who worked with Cheng to create better cameras and software for CRYO EM. o it really a huge change in what possible. etter Camera, Better Picture Yet for a long time,
At 400 frames per second, the recording provides enough data so the motion correction software developed in Cheng laboratory can correct for the molecular motion and effectively nblurthe image.
#British Smartphone Eye-exam App Hoping to Reach Millions of Blind Worldwide Thirty-nine million people are blind across the world.
Now, a British team of eye specialists are hoping to attach the diagnostic tools onto an iphone,
EEK, which stands for portable eye examination kit, is a 3-D-printed attachment that can be attached to an iphone,
the hardware lead for the company. The company has started already taking pre-orders for PEEK,
Other diagnostic uses for smartphones have included using them as low-cost microscopes, in settings from the classroom to medically underserved areas r
'The team's work has been made possible not only by improvements in the technology for recording brain activity but also the OHBA's approach to the huge amounts of data from dozens of studies,
which enables them to analyse the data faster and more effectively in order to improve our understanding of how the brain works.
It could also provide information for the development of artificial intelligence. Source: University of Oxford v
#Data Scientists Find Connections Between Birth Month and Health Columbia University scientists have developed a computational method to investigate the relationship between birth month and disease risk.
The researchers used this algorithm to examine New york city medical databases and found 55 diseases that correlated with the season of birth.
The study was published this week in the Journal of American Medical Informatics Association. his data could help scientists uncover new disease risk factors,
Ph d.,an assistant professor of biomedical informatics at Columbia University Medical center (CUMC) and Columbia Data science Institute.
The researchers plan to replicate their study with data from several other locations in the U s
The new data are consistent with previous research on individual diseases. For example, the study authors found that asthma risk is greatest for July and October babies.
For ADHD, the Columbia data suggest that around one in 675 occurrences could relate to being born in New york in November.
A previous study using Austrian and Danish patient records found that those born in months with higher heart disease ratesarch through Junead shorter life spans. aster computers
a graduate student at Columbia. e are working to help doctors solve important clinical problems using this new wealth of data.
Louveau discovered the vessels after analyzing the meninges of a mouse. According to reports, the vessels were hidden very well
and they decided to collect samples from groundwater at a remediation site in Rifle, Colorado..
probing not only the acidic pools in abandoned mines and the contaminated groundwater at the Superfund cleanup site in Colorado,
painless patch could lower blood glucose in a mouse model of type 1 diabetes for up to nine hours.
the researchers inserted a core of solid insulin and enzymes specially designed to sense glucose.
The researchers tested the ability of this approach to control blood sugar levels in a mouse model of type 1 diabetes.
In mouse brains, as in human brains, adult neural stem cells reside on the walls of cavities called ventricles,
Alvarez-Buylla and his team traced the development of mouse adult neural stem cells back to their embryonic progenitors.
when the mouse embryo is between 13 and 15 days old, uite early in embryonic brain development, said Alvarez-Buylla,
the scientists found that the mouse adult neural stem cells they studied are derived from embryonic neural stem cells that produce neurons in entirely different parts of the brain. his means that, somehow,
mouse brains have long been accepted as excellent basic research models for the human brain, he said.
#SAPH-ire Helps Scientists Prioritize Protein Modification Research Researchers have developed a new informatics technology that analyzes existing data repositories of protein modifications
SAPH-ire collects non-redundant and experimentally verified PTM data across all known members of a protein family.
"The PTM hotspots are projected onto 3d protein structures available in the Protein Data Bank (PDB),
what might be considered the meta-data that exists in the public domain, collected all the PTMS and all the structures,
The Georgia Tech researchers are also creating a database that other protein scientists can query to help them identify
and they expect to see their program become part of informatics systems used to analyze large volumes of proteomics data emerging from labs around the world."
and context to all the data that is being produced about PTMS, "Torres said.""Connecting SAPH-ire to other programs that convert mass spec data into actual PTM data could provide immediate biological relevance and prioritization for biochemists and others.
It is likely to expose many new and unsuspected relationships between protein modification, protein structure and function."
users will benefit from continuous maximum filter performance. Consistent results, ease of use, tremendous speed and linear scalability are the key characteristics of the technology.
and looked at the longstanding theory that pain is transmitted from the site of injury or inflammation through the nervous system using an immune system cell called microglia.
