lead author of the study and a researcher at the U s. Centers for Disease Control and Prevention (CDC),
#Vitamin c shown to annihilate cancer Vitamin c is a well-known antioxidant and is used commonly to fight off a cold.
Inexpensive possible cancer treatment may never reach patients Conducted in vitro, lab tests were performed by injecting high doses of Vitamin c into human ovarian cells.
This major finding could potentially save millions of lives and at only a fraction of the price of modern cancer treatments.
"Patients are looking for safe and low-cost choices in their management of cancer. Intravenous Vitamin c has that potential based on our basic science research and early clinical data."
and teeth Heal wounds Form scar tissue Helps the absorption of iron Helps thyroid hormone production Helps metabolize folic acid, tyrosine,
and epinephrine (stress hormones) Insulin production Calcium metabolism Fights free radicals The majority of people suffer from Vitamin c deficiency
Low levels of Vitamin c can increase your risk for various cancers and arthritis. Other health issues caused by low levels of Vitamin c include:
Scurvy Anemia Infertility Arteriosclerosis Artherosclerosis Cataracts Glaucoma Nosebleeds Fatigue Infection Gingivitis Gastrointestinal problems Gallstones Dermatitis Impaired hormones Low insulin production
could be the key to better understanding disease Medical professionals everywhere may be stunned by a new discovery that overturns decades of textbook teaching.
Might scientists now begin to consider the possibility that something as basic as the body's plumbing system may well hold the key to solving dozens of disease riddles?
they do need to find new answers about the workings of the brain and the diseases that plague it.
That all diseases result in morbidity, that all morbidity forms blockages, and that all degenerative processes can be reversed naturally, thanks to a relationship between the blood stream and the lymphatic system,
SCHIZOPHRENIA BIPOLAR OR MANIACO-DEPRESSION, HOW PLASMA PROTEINS PRODUCE THE CONDITION AT THE BRAIN CELLS'LEVEL OF CHEMICAL IMBALANCE,
More news on Greece deficit Learn these simple tips for preventing cancer naturallymonsanto: The world's poster child for corporate manipulation and deceitextreme bias at Wikipedia on homeopathic medicineguatemalan STD medical experiments were just one crime in a long history of medical-government collusion to use humans
#Promising antibiotic discovered in microbial ark matteran antibiotic with the ability to vanquish drug-resistant pathogens has been discovered through a soil bacterium found just beneath the surface of a grassy field in Maine.
there are signs that pathogens will be slow to evolve resistance to it. Today in Nature, a team led by Kim Lewis of Northeastern University in Boston,
and a host of other pathogens in cell cultures. If the compound behaves similarly in people
and so makes it easier to discover bacteria that naturally produce compounds deadly to other pathogens. he technology is very cool,
In 2014, the World health organization declared that the post-antibiotic era a time in which people could die from ordinary infections
and minor injuries could begin this century. MRSA has spread from hospitals into the community
and in 2013, there were 480,000 new cases of multi-drug-resistant tuberculosis worldwide, a condition that requires treatment with increasingly toxic drugs.
Lewis is excited about teixobactin mainly because of the indication that it will be difficult for pathogens to develop resistance against it.
Mycobacterium tuberculosis, which causes tuberculosis, was among the bacteria that teixobactin killed. But medical microbiologist Timothy Walsh of Cardiff University, UK, urges caution because the drug has been tested against only a small number of lab strains.
and includes deadly pathogens such as Klebsiella pneumoniae, which has evolved resistance to all known antibiotics. Walsh, however, is hopeful that the ichip technique will yield new solutions to the Gram-negative problem. t could be that these ichip systems will grow bacteria that can actually produce new drugs to take out the very resistant and very pathogenic Gram-negative bacteria.
not only detect the onset of sudden and serious illness that may incapacitate the driver, but also allow the car to monitor driver stress levels.
This would then allow the car to help reduce stress, for example by changing mood lighting, audio settings and climate control.
JLR also has a redictive Infotainment Screenprototype that uses cameras embedded in the car to track the driver hand movements
Paralyzed from the neck down after suffering a gunshot wound when he was 21, Erik G. Sorto now can move a robotic arm just by thinking about it
the motor cortex, can allow patients with paralysis to control the movement of a robotic limb.
