#New sensor chip to detect prostate cancer early Researchers have developed a smart sensor chip that can detect prostate cancer more accurately
and efficiently than current tests which rely heavily on antibodies. The sensor chip, able to pick up on subtle differences in glycoprotein molecules,
will help improve the process of early stage prostate cancer diagnosis, researchers said. Glycoprotein molecules play an essential role in our immune response, because of
which they are useful clinical biomarkers for detecting prostate cancer and other diseases. The team of chemical engineers and chemists at the University of Birmingham, created a sensor chip with synthetic receptors along a 2d surface to identify specific
the team wanted to identify the presence of disease by detecting a particular glycoprotein which has specific sugars in a specific location in the molecule."
#Sugar trail may lead to early cancer detection NEW DELHI: In a breakthrough that could lead to a new protocol for cancer detection and treatment,
scientists have identified a glucose delivery mechanism which helps cancer cells to survive and grow. The discovery can help in early detection of not only pancreatic and prostrate cancer but many others like cancer of the breast and colon.
Announcing the findings, scientists from the University of California, Los angeles (UCLA) also suggested the use of certain antidiabetic drugs to reduce the growth of tumours.
Experts and doctors say the findings can give a new protocol worldwide for cancer detection and treatment.
along with positron emission-tomography tomography (PET) that can enable early detection of these cancers cells. Experts say this is the first promising evidence that PET imaging techniques
and treat pancreatic and prostate cancers. The findings also provide strong evidence that certain type-2 diabetic drugs,
belonging to a new class known as SGLT2 inhibitors which are approved already by the US Food
and reduce tumour growth and increase survival among pancreatic and prostate cancer patients. Pancreatic cancer, estimated as the fourth leading cause of cancer-related deaths in the US behind only lung,
colon and breast cancers, is also increasing significantly in India. In most cases, the tumour is detected at a very late stage,
Prostate cancer, though generally more treatable, is also witnessing a rapid increase in incidence in India as well as globally.
While globally it is the second leading cause of cancer-related deaths in men in India, the incidence of prostate cancer among men has increased by over 220%between 1900 and 2013.
Researchers at UCLA will next begin a clinical study to further investigate the importance of sodium-dependent glucose transporters in glucose delivery.
The findings may lead to potential development of new approaches to control HIV infection by regulating cellular cholesterol metabolism."
T-cells are a type of white blood cells that play a very important role in human immunity by scanning for cellular infections."
"Instead, the disease progresses more slowly and we believe altered cholesterol metabolism in certain immune cells may be a reason,
and potentially may contribute to new approaches to manage HIV infection,"Rappocciolo added. The findings were presented at the eighth INTERNATIONAL AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Vancouver, Canada a
#New laser device spells end for diabetic finger pricking LONDON: A new technology developed by an Indian-origin scientist,
and eliminate the need for daily finger pricking for diabetics. Currently, many people with diabetes need to measure their blood glucose levels by pricking their fingers,
squeezing drops of blood onto test strips, and processing the results with portable glucometers. The new technology, developed by Professor Gin Jose and a team in the Faculty of engineering at the University of Leeds,
this technology opens up the potential for people with diabetes to receive continuous readings, meaning they are alerted instantly
and eliminate the need for daily finger pricking for diabetics. Currently, many people with diabetes need to measure their blood glucose levels by pricking their fingers,
squeezing drops of blood onto test strips, and processing the results with portable glucometers. The new technology, developed by Professor Gin Jose and a team in the Faculty of engineering at the University of Leeds,
this technology opens up the potential for people with diabetes to receive continuous readings, meaning they are alerted instantly
Scientists at the premier Regional Medical Reference Centre (RMRC) at Port Blair have found that the bacterial species that causes leptospirosis is no longer socially aloof,
In July, leptospirosis came out of nowhere to kill 16 people in two weeks. The mutation study, published in a Federation of European Microbiological Studies journal in May, was a wake-up call for public health experts to find better ways to tame the bacteria.
leptospirosis has emerged as a crucial zoonotic disease, with leptospira evolving and thriving in an array of mammal hosts
some of the leading antibiotics used to treat acute leptospirosis in humans and animals,"said Dr Paluru Vijayachari, director of the Port Blair institute."
raised a need to understand its role in epidemics better. Two rare sergroups of the bacteria, Tarassovi and Djasmin, were found responsible for the recent outbreak.
