illness

Illness

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Regulatory authorities such as the US Food and Drug Administration and the European Medicines Agency are set up to evaluate the effects of treatments on disease and disorders, not healthy people.

Every day, according to the company, 55 Filipinos die from water-related diseases. The company claims its prototype fits onto most taps,

once embedded under the skin monitors substances in the blood such as glucose and cholesterol so that chronic diseases like diabetes or the effects of treatments such as chemotherapy can be monitored.

16-year-old scientist and researcher Jack Andraka vowed to find a quick and cheap way to test for signs of the disease.

and MEK inhibitors are given to patients intermittently may reduce the aggressiveness of the disease...meaning patients could stay on therapy for more time,

This suggests that drugs that target Epha2 may prevent the development of new disease in patients who receive B-Raf and B-Raf/MEK inhibitor therapy y

"These same technologies can now be used to study the brains of people who died from unexplained neuropsychiatric diseases to determine

These findings which currently appear inbmc Genomics suggest that future therapies for this disease may need to be individualized.

Atherosclerosis is a common human disease associated with heart attack and stroke. Certain bacteria as well as high fat diet are associated with an increased risk for atherosclerosis.

sequencing of cell-free DNA soon after therapy may be used to detect minimal residual disease in solid tumors,

They discovered that byproducts of bacteria in gum disease, called metabolic small chain fatty acid (SCFA),

The researchers speculate that byproducts from other bacteria infections in other diseases might change gene expression using similar mechanisms.

their findings further support how important it is to treat bacterial infections in gum disease early.

In the interaction between gum disease and HIV, five SCFA byproducts from two prevalent oral bacteria--Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn)--are involved in activating resting immune T-cells carrying latent (inactive

"The impact on waking up T-cells and activating HIV replication was a"double whammy"find that contributes to understanding the little-known microbiome in HIV disease,

That prompted the researchers to investigate the mechanism that drives the replication of the virus in gum disease.

As long as the patient is free of gum disease, the virus sleeps and remains in check, Karn said d

#UCSD Study Shows Why Protein Mutations Lead to Familial Form of Parkinson Disease Researchers at the San diego Supercomputer Center (SDSC) at the University of California, San diego, have shown for the first time why protein mutations

lead to the familial form of Parkinson disease. The study, available online in prepublication in ACS Chemical Neuroscience and partially funded by the National institutes of health, focuses specifically on alpha-synuclein (asyn), a protein

which represents the major structural component of Lewy bodies protein clumps found in the brains of individuals with Parkinson disease and other neurological disorders.

Parkinson disease is characterized by impairment or deterioration of neurons in an area of the brain known as the substantia nigra In the familial form of the disorder,

which these mutations caused disease. s an unstructured protein, asyn is called sometimes hameleonbecause it has no stable configuration

researchers could not say why these mutations caused Parkinson disease, said Tsigelny. he discovery of Zone 2 as the distinguishing feature of the membrane-penetrating configurations of asyn paves the road to possible prevention of such a binding.

and it provides important information for a possible future hemoplasma vaccine. ur findings could help prevent the disease in cats

who is also a member of UCLA Jonsson Comprehensive Cancer Center. e combined the thermoresponsive system with downstream mutational analysis to successfully monitor the disease evolution of a lung cancer patient.

#Biogen idec Columbia to Conduct Collaborative Genetics Research Biogen idec and Columbia University Medical center have formed a $30 million strategic alliance to conduct genetics discovery research on the underlying causes of disease

The agreement will integrate genomics research conducted at Columbia with Biogen idec understanding of disease mechanisms and pathways,

and there is growing recognition that the elucidation of the genetic causes of disease will have a transformative effect on both patient care

and drug development in many different diseases said David Goldstein, Phd, founding director of Columbia University Institute for Genomic medicine. his collaboration marries the exceptional drug development expertise of Biogen with cutting-edge genomics expertise at Columbia University Medical center.

or unique disease presentations and to explore the connections among genes, pathways, and disease processes.

The ultimate goal will be to provide multiple qualified targets for new therapeutic approaches, increasing the potential for the development of new treatments. his collaboration with Biogen,

with its focus on the genetic causes of diseases, fits in perfectly with Columbia commitment to precision medicine,

It will allow for rapid population-scale DNA sequencing across a broad range of disease areas, focusing on diseases with significant unmet clinical need such as amyotrophic lateral sclerosis (ALS) and idiopathic pulmonary fibrosis.

he strong clinical and basic science programs in neurodegenerative diseases at Columbia will significantly benefit from the Columbia/Biogen alliance.

