an international team of researchers led by Dr. Brent Richards of the Lady Davis Institute at the Jewish General Hospital has identified a genetic variant near the gene EN1 as having the strongest effect on bone mineral density (BMD)
according to the Mayo Clinic. Nerve damage is often permanent. Advanced 3d printing methods may now be the solution.
and printer right at the hospital to create custom nerve guides right on site to restore nerve function."
or cadavers that hospitals could use to create closely matched 3d printed guides for patients. In addition to Mcalpine, major contributors to the research team include Blake N. Johnson, Virginia Tech;
STIS of viral origin constitute a major public health concern, notably in women from low-income countries who were shown to be infected with HIV-1 early in their sexual live,
This is a crucial step in creating a new generation of foldable electronics--think a flat-screen television that can be rolled up for easy portability--and implantable medical devices.
indicating it is a good material for implantable medical devices. Fatigue is a common problem for researchers trying to develop a flexible, transparent conductor,
and totally redesigned its core to repurpose its infectious capabilities into a safe vehicle for delivering vaccines
they would hang vaccine tags on the spikes. If on the other hand, they wanted the capsid to deliver medicines to a sick cell,
#Antimicrobial film for future implants The implantation of medical devices is not without risks. Bacterial or fungal infections can occur
Other frequently used medical devices that cause numerous infectious problems, such as catheters, may also benefit. These results are published in the journal Advanced Healthcare Materials.
Implantable medical devices (prosthesis/pacemakers) are an ideal interface for microorganisms, which can easily colonize their surface.
The challenge presented by implanting medical devices in the body is preventing the occurrence of these infections
or medical devices within a few years to control the complex microenvironment surrounding implants and to protect the body from infection n
and the inaugural director of the Joint Center for Cancer Precision Medicine at the Dana-Farber Cancer Institute, Brigham and Women's Hospital,
In 2001, he launched his laboratory at Maisonneuve-Rosemont Hospital and immediately isolated the molecule.
The Role of Metabolic syndrome The new diagnostic test has been developed by a team that included Mark Deboer, MD, of the University of Virginia Children's Hospital's Department of Pediatrics,
and Matthew Gurka, Phd, of West virginia University's School of Public health. The test relies on an evaluation of metabolic syndrome,
Penn Medicine has the one of the largest referral clinics for treatment of SS patients in the country.
Scientists at the University of Nebraska Medical center designed a new delivery system for these drugs that,
However, as gene therapy moves into the clinic and with miniaturization of optical devices, use of this all-optical technology may become possible.
#New approach toward a broad spectrum malaria vaccine Malaria affects millions of people worldwide. Plasmodium falciparum enolase participates in parasite invasion of host red blood cells and mosquito midgut epithelium.
A vaccine based on this motif could confer protection against all malaria parasites. In a recent breakthrough to combat malaria, a collaboration of Indian and American scientists have identified a malarial parasite protein that can be used to develop antibodies
The finding points towards developing a powerful malaria vaccine in the hope of eradicating this debilitating and often fatal disease.
Development of an antimalarial vaccine is an integral part of an effort to counter the socioeconomic burden of malaria.
and this conjugated system was used to vaccinate mice. Interestingly, a subsequent challenge with a lethal strain of mouse malaria parasite in these vaccinated animals showed considerable protection against malaria.
Says Prof. Dassarma, Phd, a professor of microbiology and immunology at the school,"GVNPS offer a designer platform for vaccines
and this work is a significant step forward towards a new malaria vaccine.""This study is a significant advance in the field,
since most other vaccine candidate molecules tested so far confer protection against only a single species of parasite, due to the species and strain specific nature of these molecules."
"The small segment of five amino acids that forms a protective epitope is present in all human malaria causing species of Plasmodium and hence,
Efforts are focused now at developing this into an effective vaccine against malaria a
#Turning up the heat: Holey metamaterials enhance thermal energy harvesting It's estimated that the U s. fails to use more than half of the energy it generates--mostly
While this old, simple technique may seem a quaint throwback in the age of high-technology health care tools like genetic sequencing
we also want to bring health care to the low-income population, helping to make and early detection before it can lead to more problems
#Researchers develop 3-D printing method for creating patient-specific medical devices A team of researchers at Northeastern University has developed an innovative 3-D printing technology that uses magnetic fields to shape composite materials
As far as other applications, the group's method may find use in clinics, hospitals,
Besides the possibility of treatment, the study also raises hopes for an HIV vaccine. If researchers can induce an uninfected person immune system to generate potent antibodies such as 3bnc117
Ongoing clinical research in Nussenzweig lab and The Rockefeller University Hospital aims to address the impact of additional broadly neutralizing antibodies, alone or in combination, on viral load in HIV-infected patients.
