Therapy

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Therapy (1067)

Synopsis: Domenii: Health: Health generale: Medical procedure: Therapeutics: Therapy:

wrote the authors of Beyond Therapy, a 2003 report by the US President's Council on Bioethics.

Light-switchable drugs have been explored in other fields such as cancer therapy, but not for antibiotics. Organic chemist Ben Feringa at Groningen and his co-workers used an existing light-switchable unit called azobenzene,

#Neostem and Invetech Announce Agreement to Develop Closed Processing System for Cell Therapy Manufacturing Source:

NBS), a leader in the development and manufacturing of cell therapy products and regenerative medicine, and Invetech Pty Ltd("Invetech"),a global leader in instrument development, custom automation and contract manufacturing, today announced an agreement for the development of a new closed processing system (the"System")for cell

therapy manufacturing. Under the agreement, Invetech will provide system design and engineering development and Neostem will develop applications for performing closed cell processing manipulations such as separation.

which would constitute its first branded entry into the cell therapy tools market. The System will be applicable to a range of cell therapy processes in development and commercialization stages

and will consist of an instrumentation platform, disposable flow path, and operating and application software for automated execution of user-selected protocols.

"We are pleased to be partnering with Invetech on the development of a new technology specifically designed to meet the needs of our clients as their cell therapy products progress through clinical trials on a path towards commercialization,

""Working with Neostem to create equipment that will deliver services to companies in the emerging cell therapy industry is exciting

and satisfying,"said Richard Grant, global vice president, cell therapy division of Invetech.""Our team shares a common passion with Neostem to grow the cell therapy industry by developing new technology to support successful product development and commercialization.""

""Neostem's Engineering and Innovation Center (EIC) is one of the first dedicated centers responding directly to the major challenges that are facing the manufacturers of cell based therapeutics,

"If ultimately commercialized, the sale of disposables associated with the System, especially for patient-specific therapies where one disposable set is used per patient,

#Moffitt researchers discover mechanism leading to drug resistance metastasis in melanoma Moffitt Cancer Center researchers have discovered a mechanism that leads to resistance to targeted therapy in melanoma patients

Targeted biological therapy can reduce toxicity and improve outcomes for many cancer patients, when compared to the adverse effects of standard chemotherapeutic drugs.

However, patients often develop resistance to these targeted therapies, resulting in more aggressive cells that can spread to other sites or cause regrowth of primary tumors.

However over time many patients become resistant to B-Raf and B-Raf/MEK inhibitor therapy.

meaning patients could stay on therapy for more time, "said Keiran S. Smalley, Ph d.,scientific director of the Donald A. Adam Comprehensive Melanoma Research center of Excellence at Moffitt.

This suggests that drugs that target Epha2 may prevent the development of new disease in patients who receive B-Raf and B-Raf/MEK inhibitor therapy y

"For three decades, researchers have sought to find new cancer therapies based on the idea that inhibiting

and identify new drug therapies for prevention and treatment.""Still, Goenjian cautioned, PTSD is caused likely by multiple genes

These findings which currently appear inbmc Genomics suggest that future therapies for this disease may need to be individualized.

Mitchell believes the technique will be transformative in providing improved cancer diagnostics that can both predict treatment outcomes and monitor patient responses to therapy.

not only before a patient begins therapy but also following patient responses to therapy,"said Mitchell, the paper's corresponding author and professor of Pathology, Microbiology and Immunology.

The study collected serum from more than 200 patients with prostate cancer and more than 200 controls.

sequencing of cell-free DNA soon after therapy may be used to detect minimal residual disease in solid tumors,

Mitchell further predicted that liquid biopsies will quantify immediate tumor responses to therapy y

#CWRU researchers discover byproducts from bacteria awaken dormant T-cells and HIV viruses Dental and medical researchers from Case Western Reserve University found another reason to treat periodontal disease as soon as possible.

HIV antiviral therapy prevents active HIV cells from replicating and doesn't affect the quiet viruses in sleeping T-cells.

#Radiation Hormone Therapy Prolong Survival for Older Men With Prostate Cancer Adding radiation treatment to hormone therapy saves more lives among older men with locally advanced prostate therapy than hormone

therapy alone according to a new study in the Journal of Clinical Oncology from Penn Medicine researchers.

The researchers found that hormone therapy plus radiation reduced cancer deaths by nearly 50 percent in men aged 76 to 85 compared to men who only received hormone therapy.