The therapeutic viral vector to be used in each of these injections is prepared at the UNC Vector Core Human Applications Laboratory.
Bringing such path-breaking treatments to children affected by neurogenetic disorders is really the core mission of our team here at the NINDS
OGT Cytosure Interpret Software is used for data analysis, including updated features, such as the B-allele frequency plot, that have been optimized for the identification of biologically relevant genomic variants in tumor samples s
In mouse models, delivering sirna into cancer cells inhibited the expression of Twist, which in turn reduced epithelial-mesenchymal transition
noninvasive reath testthey believe will have the potential to screen for a variety of diseases, including diabetes, infections and cancers.
and improve the analysis of data coming out of the device, he said. Although there is much research needed in breath analysis,
#Bacterial Computing The riendlybacteria inside our digestive systems are being given an upgrade, which may one day allow them to be programmed to detect and ultimately treat diseases such as colon cancer and immune disorders.
These basic computing elements will allow the bacteria to sense, memorize, and respond to signals in the gut,
such strains are only found at low levels within the human gut, according to Timothy Lu, an associate professor of biological engineering and of electrical engineering and computer science,
In addition, more advanced genetic computing circuits could be built upon this genetic toolkit in Bacteroides to enhance their performance as noninvasive diagnostics and therapeutics. or example,
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
a clinical stage biopharmaceutical company which owns the core T-cell receptor technology and funded the study.
Dr. Hauser and his team used a mouse model of Pseudomonas aeruginosa (PA) pneumonia to examine how the bacterium uses its secretion system to inject a toxin, called Exos, into cells.
Bolivia and Belgium examined data on 97 leishmaniasis patients. These were gathered through a project on drug resistance,
#Software Turns Smartphones into Tools for Medical Research Jody Kearns doesn't like to spend time obsessing about her Parkinson's disease.
Yet since she enrolled in a clinical study that uses her iphone to gather information about her condition,
She taps the phone's screen in a certain pattern, records a spoken phrase and walks a short distance while the phone's motion sensors measure her gait."
'"Smartphone apps are the latest tools to emerge from the intersection of health care and Silicon valley,
and doctors together online, applying massive computing power to analyze DNA and even developing ingestible"smart"pills for detecting cancer.
More than 75,000 people have enrolled in health studies that use specialized iphone apps, built with software Apple Inc. developed to help turn the popular smartphone into a research tool.
Once enrolled, iphone owners use the apps to submit data on a daily basis, by answering a few survey questions
or using the iphone's built-in sensors to measure their symptoms. Scientists overseeing the studies say the apps could transform medical research by helping them collect information more frequently and from more people, across larger and more diverse regions,
than they're able to reach with traditional health studies. A smartphone"is a great platform for research,
"said Dr. Michael Mcconnell, a Stanford university cardiologist, who's using an app to study heart disease."
researchers also say a smartphone's microphone, motion sensors and touchscreen can take precise readings that,
in some cases, may be more reliable than a doctor's observations. These can be correlated with other health or fitness data and even environmental conditions, such as smog levels, based on the phone's GPS locater.
Others have had similar ideas. Google Inc. says it's developing a health-tracking wristband specifically designed for medical studies.
Researchers also have tried limited studies that gather data from apps on Android phones. But if smartphones hold great promise for medical research
experts say there are issues to consider when turning vast numbers of people into walking test subjects.
The most important is safeguarding privacy and the data that's collected, according to ethics experts.
In addition, researchers say apps must be designed to ask questions that produce useful information, without overloading participants
Study organizers also acknowledge that iphone owners tend to be more affluent and not necessarily an accurate mirror of the world's population.
Apple had created previously software called Healthkit for apps that track iphone owners'health statistics and exercise habits.
Senior vice president Jeff Williams said the company wants to help scientists by creating additional software for more specialized apps
using the iphone's capabilities and vast user base-estimated at 70 million or more in North america alone."
"This is advancing research and helping to democratize medicine, "Williams said in an interview. Apple launched its Researchkit program in March with five apps to investigate Parkinson's, asthma, heart disease, diabetes and breast cancer.
For scientists, a smartphone app is a relatively inexpensive way to reach thousands of people living in different settings and geographic areas.
