that we could use them as the basis of a therapy for cancer patients. We've taken a big step toward solving that problem,
2015nanocrystalline Thin-film Solar cells July 15th, 2015better memory with faster lasers July 14th, 2015cancer Nanospheres shield chemo drugs,
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
Researchers from Polytechnique Montral and Imperial College London demonstrate the wavelike quantum behavior of a polariton condensate on a macroscopic scale and at room temperature July 14th, 2015nanospheres shield chemo drugs,
2015nanomedicine Agilent technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies July 15th, 2015nanospheres shield chemo drugs,
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
2015patents/IP/Tech Transfer/Licensing Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions July 14th,
a compound of gallium and phosphide that also serves as the basis for specific colored leds.
including increasing the self-cleaning, antibacterial, antifungal, acidic and alkaline resistance. This objective was achieved by creating a homogenous coating made of a nanocomposite of zinc oxide/nitrogen silver (N-Ag/Zno) on the fabrics.
"and since its discovery 175 years ago, all magnets have been characterized on this basis."We have discovered a new class of magnets,
and only one therapy has been approved by the Food and Drug Administration. While most of these vaccines are created with dendritic cells,
showed applying small quantities of antibiotic to the surface of medical devices, from small dental implants to hip replacements, could protect patients from serious infection.
the risk of deep bone infection is reduced substantially. ur research shows that applying small quantities of antibiotic to a surface between the polymer layers
The study, funded by the European commission and the UK Engineering and Physical sciences Research Council, is published in Acta Biomaterialia("Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide
Their two studies appear in ACS'Journal of the American Chemical Society("Structural Basis for a Six Nucleotide Genetic Alphabet".
and his work on aerogels is in the basis for the invention of soft electronics. Another partner is leading battery researcher, Professor Yi Cui from Stanford university y
Since the advent of biotechnology, researchers have modified bacteria to produce therapeutic drugs or antibiotics. In this novel study
and sensitive enough to detect small changes in air quality on a street-by-street basis. Their findings are now informing research projects aimed at improving air quality in major cities across Europe and North america.
chemicals and drugs any substance that someone wants to track closely and then detected using an optical readout device e
and to measure changes in those signals as they administered cardio-or neuro-stimulating drugs."
Gutruf said the research used zinc oxide-present in most sunscreens as a fine powder mixed into a lotion-as the UV sensing material.
#Mimicking the body on a chip for new drug testing Scientists in an EU-supported project have developed a microfluidic chip that simultaneously analyses the reactions of several human organ tissues
when they come into contact with candidates for new drugs. The ground-breaking device could save millions of euros in drug development costs.
One of the biggest challenges for pharmaceutical companies is reducing the multi-million-euro cost of drug development
and shortening the time to market of medicines in order to fully exploit them before patents run out.
called Body-on-a-Chip (BOC), replacing the 2d cell culture conventionally used for drugs testing with a multi-tissue device that better mimics real-life conditions in the body, by combining several organ
and their effectiveness prior to formal clinical testing. he pharma industry loses a lot of money by keeping drug candidates in the development process for too long,
only to find out at a late stage that the drug is not working, explained BOC coordinator, Dr Jan Lichtenberg,
They want to know the drug toxic liability as soon as possible to eliminate failures from their programme,
Understanding the long-term toxicity of drugs Traditionally the potential harmfulness of drugs has been tested on cells grown on plates in a 2d format.
The drug being tested passes in a nutrient solution across these various compartmentalised rgansand the plate is connected with analytical methods such as mass spectroscopy to analyse the drug metabolites produced.
The BOC allows these drug metabolites to be identified and their effect on other tissues studied.
and more commonly used drugs known to be toxic to the liver such as paracetamol, were passed over these tissues to test the device worked correctly.
as well as screening and translation of new classes of drugs, Singh said g
#3d potential through laser annihilation (Nanowerk News) Whether in the pages of H g wells, the serial adventures of Flash gordon,
For the first time, a functioning organic solar cell consisting of a single component has been produced on the basis of metal-organic framework compounds (MOFS.