A Surprising Discovery Now a research team led by investigators at Harvard Medical school and the Cancer Center at Beth Israel Deaconess Medical center
which patients the most, says Henrik Schmidt, consultant at the Department of Oncology at Aarhus University Hospital,
and could easily be introduced at the hospitals
#Major Advance in Artificial Photosynthesis Poses Win/Win for the Environment A potentially game-changing breakthrough in artificial photosynthesis has been achieved with the development of a system that can capture carbon dioxide emissions before they are vented into the atmosphere
Cells'energy plant also plays key role in stem cell development Researchers at NYU Langone Medical center have discovered that mitochondria, the major energy source for most cells,
and we look forward to commercializing this technology with one or more leading medical device companies that can benefit by making it easier and painless for diabetics to measure glucose,
and funding support from Mayo Clinic in Arizona. The measurements would help in the diagnosis
Professor Thomas said the project progressed from animal studies to human investigations through collaborations with the Prince Charles Hospital in Brisbane. sing heart tissue from humans undergoing heart surgery
and could ultimately lead to the design of a vaccine to prevent transmission of the virus. This innovative approach could also be part of the solution for one day eradicating the virus. Despite recent advances,
For decades, scientists have been trying to devise a vaccine to block HIV infection, which causes AIDS.
The discovery by Finzi team could help develop a two-part vaccine to prevent HIV infection:
but mass public health campaigns to administer the medication have been stalled because of potentially fatal side effects for patients co-infected with Loa loa,
#Ebola Vaccine Demonstrates 100%Protection in Latest African Trial According to an unusual new study, published last week in the world most prestigious medical journal Lancet, the deadly outbreak
might finally come to an end a vaccine, developed by the Public health Agency of Canada and manufactured by the American pharmaceutical company Merck Sharp & Dome, was shown just to confer 100%protection against the disease,
starting mere 10 days after receiving a single shot. his will go down in history as one of those hallmark public health efforts,
said Michael Osterholm, Director of the Center for Infectious disease Research and Policy in Twin cities, Minnesota,
who wasn involved in the study. e will teach about this in public health schools. he vaccine,
the researchers opted for a design called ring vaccination, whereby only the contacts, and the contactscontacts, of new Ebola patients were vaccinated.
This type of approach has never been used in a formal vaccine study ever before. The rings, also called clusters, were randomized such that 48 of them received the vaccine right after a new Ebola case sprung up in their community,
while the other 42 received a shot only three weeks afterwards. Of the 2, 380 people who were assigned to the latter group,
16 got infected. In the second group consisting of 2 014 people the count of new Ebola cases was zero,
The Director-General of THE WHO Margaret Chan called for further studies to clear up any lingering doubts about the vaccine efficacy,
M d.,Ph d.,who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical school and Boston Children Hospital,
a radiologist and director of the Center for Systems Biology lab at Massachusetts General Hospital who is familiar with the research. hatever you can do right then and there without any complicated testing,
#Could flu someday be prevented without a vaccine? Researchers have discovered a way to trigger a preventive response to a flu infection without any help from the usual players the virus itself or interferon, a powerful infection fighter.
but prevent infection altogether. he flu vaccine needs to change every year because the virus is constantly mutating.
but the scientistslong-term goal is to develop a vaccine-independent method to prevent flu infections. f we were to have an outbreak of some pandemic influenza virus similar to
55 patients with atypical moles agreed to have monitored their skin by researchers at Pisa University Hospital using a laser Doppler system.
says endocrinologist Francesco Celi of the Virginia Commonwealth University Medical center, who was not involved with the study. mportantly,
adding that his research team also hopes to advance the approach for prostate cancer detection. e think this targeted approach holds great promise for earlier imaging of high-risk cancers in the clinic.
Harvard Medical school associate professor of neurosurgery at Boston Children Hospital and senior author of the paper. he 3-D printed models allowed us to rehearse the cases beforehand
, were created in collaboration with the Boston Children Hospital Simulator Program (SIMPEDS), directed by HMS associate professor of anesthesia Peter Weinstock, the paper first author.
