The discovery and exploitation of this new drug target was made possible by an earlier discovery by Ball lab. That finding enabled researchers to identify, on a molecular level,
the target of action for drug molecules by using rhodium-based inorganic complexes that recognize specific folds in a protein chain
There a large surface area with weak interactions for which we have failed typically to find good drugs, he said.
with limited success. here no evidence people have tried to go after the coiled coil as a drug target,
Such knowledge could pave the way for new drugs for a myriad of diseases, including cancer.
therefore, of particular interest. he ability to produce kinases for study should be useful in learning how these proteins function and in developing new types of drugs,
and the University of Michigan claiming novel reagents used for screening small-molecule chemical libraries for new drug leads.
and neurodegenerative diseases, validating histone methyltransferases (HMTS) as an important class of drug targets among biomedical researchers.
Director of Drug Discovery Chemistry at Cayman Chemical. e are going after drug compounds that have a specific mechanism of action
#3d Barcode May Prevent Drug Counterfeiting A specialized barcode unveiled at The british Science Festival on Wednesday may play an important role in combating the global proliferation of fake medications.
Packing and labeling may look similar to real brand-name drugs, but these false pills could cause serious harm.
During the manufacturing process, each individual tablet would be imprinted with tiny pinpricks, reports The Guardian.
These small notches would have variations that can be customized for different types of medications. Medical professionals would then be able to check these small notches with a scanner before they give the medication to a patient.
As long as the scanner detects the appropriate barcode that corresponds to that pill, it safe for the patient to take the drug.
Sofmat managing director Dr. Phil Harrison told The Guardian this system llows more complexity than existing anti-counterfeit systems.
Using a four-pin array we can have more than 1. 7m configurations. arrison noted this project attracted interest from companies in Switzerland
. who now works in biopharmaceutical research and development at Glaxosmithkline, published their results in the journal Lab on a Chip in addition to being able to use less fluid,
while they were initially designing photosensitive polymers for drug delivery applications. Once they came up with a polymer that responded to UV LIGHT,
While the polymer released (polyethylene glycol) is recognized as safe and used in various food, pharmaceutical and cosmetics products,
meaning more absorption occurs on small nanoparticles. his is an important consideration for drug delivery
because it could explain what happens with nanoparticles with high drug encapsulation and extensive burst release.
or drugs inside a man-made biodegradable nanoparticle rapperthat patients inhale could penetrate the mucus barrier
Challenges remain Bertrand and other lead author Ferdinand Brandl both left MIT to join pharmacy schools in Quebec city, Canada and Regensburg, Germany, respectively.
That data will include the raw MRI scans and, on a randomized basis, either a physical model or a computerized 3-D model, based, again at random, on either human segmentations or algorithmic segmentations.
we can develop insights into how Alzheimer disease naturally progresses and potential drug targets, said principal investigator Michael Rafii, M d.,Ph d.,assistant professor of neurosciences and interim co-director of the Alzheimer Disease Cooperative Study (ADCS) at UC San diego. The 3-year study
M d.,a world leader in Alzheimer research, to promote the discovery, development and testing of new drugs for the treatment of AD.
The discovery provides a new platform for drug delivery systems and an entirely different view of cellular functions.
Chilkoti lab has designed self-assembling proteins for drug delivery systems for several years. Simply by adding heat,
and when drugs are released inside the body through non-temperature-related mechanisms such as changes in acidity levels.
however, drugs could be encapsulated in protein cages that accumulate inside of a tumor and dissolve once heated.
Not only would this provide a more accurate way of delivering drugs, but the cages themselves could be used therapeutically. hese packaging systems have always been inert,
This would represent a quantum leap in antiviral therapy, said Fussenegger, who was involved not in the study.
This enzyme activates a harmless drug precursor called CB 1954 which the researchers added to the petri dish where the cells were growing.
and not the type that the drug Herceptin targets. Each year, more than 100,000 women in the United states alone are diagnosed with this.
The usual treatment is followed surgery by years of a hormone-blocking drug. But many women also are urged to have chemo,
and hormone-blocking drugs. Women in the middle group were assigned randomly to get hormone therapy alone or to add chemo.
#Pseudo-platelet Drug Delivery System Targets Cancer Researchers are using patients own platelet membranes to coat drugs and use as nanovehicles for anticancer treatments.