A metal-organic solar cell produced on the basis of this novel porphyrine-MOF is presented now by the researchers in the journal Angewandte Chemie (Applied Chemistry.
the UNC Eshelman School of Pharmacy, and the UNC Diabetes Care Center. he whole system can be personalized to account for a diabetic weight and sensitivity to insulin,
njecting the wrong amount of medication can lead to significant complications like blindness and limb amputations,
By contrast, the team's previous research showed the drug was effective in preventing atherosclerosis
the nano-packaged drug improved physiologic outcomes among animals with heart muscle thickening and pumping dysfunction, the hallmarks of advanced disease."
or break a drug, "says lead investigator Subroto Chatterjee, Ph d.,a professor of medicine and pediatrics at the Johns hopkins university School of medicine and a metabolism expert at its Heart and Vascular Institute."
"In our study, the right packaging vastly improved the drug's performance and its ability not merely to prevent disease
stems from fast uptake by various tissues and organs and from the slow clearance of the encapsulated form of the drug.
Next, to observe how quickly the body broke down the nano-wrapped and the original forms of the drug,
The kidneys are the final stop on most drugs'journey inside the body just before they are cleared through urine.
and cholesterol levels as did treated animals with free-floating forms of the drug. However, animals treated with the free-floating form of D-PDMP required 10 times higher doses to achieve GSL
and cholesterol levels observed in mice given the nano-encapsulated form of the drug. When scientists measured the thickness of the animals'aortas--the body's largest vessel responsible for carrying oxygen-rich blood from the heart to the rest of the body--they observed stark differences among the groups they say.
Mice treated with either version of the drug fared better, but animals that got the encapsulated form of the drug had aortas nearly indistinguishable from the aortas of healthy mice fed a regular diet, according to researchers.
Most strikingly, they reported, D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
and pumping ability improved in animals that received treatment with the encapsulated form of the drug,
However, mice given non-encapsulated drug required 10 times higher doses to achieve similar benefits.
Researchers say their next step is to test how the drug performs in larger mammals.
and could identify new targets for cancer medications. Throughout the human body, certain signalling chemicals--known as hormones--tell various cells
or proteins that could be targeted by drugs, eventually leading to new medicines to fight cancer r
and be used to deliver anticoagulant medication directly to the effected area to prevent future blockage.
and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
microchip-based devices that store and release drugs inside the body over many years. Invented by Microchips Biotech cofounders Michael Cima, the David H. Koch Professor of Engineering,
and osteoporosis. Michael Cima (left) and Robert Langer Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the worlds largest producer of generic drugs,
Apart from providing convenience, Microchips Biotech says these microchips could also improve medication-prescription adherence a surprisingly costly issue in the United states. A 2012 report published in the Annals of Internal medicine estimated that Americans who dont stick to prescriptions rack up $100 billion
Wouldnt this be a great way to make a drug-delivery system? Langer says. He brought this idea to Cima,
and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents.
Any intense heat during final assembly, with hermetic sealing, could destroy the drugs already loaded into the reservoirs
yet carry the same volume of drugs. This means making the drugs take up more volume than the electrical and other components
he says. Thats the next major challenge e
#Researchers introduce new layered semiconducting materials as silicon alternative (Nanowerk News) When the new iphone came out,
for the first time revealing details about how deactivation of a key protein may lead to metastasis. The new findings also are providing evidence for the mechanisms involved in a cell's response to anticancer drugs,
and our previous findings that there might be a mechanical signature to drug resistance. Advanced models allow researchers to convert AFM data into properties about the cells internal scaffolding,
break open, and release the anticancer drug under the acidic conditions of the tumor microenvironment and in tumor-cell endosomes and lysosomes,
although the drug-carrying nanoparticles could bind to the variant CD44 receptors on cancerous mammosphere cells,
This achievement will also contribute to accelerating the research applications of RNAI such as to the development of RNA-based next-generation drugs,
The result of the study is published in the journal Nature Communications("Structural basis for catalytically restrictive dynamics of a high-energy enzyme state".