The SIMPEDS program is tracking use of 3-D printed models across Boston Children Hospital,
The device is expected to make a difference in medical treatments, preventive health care and sports p
Secondly, these new findings may be very helpful developing vaccines with more effective adjuvants. Adjuvants are used compounds in vaccines that activate innate immunity they are necessary ingredient of efficient vaccines.
For a long time scientists thought that the effect of adjuvant can be maintained a several days only. But this new research shows that it is not necessarily true.
which would make for much more effective vaccines. As much as human immune system still remains not completely clear for science
Knowing how to form these memories may hide the key to creating better, more effective and long-lasting vaccines a
#Team develops quick way to determine bacteria antibiotic resistance Bacteria ability to become resistant to antibiotics is a growing issue in health care:
Staphylococcus epidermis is increasingly emerging as a cause of multi-resistant hospital-acquired infections. The ability to quickly judge whether a bacteria is resistant to antibiotics could make a major difference in a patient's treatment.
Shannon Hilton and Paul Jones Staphylococcus epidermis is increasingly emerging as a cause of multi-resistant hospital-acquired infections.
however, Staphylococcus epidermidis has emerged increasingly as a cause of multi-resistant hospital-acquired infections. Immunocompromised patients
indwelling medical devices, and surgically implanted prostheses provide suitable environments for Staphylococcus epidermidis to propagate and form biofilms.
as a collaboration with orthopedic surgeon Dr. Alex Mclaren and his team member and bioengineer Dr. Ryan Mclemore of Banner Good samaritan Medical center, Phoenix,
along with Dr. Mark Spangehl of the Mayo Clinic College of Medicine, Arizona. By most metrics the antibiotic-resistant and susceptible strains of Staphylococcus epidermidis are phenotypically identical,
This separation has significant potential implications for health care, as rapid and early detection will significantly improve therapeutic outcomes.
and Wyss Institute Founding Director Donald Ingber, M d.,Ph d.,who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical school and Boston Children Hospital and Professor of Bioengineering
or plastic plates with cup-like depressions. he main advantage is cost these assays are done in labs and clinics everywhere,
and the inaugural director of the Joint Center for Cancer Precision Medicine at the Dana-Farber Cancer Institute, Brigham and Women Hospital,
claims Chiu. nbiased point-of-care testing for pathogens by rapid metagenomic sequencing has the potential to radically transform infectious disease diagnosis in both clinical and public health settings.
The researchers evaluated the new test in two sets of biological samples for example, from blood, stool and nasal secretions from patients at St louis Children Hospital.
#Medical device Breakthrough: UV LIGHT enabled catheter fixes holes in the heart without invasive surgery Researchers from Boston Children Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard university,
Harvard John A. Paulson School of engineering and Applied sciences (SEAS) and the Karp Lab at Brigham and Women Hospital have designed jointly a specialized catheter for fixing holes in the heart using a biodegradable adhesive and patch.
As the team reports in Science Translational Medicine, the catheter has been used successfully in animal studies to facilitate hole closure without the need for open heart surgery.
While medical devices that remain in the body may be jostled out of place or fail to cover the hole as the body grows,
Jeff Karp, Ph d.,a bioengineer at Brigham and Women Hospital and a cofounder of Gecko Biomedical, developed the glue product in his lab at Brigham and Women Hospital.
Gecko Biomedical will be testing the glue product in humans later this year. ur collaboration across hospitals
thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital.
In 2001, he launched his laboratory at Maisonneuve-Rosemont Hospital and immediately isolated the molecule.
lack of link to autism New research finds no evidence that thimerosal-containing vaccines cause negative behaviors or result in neuropathology in infant primates,
In the study, infant rhesus macaques received several pediatric vaccines containing thimerosal, a mercury-based preservative,
Other animals received just the measles-mumps-rubella (MMR) vaccine, which does not contain thimerosal,
or an expanded vaccine schedule similar to that recommended for U s. infants today. Control animals received a saline injection.
Regardless of vaccination status all animals developed normal social behaviors; the administration of vaccines to rhesus macaques did not result in neuropathological abnormalities or aberrant behaviors such as those often observed in autism.
Cellular analysis of the cerebellum, amygdala and hippocampus three brain regions known to be altered in autism was vaccinated similar in
and unvaccinated animals. his comprehensive study included many physiological measures and behavioral measures. Fundamentally the vaccines had no ill effects,
said Gene Sackett, UW professor emeritus of psychology and director of the lab work at the Washington National Primate Research center. o the extent that macaques mirror human physiology,
These vaccines are safe. n
#New technology enables people to take own blood samples at home A world-first prototype for taking accurate blood samples at home has been developed by a Tasmanian-led research partnership.
