#Smart probiotics: Wiring friendly bacteria to take out disease Matthew Wook Chang has opened an academy for assassins. His trainees are deadly. By rewiring the genes of the common gut bacterium Escherichia coli, Chang has created a killer that can detect, chase down and destroy microbes that make us sick. His primary target is Pseudomonas aeruginosa, a bacterium that seizes any chance to infect people with weak immune systems. It can wreak havoc in hospital wards, in the lungs of those with cystic fibrosis, and in the guts of premature babies. In 2013, Chang put his assassins through their paces in a lab flask. They have since been hanging out in the guts of mice keeping them safe.""We're about to wrap up animal studies, "he says.""The survival rate of the mice was increased significantly.""He is now training up assassins for other targets s
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