#Something Is Killing Up to Half Of America's Bees There's some kind of environmental issue/plague/apocalypse killing America's honeybees
It's going great. the problem is bayer's neonicotinoid pesticides they accumulate in the plants
#Editing The Genes Of Superbugs To Turn off Antibiotic Resistance Over the past decade deadly bacteria such as MRSA C. difficile
and even tuberculosis#have developed numerous mechanisms to keep themselves alive at all cost#mostly against antibiotics.
Some bacteria have the ability to pump invading antibiotics out of their cells. Others can produce an enzyme called NDM-1
which#chews up these drugs essentially#rendering them ineffective. These new special powers all lie in the bacteria s genes
Led by Timothy Lu the team developed their own gene-editing system capable of turning off certain bacterial genes that spur antibiotic resistance.
and even brain cancer but the MIT researchers are the first to use them to combat antibiotic resistance.#
Bacteria will often pass genes to one another so over time they will receive the antibiotic-resistant genes from their neighbors.
either to strengthen antibiotics or to kill the bacteria altogether. By removing the bacteria s genes that make them antibiotic-resistant CRISPR can boost the effectiveness of existing drugs.
But if CRISPR is designed to remove the bacteria s genes that make them deadly in the first place the system can effectively destroy the infection.
According to the Centers for Disease Control and Prevention at least 2 million people become infected with antibiotic-resistant bacteria each year in the United states resulting in at least 23000 deaths.
As antibiotic resistance becomes an even greater concern Lu hopes their technique will provide a suitable alternative as well as a way of outsmarting bacteria in the future.
The benefit of this technology is you can reprogram the antimicrobial to keep up with evolution Lu says.
The World health organization has declared that it is ethical to use experimental drugs in this outbreak? allowing some potential treatments to skip clinical trials that would validate the drug's safety and efficacy?
and U s. federal agencies want to fast-track human trials of a promising vaccine. If all goes well,
Scientists have been conducting research on micrometre-sized actuators that one day may make it possible to transport drugs or chemical sensor molecules to specific locations throughout the human body.
If such elements are to carry medications or chemical sensor molecules to specific locations in the body the actuators must be coated with the corresponding molecules.
The constituents are reviewed and rebalanced on a quarterly basis u
#A computer vision system for mining artistic influence When we look at an image we not only recognize object categories
Once this queue is fulfilled bears will be distributed to families on a first come first served basis through our network of affiliate nonprofits.
Robotics infographicthe IPO report also looks at the rate of robotics patents compared to other innovation patents on a country basis
and automobile manufacturing food processing and the manufacturing of pharmaceutical electronic and dangerous products. The document says that there will be subsidies of up to 30000 yuan (4800 US dollars) for those who purchase
We want controllers to steer them to do useful tasks such as targeted drug delivery and mobile sensing.
paves way for personalized drug treatments Panasonic, together with the Belgium-based research institution IMEC, has developed a DNA TESTING chip that automates all stages of obtaining genetic information,
we can determine that this drug will work for this person, or this drug will have severe side-effects on that person.
Investigating SNPS enables tailor-made therapy. But with the current method, it has to be done in a specialized lab,
we perform state estimation on the basis of the drone estimates of its height, speeds, angles,
and in the light of the discussion of the marker ambiguity, we decided to only update the position on the basis of the marker readings,
announced that the RP-VITA Remote Presence Robot has received 510 (k) clearance by the U s. Food and Drug Administration (FDA) for use in hospitals.
Drug delivery was via an intraperitoneal injection i e. an injection into the body cavity. While the results were outstanding more work needed to be done before this solution could be taken out of a lab situation and into a real world one.
but that is also capable of electrical stimulation and local drug delivery and this over several weeks in vivo was no small task
New research gives the first evidence of how this might be possible by treating mice with a new drug that made cancer cells less likely to grow in other parts of the body.