#A new approach to develop highly-potent drugs A new study led by University of Kentucky researchers suggests a new approach to develop highly-potent drugs
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
Published in Nanomedicine("New approach to develop ultra-high inhibitory drug using the power function of the stoichiometry of the targeted nanomachine or biocomplex),
thus reducing or possibly even eliminating their resistance to targeted drugs. The study was led by Peixuan Guo, director of UK's Nanobiotechnology Center and one of the top nanobiotechnology experts in the world.
Guo holds a joint appointment at the UK Markey Cancer Center and in the UK College of Pharmacy."
"Efficacy is the key in drug development, Guo said.""Inhibiting multisubunit targets works similar to the series-circuit Christmas decorating light chains;
multiple drugs are needed not, as well). Using this method, a single subunit targeting to the target RNA or protein subunits that is unique and assenting for the organism,
or die and thus, no longer able to cause disease. ne of the vexing problems in the development of drugs is drug resistance,
former Dean of the UK College of Pharmacy and current UK provost. r. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism,
He is well-known for his pioneering work of constructing RNA nanoparticles as drug carriers u
the antimalarial garment can be worn during the day to provide extra protection and does not dissipate like skin-based repellants.
This condition is the basis of some syndromes and neurological diseases.""If we can stimulate the remaining gene to work harder,
biomedical scientists have developed drugs with nanogold to target malignant tumours. The nanogold attracts light emitted from laser therapies
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
In a study published in Nature Nanotechnology("An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core),
People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores. The researchers used the nanoparticles to attack E coli
says that the particles could be the basis for reduced risk pesticide products with reduced cost and minimized environmental impact.
We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
but also commodities such as pharmaceuticals,"said microbiologist Alex Beliaev, Pacific Northwest National Laboratory, who led the study,
Both Brandl and Bertrand are trained as pharmacists, and describe their discovery as a happy accident:
They initially sought to develop nanoparticles that could be used to deliver drugs to cancer cells. Brandl had synthesized previously polymers that could be cleaved apart by exposure to UV LIGHT.
But he and Bertrand came to question their suitability for drug delivery, since UV LIGHT can be damaging to tissue and cells,
and approved by the Food and Drug Administration as a food additive, and polylactic acid, a biodegradable plastic used in compostable cups and glassware.
The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
Professor of Biomedical Surfaces in the School of Pharmacy and Chris Denning, Professor of Stem Cell biology in the School of medicine and funded by the Engineering and Physical sciences Research Council (EPSRC).
"More specifically, it is a drug delivery system (DDS) whereby a nano-level contrast agent (Gd)- DTPA is prepared,
which can reduce the amount of drugs needed d
#Magnetic material unnecessary to create spin current (Nanowerk News) It doesn't happen often that a young scientist makes a significant and unexpected discovery,
and could form the basis of optical computing. At its most basic level, your smart phone's battery is powering billions of transistors using electrons to flip on and off billions of times per second.
#New material opens possibilities for super-long-acting pills (Nanowerk News) Medical devices designed to reside in the stomach have a variety of applications,
including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
or extended-release drug-delivery systems that could last for weeks or months after a single administration.
which could release drugs or small devices for monitoring and imaging the GI TRACT, says Edith Mathiowitz,
In particular, the authors say they are excited for the drug-delivery applications of this technology. With further work in adjusting the polymer composition or the design of the system
they say that they could tailor devices to release drugs over a specific timeframe of up to weeks or months at a time.
MIT is negotiating an exclusive license agreement with Lyndra, an early-stage biotechnology company developing novel oral drug-delivery systems, for this and other related technologies.
Im delighted to see these new oral systems provide an opportunity that Ive not seen previously enabling patients to swallow a single pill that can then act for whatever length of time is desired,
Such single-administration events could improve medication adherence, which remains a major clinical barrier. According to the World health organization
Medication nonadherence costs the U s. an estimated $100 billion every year, the bulk of which comes in the form of unnecessary hospitalizations.