"Smartphones also offer the ability to collect precise readings, Dorsey added. One test in the Parkinson's study measures the speed at
which participants tap their fingers in a particular sequence on the iphone's touchscreen. Dorsey said that's more objective than a process still used in clinics,
Some apps rely on participants to provide data. Elizabeth Ortiz, a 48-year-old New york nurse with asthma, measures her lung power each day by breathing into an inexpensive plastic device.
who said she already used her iphone"constantly"for things like banking and email.""I figured that participating would help my family and friends,
In the future, researchers might be able to incorporate data from participants'hospital records, said Mcconnell. But first, he added,
they must build a track record of safeguarding data they collect.""We need to get to the stage where we've passed the privacy test
and remove identifying information from other data that's collected. Apple says it won't have access to any data or use it for commercial purposes.
Some studies will always require in-person interaction or supervision by a doctor, experts say. But by reaching more people and gathering more data, advocates say smartphone apps can help doctors answer more subtle questions about a disease."
"Diseases like asthma are complicated very. They're not caused by a single gene or environmental influence,"said Eric Schadt,
a genomics professor who's using an iphone app to study asthma at New york's Icahn School of medicine at Mount sinai."
transmitting their instructions in real time via internet from their home country. By virtue of its video camera, screen and wheels, the robot, located in an EPFL laboratory, was able to film itself as it moved
while displaying the face of the remote pilot via Skype. The person at the controls,
as if moving in place of the robot, was able to interact with whoever the robot crossed paths with. ach of the 9 subjects with disabilities managed to remotely control the robot with ease after less than 10 days of training,
and the computer, allowing the pilot to rest while navigating. No difference between healthy and disabled subjects In the end
Mature technology available The positive results of this research bring to a close the European project called TOBI (Tools for Brain-Computer Interaction
The varied approaches were effective in"recruiting"protective monocytes to"lesion sites"in the brain,
extracted from the bone marrow of healthy mouse donors and grafted into the bloodstream, can migrate into the brains of sick mice,
Koronyo added that the study gives unprecedented details about monocyte numbers migrating into brain lesion sites
#Smartphone-Based Device That Reads Medical Diagnostic Tests Quickly And Accurately Created, University of California,
Los angeles (UCLA) Reveals UCLA Researchers Create Smartphone-Based Device That Reads Medical Diagnostic Tests Quickly And Accurately Enzyme-linked immunosorbant assay,
A team of researchers from the California Nanosystems Institute at UCLA has developed a new mobile phone-based device that can read ELISA plates in the field with the same level of accuracy as the large machines normally found in clinical laboratories.
and two other undergraduates also contributed to the research. t is quite important to have these kinds of mobile devices,
and attaches to a smartphone, illuminates the ELISA plate with an array of light-emitting diodes. The light projects through each well and is collected by 96 individual plastic optical fibers in the attachment.
The smartphone transmits the resulting images to UCLA servers through a custom-designed app. The images are analyzed then by a machine-learning algorithm that the researchers wrote for this purpose,
and the diagnostic results are sent back to the phone within about one minute for the entire 96-well plate.
The app also creates a visualization of the results for the user. This mobile platform was compared with the standard FDA-approved well-plate readers in a UCLA clinical microbiology laboratory.
The ELISA tests included those for mumps, measles, and herpes simplex viruses 1 and 2. With a total of 571 patient samples used in the comparison,
and are looking to adapt the basic design of this ELISA cellphone reader to create smartphone-based quantified readers for other important medical tests,
#Detecting potent tumors using a smartphone! Ms Maryam Sadeghi shows off an early version of Molescope (Picture courtesy:
an innovative hand-held tool that uses a smartphone to monitor skin for signs of cancer.
Molescope comprises a mini-microscope that attaches to a smartphone, an app (ios, Android, or web compatible) and a cloud-based analytical platform called Dermengine.
Once people take high-quality, high-resolution images of suspicious moles or skin abnormalities, they can archive images
a sensor comprising multiple tiny test sites. The chip, known as proteo, functions by attracting a faintly luminous substance found in cancer patients,
Mr Hiroaki Ito, a researcher from Showa University, said the preliminary data suggests that the device could be more accurate and effective than existing blood tests."
Through animal and patient database studies, researchers found that women with an anomaly on the MEN1 gene are three times more likely to develop breast cancer at a relatively young age.