The team then used a drug in the mice with cancer that fools this oxygen sensor into behaving
They found that the cancer was then less likely to spread in those mice that had been treated with the drug than in those that hadn.
and will now form the basis for what are likely to be difficult negotiations with the Commission, the EU's executive arm.
the technology exploits the face s a major indicator of individual well-being by tracing traits of physical and expressive status. The goal is to someday implement these mirrors in home, fitness and nutritional centers, pharmacies
The new guidelines also call for offering the drugs to prevent HIV infectiono-called pre-exposure prophylaxis,
#Designer antibodies may rid body of AIDS virus Anti-HIV drugs have extended life for millions of people,
whether drugs can shock cells that are infected with latent HIV to make new viruses, setting them up for the kill by the natural immune response.
#Researchers identify new target for anti-malaria drugs A new target for drug development in the fight against the deadly disease malaria has been discovered by researchers at MIT.
the researchers describe how they identified the drug target while studying the way in which the parasites Toxoplasma gondii,
they could be used as a drug target against the diseases they cause, including malaria, he says. his very strongly suggests that you could find small-molecule drugs to target these pores,
we are one step closer to defining the computational tools that form the basis for bottom-up materials engineering
which there are no effective antibiotics, says Timothy Lu, an associate professor of electrical engineering and computer science and biological engineering. hese bacteriophages are designed in a way that relatively modular.
Customizable viruses The Food and Drug Administration has approved a handful of bacteriophages for treating food products,
which there are few new antibiotics. This group also includes microbes that can cause respiratory, urinary,
One advantage of the engineered phages is that unlike many antibiotics, they are very specific in their targets. ntibiotics can kill off a lot of the good flora in your gut,
provides he ability to pick the best heat-transfer profile on an as needed basis, rather than having to pick a single type of nucleation behavior that allows margins for the most extreme heating that is ever expected for a given device. his allows you to pick the optimum rate of heat transfer moment by moment,
"I think if you look at acquisitions outside of the traditional telco business on a single investment basis this is the largest that we have done."
"Conventionally, cells cultured on the surface of plastic dishes have been used to identify new drug targets, test chemical toxicity,
including tumor metastasis and drug/toxin sensitivity.""This is important as pharmaceutical companies and regulatory agencies look for new,
including regenerative medicine strategies involving therapeutic cells, multifunctional drug delivery, surgical implants, and tissue engineered medical products.
#New technology could speed up lifesaving drug discoveries A team of researchers from our University has developed a revolutionary new biochip device that will lead to a faster
and more cost effective way of discovering new lifesaving drugs. Preventing kinase over-activity The'Phosphosense'technology screens compounds for use in drugs
and select which one can be developed into drugs to fight against diseases. The device was developed at Bath by researchers Dr Pedro Estrela and Phd student Nikhil Bhalla in the Department of Electronic & Electrical engineering, Dr Mirella Di Lorenzo in the Department of Chemical engineering,
and Dr Giordano Pula in the Department of Pharmacy & Pharmacology. Revolutionising drug discovery Dr Giordano Pula, Lecturer in the Department of Pharmacy & Pharmacology said:"
"This technology has the potential to change the drug discovery process as we know it
and facilitate the development of new drugs for diseases like cancer, stroke and dementia.""The simplicity is the strength of this technology.
This discovery significantly simplifies the analysis of protein kinase activity and frees it from the use of radioisotopes or antibodies.""
"The work, published in the Nature Group journal Scientific Reports, explains how this technology identifies potential new drugs by combining semiconductor devices that measure protein kinase activity by calculating ph change,
which signifies the effectiveness of a potential drug compound in blocking kinase activity y
#Getting the perfect fit for artificial hips When a patient receives a new hip, it is adjusted usually only approximately to leg length.
can also be tested for drug discovery using our strategy.""The research team evaluated about 6,
000 compounds from both the KU Chemical Methodologies and Library Development Center and the Food and Drug Administration in a process known as"High Throughput Screening,"hunting for compounds that obstruct Hur's interface with healthy
instead the fund act on a case-by-case basis and that it use its role as a company shareholder to improve corporate practices.
the heavy lifting is done by the inference algorithmhe algorithm that continuously readjusts probabilities on the basis of new pieces of training data.
Antibiotics give rise to new communities of harmful bacteria More information: Interfacial self-assembly of a bacterial hydrophobin, PNAS, www. pnas. org/cgi/doi/10.1073/pnas. 141901611 1
provide a valid basis for manufacturers'warranties, and provide investors with confidence in their investments. In addition, the group aims to create guidelines for inspecting factories during module manufacturing.