Special delivery for the gut"),Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.
which can be used to create extended-release systems via swallowable pills, they envision an emerging field of orally delivered devices that can maximize adherence and therapeutic efficacy y
The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.
The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, director of the UIC College of Pharmacy Center for Biomolecular Sciences,
who then pass these drugs on to their unwitting patients.""The first few months of breastfeeding are highly dependent on the delivery hospital experience
but the concept is the basis for a new method that could enable biologists to image an entire brain in exquisite molecular detail using an ordinary microscope,
#Promising antibiotic discovered in microbial ark matteran antibiotic with the ability to vanquish drug-resistant pathogens has been discovered through a soil bacterium found just beneath the surface of a grassy field in Maine.
Although the new antibiotic has yet to be tested in people, there are signs that pathogens will be slow to evolve resistance to it.
Massachusetts, report that the antibiotic, which they have named teixobactin, was active against the deadly bacterium MRSA (methicillin-resistant Staphylococcus aureus) in mice,
it may prove to be needed a much triumph in the war against antibiotic-resistance. The device used to discover teixobactin is generating excitement also
because it has the potential to reveal further undiscovered antibiotics: it enables'unculturable'microbes to thrive in the lab,
The news comes amid continuing warnings from public-health experts about the dangers of antibiotic resistance.
In 2014, the World health organization declared that the post-antibiotic era a time in which people could die from ordinary infections
and in 2013, there were 480,000 new cases of multi-drug-resistant tuberculosis worldwide, a condition that requires treatment with increasingly toxic drugs.
Treasure hunt Many of the most successful antibiotics were found in the mid-twentieth century by scientists who trawled microbial communities for bacteria capable of killing their brethren.
But the researchers missed the type that produces teixobactin, Eleftheria terrae, plus many other potential candidates known collectively as microbial ark matterbecause of their reluctance to adapt to life on a petri dish.
That search yielded 25 potential antibiotics, says Lewis, but teixobactin is the most attractive candidate so far.
Unusually for an antibiotic teixobactin is thought to attack microbes by binding to fatty lipids that make up the bacterial cell wall,
By comparison, most antibiotics target proteins and it can be relatively easy for a microbe to become resistant to those drugs by accumulating mutations that alter the target protein shape.
says Wright. don believe there such a thing as an irresistible antibiotic, he says. ut I do believe that certain antibiotics have a low frequency of resistance.
Promising properties As well as MRSA Mycobacterium tuberculosis, which causes tuberculosis, was among the bacteria that teixobactin killed.
But medical microbiologist Timothy Walsh of Cardiff University, UK, urges caution because the drug has been tested against only a small number of lab strains.
says Barry Eisenstein, senior vice-president of scientific affairs at Cubist Pharmaceuticals, a company in Lexington, Massachusetts, that specializes in antibiotic development. oxicity is still the leading cause of failure in turning a potential antibiotic drug into a real drug,
he says. Even so, Eisenstein says that there is reason to be optimistic about teixobactin because it is rare to find a single molecule with so many promising properties.
which has evolved resistance to all known antibiotics. Walsh, however, is hopeful that the ichip technique will yield new solutions to the Gram-negative problem. t could be that these ichip systems will grow bacteria that can actually produce new drugs to take out the very resistant and very pathogenic Gram-negative bacteria.
About a decade ago, Cubist tried its hand at mining microbial dark matter, says Eisenstein. The company gave up the hunt
and form the basis of new targeted treatments that are based on an individual genetic makeup.
and screening for new drugs to overcome PICALM deficiency e
#DNA Breakage Underlies Learning and Age Related Neurodegeneration The process that allows our brains to learn
Furthermore, this will help us to understand the molecular basis of learning, as new spines are initiated readily during learning,
-or neuro-stimulating drugs. e were able to demonstrate that we could make this scaffold and culture cells within it,
The finding paves the way to a whole new approach for finding a drug that can cure
Riluzole, the only approved medication only extends the patient life by a few months. More than a dozen genes are related to ALS.
