Medicinal cannabis has been legalised in 23 US states as a therapy to treat disease or alleviate symptoms,
Separately, a similar Novartis gene therapy trial is under way to help restore hearing in people who have become deaf through damage or disease.
There are currently no approved disease-modifying treatments for disabling hearing loss, which affects some 360 million people,
disease or exposure to certain drugs, including some antibiotics. But it will not help the one to three babies per 1
which is an imperfect model for human disease
#Lexus builds car with human HEARTBEAT in connection between driver and vehicle Lexus has built a car that pulsates with light in time with the driver's heartbeat in order to display the connection between the driver and the car.
000 people in Britain, 85 per cent of them with the dry form of the disease.
which is known as Stargardt disease. For Kathy, a blind spot takes up the majority of her vision.
like heart disease or diabetes. revention is the most viable approach to reduce the socioeconomic burden of chronic and widespread diseases,
such as cardiovascular and metabolic diseases, they write. Clinical trials of the device will begin next year at three sites in France
or complete eradication of all diseases and poverty is up for debate. But the fact is this is going to have an impact bigger than any other impact that man has seen before.
#Powerful MRI SCANNERS could predict diseases Cutting-edge technology, designed to delve deeper into the human body, has arrived at a research centre in Portugal.
In the future, diseases could be predicted in advance. n the normal scanners, the spinal cord is too blurry and we don distinguish too many fine details.
Champalimaud Foundation. here are some very important diseases of the spinal cord, like multiple sclerosis. So when the diseases begin,
there are some microstructural changes in the spinal cord. For example, the diameter of the cell can change,
if the person is going to have a disease or not, or if he is in an early stage.
to carry out comprehensive analysis of some brain diseases, the brain has to be cut and examined after death.
during depression. epression is a widespread disease. It one of the major causes of disability worldwide.
The study looked at 301 acute and chronic diseases and injuries in 188 countries, finding that developing nations like India and China are now mimicking a trend that had began earlier in Western nations.
the most common form of the disease which is linked most often to obesity. Endocrinologist Anoop Misra told Times of India that diabetes was an escalating problem in India
Diabetes did no feature in the top 10 of India diseases in 1990, whereas it is the country eighth-biggest killer.
and lowering viral loads to virtually undetectable levelshese therapies cannot cure the disease alone. Once treatment is discontinued,
When disease-causing bacteria invade disease-resistant rice, a small protein produced by the bacteria betrays the invader.
Identification of the tiny protein, called Raxx, holds promise for developing more disease-resistant crop varieties and therapeutic treatments for blocking microbial infections in both plants and animals, say the researchers,
Disease protection for our food In this new study researchers discovered that the Raxx protein was present in at least eight species of the disease-causing Xanthamonas bacteria that are known to attack ricehe staple food for half of the world populations well as maize, cassava, sugar cane, tomatoes, peppers
, wheat, alfalfa, onions, banana, and citrus. ur research team is delighted to announce the discovery of the Raxx protein,
and disease resistance for more than two decades and in 1995 announced that a gene called Xa21 confers resistance to the bacterial blight pathogen.
and sparked further research into other key parts of the disease-resistance puzzle. Researchers were confident that
researchers were able to verify the same effect from just the mutation and link it to human disease.
professor of psychiatry at University of Iowa. o it really providing a new picture and new insight into the composition and function of the brain in bipolar disease.
The study is the first time this MRI technique has been used to investigate a psychiatric disease. One reason researchers didn know that the cerebellum might be important in bipolar disorder,
and other diseases that involve neurotoxic aggregation. MRI probe detects Alzheimer's at earliest stage Spurred on by the finding,
The researchers hope that the new insights provided by the T1 rho imaging might help refine understanding of the abnormalities that underlie bipolar disease
or even tissue death. any diseases result in inflammation, says Samir Mitragotri, professor of chemical engineering at University of California, Santa barbara,
Whether inflammation is a byproduct of the disease or the inflammation is the disease, it is a common indicator of a problem with the system. f we could target the common denominator,
whether the inflammation is coming from cancer or arthritis, we could deliver the drug there,
in a deal that expands the buyer gastrointestinal (GI) disorders and rare-disease portfolios, as well as its global footprint.