Thus, the combined treatment with inhibitors of fork reversal and currently used chemotherapeutics could improve the specificity of these drugs toward cancer cells."
#Crystal breeding factory uncovered A breakthrough in understanding the way in which crystals develop will have a major impact for the pharmaceutical, chemical and food industries.
and Professor Lennart Lindfors, of Astrazeneca, Sweden, have mapped out'in diagram format the actual movements made by chemical molecules on their breeding journey using computer simulations.
"For some drugs, having the correct'handedness'is essential as you need the right key in the lock to make the drugs work.
we can hope for significant development of the chemical, pharmaceutical and related industries and recovery of high skill manufacturing in Japan
Stealing oil has become a lucrative activity among drug cartels, forcing Pemex to stop shipping finished fuel through its pipelines after discovering 3, 674 illegal taps last year.
#New Polymer Gel Could Create Edible Devices for Ultra-Long Drug Delivery A team of scientists has developed a polymer gel that could allow for the development of long-acting devices that reside in the stomach,
including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
or extended-release drug-delivery systems that could last for weeks or months after a single administration. his delivery system provides a flexible and smooth external covering that slowly disintegrates,
which could release drugs or small devices for monitoring and imaging the GI TRACT, says Edith Mathiowitz,
In particular, the authors say they are excited for the drug-delivery applications of this technology. With further work in adjusting the polymer composition or the design of the system
they say that they could tailor devices to release drugs over a specific timeframe of up to weeks or months at a time.
MIT is negotiating an exclusive license agreement with Lyndra, an early-stage biotechnology company developing novel oral drug-delivery systems,
Ie not seen previously enabling patients to swallow a single pill that can then act for whatever length of time is desired,
Such single-administration events could improve medication adherence, which remains a major clinical barrier. According to the World health organization
Medication nonadherence costs the U s. an estimated $100 billion every year, the bulk of which comes in the form of unnecessary hospitalizations.
In a March 2015 commentary piece in Nature, Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.
The findings open the door to new possibilities for developing drugs to fight asthma as well as other diseases
Because X-ray crystallography doesn reveal the structure of a material on a per-atom basis,
This would represent a quantum leap in antiviral therapy, says Fussenegger, who was involved not in the study.
This enzyme activates a harmless drug precursor called CB 1954 which the researchers added to the petri dish where the cells were growing.
provides he ability to pick the best heat-transfer profile on an as needed basis, rather than having to pick a single type of nucleation behavior that allows margins for the most extreme heating that is ever expected for a given device. his allows you to pick the optimum rate of heat transfer moment by moment,
Though that interpretation allows researchers to create a virtual 3-D model of the heart that serves as the basis for a 3-D printed model
Its development could usher in a new generation of portable sensors that can use polarized light for applications ranging from drug screening to quantum computing.
Chirality is critically important in drugs because whether they are left handed or right handed determines their biological activity.
Having a portable sensor capable of detecting a drug chirality could be a game changer. nexpensive CPL detectors could be integrated into the drug production process to provide real time sensing of drugs
in a press release. ortable detectors could be used to determine drug chirality in hospitals and in the field. n research published in the journal Nature Communications,
For example, a baby with liver failure received the proper surgeries and pharmaceutical treatments based on the accurate diagnosis of a rare genetic disorder,
The information would be made available to contacts looking to connect on an on-demand basis,
Downey told Techcrunch that every customer starts on a paid basis since theye mostly industrial or nterpriseclients who already have their own drones,
The team is currently using the tool to etect the presence of malaria-related drug resistance. g
Patients input their symptoms and medication intake into Microhealth, which scans prescription labels and prompts them with text messages to enter periodic updates.
or recommend a different type of medication, and family, especially when the patient is a child.
they don take the medication as they should, or they have a metabolism that not the average. he doses of protein that patients are prescribed,
some patients are bleeding a lot less with certain medications than others, and right now doctors don know that. y simply prompting patients to log the exact amount of medication that theye injecting,
and how often theye getting bleeds, doctors can personalize treatment to match the metabolism and the daily activity of each patient.