"Humans can literally catch infection in the blink of an eye. The infection can enter through membranes of the eyes, nose or mouth,
or through cuts and abrasions,"said Dr Jayanti Shastri, head of microbiology at BYL Nair Hospital.
"says John-Arne Rottingen, head of infectious disease control at the Norwegian Institute of Public health and chair of the trial's steering group."
Jeremy Farrar, a leading infectious disease specialist and director of the Wellcome Trust, said the trial"dared to use a highly innovative and pragmatic design,
which allowed the team in Guinea to assess this vaccine in the middle of an epidemic"."""Our hope is that this vaccine will now help bring this epidemic to an end
and be available for the inevitable future Ebola epidemics, "his statement said. The medical charity Doctors without Borders (MSF),
which has led the fight against Ebola in West Africa, is now calling for VSV-ZEBOV to be rolled out to the other centres of the outbreak, Liberia and Sierra leone,
The researchers found that the notification system brought about a 30 percent increase in the number of volunteers providing emergency CPR for victims of heart attack.
they said that the 30-day survival rate after heart attack, was 10 percent when onlookers provided CPR,
whether he had a headache, was hungry or he simply wanted to say love you
and technologies that can handle a range of people with different disabilities that make communication difficult.
Among others, these include people with nonverbal autism, people with nonverbal learning disorders, people with ALS, people with Rett Syndrome,
people who have suffered traumatic brain injury, stroke victims and anyone else with limited mobility. ur goal is to create an affordable, customizable,
#Chinese doctor removes kidney tumor with the aid of a 3d printed replica May 23, 2015 By Simonwhile wee seen how developments to additive manufacturing technologies have helped both bring down the cost of getting something 3d printing as well as delivering results faster,
More recently, doctors at the Xiangya Hospital of Urology at Central South University in China were able to leverage 3d printing technology in an effort to help successfully remove a tumor from a 60-year-old woman kidney.
Thanks to the use of a 3d printed model in advance of the surgical procedure, the doctors were not only able to remove the tumor-but also save the kidney itself;
Because the left renal tumor was located directly next to the renal hilum-an area of the kidney that features many vital arteries
Dr. Qi Lin took a series of CT SCANS of the patient kidney, tumor and surrounding area
and were successfully able to remove the tumor while keeping the kidney intact with patient.
and allowed us to pinpoint the tumor, the arteries and the surrounding kidney tissue before surgery,
At age 18, Erik Gatenholm started his first medical device company, manufacturing meniscus implants and other implants, such surgical meshes for ventral hernia repairs and wound dressings.
but even in bone disease, changing toe forms and other complications over time, chief advisor of Jiaodukeji, Xu Chaoyi, explained. his is
#The 3d printed Peek smartphone adapter helps diagnose eye disease in developing countries While we come across so many interesting 3d printed applications,
Perfect for use in third world countries and remote locations far from medical help, this kit essentially consists of a 3d printed add-on for smart phones that can be used to treat preventable blindness.
it has the potential to help more than 39 million people around the world who lack access to basic optical healthcare. 0%of this blindness is avoidable,
Think about eye diseases like cataracts, glaucoma and others. While equipment for diagnosing such diseases already exist
they are heavy, expensive, fragile and require extensive training not at all suitable for use in remote regions without proper electricity.
This helps us to diagnose eye diseases, ready for treatment. Peek Retina combines both a traditional ophthalmoscope and a retinal camera in a mobile phone, providing a portable,
Previously, wee seen how medical researchers have been experimenting with something similar to create 3d bioprinted scaffolding for slowly introducing cells for a diabetic treatment process.
just as much of an impact on internal injuries including broken bones; rather than having a traditional cast on for months,
The team has developed a new 3d bioprinting technique that allows them to 3d print a thick paste filled with protein-releasing microspheres that can be used to greatly speed up bone regeneration after fractures.