Past studies have shown that 40 percent of men with aggressive prostate cancers are treated with hormone therapy alone exposing a large gap in curative cancer care among baby boomers aging into their 70s.#

#Radiation plus hormone therapy is such a treatment for men with aggressive prostate cancerssaid lead author Justin E. Bekelman MD an assistant professor of Radiation Oncology Medical Ethics and Health policy at Penn

and reduce the use of hormone therapy alone. ocally advanced prostate cancer is cancer that has spread outside but near the prostate gland.

Hormone therapy lowers or blocks the levels of testosterone and other androgens (male hormones) that feed prostate cancer tumors.

Two landmark clinical trials have shown that radiation plus hormone therapy produces a large and significant improvement in survival in younger men relative to hormone therapy alone

Addressing this question for the first time Penn research team compared the combination of radiation plus hormone therapy

versus hormone therapy alone among 31 541 men with prostate cancer ranging in age from 65 years to 85 years.

Among men age 65 to 75 years old radiation plus hormone therapy was associated with a reduction in prostate cancer deaths of 57 percent relative to hormone therapy alone

Similarly among men age 76 to 85 years old radiation plus hormone therapy was associated with a reduction in prostate cancer deaths of 49 percent relative to hormone therapy alone

In both groups radiation plus hormone therapy was associated also with about one-third fewer deaths from any cause.

Importantly the clinical trials have shown that the side effects of radiation plus hormone therapy are very acceptable relative to hormone therapy alone. lder men with aggressive prostate cancers should know that the combination of radiation plus

hormone therapy is both tolerable and effective in curing prostate cancersaid Bekelman. In addition to offering new evidence for older men Bekelman research also demonstrates that the prior clinical trial findings for younger men apply in the eal-worldof routine clinical practice.#

The Penn-led study examined radiation treatment and hormone therapy in the Surveillance Epidemiology and End Results (SEER) Medicare database.

and provide clinicians with currently unavailable information about the risk of metastatic relapse and the best therapy.

able to closely follow the rapid evolution of targeted therapies. Having created the system and established its effectiveness,

she explains. hey can even incorporate molecules with a capability for photo-stimulated killing for combined chemo-and photo-therapy as well as imaging.

so we thought they can provide effective complimentary therapies in different diseases. This videogame is like a bonding factor between patients and their therapists and doctors."

Studies show that as few as 56 percent of glaucoma patients follow the therapy protocol.

The first study shows that the microneedle therapy would inject drugs into space between two layers of the eye near the ciliary body

The researchers hope to produce a time-release version of the drug that could be injected to provide therapy that lasts for months.##

#How to coax doctors out of their comfort zones Hearing about a new therapy from an influential colleague increases a doctor s odds of trying it out.

It s difficult to get doctors to adopt new therapies because you are invading people s comfort zones

The current belief is physicians catch a new therapy in what is known as a contagion model.

if you don t see a patient with that condition for six months you may have forgotten the therapy.

and emphasize using the new therapy (or best practice) closer to the point at which they would actually use it.

In regard to potential future therapies the ability to convert adult human cells presents the possibility of using a patient s own skin cells

#Therapy cures hearing loss from loud noises University of Michigan rightoriginal Studyposted by Kara Gavin-U. Michigan on October 21 2014scientists restoredâ#hearing to mice that were deafened partly by noise.

#Stop cancer from spreading without chemo Stanford university rightoriginal Studyposted by Tom Abate-Stanford on October 6 2014 Researchers are testing a protein therapy that stops breast

The new therapy doesn't have side effects. It works by preventing two proteins Axl and Gas6 rom interacting to initiate the spread of cancer.

This is a very promising therapy that appears to be effective and nontoxic in preclinical experiments Giaccia says.

whether this therapy is safe and effective in humans. Source: Stanford Universityyou are free to share this article under the Creative Commons Attribution-Noderivs 3. 0 Unported license e

and the Proceedings of the National Academy of Sciences (PNAS) provide a promising new target for antiviral therapies.

Such a therapy could be generalizable across all types of Herpes viruses and wouldn't be prone to developing resistance The exciting part of this is that the physical properties of packaged DNA play a very important role in the spread of a viral infection

This could lead to a therapy that isn't linked to the virus gene sequence or protein structure

which would make developing resistance to the therapy highly unlikely. Most viruses whether they infect bacteria plants

or using rib perichondrium-like cells for regenerative therapy. The lab received support for this study and future work from the NIH the Merck Investigator Studies Program and the USC Regenerative medicine Initiative Award.