Corresponding author Zhen Gu, an assistant professor in the joint biomedical engineering program at North carolina State university and the University of North carolina Chapel hill, said there are two significant benefits in using platelet membranes to coat anticancer drugs.
comparted to about six hours for nanoscale vehicles without the coating. his combination of features means that the drugs can
which are placed then in a solution with a nanoscale gel containing the anticancer drug doxorubicin (Dox).
The surface of the spheres are coated then with the anticancer drug TRAIL, which attacks the cell membrane of cancer cells.
Studies on mice found that using the combination drug delivery system in the form of a pseudo-platelet was significantly more effective against large tumors
and circulating tumor cells than using the drugs in a nanogel delivery system without the platelet membrane. e like to do additional preclinical testing on this technique,
Gu said. nd we think it could be used to deliver other drugs, such as those targeting cardiovascular diseases, in
#An Accessible Approach to Making a Mini-brain If you need a working miniature brain say for drug testing, to test neural tissue transplants,
said study senior author Diane Hoffman-Kim, associate professor of molecular pharmacology, physiology and biotechnology and associate professor of engineering at Brown. e knew it was a relatively high-throughput system,
and that could eventually lead to the development of a drug to enhance recovery from strokes.
including the cost of health care, medications and missed days of work. The study was funded by the National Institute of Neurological disorders and Stroke at the National institutes of health, the American Heart Association, the Richard Merkin Foundation for Neural Regeneration at UCLA, the Dr. Miriam and Sheldon G. Adelson
#Radiotherapeutic Bandage Could Treat Skin cancer Research behind a new radiotherapeutic bandage that could potentially treat squamous cell carcinoma (SCC) cancer was presented Wednesday, at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Expo in Orlando.
was developed by a team from the University of North Texas System College of Pharmacy, led by professor Anthony J. Di Pasqua, Ph d,
#Scientists Work on the Drug Building Process One Block at a time, University of Illinois Reveals Molecule-Making Machine Simplifies Complex Chemistrychampaign, Ill.
and enable new drug development and other technologies that rely on small molecules. We wanted to take a very complex process, chemical synthesis,
They are very important in medicine most medications available now are small molecules as well as in biology as probes to uncover the inner workings of cells and tissues.
a highly trained chemist spends years trying to figure out how to make each one before its function can even be explored, a slowdown that hinders development of small-molecule-based medications and technologies.
The company initially is focusing on antifungal medications, an area where Burke s research has made already strides.
This procedure could eventually also be extended to men who have lost their penises from penile cancer or as a last-resort treatment for severe erectile dysfunction due to medication side effects.
#Britain Becomes First Nation to Offer Meningitis B Vaccine After Tense Novartis AG Stand-Off The United kingdom will officially become the first country in the world to offer a vaccine for meningitis B after to infants covered under its national health system,
after reaching a hard-fought deal with Glaxosmithkline (GSK), said health officials Monday. Britain will now be able to offer Glaxo Bexsero vaccine, formerly part of Novartis AG (NVS) vaccine portfolio under its massive asset swap earlier this year.
Neither part disclosed the cost of the program, but Nikki Yates, general manager of GSK in Britain,
#Genentech???s Alectinib Shrank Tumors in Nearly Half of Patients With Specific Lung cancer Mutation Genentech Investigational Medicine Alectinib Shrank Tumors in Nearly Half of People With Specific Type of Lung cancer--Alectinib showed response rates of up to
69 percent in the central nervous system (CNS) in people with advanced ALK-positive non-small cell lung cancer---Genentech plans to submit these Phase I/II data to the FDA as part of a New
Drug Application for alectinib, which has been granted Breakthrough Therapy Designation--2015 ASCO Annual Meeting SOUTH SAN FRANCISCO, Calif.--BUSINESS WIRE)--Genentech,
a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced positive results from two pivotal studies (NP28673 and NP28761) that showed alectinib,
its oral investigational anaplastic lymphoma kinase (ALK) inhibitor, shrank tumors (overall response rate; ORR: 50.0 percent and 47.8 percent, respectively) in people with advanced ALK-positive non-small cell lung cancer (NSCLC) whose disease had progressed following treatment with crizotinib.
Alectinib was granted Breakthrough Therapy Designation by the U s. Food and Drug Administration (FDA) in June 2013 for people with ALK-positive NSCLC
About Genentech in Lung cancer Lung cancer is a major area of focus and investment for Genentech, and we are committed to developing new approaches,
About Genentech Founded more than 35 years ago Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions.