The NPS Pharma organization will be a welcome addition to Shire as we continue to help transform the lives of patients with rare diseases."
#Ultra-Fast Software Developed to Scan the Human genome Researchers at Nationwide Children's Hospital say they have developed an analysis pipeline that cuts the time it takes to search a person's genome for disease-causing variations from weeks to hours.
Rapid diagnosis of monogenic disease can be critical in newborns, so our initial focus was to create an analysis pipeline that was extremely fast,
and reveals some potentially important clues as to how the disease could be treated more effectively, stated Paul Workman, Ph d.,chief executive of ICR.
The goal of the new procedure is to avoid the transmission of mitochondrial diseases. Under the decision, the embryo would receive nuclear DNA from its mother and father along with healthy MITOCHONDRIAL DNA from a female donor.
Researchers at the Wellcome Trust Centre for Mitochondrial Research at Newcastle University estimate that about 2, 500 women of childbearing age in Britain carry mitochondrial disease.
We have great sympathy for families affected by mitochondrial disease and are opposed not in principle to mitochondrial replacement.
as well as disease-focused patient advocacy groups, regulators, and overseers such as institutional review boards, research ethics committees, investigators, their research institutions or universities, journals,
From these clinical features of the disease, the team predicted that there would be a block to the production of pain-sensing neurons during the development of the embryo.
Most often the majority of prostate cancer is thought of as an organ-confined disease with little genetic variation.
what they describe as a localized, multi-focal disease within the prostate gland, as well as identifying a new gene subgroup acting as a molecular driver for tumor progression. ur research shows how prostate cancers can vary from one man to anotherespite the same pathology under the microscopes well as how it can vary within one man who may have multiple
The data revealed that even small cancers within the prostate can contain very aggressive cells capable of varying long term disease prognosis.
The researchers identified C-MYC as being the driver of aggressiveness for the disease and L-MYC,
"This discovery of a new prostate cancer-causing gene gives researchers a new avenue to explore the biology of the disease
which gene is present to determine a patients'disease aggression in terms of the risk of spread outside the prostate gland at time of treatment,
As for pricing rare-disease drugs higher, Dr. Bach added: dispassionate economist would say that inefficient.
or at least slow the progression of such neurodegenerative diseases as ALS, Alzheimer's, Parkinson's, and Huntington's diseases.
and trigger the disease, said Alex Parker, Ph d.,CHUM researcher and associate professor in the department of neuroscience at the University of Montreal.
Amyotrophic lateral sclerosis is a neuromuscular disease that attacks neurons and the spinal cord. Those affected gradually become paralyzed and typically die less than five years after the onset of symptoms.
the person develops the disease. Scientists introduced a mutated human gene (TDP-43 or FUS) into C. elegans.
because we caused the disease. This allows us to administer treatment very early in the worm's life.
But ALS is a disease of aging, which usually appears in humans around the age of 55.
But we have demonstrated clearly that blocking this key protein curbs the disease's progress in this worm
The scientists believe that the inhibition of this enzyme could accelerate tissue recovery from injury, disease,
particularly in light of the huge disease burden of malaria,"explained senior author Manoj Duraisingh, Ph d.,professor of Immunology and Infectious diseases at the T. H. Chan School of Public health."
as it prevented cellular attachment in this parasite species as wellpening up the potential that calcineurin could target other parasitic diseases in addition to malaria."
and disease recurrence, then, Dr. Burris hypothesized, targeting glycolysis and lipogenesis could offer a way to stop a broad range of cancers.
and brings the risk of needle-related diseases and injuries. The new microneedle patch is made of dissolvable material,
which are linked closely to early embryonic development and to diseases such as cancer. In plants as in animals and humans, intricate molecular networks regulate important biological functions, such as development and stress responses.
leading to the onset of diseases. Now, VARI scientists report that they have unraveled how a plant protein known as TOPLESS interacts with other molecules responsible for turning genes off.