By answering these questions we are accelerating the discovery of new regenerative therapies for the patients who need them the most.

and help us target therapies.####Warner says she and her colleagues don t yet know the significance of the three bacterial classes that dominated the preemies gut microbiota.

we can move forward to consider novel therapies that may help treat this devastating condition.

COLLATERAL DAMAGE or breast cancer prevention and DCIS therapy effective drug concentrations are required in the breast.

Tamoxifen is an anti-estrogen therapy for a type of breast cancer that requires estrogen to grow.

People who have persistent difficulties sleeping after a divorce may address the issue by seeking out cognitive behavioral therapy,

and is typically aggressive. here is an urgent and ongoing need for the development of novel therapies

They report their results in Cancer Biology & Therapy. The AAV2 killed 100 percent of the cells in the laboratory by activating proteins called caspases,

since tumor necrosisr deathn response to therapy is used also as the measure of an effective chemotherapeutic,

and could ultimately aid in finding a potential probiotic therapy. Grow the needle without the hay

Haller treated 17 adult Type 1 diabetes patients for two weeks with the cocktail therapy and then followed them for a year.

and two years. he model has mostly been to test therapies aimed at beta cell preservation in people who have just been diagnosed,

COMBINATION THERAPIES Atkinson began considering Thymoglobulin as a treatment for diabetes nearly a decade ago.

Based on Schatz belief in combination therapies, the group began shepherding a cocktail of Thymoglobulin and Neulasta through early studies done with mouse models. espite tremendous strides in our understanding of the natural history of Type

the study could potentially be paradigm-shifting for our field in that it documents we should really be looking at combination therapies in treating Type 1 diabetes,

says principal investigator and senior author Edward Damiano of the Boston University department of biomedical engineering. here no current standard-of-care therapy that could match the results we saw. ne of the key virtues of this device is its ability to start controlling the blood sugar instantly,

He says perhaps there will be a way to combine behavioral therapy and stem cell treatments after a brain injury to rebuild some of the damage.

and monitor brain disease and therapy. Portable scans Another commonly used method for mapping brain function is positron emission tomography (PET),

The work creates the potential to develop lectroceuticaltreatments as alternatives to drug therapies, says William Newsome, professor of neurobiology and director of the Stanford Neurosciences Institute.

when selecting the most effective therapy and appropriate dosage. The investigators are currently designing a study to correlate pharmacokineticshe time course of drug metabolismith genotype.

and potentially provide therapies for diseases such as amyotrophic lateral sclerosis (Lou Gehrig disease), Huntington, or Alzheimer. In the specially engineered growth systemhe arpetsfu

discoveries like this provide tools for modeling disease in the laboratory and for developing cell-replacement therapies.

pave the way for an urgently needed therapy that is highly effective against the flu virus

a Mcgill Phd student and the study first author. nderstanding their individual role is crucial in developing a new therapy.

and that specific inhibition of PGE2 will be an effective therapy against influenza viral infection by boosting immune responses. i

The findings in adolescent mice are an especially promising step in efforts to develop better therapies for schizophrenia in humans,

the greater understanding of the biology of vision gained from such studies also informs the search for new forms of therapy,

Inglehearn says. ince new therapies are often specific to particular forms of inherited blindness, it is essential for each patient to know which condition they have,

helping to test the new therapies and potentially benefiting from them themselves. A grant from the National Eye Research Centre, together with funding from other sources, supported the research s

then this could be a potential target for new therapies, Canaan says. The immune system response that produces inflammation is crucial in warding off infections. hus it has short-term beneficial effects on survival

as well as the new 3d method, to compare the radiologistsanalyses with pathologic review of tumor samples after therapy and surgical removal.

and each received pre-and post-chemoembolization MRI scans to assess the effects of therapy on the tumors.

and whether these therapy choices help people live longer. The software used in the MRI scans was developed at Johns Hopkins and at Philips Research North america.

and social behaviors nd if you don t understand the circuitry you are never going to understand how the gene mutation affects the behavior. oing forward he says such a complete understanding will be necessary for the development of future therapies.