if a patient stops logging his medication intake. Eventually, with a broader dataset of medication intake and results
Microhealth will be able to advise patients on more effective courses of treatment or detect outliers,
which will inform the drug discovery process. And hemophilia is just the first chronic disease that the company will tackle.
so choosing the right medication is saving his life, Miguel says. y analyzing data at a macro level,
Moves like these are smart in a world where 1. 8 billion digital photos are shared on a daily basis
#Hack Helps Patients Prevent Adverse Drug Reactions For anyone who ever Googled hat happens when you take prescription drug with other prescription drug,
and doctors search through pharmaceutical research, sourced from eight NIH-and FDA-approved medical databases,
to learn about adverse reactions to prescription drugs. his allows you to put in the drugs youe taking,
or post it work that scientists are doing to tie that drug to an adverse event.
idodrugs. club first identifies the chemical ingredient in the drug you enter. italin, for instance, is the brand name that most people probably recognize,
Unfortunately, lcoholdoes not count as a drug on this platform, at least from my own (brief) research.
while youe still taking those antibiotics you were prescribed last week for your sinus infection. The hack is potentially a lot more useful for patients with serious conditions who are taking multiple prescription drugs for an extended period of time.
For the results, a team of researchers used different types of an analytical chemistry technique to analyse the fingerprints of patients attending drug treatment services.
and not whether they have taken actually the drug. When someone has taken cocaine, they excrete traces of benzoylecgonine
and methylecgonine as they metabolise the drug and these chemical indicators are present in fingerprint residue.
It is anticipated that this technology could see the introduction of portable drug tests for law enforcement agencies to use within the next decade.
For the results, a team of researchers used different types of an analytical chemistry technique to analyse the fingerprints of patients attending drug treatment services.
and not whether they have taken actually the drug. When someone has taken cocaine, they excrete traces of benzoylecgonine
and methylecgonine as they metabolise the drug and these chemical indicators are present in fingerprint residue.
It is anticipated that this technology could see the introduction of portable drug tests for law enforcement agencies to use within the next decade.
new effective drugs are increasingly available to treat the disease and prevent deformed joints. To conduct the research, scientists from University college Dublin and the University of Sheffield,
#More effective drugs for diabetes in the offing Scientists have found a new way to lower blood sugar levels by reducing glucose production in the liver,
paving the way for more effective drugs for type 2 diabetes. Some treatments for type 2 diabetes make the body more sensitive to insulin,
"We think this strategy could lead to more effective drugs for type 2 diabetes, "said principal investigator Brian N Finck, associate professor of medicine in the Division of Geriatrics and Nutritional Science."
"A drug that shuts down glucose production has the potential to help millions of people affected by the most common form of diabetes,
and the biopharmaceutical company Metabolic Solutions Development Co. The company is involved in clinical trials that are evaluating the drug compound MSDC-0602 as a treatment for diabetes.
change the genetic basis of various traits-from correcting diseasecausing mutated genes to genes that determine
"said Ghodbane, who now works in biopharmaceutical research and development at Glaxosmithkline. The breakthrough also requires one-tenth of the chemicals used in a conventional multiplex immunoassay,
#New drug approach could overcome antibiotic resistance WASHINGTON: Researchers have discovered a new group of antibiotics that may provide relief to those affected by antibiotic resistance.
The new antibiotics target the bacteria Staphylococcus aureus, or staph, and the antibiotic resistant strains commonly known as MRSA, short for methicillin-resistant Staphylococcus aureus.
In 2013, invasive MRSA infections were estimated responsible for an 9, 937 deaths in the US, researchers said.
Although current infection rates are declining, the majority of these deaths, about 8, 150, were associated with inpatient stays in health care facilities, according to the Active Bacterial Core surveillance report by the Centres for Disease Control and Prevention in US.
The discovery shows that the potential new antibiotics are unlike contemporary antibiotics because they contain iridium,
which is important for delivery of antibiotics to where they are needed to fight infections in the body.
Researchers showed the antibiotics effectively kill the bacteria without inhibiting mammalian cells. A version of the antibiotic was tested for toxicity in mice with no ill effects."