We expect that the alliance will dramatically advance our understanding of the genetics of these devastating diseases and ultimately lead to mechanism-based treatments, a key aspect of Columbia precision-medicine initiative. c

causing the spread of disease. But western-style toilets require sewage lines and treatment plants that aren feasible in many places.

Early diagnosis and management of the disease is fundamental, but in spite of the fact that it is inherited in up to half of all cases,

That means several different genes may cause the disease. INHERITANCE researchers have worked to characterise different types of DCM,

and they undertook genetic studies to explore the molecular makeup behind the different mutations that cause the disease.

meaning researchers can identify family members at risk before they develop the disease. They have developed also ground-breaking,

even in the early phases of the disease. nother major achievement of INHERITANCE has been to provide policy makers with a healthcare model that can be applied across the continent,

28th february 2014 Rare Diseases Day 2014 Project details Project acronym: INHERITANCE Participants: Italy (Coordinator), France, UK, Nederlands, Spain, Denmark, Germany, Sweden FP7 Proj.

People developing symptoms of schizophrenia don usually attribute their altered sense of reality to an illness.

The blood test could also help to detect the disease in the early stages, improving the chances of successful management.

the partners wanted to advance the understanding of these diseases in general, so as to generate leads for the development of new drugs,

It causes lung diseases like the malignant form of cancer called mesothelioma. Yet asbestos is still with us.

while the International labour organization (ILO) estimates that 100,000 workers worldwide die each year from all asbestos-related diseases.

#The artificial hand that'feels'like a real one As far as medical research has come towards treating illness and injury,

and in recent years, new technologies have improved steadily the odds of beating the disease. According to the Organisation for Economic Cooperation and Development (OECD), the five-year survival rate for breast cancer in most member countries is now over 80%.

What kind of diseases has had the patient before? Are there any earlier injuries, and what kind of injuries?

Unfortunately, when it comes to disease, complex diseases are also the most common ones. Over-forested and degraded land is threatening the country's wealth of biodiversity.

Agricultural lands for olive orchards and other crops are being damaged. Unregulated quarrying has deteriorated coastal mountain ecosystems and soil quality.

which is based on an ultra-sensitive detection system that is able to pick up minute concentrations of disease-related molecules in body fluids.

these sensors could then clearly identify the disease'biomarkers'the telltale signs of diseased cells.

the stronger the signal and the better the ability to'sense'it the greater the chances of detecting disease.

and would enable much earlier diagnosis of the disease. Writing in Nature Nanotechnology, Dr de la Rica and Professor Stevens also state that affordable methods for detecting disease biomarkers at ultra-low concentrations can potentially improve the standard of living in countries lacking costly

medical resources. Current strategies for ultra-sensitive detection often require sophisticated instruments that may not be available in laboratories with fewer resources

and more effective route to the creation of vaccines to combat some of the most devastating diseases affecting farm livestock.

the PLAPROVA consortium focused on the use of plants proteins to produce vaccines against diseases such as avian flu, bluetongue, foot and mouth disease,

usually in a matter of months from the time the strain of disease is first indentified.

This is now being tested for its ability to protect plants from disease -and it is possible it will also be able to influence wound healing in human tissue.

#Expanding insight into Alzheimer's disease Chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's, are all characterised by an inflammatory reaction within the brain.

The fellow, Diego Gómez-Nicola, from the CNS Inflammation group at the University of Southampton in the United kingdom, examined how a specific cell protein receptor called CSF1R controls the spread and inflammation in neurodegenerative diseases.

As part of the European union (EU)- funded Marie Curie project called PRONEURODEG, Gómez-Nicola discovered that a laboratory drug targeting the identified protein could help effectively combat the disease.

I was able to delay the symptoms of the disease and also prevent the loss of neurons,

which slowed the onset of the clinical and pathological course of prion disease, and extended the survival rate,

He found that some activity during the disease compensated for cell death at the hippocampus,

says the research looked at an aspect that all neurodegenerative diseases have in common: the activation of immune cells and their increase in number.

It has allowed also the resurgence of'old'diseases that we thought were things of the past,

the decision opened the way for trials of other plant-derived medicines to treat a range of diseases.