and how they interact with other molecules in health and disease states.""Although the new study provides further insight into human molecular pathways,
According to those findings, all individuals who received the vaccine were protected against Ebola virus infection within 6 to 10 days of vaccination. he results of this interim analysis indicate that rvsv-ZEBOV might be highly efficacious and safe in preventing Ebola virus disease
when delivered during an Ebola virus disease outbreak via a ring vaccination strategy, the study team concluded.
that enough. n the immediate vaccination group, there were no cases of Ebola virus disease with symptom onset at least 10 days after randomization,
whereas in the delayed vaccination group there were 16 cases of Ebola virus disease from seven clusters,
and Médecins sans Frontières. he extraordinary efforts of the team in Guinea and other experts have yielded interim results that suggest a potential role for our rvsv-ZEBOV vaccine in the fight against Ebola disease, Roger
and Sanitation and the U s. Centers for Disease Control and Prevention (CDC); The Partnership for Research on Ebola Vaccines in Liberia (PREVAIL) Phase II study being conducted by a Liberia-NIH partnership in Liberia.
and replacing it with a single Ebola virus gene that alone cannot cause the disease. In November 2014
Some also see potential for the portable paper power tech to create diagnostic tools for disease control in the developing world.
#Pill on a string pulls early signs of cancer As with every form of the deadly disease,
which has led researchers to hunt for signs of a condition that precedes the disease, known as Barrett's oesophagus.
or another that the disease was psychological, all in their head, said Dr Pimentel. he fact that we can now confirm the disease through their blood,
not their head, is going to end a lot of the emotional suffering I have seen these patients endure.
The discovery could also lead to new treatments for chronic bronchitis or chronic obstructive pulmonary disease (COPD), a disease that kills tens of millions of people every year and for
and it Will be Not-for-Profit The world first malaria vaccine has been given approval by a European medical agency for future use in Sub-saharan africa, where more than a quarter million children under the age of five die every year from the disease.
a disease-agnostic universal score for predicting patient readmission and mortality risk, Perahealth software automatically pulls data from any major electronic health record in real-time.
finding cures to Alzheimer and other diseases, developing new clean energy technologies, and promoting new advanced manufacturing opportunities.
such as disease fighting drugs from entering the nervous system. It only allows a selected few types of molecules to cross including water, some gases and lipid soluble molecules.
The scientists add that the method allows them to target multiple types of diseases by producing different carrier molecules.
which has been developing special carrier molecules for the past six years. t really opens the possibilities to use many different types of therapeutics for different diseases that we couldn really use before
Scientists add that it could become a significant step towards slowing the spread of brain diseases like Alzheimer, multiple sclerosis and Parkinson.
If the rods and cones that make up the photoreceptors of the eye fail because of injury or illness,
how proteins aggregate in the earliest stages of diseases like Alzheimer and Huntington, has begun just.
Understanding disease progression at the single-molecule level could help identify when early intervention might be advantageous.
This results in disease that kills about 700,000 children every year, and stunts the physical and mental development of many more,
whether they've been exposed to certain diseases. But now, researchers at Brigham and Women's Hospital in Boston say they have created a tool that could reveal many of the viruses that have infected a person in the past.
if individual viruses are correlated to other diseases, or try to figure out why only a fraction of patients"are helped by certain cancer treatments,
or other therapies safely to sites of disease are already seeing the light of day.
particularly for new therapies to combat motor neuron disease. Here we show direct optogenetic stimulation of skeletal muscle from transgenic mice expressing the light-sensitive channel Channelrhodopsin-2 (Chr2.
#Wize Mirror to Monitor Health, Prevent Cardio-Metabolic Diseases Seasoned primary care physicians often have an uncanny ability to notice symptoms by simply looking at their patients.
and help spot signs of cardio-metabolic diseases. There is a 3d scanning camera that notices changes to the structure of the skin,
Pseudomonas aeruginosa, a common disease-causing bacterium; Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species;
Pseudomonas aeruginosa, a common disease-causing bacterium; Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species;
and as we learn more and more about the responses the body has to disease and injury,
because it can't predict which men with elevated PSA levels will actually develop an aggressive form of the disease."