Professor Breadmore said. his is often time-consuming and costly for both the individual and health care systems.
thanks to a new diagnostic test developed by a University of Virginia Children Hospital pediatrician and his collaborators.
and Matthew Gurka of West virginia University School of Public health developed the new diagnostic test. The test relies on an evaluation of metabolic syndrome,
The research team included U. Va. Deboer, West virginia Gurka and Jessica Woo and John A. Morrison, both of Cincinnati Children Hospital.
Aiming for the clinic The development of LRA is the product of a collaboration led by Tripathi and Dr. Rami Kantor, associate professor of medicine in the Warren Alpert Medical school.
Kantor, who is also an HIV specialist at The Miriam Hospital and co-senior author of the paper, works in developing nations such as Kenya and India, monitoring HIV resistance.
however, the door is now open on the possibility that humans could one day receive lifesaving organ transplants from pigs.
surpassing a significant obstacle on the path to bringing xenotransplantation to the clinic. With more than 120,000 patients currently in the United states awaiting transplants and fewer than 30
said David H. Sachs, director of the TBRC Laboratories at Massachusetts General Hospital, the Paul S. Russell Professor of Surgery Emeritus at HMS and professor of surgical sciences at Columbia
professor of neuroscience in Penn School of veterinary medicine and Perelman School of medicine, provides important clues for understanding how a father life experiences may affect his children brain development and mental health through a purely biological and not behavioral means. t remarkable to
as gene therapy moves into the clinic and with miniaturization of optical devices, use of this all-optical technology may become possible.
has direct implications for our climate and public health. Seismic Research/Disaster Prevention: Keys to hazard management for major earthquakes, hurricanes,
as gene therapy moves into the clinic and with miniaturization of optical devices, use of this all-optical technology may become possible.
the researchers showed their system was effective in mice with equine encephalitis virus and with strains of influenza virus relevant to public health,
who led the studies at Brigham and Women Hospital in Boston. He is now an assistant professor of medicine in the Division of Nephrology at the University of Washington and a UW Medicine researcher. nswering this question
and Women Hospital and a principal faculty member at Harvard Stem Cell Institute. hese genetically engineered mini-kidneys, Freedman added,
and Women Hospital have combined cutting-edge, gene-editing techniques with stem cell science to for the first time successfully model genetic kidney disease in lab-grown, mini-kidneys.
Chief of the Renal Division at Brigham and Women Hospital at Harvard and the study senior author. e were interested in creating disease models using these kidney organoids,
together with scientists from the departments of Experimental Epileptology and Neuroradiology of the University of Bonn Hospital as well as from the Hebrew University in Jerusalem (Israel), have decoded now a signaling pathway
says Jean Robillard, M d.,interim president of the University of Iowa and vice president for medical affairs, University of Iowa Health care s
and Health Conference, being held this week at the University of North carolina School of Global Public health.
Smith said. e are actively raising additional capital to help us bring this innovative public health product to people in need around the world. adidrop PBC administrative office is located on Allied Street in Charlottesville
and eggs has lead to numerous breakthroughs in reproductive health, and now he believes his team has discovered a revolutionary strategy to treat cancer. he focus of my work has always been to define the signature molecules that are on
or to the sperm gives you opportunities to create small-molecule drugs for female and male contraception, contraceptive vaccines,
#Researchers Smash Records with Pig-to-Primate Organ transplants A biotech company is genetically engineering pigs so that their organs might work in people.
or between-species organ transplants. The researchers say they have kept a pig heart alive in a baboon for 945 days
achieved by Massachusetts General Hospital. Also this summer, transplant experts at the University of Pittsburgh said they kept a baboon alive with one of Revivicor pig kidneys for more than four months.
including new vaccines. It might be possible, for instance, to make a tuberculosis virus with unnatural DNA in it.
but also benign, that would be the perfect vaccine, says Schultz. Synthetic life forms have implications far beyond new products.
And once synthetic biology leads to a new drug or vaccine, he thinks, wel get used to the idea of inventing life for our own good. ne has to pick the most near-term applications of this technology to show what it can really do for the good of mankind,
surgeons at St vincent Hospital in New south wales described three cases in which they waited as little as two minutes after a person heart stopped before they began removing it.
says Stephen Large, a surgeon at Papworth Hospital in the United kingdom, which has used the system as part of eight heart transplants.
a transplant surgeon at the Massachusetts General Hospital. arm is the way to go with metabolically active tissue.