Meanwhile, other diseases for which it is envisaged that GM plants could provide new drugs include cancer, rheumatoid arthritis and others which,

"Under study in Barcelona is the complex disease, Binge Eating Disorder, which leads to a total loss of control when eating.

so we thought they can provide effective complimentary therapies in different diseases. This videogame is like a bonding factor between patients and their therapists and doctors."

The Consortium has developed the core e-Infrastructure (neugrid) required to develop disease markers on extra large brain imaging datasets.

Core grid-based applications have been integrated of acknowledged utility for early diagnosis and disease marker development.

Early diagnosis and disease markers to test drugs quickly and efficiently are critical success factors.

Extra large brain imaging datasets are lately available that will allow to develop disease markers. The community of imaging scientists working on Alzheimer's disease need new powerful environments to perform experiments on such datasets.

and Genève (CH), representing the community working in the fields of Alzheimer's and other neurodegenerative diseases,

and psychiatric diseases including bipolar disorder and schizophrenia. Four technical partners based in Archamps (FR), Paris (FR), Bristol (UK),

The neugrid e-infrastructure is so far the first and only European effort aiming to offer a distributed working environment to computational neuroscientists. neugrid has been developed for the front runner community of neuroscientists working in the field of Alzheimer's disease and other neurodegenerative diseases (i e.

They are now working to bring their low-cost innovations to market quickly a boost to the global battle against this deadly disease.

and 600 000 die from the disease, mostly children and women in Africa, according to the World health organization.

The netherlands-based research company specialises in developing products to control disease-transmitting insects. have been working in the field of malaria research for the past 22 years,

By this time, the chronic disease arsenicosis has set in. Prevention is the only way to stop it, the experts lament.

and the Centers for Disease Control and Prevention, is measured even more, stating that current evidence is not conclusive

"It's quite plausible that there would be excess reporting in people who suffered a life-threatening disease.

and could provide a new way to deliver drugs to specific areas within the eye relevant to these diseases.

In the second disease corneal neovascularization corneal injury results in the growth of unwanted blood vessels that impair vision.

##and could become the first treatment technique to use microneedles for delivering drugs to treat diseases in the front of the eye.

In the United states alone human noroviruses cause 19 million to 21 million cases of illness everyâ#year

Copsin belongs to the group of defensins a class of small proteins produced by many organisms to combat microorganisms that cause disease.

unless you have an animal model that mimics the Ebola virus disease spectra##says study coauthor Ralph Baric professor of epidemiology at the University of North carolina at Chapel hill.

Typical laboratory mice usually do not develop humanlike Ebola disease including the severe symptoms that can prove fatal in humans.

and if some are susceptible could they harness the power of mouse genetics to figure out what genes make someone susceptible to the disease.

when infected with the virus. The team was able to show that a combination of genes were involved in producing a range of disease symptoms such that the genetic variation of the mice directly led to the variety of symptoms that the disease produced.

and affect disease development is absolutely critical to creating much needed therapeutic interventions.####says William Fischer an assistant professor of medicine who has treated Ebola patients in Africa.##

but Ebola actually produces a range of disease symptoms.####During an outbreak it is often difficult to assess the role that genetic variation plays in determining disease severity in people.

And if we re going to develop treatments then we need to know about this genetic variation.##

To study the cellular properties associated with the disease the investigators now are taking skin cells from patients with Huntington s disease

Previous studies have uncovered links in adults between shorter telomeres and premature death more frequent infections and chronic diseases.

and Sierra Leona could be infected with Ebola by late January according to the US Centers for Disease Control and Prevention.

and difficulty of diagnosing the disease when a patient is seen first. Conventional fluorescent label-based virus detection methods require expensive lab equipment significant sample preparation transport and processing times and extensive training to use.

The device could be used to diagnose Ebola and other hemorrhagic fever diseases in resource-limited countries.

and hemorrhagic fever diseases our collaborative research effort has produced a highly sensitive device with the potential to perform rapid diagnostics in clinical settings.##

#Diabetes may raise risk for heart valve disease Rice university right Original Studyposted by Mike Williams-Rice on October 21 2014 There appears to be a link between high blood sugar and heart valve hardening.

The results that high glucose concentration can also cause pathologic remodeling by the aortic-valve cells could suggest that diabetes is also directly a cause of aortic-valve disease he adds.