The company, a member of the Roche Group, has headquarters in South San francisco, California. For additional information about the company, please visit http://www. gene. com
#New Test Detects Drug Use From A Single Fingerprint, University of Surrey Study Research published today in the journal Analyst has demonstrated a new,
used different types of an analytical chemistry technique known as mass spectrometry to analyse the fingerprints of patients attending drug treatment services.
a drug often used to treat anxiety disorders. Researchers placed electrodes at strategic points on the skin
The achievement was made possible by a new generation of drug-containing coating applied to the inner surface of the vessel.
The team managed to synthesize a thin film made of densely packed aluminum oxide nanorods blended with molecules of a thrombolytic enzyme (urokinase-type plasminogen activator.
The lifetime of such grafts is determined often by the amount of drug stored within the graft,
The system, developed by the researchers, is based on the entrapment of the drug inside a porous protective shell,
You just need to take the right kind of drug. For example, after the implantation of an artificial ureter, urease crystals often start to grow inside
It is possible to apply a similar drug-containing coating that dissolves urease. The same approach may be used for kidney or liver surgery,
Hydrocodone and its chemical relatives such as morphine and oxycodone are opioids, members of a family of painkilling drugs sourced from the opium poppy.
It can take more than a year to produce a batch of medicine, starting from the farms in Australia,
processed and shipped to pharmaceutical factories in the United states, where the active drug molecules are extracted
and refined into medicines. hen we started work a decade ago, many experts thought it would be impossible to engineer yeast to replace the entire farm-to-factory process,
or later refined into pills using chemical processes to extract and concentrate their active ingredients. Smolke team is modernizing the process by inserting precisely engineered snippets of DNA into cells, such as yeast,
or no access to pain medications. iotech production could lower costs and, with proper controls against abuse, allow bioreactors to be located where they are needed,
Bio-produced thebaine would still need to be refined through sophisticated processes in pharmaceutical factories but it would eliminate the time delay of growing poppies. he molecules we produced
Current drug treatments have to be taken for a lifetime, which causes side effects and many other issues,
Some promising experimental Alzheimer drugs require early determination of how the disease is likely to progress,
electrical devices (pacemakers or defibrillators) or drugs (eg beta blockers. However, these methods are relatively crude: they can stop
"says research supervisor Dr James St john, from Griffith's Eskitis Institute for Drug Discovery. The technique was developed
"In light of the overwhelming impact of spinal cord injury, new therapeutic interventions for drug discovery and cell therapy are needed urgently."
We believe our design idea could also be applied to other compounds such as terpenoids and alkaloids,
and drug responses and personalizing treatments in a rapid, cost-effective manner. The findings are reported currently in the Advance Online issue of the journal Nature Medicine."
and validation of new drugs and targets and modeling resistance to therapy,"says Muthuswamy.""By using a cohort of patient samples from
which we can screen for drugs and mutations, we can begin to understand why some patients respond to a treatment
and for drug screening to identify precision therapy strategies
#New lab-on-chip device promises faster TB diagnosis Singapore: US researchers have developed a new low-cost lab-on-a-chip device to aid analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Jay z has admitted also dealing drugs as a teenager. Here's what he told Vanity fair magazine in 2013:
I was a drug dealer. To be in a drug deal, you need to know what you can spend,
what you need to re-up. Or if you want to start some sort of barbershop or car wash those were the businesses back then.
Horse poop yields antibiotic-laced mushrooms European biologists have discovered a bacteria-killing compound in common mushrooms that grow in horse dung.
Unusually for an antibiotic, copsin is a protein; but laboratory trials showed it to have the same effect on bacteria as traditional antibiotics.
Chemists around the world are involved in a race against time to find a solution to the growing problem of bacteria becoming resistant to antibiotics.
It's a major threat to the health of the global population, which had assumed long that antibiotics would always be available to cure bacterial illness.
The scientific community hopes to be able to develop a new range of antibiotics to replace those that are increasingly losing their ability to work against infections like tuberculosis.
A research team led by Markus Aebi Professor of Mycology at ETH Zurich (The swiss Federal Institute of technology in Zurich), believes it may have found the answer.