And that has held back certain medical therapies. MAGIS: The new method Unlike the calutron, which requires huge amounts of energy to maintain a magnetic field with electromagnets,

cancer therapies, and nutritional diagnostics. The new method also has the potential to enhance our national security.

scanning medical therapy and imaging and research in biology and materials science. ecause it employs commercial lasers

also called mitochondrial gene replacement therapy, is not to tweak the physical characteristics or personality traits of a child those reside in the nucleus,

and therapies we validate in animal models often fail to be tested effective when in humans,

Products that use silica-based nanoparticles for biomedical uses such as various chips drug or gene delivery and tracking imaging ultrasound therapy and diagnostics may also pose an increased cardiovascular

These include rooftop garden loral therapy, art classes making realistic representations of everyday objects, music therapy with bongos sounding ike a heartbeat.

doing art therapy and attempting physical therapy with dances and alloon badminton (the racket is stretched pantyhose on a frame).

and the project is expected to be completed 2018.20 years from now there will be therapies, instead of chemo, that will be a much more targeted approach to treatment,

One example of such a therapy that already exists is Herceptin, a drug specifically designed for women with a type of breast cancer characterised by over-activity of the Her2 gene..

whichassuming robo-therapy is much, much cheaper than human-therapywill also vanish from the economy.)

and the growth of new neurons or neurogenesis is an important step in developing therapies to address impaired learning

The therapy has been tricky to administer, because it requires placing ultrasound leads on the skin directly over the bone injury.

and control of the nanobots is equivalent to a computer system. his is the first time that biological therapy has been able to match how a computer processor works,

But because stem cell therapies remain cutting edge, they have largely been used to target life-threatening problems such as heart failure.

The lab most recent findings suggest that stem cell therapy could be used to help older patients recover from muscular injuries, for example from falls,

Our data pave the way for such a stem cell therapy, Blau said. Other recent work in stem cell therapy has looked similarly for ways the cells could improve functioning of existing organs, rather than building replacements through regenerative medicine.

For instance one recent study suggested that the cells may be able to kick-start insulin-making in pancreas in Type-1 diabetics by replacing Beta cells.

and that it could lead to personalized reprogrammed cell therapies to treat a variety of conditions.

Nature News In a milestone for a politically charged field, the US Food and Drug Administration (FDA) has approved the world's first clinical trial of a therapy generated by human embryonic stem cells.

phase I safety study of a stem cellerived therapy for spinal cord injury. The publicly traded company has an extensive patent portfolio relating to embryonic stem cell research,

and may soon try out the therapy on stronger fearful memories. To discover whether drug treatment would change this,

and may soon try out the therapy on stronger fearful memories r

#The genomics of the sniffles: Nature News Genome sequences of the cold virus could reveal new secrets behind its prowess.

could be used to design new therapies against colds or to determine, for example, why one strain can cause more severe symptoms than another."

The risks involved with a bone-marrow transplant far outweigh those that come with years of antiretroviral drug therapy

whether a patient is responding to therapy. Whereas Magnetic resonance imaging (MRI) is a useful tool, tumors only show up on imaging scans once they are at least one millimeter in diameter

say#for cell therapy. Although the number of published papers from ips-cell research has not yet caught up with that of ES-cell work (see Inducing a juggernaut),

the spinal-cord trial would double the number of companies sponsoring human clinical trials for ES-cell therapies.

and Japan is setting up a stem-cell bank of some 75 ips-cell lines intended for future therapies.

saying that work on embryonic-stem-cell lines could lead to therapies for Parkinson s disease, diabetes and other ailments."

Jay Cohn, a cardiologist at the University of Minnesota Medical school in Minneapolis, also worries that the focus on LDL levels offers up the wrong patients for statin therapy.

and motivated many patients to get the statin therapy that he believes they need.""Just to throw that out the window doesn t seem like the ideal scenario.

which has long been a target for cancer researchers looking for drugs that would avoid the debilitating effects of conventional therapies."