We know that calcific aortic-valve disease is associated heavily with metabolic syndrome which can lead to type 2 diabetes.

To understand any heart valve-related disease we need to understand the mechanism of how the cells interact with excess lipids

He also notes that the research may have implications for neurodegenerative diseases. Researcher from Harvard university collaborated on the project

#Can mom s age help predict mitochondrial disease? The discovery of a aternal age effectfor mitochondrial diseases could be a valuable tool for genetic counseling, report researchers.

Their findings could be used to predict the accumulation of MITOCHONDRIAL DNA mutations in maternal egg cells, as well as the transmission of these mutations to children.

These mutations cause more than 200 diseases and contribute to others such as diabetes, cancer, Parkinson disease,

and Alzheimer disease. The study found greater rates of the MITOCHONDRIAL DNA variants in children born to older mothers,

and that contain their own DNA. any mitochondrial diseases affect more than one system in the human body,

They are devastating diseases and there is no cure, so our findings about their transmission are very important.

Studying healthy individuals gave the researchers a baseline for future studies of disease-causing mutations.

This finding is especially important for mothers who have a mitochondrial disease. For many mitochondrial diseases, 70 to 80 percent of molecules need to have the disease-causing variant for the disease to manifest itself.

But for others, only 10 percent of the mtdna molecules with the variant are needed to cause disease. f the bottleneck is very small,

as wee found in our study, these percentages can change dramatically, Makova says. nowing the size of the bottleneck allows us to predict, within a range,

the percentage of disease-carrying molecules that will be passed on to the child. Knowledge about both the maternal age effect and the bottleneck size is useful in family planning. e have some predictive power now

and can assist genetic counselors in advising couples about the chances of mitochondrial diseases being passed to the next generation,

Researchers studied roughlyâ#80000 households from 600 villages and found a 64 percent drop in mortality from diseases covered by insurance.

##Rates of early death and illness from chronic conditionsâ##such as heart disease and cancerâ##have increased dramatically in India in the past few decades putting the poor at high risk of not having access to services they need

The Centers for Disease Control and Prevention projects that 40 percent of all Americans now alive will develop type 2 diabetes.

Researchers say it s important to find a suitable medication to correct the cause of the disease as quickly as possible

The majority of patients who succumb to cancer fall prey to metastatic forms of the disease says Jennifer Cochran an associate professor of bioengineering at Stanford university.

The findings which appear in PLOS Pathogens provide knowledge that could help researchers treat the disease more effectively.

For years the conventional approach to target the dengue virus was through control of the vectorâ the mosquito that carries the disease from one host to another.

It is exciting to be involved in the development of new diagnostic approaches for this deadly disease says Martin Antonio head of the TB diagnostics laboratory at the Medical Research Council Unit in The gambia.

and more convenient monitoring of patients with chronic anemia the device could help patients receive treatment before the disease becomes severe potentially heading off emergency room visits and hospitalizations.

The team also plans to study how the test may be applied to specific diseases such as sickle cell anemia.

Mounting evidence suggests that these microscopic teeming communities play a role in human health and disease treatment and transmission.

and in our environmentâ but it only causes disease when our immune systems are disrupted otherwise. Home microbiome studies also could potentially serve as a forensic tool Gilbert says.

and diagnose cardiac disease using contactless video monitoring##says Jean-Philippe Couderc from the University of Rochester Medical center s Heart Research Follow-up Program.

Â#More than three million Americans suffer from the disease. While the condition can be diagnosed readily it often goes undetectedâ

According to the Centers for Disease Control and Prevention 15 to 25 percent of hospitalized patients receive urinary catheters during their hospital stay.

what diseases and when additional booster shots are needed. The new electronic registry system will help overcome the lack and loss of information

but most severely the lungs and currently it can take several months to measure how effective treatment is for the early-fatal lung disease.

The new imaging method which was developed using a synchrotron x-ray source may also open up possibilities in assessing how effective treatments were for other lung heart and brain diseases.

and diseases but only if we can figure out how they are generated in the first place. Our study brings this possibility a step closer##he says.