Copsin promotes antibiotic effect"Horse dung is a very rich substrate that harbours a diversity of microorganisms,
therefore very likely to find potent antibiotics in such an environment, which are used by the different organisms to inhibit the growth of the competitors."
Further research demonstrated that the copsin produced by the mushroom was responsible for this antibiotic effect."
and therefore copsin is active against bacteria resistant to conventional antibiotics.""Copsin is a protein,
whereas traditional antibiotics are often non-protein organic compounds. It belongs to the group of defensins,
Patent pending To yield larger amounts of the antibiotic, copsin is produced in liquid culture via a methylotrophic yeast called Pichia pastoris.
whether copsin could be used in an antibiotic, but that even if it cannot it remains important research.
and other naturally antibiotic substances for millions of years to protect themselves against bacteria, while antibiotics used in medicine by humans have developed resistance in just 70 years.
The team has registered copsin for patent approval l
#Ubisoft offers new video game it says can treat lazy eye The Montreal-based gaming company Ubisoft has developed a video game it says could be used to treat amblyopia, also known as lazy eye.
comparing it to a prescription medication that someone needs to take everyday. ou stop taking your medication for a few days
said Ferland. hink of it as pills, but those are intelligent pills. Daniel Doyon participated in the clinical tests for Dig Rush.
He said he noticed a big difference in his recreational volleyball games after finishing the treatment. hen
and Drug Administration in the United states to market this therapy. The company says it will look to receive approval from Health Canada once Dig Rush has been approved by the FDA g
and prescribe medication right away if any of the results came back positive.""Currently a large percentage of people don't come back to see the results,
and your favorite pharmaceuticals. It all helped along by the notorious bacteria E coli and some other bacteria we never heard of before.
In terms of efficiency including solar conversion efficiency so far the results have been good for butanol, amorphadiene (a pharmaceutical precursor for an antimalarial drug),
and didn't involve drugs or ear-plugs.''EEG or Electroencephalography measures electrical activity in the brain using pads on the scalp,
But current medications to treat these symptoms cause debilitating side effects including poor memory, which can stop sufferers being able to work or study.
As yet no medication has been developed to treat the impairment -which is why scientists at Cambridge university developed the brain training app to help.
and is aimed at people who suffer with poor episodic memory-one of the main side effects of schizophrenia drugs.
but slow progress is being made towards developing a drug treatment.''So this proof-of-concept study is important
because it demonstrates that the memory game can help where drugs have failed so far.''Because the game is interesting,
used in conjunction with medication and current psychological therapies, this could help people with schizophrenia minimise the impact of their illness on everyday life.'
Intelligent mapping systems like HERE's are the basis on which self-driving cars linked to wireless networks can perform functions such as recalculating a route to the nearest electric charging station or around a traffic jam or accident.
'said Steve Clapcote, a lecturer in pharmacology at Leeds University, who led the study. He said his team is now working on developing drugs that will specifically inhibit PDE4B.
The drugs will be tested first in animals to see whether any of them might be suitable to go forward into clinical trials in humans.
In the experiments, published on today in the journal Neuropsychopharmacology, the scientists ran a series of tests on the PDE4B-inhibited mice.
and understanding the effect of genes can be a key early step on the road to developing new drugs.'
and fibres will prove to be a valuable research tool for non-animal testing of new drugs and investigating brain disorders such as Alzheimer's.
#Scientists brew cannabis chemical THC for better drugs for cancer sufferers An active ingredient typically found in cannabis has been engineered genetically in the lab for the first time.
Synthetic THC already exists in pill form and is sold under brand names such as Cesamet. It's often used to treat nausea associated with HIV or cancer therapies
Synthetic THC already exists in pill form and is sold under brand names such as Cesamet. It's often used to treat nausea associated with HIV or cancer therapies,
Drone aircraft could also be used to deliver antibiotics or blood to front-line units to keep them in the fight,
drug development, code-breaking and encryption, and exploring the fundamental nature of the universe
#HIV breakthrough could lead to a CURE as markers on immune cells identified The way a patient's immune system responds to HIV infection could offer clues as to
The breakthrough sheds light on the phenomenon known as'post-treatment control'-where the virus remains undetectable in some patients even after medication is stopped.
and they stop their medication, the virus can be detected back in the blood stream within days.'