The USC Neurorestoration Center primary mission is to leverage partnerships to create unique opportunities to translate scientific discoveries into effective therapies. e are at a point in human research where we are making huge strides in overcoming a lot of neurologic disease,
that involve paralysis such as stroke, brain injury, ALS and even multiple sclerosis. The Rehabilitation Sixteen days after his implant surgery, Sorto began his training sessions at Rancho Los Amigos National Rehabilitation Center,
and treatment of neurological diseases ranging from autism to Alzheimer disease to multiple sclerosis. nstead of asking,
hy do multiple sclerosis patients have the immune attacks? now we can approach this mechanistically. Because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,
Alzheimer, Autism, MS and Beyond The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both about the workings of the brain and the diseases that plague it.
For example, take Alzheimer disease. n Alzheimer, there are accumulations of big protein chunks in the brain,
And there an enormous array of other neurological diseases, from autism to multiple sclerosis, that must be reconsidered in light of the presence of something science insisted did not exist u
and his colleagues could one day be used to culture tissue that can be transplanted into a human retina damaged by conditions such as macular degeneration and retinitis pigmentosa,
which lead to blindness. he protocol developed here allows us to generate retinal tissue that closely resembles the biological retina with high efficiency and stability,
#Disruption of Delicate Chemical Balance Implicated as a Cause of Schizophrenia Scientists produce strongest evidence yet of schizophrenia causes.
what causes schizophrenia a condition that affects around 1%of the global population. Published today in the journal Neuron,
the team found that disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance
published last year in the journal Nature. ee finally starting to understand what goes wrong in schizophrenia,
and Genomics. ur study marks a significant step towards understanding the biology underpinning schizophrenia, which is an incredibly complex condition
what we hope is a pretty sizeable piece of the jigsaw puzzle that will help us develop a coherent model of the disease,
while helping us to rule out some of the alternatives. reliable model of disease is needed urgently to direct future efforts in
his work builds on our understanding of the genetic causes of schizophrenia unravelling how a combination of genetic faults can disrupt the chemical balance of the brain. cientists in the UK,
as part of an international consortium, are uncovering the genetic causes of a range of mental health issues, such as schizophrenia. n the future,
this work could lead to new ways of predicting an individual risk of developing schizophrenia
Researchers studying psychiatric disorders have suspected previously that disruption of this balance contributes to schizophrenia. The first evidence that schizophrenia mutations interfere with excitatory signalling was uncovered in 2011 by the same team,
based at Cardiff University MRC Centre for Neuropsychiatric Genetics and Genomics. This paper not only confirms their previous findings,
To reach their conclusions scientists compared the genetic data of 11,355 patients with schizophrenia against a control group of 16,416 people without the condition.
Comparing the CNVS found in people with schizophrenia to those found in unaffected people the team was able to show that the mutations in individuals with the disorder tended to disrupt genes involved in specific aspects of brain function.
The disease-causing effects of CNVS are suspected also to be involved in other neurodevelopmental disorders such as intellectual disability, Autism Spectrum Disorder and ADHD.
Around 635,000 people in the UK will at some stage in their lives be affected by schizophrenia.
The estimated cost of schizophrenia and psychosis to society is around £11. 8 billion a year.
The symptoms of schizophrenia can be extremely disruptive, and have a large impact on a person ability to carry out everyday tasks,
#Deficiency of Specific Protein in Brain Blood vessels Increases Risk for Alzheimer Disease New study finds that PICALM protein regulates removal of toxic plaques from brain.
which could be a potential therapeutic target for the treatment of Alzheimer disease. In a study that appeared in a recent edition of Nature Neuroscience,
which is known a genetic risk factor for Alzheimer disease. Alzheimer is the most common type of dementia
characterized by the loss of memory and other mental abilities linked to an accumulation of amyloid-beta and other toxic compounds in the brain.
disable amyloid-beta from being cleared out of the brain across a region known as the blood-brain barrier. here have been many new genes discovered to be associated with Alzheimer disease,
director of the Zilkha Neurogenetic Institute and holder of the Mary Hayley and Selim Zilkha chair for Alzheimer Disease research at the Keck School of medicine. ur new study shows that a deficiency in PICALM in blood vessels
and its variants associated with increased risk for the disease inactivate amyloid-beta clearance from the brain,
and brings to light novel potential therapeutic targets for increasing amyloid-beta clearance in Alzheimer disease.
Autopsies from Alzheimer patients and recent research in experimental models have shown the importance of brain blood vessels in the disease initiation and progression.
Zlokovic and his research team have studied the cellular and molecular mechanisms of brain blood vessels that maintain normal cognition with hopes of developing new treatments for Alzheimer and other neurodegenerative diseases.
and using transgenic animals to model the disease, the group found that low levels of PICALM in brain endothelial cells lead to amyloid-beta accumulation in the brain.