This makes it quite easy to imagine complicated applications like filling bone fractures with this doughy material to not only make bones stronger during recovery from fractures
#MEDPRIN 3d prints world first biological meningioma Redura for use in brain surgery While 3d bioprinting innovations sound lifesaving and revolutionary, most are still years away from impacting ordinary
Called MEDPRIN, they have developed the world first 3d printed biological meningioma called Redura a replica of tissue covering the brain
When patching everything up, they'paste'an artificial Meningioma layer on the area in question and sew everything together.
and have a tendency to disrupt a patient life-as most artificial meningioma layers contain metal parts
Over a course of up to three months, a completely new Meningioma beings to grow, while the artificial structure naturally degrades.
a tensionless urethral sling, a hernia repair piece, and artificial skin, blood vessels and ligament, many of which rely on the exact same 3d printing technique.
comparing 571 patient samples to FDA-approved samples of mumps, measles, and herpes simplex viruses 1 and 2. The platform achieved an accuracy of 99.6 percent in diagnosing mumps, 98.6 percent for measles,
and 99.4 percent each for herpes simplex 1 and 2. Schematic overview and different perpsectives of the colorimetric readeraccording to the research paper,
hand-held platform could assist healthcare professionals perform disease screening and vaccination tracking campaigns in resource-poor and field settings.
In addition to serving low-resource or remote areas, the researchers noted that intrinsic wireless connectivity can serve epidemic-related studies,
spatiotemporal maps of disease prevalence and immunity. e are always looking toward the next innovation, and are looking to adapt the basic design of this ELISA cellphone reader to create smartphone-based quantified readers for other important medical tests,
physics and astronomy, to bioengineering, pathology and laboratory medicine. The Californa Nanosystems Institute and the Johnsson Comprehensive Cancer Center also contributed, with support from the National Science Foundation and the Howard hughes medical institute.
Since 3d printing technology is acknowledged already for being affordable and easily transportable to low-resource areas,
of which are at high risk for virus-related epidemics. And, given the incredibly high success rates of the clinical trials so far, it can only be hoped that this lifesaving device is put to good use as soon as humanly possible. a
and feet to an infection several years ago and has learned since how to live without them.
people with disabilities will be able to feel the relative temperature level of an object. The higher the temperature of the objects, the stronger the cautionary electrical impulse sent from the micro control panel is.
and authenticity of experience for persons with disabilities using a prosthetic. It will help them live better independently
s far as people with disabilities are concerned, they have a great wish to be able to live as normal healthy people.
safer future for those with disabilities. he design is currently undergoing commissioning and testing, according to Siyi.
as well as for specific pathological abnormalities and diseases. Perhaps eventually, they could extend their work to plant dissection as well.
screening populations for particular diseases, or tracking vaccination campaigns in most resource-poor settings. It fantastic for an undergrad to be first author on the publication.
measles, and herpes simplex viruses 1 and 2 were all part of the dual ELISA tests. From 571 patient samples, the mobile platform was 99.6 percent accurate at diagnosing mumps, 98.6 percent for measles,
and 99.4 percent for both herpes simplex 1 and 2. ur team is focused on developing biomedical technologies that work with mobile platforms to assist with on-site testing
#Plasmons Influence Carbon-Based Nanoparticles for Sensitizing Cancerous Tumors In a study published in EPJ D,
one atom may move down a peak providing a little stress for another atom to move up a trough,
may change the way doctors approach treatment for patients who develop potentially deadly infections and may also help the food industry screen against contamination with harmful pathogens, according to researchers at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, South korea.
Described this week in The Optical Society (OSA) journal, Optics Express, the new approach involves bouncing laser light off individual bacteria under the microscope,
"Why Speed Matters in Infection Control In hospitals and clinics worldwide, bacterial infections are a major source of illness,
In the most severe cases, bacterial poisoning causes severe disease and syndromes like sepsis, meningitis, pneumonia,
and gastroenteritis all of which can be deadly unless the patient is given immediate and appropriate treatment.
The true challenge of fighting those infections is time. In order to best treat their patients, doctors would like to know exactly which bacteria they are infected with,
but the lost hours or days spent identifying the exact pathogen can make the road to recovery that much steeper.
Sepsis, for instance, can develop so rapidly that mortality has been seen to increase by 9 percent per hour until treatment is given.
For that reason, many hospital-acquired infections are treated presumptively, before they are identified definitively, using broad-spectrum antibiotics.
allowing doctors to prescribe the best drugs available to treat an infection and improving outcomes for people with hospital-acquired infections though the effectiveness of the approach remains to be proven in future clinical trials.
In their initial experiments, Park and his colleagues showed as a proof of principle that they could identify bacteria with high accuracy.