"Within the next few years, we hope to identify various characteristics of these antibiotics, such as their stability, their distribution and concentration in animal tissue, their penetration into white blood cells,
and their metabolism in animals,"said Joseph Falkinham, a professor of microbiology in the College of Science and an affiliate of the Virginia Tech Centre for Drug Discovery.
The team is currently testing the compounds in human cell lines and so far, the cells have remained normal and healthy.
This enzyme activates a harmless drug precursor called CB 1954, which the researchers added to the petri dish where the cells were growing.
"In the lab, 100 mealworms ate between 34 and 39 milligrams of Styrofoam-about the weight of a small pill-per day.
"In the lab, 100 mealworms ate between 34 and 39 milligrams of Styrofoam-about the weight of a small pill-per day.
which is also a clinically used drug, "said co-author Hongtao Zhang, from the Perelman School of medicine at the University of Pennsylvania in US.
"A drug that interferes with these initial metabolic changes could make very effective treatment for myeloma,
3d printed pills that can be taken orally. What more, Aprecia have just been awarded FDA approval for the first of 3d printed drug of its kind, the epilepsy drug Spritam.
The company in question is a relatively young pharmaceutical company based in East Winsor, New jersey, and claims to be the world only company to utilize 3d printing technology to develop drugs.
And as they say in their press release, Spritam is only the first of the 3d printed drugs they are planning to develop.
As the company argues, their new drug could play a key role in treating a variety of seizure afflictions.
It a prescription adjunctive therapy in the treatment of partial onset seizures myoclonic seizures and primary generalized tonic-clonic seizures in adults and children with epilepsy,
This new drug is set to be released in the first quarter of 2016. But why, you can rightly ask,
does a drug like this need to be 3d printed? Surely epilepsy drugs already exist? Well you would be absolutely right,
but the company argues that many patients have reported finding it difficult swallowing the large pills necessary. n my experience,
or the daily struggle of getting a child to take his or her medication, adherence can be said a challenge
and seniors, having an option for patients to take their medication as prescribed is important to managing this disease. nd that where 3d printing comes in.
Essentially, this creates a very efficient way of delivering high doses of the medication. And while most pills disintegrate
when put in a glass of water, these 3d printed pills are (as you can see in the clip below) insanely quick. precia developed its Zipdose Technology platform using the 3dp technology that originated at MIT.
Using 3dp as a catalyst, Aprecia is developing formulations of medicines that rapidly disintegrate with a sip of liquid, even at high dose loads,
SPRITAM is designed to fill a need for patients who struggle with their current medication experience, Don Wetherhold,
He further stated that this same approach will be used on other drugs in the near future as well. his is the first in a line of central nervous system products Aprecia plans to introduce as part of our commitment to transform the way patients experience taking medication,
this 3d printed approach to drugs does open up a wide range of options for more customized drugs.
Tao Levy, an analyst at Wedbush Securities, has speculated already that this could be used to develop custom drugs featuring a dosage perfect for a single patient,
and 3d printed drugs could be a welcome addition to that system. In short, Spritam is definitely paving the way for a new generation of 3d printed drugs.
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as China's Food and Drug Administration announced that China's self-developed 3d printed hip replacement (joint) has been certified commercially,
adding that he hopes that these 3d printed hip parts will act as promotional pieces within the drug administration system. t is said that at the end of year,
Developed to be swallowed just like a large pill (it is a bit bigger than a small coin),
3d printed Wearable If a Makerbot Replicator 3d printer can be used in pharmacological research labs for advances studies on how to administer cancer fighting drugs,
as a drug delivery system, as well. Chen and Wang have conducted demonstrations to show the great potential of combining 3d printing with nanoengineering, installing polydiacetylene (PDA) nanoparticles within the microfish.
"or manipulating drug delivery in the human body. Co-author Bruce Drinkwater, Professor of Ultrasonics at the University of Bristol, said
similar to an ultrasound scanner but for manipulating particles (that is, drug capsules, kidney stones or microsurgical instruments),
However he was excited most about the technology's potential in treating diseases such as cancer by delivering drugs more efficiently."
"If we could hold drugs (or more likely microcapsules with drugs inside) in the place where they are needed
and then slowly release them we could use much smaller doses, which would result in less side effects,
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