Scientists believe gut microbes play a part in the disease.####Research has made not an impact in either prevention

and possibly Alzheimer and Parkinson diseases.""The continuity field smoothes what would otherwise be a jittery perception of object features over time,

Some of the most damaging brain diseases can be traced to irregular blood delivery in the brain.

though, the technique provides a new technique for studying human cerebral-vascular diseases, such as stroke and migraines, in animal models.

and Parkinson diseases might elicitr be caused in part byhanges in blood flow to certain parts of the brain.

NIR-IIA imaging might offer a means of better understanding the role of healthy vasculature in those diseases,

thus gradually eliminating the disease from the Newfoundland breed, says Joshua Stern, a veterinary cardiologist at the University of California, Davis,

This same gene mutation has been associated with the formation of plaque-like lesions in the brains of people with Alzheimer disease,

which only one parent needs to be carrying the gene mutation in order for the offspring to inherit the disease,

and that not all dogs carrying the mutation will develop the disease. SAS shows up in the dog heart as abnormal tissue growthften forming a ridge or ring below the aortic valve,

because the disease may appear in mild to severe forms. The first sign that a dog has SAS may be a collapse,

Veterinarians sometimes discover the disease when they detect a heart murmur and conduct further diagnostic tests such as chest X-rays,

#Wearable vapor sensor can smell diabetes A wearable vapor sensor could monitor diseases such as diabetes

or released through the skin. ach of these diseases has its own biomarkers that the device would be able to sense,

or lung disease. Fan is developing the sensor with Zhaohui Zhong an associate professor of electrical and computer engineering,

Other applications Beyond disease monitoring, the sensor has other applications. It would be able to register the presence of hazardous chemical leaks in a lab,

BIOPSY CANCER The Cell paper focuses on the use of PACT and PARS as research tools for studying disease and development in research organisms.

and potentially change the trajectory of the illness so that it is less likely to be chronic

The Centers for Disease Control and Prevention (CDC) calls insufficient sleep an epidemic and says it linked to vehicle crashes, industrial disasters,

and chronic diseases such as hypertension and diabetes. The researchers conducted experiments to gauge the effect of insufficient sleep on memory.

so that doctors can stop the disease in its tracks before it takes hold and kills.

Penn State Embedded journalists offer dark view of Afghan war The disease, which is caused by the malaria parasite, kills 1. 2 million people every year.

As a result the disease is spotted often only when the parasites have developed and multiplied in the body.

Professor Leann Tilley from the University of Melbourne says the test could make an impact in large-scale screening of malaria parasite carriers who do not present the classic fever-type symptoms associated with the disease. n many countries only

either individually or together. y combining the two molecules into one we got much greater potency against several diseases and completely unique effects in terms of blocking tumor growth and metastasis. LUNG AND BREAST TUMORS Both

The research could eventually lead to the development of a safe vaccine against strep throat, necrotising fasciitis (flesh-eating disease),

Previous efforts to develop a strep throat vaccine had resulted in immune system reactions that caused other diseases such as rheumatic fever

The group A carbohydrate was thought previously to play a largely structural role in the bacteria cell walls. e have confirmed now that it actually plays a critical role in how the bacteria resist the immune response. his may trigger diseases such as rheumatic heart disease,

#Common virus targets triple-negative breast cancer A virus not known to cause disease kills triple-negative breast cancer cells

and also to probe the origins of brain diseases. CLEARING OUT THE FAT When you look at the brain

Many groups have begun to apply CLARITY to probe brains donated from people who had diseases like epilepsy or autism

and eventually treat the disease. But scientists, including Deisseroth, had been wary of trying electrophoretic CLARTY on these valuable clinical samples with even a very low risk of damage. t a rare and precious donated sample,

Another new aspect of the study is worked that it with patients who had been diagnosed long with the disease.

the majority of patients living with the disease have been living with the disease for a long time, so people become disenfranchised from the research process.

and prevent the disease, Schatz says. his study is a step in that direction, toward a biological cure.

The researchersnext step will be to recruit patients who have been diagnosed newly with the disease to conduct a larger trial.

Haller says he hopes the approach will help patients manage their disease more easily. f we can confirm the results in a larger effort,

and cure this disease, but we have to crawl before we walk, and walk before we run.

and monitor for diseases like glaucoma. The sensor would be embedded with an artificial lens during cataract surgery

a group of diseases that damage the eye optic nerve and can cause blindness. Right now there are two ways to check eye pressure,

many patients with the disease aren diagnosed early enough or aren on an accurate treatment plan.