The first three are known all pathogens to infect humans through the food chain or via hospital-acquired infections.
which is the base for Anthrax. Under a microscope, all four of these rodlike bacteria look nearly identical.
#Once people take high-quality, high-resolution images of suspicious moles or skin abnormalities, they can archive images
It was released in June 2011 and donated to the BC Cancer Agency at Vancouver General Hospital.
stretchy electronic sensors are also capable of detecting harmful levels of UV radiation known to trigger melanoma.
#Ultracompact Highly sensitive Nanomechanical Sensor Can Detect Viral Disease Markers Two young researchers working at the MIPT Laboratory of Nanooptics and Plasmonics,
such as viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases,
including HIV, hepatitis, herpes, and many others. The sensor will enable doctors to identify tumor markers,
whose presence in the body signals the emergence and growth of cancerous tumors. The sensitivity of the new device is characterized best by one key feature:
according to its developers, the sensor can track changes of just a few kilodaltons in the mass of a cantilever in real time.
One Dalton is roughly the mass of a proton or neutron, and several thousand Daltons are the mass of individual proteins and DNA molecules.
So the new optical sensor will allow for diagnosing diseases long before they can be detected by any other method,
#Nanoparticles Arrest Destruction of Beta Cells and Avoid Diabetes Development This work led to more studies with the support of the Spanish Government, Catalan Government and private patrons with a keen interest in it.
and even curing the disease in humans. Initially the researchers avoided the destruction of the insulin-producing pancreatic cells (beta cells) in the body by modifying the individual's immune cells, known as dendritic cells.
and avoid Diabetes development. This technique could be a much better candidate for a human vaccine.
The Catalan researchers are the first group in the world to use liposomes that imitate naturally dying cells to fight against Diabetes.
Next stepsafter showing that liposomes prevent the onset of Type 1 Diabetes in mice, the next steps are to test it in human cells in vitro,
and to cure the disease by combining the vaccine with regenerative therapies. The Germans Trias Institute plans to carry out these steps with patients at the hospital
Growing incidence and complex consequencestype 1 Diabetes is an illness where the body does not recognize the beta cells of the pancreas as its own
The most serious is that in the long term hyperglycemia provokes retinal damage that can lead to blindness renal insufficiency, destruction of nerve fibers or
what is called"Diabetics Foot"where ulcers form, leading eventually to the need to amputate. The causes of the disease are unknown,
although there are both genetic and environmental factors involved. About 0. 3%of the population is affected
This immunotherapy presents a possible solution for Type 1 Diabetes. Source: http://www. uab. es e
. a professor of chemistry at Tufts and senior author on the paper, worked with iodine-125 radioactive isotope that is routinely used in cancer therapies.
Gold-Plated Cancer Fighters? Then Alex Pronschinske, Ph d.,first author on the paper and a postdoctoral researcher in Sykeslab, suggested that they measure the electrons emitted by the sample without prodding from X-rays in the photoelectron spectrometer.
because they break cancer cellsdna into pieces. Because these electrons can travel only 1 to 2 nanometers human hair is about 60,000 nanometers widehey do not affect healthy tissue and organs nearby.
then affix the nanoparticles to antibodies targeting malignant tumors and put them in a liquid that cancer patients could take via a single injection.
Theoretically, the nanoparticles would attach to the tumor and emit low energy electrons, destroying the tumor DNA.
The gold-based nanoparticles would be flushed out of the body, Sykes says, unlike free iodine-125,
which can accumulate in the thyroid gland and cause cancer. If proven, this approach could be a potential improvement over current radiation therapy protocols, in
which doctors treat some cancers by putting radioisotopes, including iodine-125, into tiny titanium capsules and implanting them in tumors.
Instead of emitting large amounts of low energy electrons as the gold-bound iodine does, the titanium capsules inhibit radiation,
Sykes says, making such therapies less effective than they could be. He has applied for a patent on the new technique.
#Polymer Nanobrushes Grab Selected Bacteria for Pathogen Detection A Texas A&m Agrilife Research engineer and a Florida colleague have developed a biosensor that can detect listeria bacterial contamination within two
The same technology can be developed to detect other pathogens such as E coli O157: H7, she said.
But listeria was chosen as the first target pathogen because it can survive even at freezing temperatures.
