release the anticancer drug.
The researchers also determined which topical applications penetrated the skin to a desired depth. In further experiments, the researchers found they could alter the infusion of the particles into melanoma cells by adjusting the polymer coatings.
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,
You can load it with two drugs, or three, or four, so you can do multidrug therapy with the same particles.""
and also we can tune them to release the drugs in the presence of the cellular environment.
2015nanomedicine Toward nanorobots that swim through blood to deliver drugs (video) June 17th, 2015arrowhead Receives Regulatory Clearance to Begin Additional Phase 2b Studies of Hepatitis b Candidate ARC-520 June 17th,
2015cellulose from wood can be printed in 3-D June 17th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th, 2015discoveries Scientists film shock waves in diamond:
Method could be useful in developing green energy and a better understanding of rust June 18th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th,
Method could be useful in developing green energy and a better understanding of rust June 18th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th,
#Nanowire implants offer remote-controlled drug delivery Abstract: Remote-controlled Eradication of Astrogliosis in Spinal cord Injury via Electromagnetically-induced Dexamethasone Release from"Smart"Nanowireswen Gao and Richard Borgenswe describe a system to deliver drugs to selected tissues continuously,
if required, for weeks. Drugs can be released remotely inside the small animals using pre-implanted,
novel vertically aligned electromagnetically-sensitive Polypyrrole Nanowires (Ppynws). Approximately 1-2mm 2 Dexamethasone (DEX) doped Ppynws was lifted on a single drop of sterile water by surface tension,
We conclude that the administrations of drugs can be controlled locally and non-invasively, opening the door to many other known therapies,
A team of researchers has created a new implantable drug-delivery system using nanowires that can be controlled wirelessly.
which can be used to control the release of a preloaded drug. The system eliminates tubes
"This tool allows us to apply drugs as needed directly to the site of injury, which could have broad medical applications,
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
"The team tested the drug-delivery system in mice with compression injuries to their spinal cords
The nanowires can be loaded with a drug and, when the correct electromagnetic field is applied, the nanowires release small amounts of the payload.
The magnitude and wave form of the electromagnetic field must be tuned to obtain the optimum release of the drug,
and the precise mechanisms that release the drug are understood not yet well, she said. The team is investigating the release process.
The electromagnetic field is likely affecting the interaction between the nanomaterial and the drug molecules, Borgens said."
and release drugs, "he said.""It is a reversible process. Once the electromagnetic field is removed, the polymer snaps back to the initial architecture
and retains the remaining drug molecules.""For each different drug the team would need to find the corresponding optimal electromagnetic field for its release,
Gao said. This study builds on previous work by Borgens and Gao. Gao first had to figure out how to grow polypyrrole in a long vertical architecture,
which allows it to hold larger amounts of a drug and extends the potential treatment period.
Functional Drug Delivery Using Electromagnetic field-Responsive Polypyrrole Nanowires, "was published in the journal Langmuir. Other team members involved in the research include John Cirillo,
In addition, the concentration of drug maintained during treatment is known not because it is below the limits of systemic detection,
very small dose of a drug to effectively serve as a big dose right where you need it,
"By the time the drug diffuses from the site out into the rest of the body it is in amounts that are undetectable in the usual tests to monitor the concentration of drugs in the bloodstream."
which the drug delivery device will work. The current system appears to be limited to a depth in tissue of less than 3 centimeters,
Updates to the Basis of the Company's Industry-Changing Nanotechnology Designed to Strengthen Position in Global Air, Energy,
#New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment Iranian researchers designed a biosensor with application in assessment of effectiveness of drugs on the stability of the four-strand structure of DNA to prevent the growth
and to create a simple method to investigate their interactions with a number of drugs and compounds.
The studies can be used in the diagnosis, designing and production of anticancer drugs. The research team presented an effective method to detect the four-strand structure of DNA by using biosensors.