But the drug treatment is not a cure. The infection persists in latent cells,'hidden'reservoirs,
'We want to be able to predict how the virus will behave before we take patients of anti-retroviral therapy to test drug therapies aimed at eradicating HIV,
Immune cells with the PD1 biomarker have already been identified as a target for drugs to treat stage-four melanoma
'In the 1980s we saw the first wide scale use of selective serotonin reuptake inhibitors (antidepressants), such as Prozac, Paxil and others.'
'Hundreds of studies have shown that these antidepressants have side effects that include violent thoughts.''A few minutes of research will tell us that 8%of the US population is taking antidepressants,
yet a known 30%of all mass murderers since 1980 were taking antidepressants, and it is suspected highly that the real number approaches 90%a statistical anomaly of egregious proportions.''
''But it is much easier to disprove a cause (as we did with guns above) than it is to prove a cause.''
endorphins, and through prescribed opiates such as morphine. The researchers believe that if we can find out how the body increases the number of opiate receptors,
and designing smart molecules or simple non-drug interventions to do a similar thing is potentially attractive. rof Jones said that as well as drug treatments,
we may find ways of naturally increasing resilience to pain without the side effects associated with many pain killing drugs. al Derbyshire,
yet still have to take opioid medication to relieve my symptoms, she added. he fact that this medication has to be increased from time to time concerns me greatly,
due to the addictive nature of these drugs. he notion of enhancing the natural opiates in the brain, such as endorphins,
as a response to pain, seems to me to be infinitely preferable to long term medication with opiate drugs. nything that can reduce reliance on strong medication must be worth pursuing. piate receptors were discovered first in the brain in 1973.
Since then they have been found to have several different sub-types with different roles. r
By borrowing an antiviral mechanism called CRISPR-Cas9 from bacteria, they created an easy way to tweak the genetic information in a cell nucleus. This has implications for medicine and agriculture.
It might also be used to produce new classes of antiviral treatment, and thus curb infectious disease.
#A drug used to rid people of worms is a new weapon against malaria IVERMECTIN,
a drug employed for the treatment of worm infections, has a side effect. It has been known since the 1980s that it kills arthropods (lice, mites,
when they bite people who have taken the drug. Moreover, even if a mosquito does not succumb
Dr Foy and his colleagues ran a small clinical trial in Burkina faso that is the first to measure the effect of the drug on rates of malaria.
themselves, receiving the drug. That equates to about one episode per child being averted over the course of two years.
Dr Kobylinski and his colleagues fed mosquitoes malaria-infected human blood mixed with the drug.
the drug cut the number of parasites in half. In Thailand, a country well on its way to eliminating the scourge of malaria,
If ivermectin can be pressed into service as an antimalarial agent, too, it will increase the chance that the disease can be knocked on the head once and for all r
electrical devices (pacemakers or defibrillators) or drugs (eg beta blockers. However, these methods are relatively crude: they can stop
#Sensing small molecules may revolutionize drug design Most pharmaceutical drugs consist of tiny molecules, which target a class of proteins found on the surfaces of cell membranes.
Studying these subtle interactions is essential for the design of effective drugs, but the task is extremely challenging.
The new work has broad implications for basic research into biological function at the cellular level as well as providing an efficient platform for new drug design
Targeted approach"Most drugs are small molecules and most drug targets are membrane proteins, "says Tao,
who directs the Biodesign Center for Bioelectronics and Biosensors, which focuses on developing new detection technologies."
and membrane proteins is very important from a pharmaceutical point of view but also for the understanding of basic cellular processes."
"Accurate drug design requires an understanding not only of the small molecule drugs and the membrane proteins they bind to,
The rates at which drugs bind with and dissociate from receptors have a direct impact on drug efficacy and safety.
The optimization of binding kinetics allows drug designers to precisely control two critical parameters known as Kon and Koff.
Small molecules used for most drugs are on the order of a few hundred Daltons in size,
This fact has made the process of drug screening an arduous and costly affair. The path from drug discovery to eventual commercialization often requires 10-12 years of research and close to $1 billion for development of a single new drug.
In addition to examining binding kinetics for membrane proteins immobilized on a surface, animal testing is used often to attempt to validate new drugs,
though the costs are high, the methods are inefficient and ethical concerns come into play. Further, even successful results are not always applicable for human patients.
the field of drug discovery is moving toward cell-based, high-throughput screening methods, where interactions of small molecules and membrane proteins are examined in their native environment.
cheaper and more precise drug design while yielding new insights into foundational issues in cellular biology."
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