Genetic variants associated with the PICALM gene have been shown to increase the risk of Alzheimer disease.
could ultimately help researchers develop new approaches to preventing cognitive decline in disorders such as Alzheimer disease.
In previous research into Alzheimer disease in mice, the researchers found that even in the presymptomatic phase of the disorder,
neurons in the hippocampal region of the brain contain a large number of DNA lesions, known as double strand breaks.
even though conventional wisdom dictates that DNA lesions are very bad as this amagecan be mutagenic
and sometimes lead to cancer it turns out that these breaks are part of the physiological function of the cell,
he says. anticipate that this advance will have broad implications ranging from the basic biology of transcription to pathological mechanisms involved in diseases such as Alzheimer disease
and schizophrenia resist complete reprogramming. A team of researchers led by the University of Cambridge has described for the first time in humans how the epigenome the suite of molecules attached to our DNA that switch our genes on
and schizophrenia resist complete reprogramming. Although our genetic information the ode of lifeis written in our DNA,
Professor Azim Surani from the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge, explains:
However, data analysis of human diseases suggests that such genes are associated with conditions such as schizophrenia, metabolic disorders and obesity.
and epigenetic reprogramming that subsequently impacts human development and disease. Unique Gene Regulatory Network Resets the Human Germline Epigenome for Developmentby Walfred W c. Tang
In many central nervous system diseases, the dendritic spine density is altered. nderstanding of the molecular mechanisms underlying the initiation process of dendritic spines enables us to manipulate their initiation rate and density.
this knowledge can be helpful in the development of therapeutic interventions for neurological diseases underlined by altered dendritic spine density, such as autism spectrum disorder, Schizophrenia or Alzheimer's disease.
#Injectable Device Delivers a Nano-View of the Brain Promise against disease in electronic scaffolds.
and treat everything from neurodegenerative disorders to paralysis. Sounds unlikely, until you visit Charles Lieber lab. Led by Lieber, the Mark Hyman Jr.
also known as Lou Gehrig disease, has been discovered by scientists at the CHUM Research Centre and the University of Montreal.
or at least slow the progression of such neurodegenerative diseases as ALS, Alzheimer, Parkinson and Huntington diseases.
and trigger the disease, said Alex Parker, CRCHUM researcher and associate professor in the Department of Neuroscience at the University of Montreal.
Amyotrophic lateral sclerosis is a neuromuscular disease that attacks neurons and the spinal cord. Those affected gradually become paralyzed and typically die less than five years after the onset of symptoms.
the person develops the disease. Scientists introduced a mutated human gene (TDP-43 or FUS) into C. elegans,
and suffered far less paralysis, she added. This study highlights a never previously suspected mechanism:
that system triggers a misguided attack against the worm own neurons. he worm thinks it has a viral or bacterial infection and launches an immune response.
because we caused the disease. This allows us to administer treatment very early in the worm life.
But ALS is a disease of aging, which usually appears in humans around the age of 55.
But we have demonstrated clearly that blocking this key protein curbs the disease progress in this worm
10.1038/ncomms8319abstractneurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neuronsamyotrophic lateral sclerosis (ALS) is a neurodegenerative disease thought to employ cell nonautonomous
mechanisms where neuronal injury engages immune responses to influence disease progression. Here we show that the expression of mutant proteins causative for ALS in Caenorhabditis elegans motor neurons induces an innate immune response via TIR-1/Sarm1.
recruiting a pathogen resistance response that is ultimately harmful and drives progressive neurodegeneration. eurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neuronsby Julie Vérièpe, Lucresse Fossouo and J Alex
#Imaging Technique Provides Color Coded Map Showing Cancerous Brain areas New imaging technique could make brain tumor removal safer and more effective,
When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible
while keeping crucial brain tissue intact and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient brain showing
and are not cancer. A summary of the research appears June 17 in Science Translational Medicine. s a neurosurgeon,
I in agony when I taking out a tumor. If I take out too little the cancer could come back;
too much, and the patient can be disabled permanently, says Alfredo Quinones-Hinojosa, M d.,a professor of neurosurgery,
thought OCT might provide a solution to the problem of separating brain cancers from other tissue during surgery.