This makes the TIR-1 protein (or SARM1 in humans) an excellent therapeutic target for development of a medication.
which can be blocked by existing drugs. Alex Parker team is already actively testing drugs that have been approved previously by the US Food and Drug Administration for treatment of such disorders as rheumatoid arthritis
to see if they work with ALS. Obstacles still remain, however, before finding a remedy for curing
if a potential medication will prove effective if it is given only after appearance of symptoms.
10.1016/j. bios. 2015.04. 058abstractan organic electronic biomimetic neuron enables auto-regulated neuromodulationcurrent therapies for neurological disorders are based on traditional medication and electric stimulation.
how we develop the next generation of medications for chronic painhich is by far the most prevalent human health conditionnd the way we execute basic biomedical research using mice. esearch has demonstrated that men
. E. P. Taylor Professor of Pain Studies at Mcgill University and Director of the Alan Edwards Centre for Research on Pain. he realization that the biological basis for pain between men and women
targeted pain medications, said Michael Salter, M d.,Ph d.,Head and Senior Scientist, Neuroscience & Mental health at Sickkids and Professor at The University of Toronto,
so these findings tell us there are important questions raised for human pain drug development. The discovery comes as there is increased attention to the inclusion of female animals and cells in preclinical research.
described in a study led by researchers in the Department of Pharmacology and Systems Therapeutics at the Icahn School of medicine at Mount sinai,
Assistant professor of Pharmacology and Systems Therapeutics at the Icahn School of medicine at Mount sinai. y identifying this new mechanism of epigenetic regulation,
It it also dedicated to biomedical and pharmaceutical research, to develop diagnostics and equipment, applicable to society. e want to give back to our community everything it gives to us,
The herpes-based drug is called T-VEC and has already been sent to the US Food
and Drug Administration and the European Medical Agency for approval and researchers hope it will be available for consumers as early as next year.
Over 16 per cent of patients responded positively to the drug after more than six months,
Hopes for such fake DNA range from developing new drugs to creating artificial life. In 2006, Benner and his colleagues built two bases,
which is so deadly partly because of its limited treatment options, with few new and effective drugs and therapies available l
may be useful for testing new drugs or monitoring diseases. We've levitated living things using magnets before,
and E coli and yeast die one by one from antibiotics and antifungals, respectively. Understanding the varied responses of cells could be a great boon to testing out new drugs and diagnosing diseases,
they say. The technique, like others to measure cell density, comes with strengths and weaknesses."
"We've failed so far to find drugs to treat diarrhea using cell culture models
"We think this could be a real step forward in terms of reducing waste-of-time drug development, "Donowitz says.
and Drug Administration have also been looking into the process. The United Mitochondrial Disease Foundation estimates that from 1000 to 4000 American children are born each year with a mitochondrial disease e
The results also suggests that a drug to help the body seal up leaky blood vessels could delay
and also to protect them against viruses that can wreak havoc on pharmaceutical production. To understand what they've done,
"Church says, pointing to an episode at Genzyme Corp.,a Cambridge, Mass.,pharmaceutical manufacturer, in 2009.
Viruses there contaminated a plant where bacteria were used to make drugs for two rare genetic disorders, Gaucher disease and Fabry disease, cutting off supplies.
And industrial uses are potentially just the start for engineered organisms.""This also sets the stage for opening up new types of applications going forward,
because there was nothing that could protect people against Ebola no drug, vaccine or medicine,"says Dr. Marie-Paule Kieny, assistant director-general for health systems and innovation at the World health organization,
preliminary results of this vaccine trial from Guinea,"says Dr. Jesse Goodman, an infectious disease specialist at Georgetown University, who once led vaccine development at the U s. Food and Drug Administration.
and Drug Administration initially wanted to take a"watch and wait"approach when told about the project."
Over recent years, Proximion has been developing complete temperature monitoring systems including interrogator and analysis software on an OEM basis. In addition to the launch of Wistheat,
The terahertz technology may also prove useful in discovering concealed goods in the retail industry or for non-destructive monitoring, for example quality control in drugs or food.
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