This is the first study to use PWS to predict a cancer prognosis, the likely course of the disease.
deadly form of the disease. However, because their prognosis is unknown, many opt for aggressive treatments that have side effects that cause urinary,
which funds transformative technological innovation designed to solve major medical problems with a substantial disease burden,
"and then attack the molecular structure of the disease. If laboratory research with mice is borne out in human studies,
and lung cancers into laboratory mice to represent metastatic disease-with one type of cancer implanted on each side of the brain.
"finding a nanothermometer sensitive enough at this scale is a great step forward in the field of nanotechnology, with applications in biology, chemistry, physics and even in the diagnosis and treatment of diseases
2015new sensing tech could help detect diseases, fraudulent art, chemical weapons June 1st, 2015thin coating on condensers could make power plants more efficient:
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,
its high concentration causes digestive malfunctions and results in the related diseases due to its toxicity.
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
2015researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th,
This venture holds great promise for using nanotechnologies to overcome cancer and other major diseases around the world.
said UCSB mechanical engineering professor Sumita Pennathur. t a big step forward in terms of bringing out nanofluidic technology to real biomedical applications of disease diagnosis
Because of their essential role in our immune response, they are useful clinical biomarkers for detecting prostate cancer and other diseases.
the team wanted to identify the presence of disease by detecting a particular glycoprotein which has specific sugars in a specific location in the molecule.
and collaboration with commercial partners, will open the door to adapting the current technology for other diseases.
Lots of diseases produce specific glycoproteins, so there are a number of possible avenues to improve the accuracy of our diagnoses
or die and thus, no longer able to cause disease.""One of the vexing problems in the development of drugs is drug resistance,
"Dr. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism,
Pseudomonas aeruginosa, a common disease-causing bacterium; Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species;
hold great promise for treating cancer and other diseases. However, several inefficiencies have limited their translation to the clinic,
Gail Bishop, a professor of microbiology at the University of Iowa Carver School of medicine and director of the schools Center for Immunology and Immune-Based Diseases, says that this paper presents a creative new approach with considerable
and putting them back into your body to fight your disease, whatever that may be, Sharei says.
A Universal Surface-Enhanced Raman Spectroscopy Substrate for All Excitation Wavelengths"),the photonics advancement aims to improve our ability to detect trace amounts of molecules in diseases, chemical warfare agents, fraudulent
#Intelligent bacteria for detecting disease Another step forward has just been taken in the area of synthetic biology.
in association with Montpellier Regional University Hospital and Stanford university, have transformed bacteria into"secret agents"that can give warning of a disease based solely on the presence of characteristic molecules in the urine or blood.
and are considered often to be our enemies, causing many diseases such as tuberculosis or cholera. However, they can also be witnessed allies,
Medical diagnosis is a major challenge for the early detection and subsequent monitoring of diseases.""In vitro"diagnosis is based on the presence in physiological fluids (blood and urine, for example) of molecules characteristic for a particular disease.
Because of its noninvasiveness and ease of use, in vitro diagnosis is of great interest. However, in vitro tests are sometimes complex,
in association with Professor Eric Renard (Montpellier Regional University Hospital) and Drew Endy (Stanford university), applied this new technology to the detection of disease signals in clinical samples.
The authors used the transcriptor's amplification abilities to detect disease markers, even if present in very small amounts.
"Our work is focused presently on the engineering of artificial genetic systems that can be modified on demand to detect different molecular disease markers,
In future, this work might also be applied to engineering the microbial flora in order to treat various diseases, especially intestinal diseases
decades of exposure to only slightly higher levels a level we wouldn even notice can increase the risk of heart and lung diseases,
For the authors of the research, finding a nanothermometer sensitive enough at this scale is a great step forward in the field of nanotechnology, with applications in biology, chemistry, physics and even in the diagnosis and treatment of diseases s
#Injectable nanoelectronics for treatment of neurodegenerative diseases It's a notion that might be pulled from the pages of science-fiction novel-electronic devices that can be injected directly into the brain,
such as viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases,
including HIV, hepatitis, herpes, and many others. The sensor will enable doctors to identify tumor markers,
So the new optical sensor will allow for diagnosing diseases long before they can be detected by any other method,
The relationship between genes and specific traits is complicated more than simple one-to-one relationships between genes and diseases.