Kut first built on the idea that cancers tend to be relatively dense, which affects how they scatter
Once they had found the characteristic OCT ignatureof brain cancer, the team devised a computer algorithm to process OCT data and,
nearly instantaneously, generate a color-coded map with cancer in red and healthy tissue in green. e envision that the OCT would be aimed at the area being operated on,
and the surgeon could look at a screen to get a continuously updated picture of where the cancer is
and in surgeries to remove brain tumors from mice. The researchers hope to begin clinical trials in patients this summer.
The system can potentially be adapted to detect cancers in other parts of the body, Kut says.
In the process, they considered three important features of the disease: loss of neurons, reduced metabolism and deposition of amyloid protein in the affected brain areas.
but does not lead to the deficits otherwise associated with advanced stages of the disease.
It can therefore remain largely intact even in advanced stages of the disease. ur findings also lend support to a theory previously proposed in connection with other studies that found stronger network connections between the anterior gyrus cinguli and other nodes
This suggests that this area of the brain also provides specific compensatory functions as the disease progresses,
For someone suffering from paralysis or limited mobility, visiting with other people is extremely difficult.
was able to interact with whoever the robot crossed paths with. ach of the 9 subjects with disabilities managed to remotely control the robot with ease after less than 10 days of training,
The TOBI project, funded by the European commission, aims at developing brain-machine interfaces for people with disabilities to control telepresence robots or a wheelchair using only mental commands.
Will robots soon become a fact of daily life for people suffering from a disability?
and active prosthetics. se of Brain MRI Atlases to Determine Boundaries Of age-Related Pathology: The Importance of Statistical Methodby David Alexander Dickie, Dominic E. Job, David Rodriguez Gonzalez, Susan D. Shenkin,
and looked at the longstanding theory that pain is transmitted from the site of injury or inflammation through the nervous system using an immune system cell called microglia.
this work provides a novel conceptual framework for further studies aimed at identifying the molecular underpinnings of neurodevelopmental disease and psychiatric illness. pecifically,
and reacts to changes in the environment can help us to find new ways to treat neurodegenerative diseases and mental illness. ource:
#Detecting Eye diseases With Help of a Smartphone Researchers at the Medical and Surgical Center for Retina developed software that detects eye diseases such as diabetic macular edema using a smartphone.
The system is aimed at general physicians who could detect the condition and refer the patient to a specialist.
and uses the camera of the phone to detect any abnormality in the thickness of the retina. he idea is to detect
and prevent diseases in general practice. We are not replacing the specialist we want to know which patients have a disease
and make an early detection, says Dr. Juan carlos Altamirano Vallejo, medical director of the Medical and Surgical Center for Retina.
with this tool, detect certain abnormalities and send the patient to the specialist. sing the software will reduce costs
immediate results will be obtained. e start off the fact that it is much cheaper to prevent than to cure blindness. he app also has utility in rural communities,
because equipment to detect these diseases are expensive and so far only the visiting specialist can do this kind of diagnosis. t will help those that
#Novel Disease Gene Linked to Neurodegenerative Disorders Identified Researchers at the University of Miami (UM) have discovered
and characterized a previously unknown disease gene linked to the degeneration of optic and peripheral nerve fibers.
cause an optic atrophy spectrum disorderis published in the journal Nature Genetics. Patients with mutations in this gene present symptoms similar to optic atrophy and Charcot-Marie-Tooth Type 2 (CMT2), including vision loss and weakening of the lower leg and foot
muscles beginning in the first decade of life. The novel variants occur in a gene called SLC25A46 that functions in mitochondria
Ph d. student in Neuroscience at the UM Miller School of medicine and first author of the study. lthough we study rare diseases such as CMT2 and optic atrophy,
the implications encompass all forms of neurodegeneration including Lou Gehrig and Parkinson Diseases. Mitochondria constantly undergo fusion
Given the similarities between the diseases caused by mutations in OPA1, MFN2 and SLC25A46, these genes could be involved in common pathological mechanisms of neurodegeneration,
the study says. his finding builds on our discovery of MFN2 as a major disease gene in this area over 10 years ago,
said Dr. Stephan Züchner, professor and chair of the Dr. John T. Macdonald Foundation Department of Human genetics, at UM Miller School of medicine,
#Herpes used in cancer treatment Researchers used a modified herpes virus to successfully treat patients with aggressive skin cancer
and believe the method could pave the way for a new generation of cancer treatments.
said Dr Kevin Harrington, professor of biological cancer therapies at the Institute of Cancer Research London (ICR),
The herpes-based drug is called T-VEC and has already been sent to the US Food
durable benefit for people with melanoma, said Dr Harrington. Professor Paul Workman, Chief executive of the ICR, said in a statement,
and kill human cells that can make them such promising cancer treatments. Australian has one of the highest rates of skin cancer in the world and according to the Cancer Council,
two in three Australians will be diagnosed with skin cancer by the time they are 70. While the trials have provided great optimism in regards to future cancer treatments,
the successful results have yet to be replicated. The Australian Cancer Research Foundation refrained from commenting on the story
and are waiting for more clinical trials to be done in the field of virotherapy and cancer.