Donors at the Papworth hospital have included victims of car accidents and failed suicide attempts by hanging.
Large hospital, in a rural area a half hour drive from Cambridge, has taken some new and even more radical steps,
returning to the hospital the following day for the clinician to retrieve images from the pad. uture works include optimising the system model
such as those transporting people between hospitals, cutting NHS fuel costs and improving patient care. So far, 20 traffic lights are using the system in Newcastle city centre.
Figure 1 will verify someone is a medic by contacting their hospital or a suitable authority database.
Dr Vikas Shah a consultant radiologist at University Hospitals Leicester. upload radiology cases such as x-rays or CT SCANS with a question or two,
and forms part of their adoption of social media and the new smartphone and tablet tools that are increasingly being used in hospitals,
was tested for four weeks by 22 participants with a schizophrenia diagnosis. Schizophrenia is a long-term mental health condition
#SAP and Heidelberg University Hospital Personalize Pregnancy Care This Sunday is International Women's Day,
Heidelberg University Hospital, one of the largest hospitals in all of Europe is a perfect example of connected care working to improve women's lives.
In partnership with SAP and abcmedien, the University Hospital developed an app to provide pregnant women all information needed along their pregnancy and beyond.
which only pushes consumer product information, the healthcare experts at Heidelberg University Hospital created this app to serve as a dual resource for both mothers and physicians alike.
At Heidelberg University Hospital, doctors can analyze the answers obtained through the app, and proactively identify mothers at risk for such illness
and was built on the SAP Mobile Platform to provide Heidelberg University Hospital an intuitive interface to connect doctors with patients and vice versa.
In the future, Heidelberg University Hospital hopes to expand the app to help treat and monitor cancer patients as well as other diseases.
Heidelberg University Hospital can reduce immediate and long-term risks for mother and for baby. The traditional relationship between patient and doctor still exists
The health care and liability costs associated with infections are astronomical, and despite increasingly rigid policies and best practices designed to keep hospitals sterile,
human workers aren't great at disinfecting the thousands of surfaces in a hospital room where viruses
but some hospital administrators have come to view them as the first must-have robot tech in a health care industry that's bracing for big changes with the imminent arrival of robot cleaners, diagnosticians, surgeons, and nurses."
"The acquisition of this technology is simply another way that we're working to protect the integrity of our health care environment,
"says Khiet N. Trinh, M d.,chief medical officer at Bon Secours St mary's Hospital in Richmond, Virginia,
and simultaneously uploads the information to the hospital's web portal, meaning it integrates well into a new health care paradigm centering around data collection and analysis."With rising issues around health care-associated infections,
hospitals that provide an extra level of care for patients by disinfecting rooms with TRU-D are not only protecting patients'well-being,
but also ensuring that patients aren't being held financially responsible for things like preventable hospital-acquired infections,
"says Chuck Dunn, president of TRU-D LLC.""TRU-D can achieve 99.99 percent disinfection of all viruses and bacteria.
they inadvertently drew attention to the problem of hospital-acquired infections. Hospitals are interested in technology that integrate into existing protocols and workflows,
which these bots do need, and that has led to lots of activity in the space. TRU-D's biggest competitor is Xenex,
what technology works best and whether their use reduces rates of hospital-acquired infections. As more hospitals adopt the robots,
it's expected that more data will become available about the advantages and flaws of each product
) treated at the Children's Hospital of Philadelphia and first five adults (ages 26 to 60 treated at the Hospital of the University of Pennsylvania.
for Childhood Cancer Research at the Children's Hospital of Philadelphia. The durable responses we have observed with CTL019 therapy are unprecedented.
and Vaccine Production Facility with a gene transfer technique that teaches the T cells to target
which are thought to provide long-term vaccine-like activity preventing tumor recurrence. Since B cells play a role in helping fight infection patients typically receive immunoglobulin replacement to maintain healthy immune function.
and power wearable sensors or medical devices or perhaps supply enough energy to charge your cell phone in your pocket says James Hone professor of mechanical engineering at Columbia and co-leader of the research.
and can be collected easily in places where public smoking is allowed it could be part of a low-cost solution for a serious public health issue they say.
The team lead by Professor Lester Kobzik at the Harvard university School of Public health introduced Streptococcus pneumoniae into the lungs of mice to mimic the inhalation of bacteria that occurs naturally as we breathe.
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