It is also one of the most common foodborne pathogens in the world and the third-leading cause of death from food poisoning in the U s."It can grow under refrigeration,
000 National Science Foundation grant to continue their work on nanobrushes for pathogen detection n
#Nano-Packaged Drug Can Halt and Reverse Progression of Atherosclerosis in Rodents In what may be a major leap forward in the quest for new treatments of the most common form of cardiovascular disease,
scientists at Johns Hopkins report they have found a way to halt and reverse the progression of atherosclerosis in rodents by loading microscopic nanoparticles with a chemical that restores the animals'ability to properly handle cholesterol.
known as atherosclerotic vessel disease, is the leading cause of heart attacks and strokes that claim some 2. 6 million lives a year worldwide, according to the World health organization.
That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound
but not potent enough to stop the disease from advancing. Perhaps, most importantly, the team says,
and pumping dysfunction, the hallmarks of advanced disease.""Our experiments illustrate clearly that while content is important,
and its ability not merely to prevent disease but to mitigate some of its worst manifestations."
D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
#Encapsulated, Nanobody-Targeted Drugs Cold Help Treat Sleeping sickness Sleeping sickness, or African trypanosomiasis, is caused by trypanosome parasites transmitted by tsetse flies
The disease is considered fatal if untreated, but as it affects mostly poor people in low-income countries,
A study published on June 25th in PLOS Pathogens reports a new way to circumvent drug resistance
a high-tech approach with potential applications to other infectious diseases. Current treatment of sleeping sickness relies primarily on four drugs.
Three of these drugs get into the interior of the parasite cells via the trypanosome's transport proteins that normally supply the parasite with nutrients,
They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and,
#Nanotechnology Drug in Droplets for Painless Treatment of Secondary Blindness The Mexican company"Medical and Surgical Center for Retina"created a way to transport drugs,
in order to avoid risks and painful treatments in people with secondary blindness due to chronic degenerative blindness such as diabetic retinopathy and degeneration of the eye.
"The doctor Juan carlos Altamirano Vallejo, medical director of the Medical and Surgical Center for Retina, mentions that the conditions that originate in the retina are caused mostly by chronic degenerative diseases such as diabetes (diabetic retinopathy
but without the inherent risks of this procedure, such as infection or retinal detachment. Current talks are being held with COFEPRIS to conduct a study within several diseases and increase its use for different conditions.
In the United states, patients who have followed the treatment have had positive results. The Medical and Surgical Center for Retina provides medical care
and prevent blindness.""It is the most important prize delivered by the Presidency of the Republic in the area of`technology and innovation.
and prevent blindness. Source: http://www. invdes. com. mx
#MEMS Innovations Enable Commercialization of Implantable Microchips for Drug-Delivery An implantable, microchip-based device may soon replace the injections
and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world largest producer of generic drugs,
to treat specific diseases, with licensing potential for other products. Teva paid $35 million up front, with additional milestone payments as the device goes through clinical trials before it hits the shelves. bviously,
this is a huge validation of the technology, Cima says. major pharmaceutical company sees how this technology can further their efforts to help patients.
While its first partnership is for treating chronic diseases, Microchips Biotech will continue work on its flagship product, a birth-control microchip, backed by the Bill and Melinda Gates Foundation,
and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents. e were trying to find the killer application.
and researchers from Microchips, conducted the microchipsfirst human trials to treat osteoporosis this time with wireless capabilities.
of life-a cellular recycling unit with a role in many diseases. The proteasome complex is present in all multicellular organisms,
and plays a critical role in cancer by allowing cancer cells to divide rapidly. Researchers used a technique called electron cryo-microscopy,
Scientists from The Institute of Cancer Research, London, and the Medical Research Council (MRC) Laboratory of Molecular biology in Cambridge were able to visualise the proteasome complex down to a resolution of around 3. 5 Angstroms,
and was funded by Cancer Research UK and the MRC. The research could help other scientists to use CRYO EM in structure-based drug design studies-in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.
Blocking the proteasome prevents this regulated recycling of amino acids and triggers controlled cell death, particularly in fast-dividing cells typical of cancer.
Senior study author Dr Edward Morris, Team Leader in Structural Electron microscopy at The Institute of Cancer Research, London, said:"
"Dr Emma Smith, senior science communications officer at Cancer Research UK, said:""Revealing the molecule's detailed shape could be the first step towards designing more precise drugs to block it.
This molecule plays an important role in some cancers and drugs that block it are already available to patients
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