The potential for TRAIL to usher in a new age in cancer therapy was identified first in the mid-1990s3.

although early clinical trials for TRAIL-based therapies showed little toxicity, they were not very successful at treating cancer,

The discovery suggests new approaches to combat antibiotic resistance and boost the power of cancer therapies,

and represent the latest success for a'fringe'therapy in which a type of immune cell called T cells are extracted from a patient, genetically modified,

as they indicate not only that drug therapies might be effective to improve cognition and behavior in affected individuals,

as candidate therapies become available, we hope to be able to use the genetic data from each ALS patient to direct that person to the most appropriate clinical trials and,

if these can be used as the starting point for developing a future therapy. e

#Tau Associated MAPT Gene Increases Risk for Alzheimer's disease A international team of scientists, led by researchers at the University of California,

it could give future amputees a natural transplant option that doesn require immunosuppressive therapies. The rat limb was grown by a team from the Massachusetts General Hospital in Boston.

and pave the way to an alternate therapy Now, it looks like a team led by University of California (UC), San diego,

One is the lack of detectable virus in the blood plasma of patients on effective ARV therapy

targeted therapies designed to remove add or even modify specific bacteria; or medical interventions based on reprogramming an individual s immune system.

The properties of the drug molecule have to be taken into account in the design of local therapy that s effective says Cima.

This type of technology can revolutionize how we do drug therapy in urology, says Cima,

#RNA combination therapy for lung cancer offers promise for personalized medicine Small RNA molecules including micrornas (mirnas)

This week in the journal Proceedings of the National Academy of Sciences researchers at the Koch Institute for Integrative Cancer Research at MIT report that they have delivered successfully small RNA therapies in a clinically relevant mouse model of lung cancer to slow

Their research offers promise for personalized RNA combination therapies to improve therapeutic response. Delivering combination therapiesusing the KP mouse model in

Instead of just slowing tumor growth this combination therapy caused tumors to regress and shrink to about 50 percent of their original size.

They found that the nanoparticle treatment extended life just as well as the cisplatin treatment and furthermore that the combination therapy of the nanoparticles and cisplatin together extended life by about an additional 25 percent.

Potential for personalized cancer treatmentsthis early example of RNA combination therapy demonstrates the potential of developing personalized cancer treatments.

Furthermore these RNA therapies could be combined with more traditional drug therapies for an enhanced effect.

Small-RNA therapy holds great promise for cancer Jacks#says. It is appreciated widely that the major hurdle in this field is efficient delivery to solid tumors outside of the liver

RNA therapies are very flexible and have a lot of potential because you can design them to treat any type of disease by modifying gene expression very specifically says James Dahlman a graduate student in Anderson s

and for one of the first times we demonstrate targeted RNA combination therapy in a clinically#relevant model of lung cancer.

This study is a terrific example of the potential of new RNA therapies to treat disease that was done in a highly collaborative way between biologists

The discovery of specific genes associated with these disorders provides significant clues to their biological basis and points to possible molecular targets for novel therapies.

and lay the groundwork for effective therapies. Human genomics has begun to reveal the causes of these disorders.

and applied this knowledge to begin to invent new targeted forms of therapy. Broad scientists have invented also powerful new tools that allow researchers to precisely manipulate the genome and measure the millions of complex chemical interactions within cells.

and correctly predict which therapies will be effective in humans. Now with growing knowledge of the genes underlying psychiatric disorders Broad researchers plan to create cellular models in the laboratory

or networks that are involved with a brain disorder, leading to new ideas for therapies. Boyden team developed the brain-mapping method with researchers in the lab of Alipasha Vaziri of the University of Vienna and the Research Institute of Molecular Pathology in Vienna.

Tumors in low-oxygen environments tend to be more resistant to therapy and spread more aggressively to other parts of the body.

and also identifies several of the challenges that will need to be addressed moving forward to the development of human therapies says Charles Gersbach an assistant professor of biomedical engineering at Duke university who was not part of the research team.

Many other robotic therapies are designed to do most of the work for the patient in an attempt to train the muscles to walk.

Hogan says. hat wee trying to do with machines in therapy is equivalent to helping the patients,

who did not participate in the research. more immediate benefit of the study is that it presents a method for quantifying the impact of existing rehabilitation therapies on the mechanical properties of the ankle.

as they indicate not only that drug therapies might be effective to improve cognition and behavior in affected individuals,

sees this hormone-releasing microchip as one of the first implantable rtificial organsecause it acts as a gland. lot of the therapies are trying to chemically trick the endocrine systems Cima says. e are doing that with this artificial organ we created. ild ideasinspiration for the microchips came in the late 1990s,

Products that use silica-based nanoparticles for biomedical uses such as various chips drug or gene delivery and tracking imaging ultrasound therapy and diagnostics may also pose an increased cardiovascular

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