| Apoptosis (26) |  |
| Assisted living (5) | |
| Autophagy (23) | |
| Caregiving (22) | |
| Apoptosis (26) | |
| Assisted living (5) | |
| Autophagy (23) | |
| Caregiving (22) | |
inflammation (a reaction to injury or infection) and autophagy (a cellular process involved in the removal of damaged cellular components.
especially since the inflammatory and autophagy pathways have been implicated previously in the disease, said Lucie Bruijn, Phd,
Both proteins are required for the normal function of inflammatory and autophagy pathways, and now we have shown that mutations in either gene are associated with ALS,
and switch on this process--known as autophagy.""This gives us a therapeutic avenue to target autophagy in tumors,
"said Josh Andersen, a BYU chemistry professor.""The idea would be to make tumors more chemo-sensitive.
You could target these proteins and the mechanism of this switch to block autophagy, which would allow for lower doses of chemotherapy while hopefully improving patient outcomes."
they forced tumor cells to undergo autophagy by depriving them of oxygen and glucose. A comparison with a control group let them see that the two proteins hook up only when under attack.
Andersen notes that several medicines already exist that could block autophagy and make chemotherapy more effective.
at UC San diego and colleagues found that a microrna known as let-7 controls autophagy through the amino acid sensing pathway which has emerged as the most potent activator of mtorc1 complex activity.
Autophagy is a fundamental process used by cells to degrade unnecessary components in times of starvation releasing energy stores that help promote cell survival.
Cells have adapted further autophagy for other purposes as well including recycling dysfunctional components immune response to pathogen invasion surveillance against cancer
and growth in cells. he ability of let-7 alone to activate autophagy in this way was totally unknown
and is very surprisingsaid La Spada. s let-7 is known to be a tumor suppressor its ability to activate autophagy could be a major component of its anti-tumor forming activitythough La Spada noted that autophagy may also contrarily promote tumor progression
and colleagues have shown that a lentivirus encoding let-7 injected into mouse neurons promotes the autophagic turnover of toxic misfolded proteins associated with neurodegenerative disease. e also demonstrate that treatment with anti-let-7 can block autophagy
Cancer cells maintain themselves by coopting autophagy, an energy harvesting process that is normally used to recycle damaged organelles and proteins.
And autophagy is especially important to cancer cells that have been cut off from nutrient pathways, due to the attacks of cancer drugs such as rampamycin (mtor) inhibitors.
a small molecule called SBI-0206965 that inhibits autophagy. Such a coordinated attack could effectively overrun cancer before it could muster one last defense,
The new drug targets ULK1, an enzyme that initiates autophagy. The drug, which was developed by scientists at Salk Institute
and Sanford Burnham Prebys Medical Discovery Institute (SBP), was described June 25 in Molecular Cell, in an article entitled, mall Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1
and discovered 15 phosphorylation sites in core autophagy proteins that were verified as in vivo ULK1 targets,
and it suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. In addition, SBI-0206965 combined with starvation or mtor inhibition leads to ULK1 degradation.
when we combined Reuben's deep understanding of the fundamental biology of autophagy with our chemical expertise,"says Cosford."
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