This database includes 90 percent of all MEN1 patients which were 16 years or older living in The netherlands;
I have noticed a promising trend the rise of open source drug R&d consortia that include large biotech
and data that can be shared in order to accelerate research at the early stage to collectively reduce costs,
and this has been flat for nearly 20 years (See this blog post)..Other challenges I see include low commercial investment in pediatric medicine and devices, development of effective therapeutics for neurodevelopmental disorders,
and clinical interpretation of genomic data into pediatric clinical care. At the Technology and Innovation Development Office (TIDO) at Boston Children, we have the honor
drawing on the expertise of our external advisory board made up of pharma, device, diagnostic and software experts,
Leaders from companies like IBM Vertex and Johnson & johnson will interact with thought leaders from leading children hospitals in the US
Most of the attention has focused on initiatives where big pharma offers access to non-core assets to outside researchers in the hope that they will develop them successfully or form collaborations.
Bayer developed an entire website page dedicated to bee care. It holds general information on bees and
How Innovation is Transforming Agriculture Data analysis and computational technologies are giving farmers the ability to monitor their land better,
and allow them to access information quickly through their smartphones. Nanette Byrnes, writer for the MIT Technology Review, calls this the ew food economy. y combining this information with data generated by soil sensors and weather reports,
farmers could find ways to use water, seed, and fertilizer more efficiently, lowering their costs enough to more than pay for the technology investment
and is popular among Google Ventures, Silicon valley, and Monsanto investors. Such investments led to the creation of water sensors and drones
One of the stations transmits that information to a main database via cell signal. Larrabee uses his smartphone
or tablet to log on to see that data, which is available almost instantaneously. It is nearly common knowledge that by 2050 farmers will struggle to feed the massive growing population;
this industry relies on innovative technologies and creative investors to ensure economic stability and food for all.
a data modeling firm that Monsanto bought for $930 million in 2013
#Computers can now see images Artificial intelligence has graduated past the infancy stage of figuring out what's in an image.
Computers have previously been capable of little more than a simple game of I Spy: Name a specific object or person,
and they'll show you an image containing it. But thanks to new developments in AI research, machines can now answer more complex questions,
The research was conducted by a team comprised of experts from the Chinese Internet search company Baidu and a student at the University of California at Los angeles,
and coincides with similar research from Microsoft, Virginia Tech, and various other academic institutions that came out recently."
"Our goal is to enable the computer to connect language with experiences in the physical world,
"says Wei Xu, a distinguished scientist in Baidu's research group.""This is important for solving the problem of common sense reasoning."
"Bloomberg put the Baidu and UCLA system to its own test. I took a picture of a small citrus fruit in the palm of my hand,
and sent it to Baidu with the question, "What is in the centre of the hand?"
"The software answered:""An orange."("It's actually a satsuma, but we'll let it slide.)
but teaching computers to discern what's inside of images and associate them with language has proved immensely challenging.
when we may be able to ask a search engine like Google or Baidu to ferret through millions of images,
The development from Baidu and UCLA, while important, is far from perfect. The system can't handle multiple questions in a row
Creating computers that can look at images and answer specific questions about them"has the distinctive advantage of pushing the frontiers on'AI-complete'problems,
"Microsoft says.""Given the recent progress in the community, we believe the time is ripe to take on such an endeavour."
Baidu is interested in other aspects, too.""In the future, potential applications are education and mobile image search,
With the new research, computers have reached a milestone, not unlike that of many young kids figuring out the world.
#Soon, a Mastercard phone app to verify online payments via selfies Mastercard is experimenting with a smartphone app
Users will have to download the Mastercard phone app and at checkout they will be asked to hold up their phone to stare
and blink at it.""The new generation, which is into selfies...I think they'll find it cool.
Currently, users can set up something called"Securecode, "which requires a password when shopping online. However, passwords can be forgotten,
Mastercard said it has partnered with every smartphone maker to make this method of verification possible.
They can choose fingerprint or facial recognition. Users who choose facial recognition have to stare at the phone and blink once.
Mastercard's security researchers believe blinking is the best way to prevent a thief from just holding up a picture of a person
Mastercard said it does not actually get a picture of the user's finger or face.
The facial recognition scan will map out a user's face, convert it to 1s and 0s and transmit that over the Internet to Mastercard.
Bhalla said Mastercard is also experimenting with voice recognition, so people may be able to simply approve an online transaction by speaking to their phone.
