Tropes

www.sciencedaily.com 2015 00001644.txt

#Diabetes debate: Triglycerides form in liver despite insulin resistance In type 2 diabetics insulin fails to suppress blood sugar production by the liver while paradoxically allowing the production of hepatic triglycerides. This combination results in multiple health risks including high blood sugar and fatty liver disease. For years to gain insight into this phenomenon researchers focused on the role of altered insulin action in the liver in the production of triglycerides. However Yale researchers tested a theory that triglycerides formed in the liver were more dependent on the delivery of fatty acids to the liver than on insulin action. In their study the Yale team--led by Gerald I. Shulman the George R. Cowgill professor of medicine and cellular & molecular physiology--developed a novel method to measure the rate of triglyceride production from fatty acids in three types of animals: normal rats insulin-resistant rats fed a high-fat diet and rats with genetically modified insulin receptors. They found that in all of the animals tested increased triglyceride production was primarily dependent on fatty acid delivery and not on insulin action in the liver. The findings also explain the longstanding paradox of why insulin therapy does not exacerbate but instead reduces fatty liver disease in patients with type 2 diabetes. These results provide new insights into the pathogenesis of nonalcoholic liver disease and provides new approaches to treat fatty liver disease which is now the most common liver disease in the world said Shulman. Shulman and his team plan to apply similar methodology to translate their findings to insulin-resistant patients with type 2 diabetes hyperlipidemia and fatty liver disease e

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