but scientists are just beginning to explore how, specifically, genetic variations affect health and disease. Two major statistical challenges to finding these connections involve analysing associations between many different genetic variants and multiple traits,
"But the simple models we use to do this are too simplistic to uncover the complex dependencies between sets of genetic variants and disease phenotypes."
known as atherosclerotic vessel disease, is the leading cause of heart attacks and strokes that claim some 2. 6 million lives a year worldwide, according to the World health organization.
but not potent enough to stop the disease from advancing. Perhaps, most importantly, the team says,
and pumping dysfunction, the hallmarks of advanced disease.""Our experiments illustrate clearly that while content is important,
and its ability not merely to prevent disease but to mitigate some of its worst manifestations."
if a poor state of health is caused by disease or a lack of water anyway,
They contribute to the early detection of diseases that affect grapevines, such as flavescence dore and black wood, declares Stefano Sgrelli, Ceo of Salt&lemon.
It also helps improve our understanding of the development of some diseases that involve a defective transportation to the nuclear pores-such as intestinal ovarian and thyroid cancer r
and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
to treat specific diseases, with licensing potential for other products. Teva paid $35 million up front, with additional milestone payments as the device goes through clinical trials before it hits the shelves.
While its first partnership is for treating chronic diseases, Microchips Biotech will continue work on its flagship product, a birth-control microchip, backed by the Bill and Melinda Gates Foundation,
and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents.
for example as gene therapy to suppress the production of a disease-causing protein n
#Photonic crystal fibre: a multipurpose sensor Glass fibres can do more than transport data. A special type of glass fibre can also be used as a high-precision multipurpose sensor,
or die and thus, no longer able to cause disease. ne of the vexing problems in the development of drugs is drug resistance,
former Dean of the UK College of Pharmacy and current UK provost. r. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism,
which could help in warding colds, flu and other diseases. Two of Hinestrozas students created a hooded bodysuit embedded with insecticides using metal organic framework molecules,
we can reduce the symptoms of the disease in some cases, "says Fimiani.""Hopefully our study will encourage others to repeat our research
On the other hand, nanosilver could have potential applications in fighting bacterial diseases. Uncovering shape The shape of the surface of nanoparticles is key,
Pseudomonas aeruginosa, a common disease-causing bacterium; Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species;
and to certain diseases, said Hickson, who has devoted the last 15 years of his research life to cell biology.
enabling epigenomic analysis with a mere 100 cells A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation,
This epigenomic characterization potentially allows medical doctors to create personalized treatment of diseases, by understanding the state of a patient,
Chang Lu, a professor of chemical engineering at Virginia Tech, has worked on the development of tools to effectively analyze living cells with the long-term goal of gaining a better understanding of a range of diseases.
lead author of the study and a researcher at the U s. Centers for Disease Control and Prevention (CDC),
could be the key to better understanding disease Medical professionals everywhere may be stunned by a new discovery that overturns decades of textbook teaching.
Might scientists now begin to consider the possibility that something as basic as the body's plumbing system may well hold the key to solving dozens of disease riddles?
they do need to find new answers about the workings of the brain and the diseases that plague it.
That all diseases result in morbidity, that all morbidity forms blockages, and that all degenerative processes can be reversed naturally, thanks to a relationship between the blood stream and the lymphatic system,
not only detect the onset of sudden and serious illness that may incapacitate the driver, but also allow the car to monitor driver stress levels.
The USC Neurorestoration Center primary mission is to leverage partnerships to create unique opportunities to translate scientific discoveries into effective therapies. e are at a point in human research where we are making huge strides in overcoming a lot of neurologic disease,
and treatment of neurological diseases ranging from autism to Alzheimer disease to multiple sclerosis. nstead of asking,
Alzheimer, Autism, MS and Beyond The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both about the workings of the brain and the diseases that plague it.
For example, take Alzheimer disease. n Alzheimer, there are accumulations of big protein chunks in the brain,
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