However Dr Hayley Frend, science information manager at Cancer Research UK said she was excited by the results. sing a virus to both kill cancer cells
and nudge the immune system into attacking them is exciting, she said. While previous testing has shown benefits of such treatments,
People with similar injuries have controlled previously prosthetic limbs using implants placed in their motor cortex an area of the brain responsible for the mechanics of movement.
but this is not possible for people with a spinal injury because the messages from the nerves cannot reach the brain.
"At present, if you lose an arm, a leg or soft tissue as part of cancer treatment or burns,
but what about that time you had measles or was it chicken pox? Your blood knows:
It could also be used to identify links between viral infections and mysterious diseases like chronic fatigue syndrome.
and could help doctors identify hidden infections.""A lot of people have hepatitis C, for example, without realising,"says Elledge.
You could imagine routinely screening people in this way, he says. To develop Virscan, Elledge and his colleagues used an international database to look up all viruses known to infect humans around 1000 strains from 206 viral species. Using this information,
so you might not find a strong antibody response in the early stages of an infection.
as a result of an infection and those triggered by a vaccine. Instead the technique might be useful in outbreaks of new viruses. Understanding how our immune system responds to other viral fragments might reveal clues as to
For example, Elledge's team will be collaborating with another group to test people with chronic fatigue syndrome,
to see if they might have been infected with any of the same viruses."Multiple sclerosis is wheeled usually out as being linked to a virus,
He envisages screening wild populations of animals thought to be linked to emerging diseases.""You could test the wild bat population to get a good idea of
Wiring friendly bacteria to take out disease Matthew Wook Chang has opened an academy for assassins. His trainees are deadly.
It can wreak havoc in hospital wards, in the lungs of those with cystic fibrosis, and in the guts of premature babies.
and shell enter a wound. They can also self-amputate if they get too hot,
#Laser'tricorder'can diagnose malaria through the skin It's a weapon that fights malaria a laser scan can give an accurate diagnosis in seconds,
detecting malaria infections in only 20 seconds.""It's the first true noninvasive diagnostic, "says Dmitri Lapotko of Rice university in Houston, Texas,
whose team used the probe to correctly identify which person had malaria in a test of six individuals.
Malaria threatens half the world's population, killing 584,000 people in 2013. Existing tests for malaria are already quick,
taking only 15 to 20 minutes to give a diagnosis, but they could be simpler.
"The possibility of diagnosing a malaria infection with the device, without any blood-taking and with results available in seconds will provide a fantastic new tool for the control
and eventual elimination of malaria,"says Umberto D'Alessandro of the UK Medical Research Council Unit in Gambia."
and its capability of identifying infections with low densities of parasites in the blood,"says D'Alessandro,
if a patient has a dark skin a potentially huge pitfall given that children living in Africa account for the majority of malaria deaths.
#Finally, a way to catch symptomless pancreatic cancer in time It's the sneakiest of cancers and as many as 80 per cent of cases are identified too late.
The disease has one of the worst cancer survival rates, with less than 4 per cent of people living for five years or more after diagnosis. A major cause of this is that
The disease is identified only in time for curative surgery in about 15 per cent of people
when a person has the disease, giving us a way to test for it. The protein, glypican-1, sticks out from the surface of exosomes little globules that are thought to bud off from pancreatic cancer cells.
Raghu Kalluri of the University of Texas MD Anderson Cancer Center in Houston found that there is so much more glypican-1 in people with pancreatic cancer that a blood test can be used to accurately distinguish them from both healthy controls and people with the disease pancreatitis."
"The margin is always large enough to detect cancer exosomes, "says Kalluri. When to test?"
"says Nell Barrie of the charity Cancer Research UK.""This could, in turn, one day offer a way to spot diseases like pancreatic cancer at a much earlier stage,
although there is much more work to be done to develop this into an actual test, "she says.
and have a family history of the disease. The test could also be used for tracking the progress of therapies
His team found that the concentration of glypican-1 increases with the disease's severity,
potentially providing doctors with a measure for how advanced the cancer is and a way to monitor the effectiveness of treatments.
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