Mastercard is also working with a Canadian firm Nymi, to develop technology that will approve transactions by recognising a person's unique heartbeat t
#Google wants you to buy things straight through Youtube videos (GOOG) Youtube is rolling out a new feature that will let advertisers easily lists goods that they are selling alongside or within their video ads.
and links to their websites on their videos. Now, Youtube is linking videos ads into the same dashboard it uses for Google Shopping,
so instead of manually connecting individual products and ads, advertisers can have added product links automatically. Essentially, Google its taking the technology and infrastructure it built for Shopping
and letting advertisers use it in on Youtube.;With Trueview ads, which the company launched five years ago,
Google only charges advertisers if a viewer doesn't skip their ad and watches for at least 30-seconds or to the end of the video (whichever is less.)
When it rolled out cards, it started charging either for a click or a full-view,
The key is that Youtube bets the greater emphasis on this shopping element will make its ads more effective.
and then the more that Youtube can charge per view. Trueview for shopping is optimized for both desktop and mobile."
"Advertisers had used annotations in the past to make their videos interactive, but these didn't work on all screens
and viewers didn't always know what to expect, "Youtube product Manager Avi Fein told Business Insider via email."
"So with cards and Trueview for shopping we created a very consistent experience that creates a much more engaging and interactive format for viewers."
"Along with the feature announcement, Google also stressed that people are using Youtube to help them make shopping decisions more than ever.
There are now more than 1 million channels on Youtube focused on product reviews, and views of those videos have grown 50%year-over-year.
For example, Wayfair said it saw a 3x revenue increase per ad impression served over its previous Youtube campaigns.
This rollout comes not long after the Wall street journal reported that Google plans to roll out a new"buy"button in its Google Shopping search results that will let users make a purchase without being shuttled to a brands website e
the bulk collection of American phone records by the National security agency will no longer be permitted legally, Spencer Ackerman of the Guardian reports.
since October 2001 that US phone calls weren't collected en masse from America's three largest telecommunications providers.
for another 90-day extension of the order needed to continue the collection of domestic phone records. e did not file an application for reauthorization,
which would ban bulk collection of data by the NSA but renew an expiring provision permitting the FBI to access business records
The section, known as the business-records provision, gave intelligence agencies authorization to seek communications data if he records are relevant to an ongoing foreign intelligence investigation. n appeals court ruled earlier this month that most of the NSA surveillance
Mcconnell, whose bill would continue all phone-records collection by the FBI and NSA, and the rest of the Senate will meet again on May 31.
At that point, discovery was done by literally printing out every possible relevant e-mail for attorneys to sift through.
That print shop got tapped to print the emails for the landmark 2001 Microsoft antitrust case. Wilson recalls printing out piles and piles of Bill gates'and Steve Ballmer's emails
boxing them up, putting them on trucks, and delivering them to the courthouse, where as many as 300 attorneys would be searching them for anything relevant to the case."
000 per gigabyte.""ediscovery sucks, "says Wilson.""It's an insanely inefficient process that would drive any normal human insane."
"The way you pay for ediscovery software from legacy vendors like HP Autonomy and Symantec involves a lot of nickel-and-diming, according to Wilson.
First, you pay for the ediscovery software itself. Then, you pay for having your data processed. Then, you pay to keep your files in the system until the case is resolved
which can take a while, since some lawsuits can take years. Even once those documents are in the ediscovery software,
it usually goes into"really s---y databases, "Wilson says. You can search by keyword,
or by column heading, but you can't do a lot of deep searching. And usually you could only access the database from a Windows computer running an outdated version of Internet explorer,
if you could get to it from the browser at all. Logikcull pricing starts at a flat $2, 000 monthly fee for four cases,
with 50 gigabytes of uploading per month included and $30/GB after that. That may seem expensive,
but remember that it's still a lot less than that $18, 000-per-gigabyte average from other vendors.
Wilson says it can save law firms as much as 80%on their litigation costs. And the e-mails themselves get tagged
Wikimedia Commonsbill Gates gives his deposition during the landmark United states v. Microsoft case. Logikcull got its start as Logik. com,
Charging $2, 500 per gigabyte, Logik. com took in $4. 5 million in revenue and $3 million in profit every year between 2004 and 2009 with only seven employees.
Even without outside investment, Logikcull was able to hire the experts it needed to develop a browser-based, computer-plus-smartphone software solution,
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