Electrochemical studies showed that the designed biosensor creates an appropriate environment for the evaluation of the drug abilities to stabilize the structure.
and to study its interaction with a number of drugs s
#Miniature Technology, Large-scale Impact: Winner of the 2015 Lindros Award for translational medicine, Kjeld Janssen is pushing the boundaries of the emerging lab-on-a-chip technology The postage stamp-sized square of fused silica Kjeld Janssen is holding
#UK study reveals new method to develop more efficient drugs A new study led by University of Kentucky researchers suggests a new approach to develop highly-potent drugs
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
thus reducing or possibly even eliminating their resistance to targeted drugs. The study was led by Peixuan Guo
Guo holds a joint appointment at the UK Markey Cancer Center and in the UK College of Pharmacy."
"Efficacy is the key in drug development, "Guo said.""Inhibiting multisubunit targets works similar to the series-circuit Christmas decorating light chains;
multiple drugs are needed not, as well). Using this method, a single subunit targeting to the target RNA or protein subunits that is unique and assenting for the organism,
"One of the vexing problems in the development of drugs is drug resistance, "said Tim Tracy, former Dean of the UK College of Pharmacy and current UK provost."
"Dr. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism,
He is well-known for his pioneering work of constructing RNA nanoparticles as drug carriers. Guo's research team also includes Dan Shu, Farzin Haque, Mario Vieweger, Fengmei Pi, Hui Zhang, Yi Shu, Chi Wang, Peng Zhang, Ashwani
2015uk study reveals new method to develop more efficient drugs July 8th, 2015superconductor could be realized in a broken Lorenz invariant theory July 7th, 201 0
Researchers at EPFL and ICFO have developed a reconfigurable sensor made from graphene to detect nanomolecules such as proteins and drugs;
2015new Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015discoveries Super graphene can help treat cancer July 10th,
2015nanobiotechnology UK study reveals new method to develop more efficient drugs July 8th, 2015bonelike 3-D silicon synthesized for potential use with medical devices:
2015uk study reveals new method to develop more efficient drugs July 8th, 201 0
#Researchers find nanowires have pronounced unusually'anelastic'properties Anelastic materials exhibit gradual full recovery of deformation once a load is removed, leading to efficient dissipation of internal mechanical energy.
Silver nanoparticles have antibacterial properties, but their use has been a cause for concern because they persist in the environment.
Our results demonstrate that the application of green chemistry principles may allow the synthesis of nanoparticles with biodegradable cores that have higher antimicrobial activity and smaller environmental impact than metallic silver nanoparticles.
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
"People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores.""The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning;
says that the particles could be the basis for reduced risk pesticide products with reduced cost and minimized environmental impact."
"We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
#Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize.
That is, they have engineered a drug delivery system so that the very enzymes that make cancers dangerous could
and deliver a payload of drug, "said Cassandra Callmann, a graduate student in chemistry and biochemistry at the University of California, San diego,
Callmann created tiny spheres packed with the anticancer drug paclitaxel (also known by the trade names Taxol and Onxal) and coated with a peptide shell.
MMPS tear up that shell releasing the drug. The shell fragments form a ragged mesh that holds the drug molecules near the tumor.
The work, led by Nathan Gianneschi a professor of chemistry and biochemisty at UC San diego, builds on his group's earlier sucess using a similar strategy to mark tumors for both diagnosis and precise surgical removal.
To package the drug into the spheres, Callmann had to add chemical handles. As it turns out, a group of atoms essential to the drug molecule's effectiveness,
and also toxicity, made for a good attachment point. That means the drug was inactivated as it flowed through the circulatory system until it reached the tumor.
The protection allowed the researchers to safely give a dose 16 times higher than they could with the formulation now used in cancer clinics,
using a single lower dose of the drug. In mice treated with the nanoparticles coated with peptides that are impervious to MMPS or given saline,
We'll test this in other models-with other classes of drug and in mice with a cancer that mimics metastatic breast cancer, for example."
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