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wrote the authors of Beyond Therapy, a 2003 report by the US President's Council on Bioethics.
Light-switchable drugs have been explored in other fields such as cancer therapy, but not for antibiotics. Organic chemist Ben Feringa at Groningen and his co-workers used an existing light-switchable unit called azobenzene,
ecause it implies that therapeutics that reduce microglial activation should be promising for treating major depression.
#Neostem and Invetech Announce Agreement to Develop Closed Processing System for Cell Therapy Manufacturing Source:
NBS), a leader in the development and manufacturing of cell therapy products and regenerative medicine, and Invetech Pty Ltd("Invetech"),a global leader in instrument development, custom automation and contract manufacturing, today announced an agreement for the development of a new closed processing system (the"System")for cell
therapy manufacturing. Under the agreement, Invetech will provide system design and engineering development and Neostem will develop applications for performing closed cell processing manipulations such as separation.
which would constitute its first branded entry into the cell therapy tools market. The System will be applicable to a range of cell therapy processes in development and commercialization stages
and will consist of an instrumentation platform, disposable flow path, and operating and application software for automated execution of user-selected protocols.
"We are pleased to be partnering with Invetech on the development of a new technology specifically designed to meet the needs of our clients as their cell therapy products progress through clinical trials on a path towards commercialization,
""Working with Neostem to create equipment that will deliver services to companies in the emerging cell therapy industry is exciting
and satisfying,"said Richard Grant, global vice president, cell therapy division of Invetech.""Our team shares a common passion with Neostem to grow the cell therapy industry by developing new technology to support successful product development and commercialization.""
""Neostem's Engineering and Innovation Center (EIC) is one of the first dedicated centers responding directly to the major challenges that are facing the manufacturers of cell based therapeutics,
"said Brian Hampson, vice president, manufacturing development and engineering.""If ultimately commercialized, the sale of disposables associated with the System, especially for patient-specific therapies where one disposable set is used per patient,
could potentially become a meaningful revenue area for Neostem
#Moffitt researchers discover mechanism leading to drug resistance metastasis in melanoma Moffitt Cancer Center researchers have discovered a mechanism that leads to resistance to targeted therapy in melanoma patients
and are investigating strategies to counteract it. Targeted biological therapy can reduce toxicity and improve outcomes for many cancer patients,
when compared to the adverse effects of standard chemotherapeutic drugs. However, patients often develop resistance to these targeted therapies,
resulting in more aggressive cells that can spread to other sites or cause regrowth of primary tumors.
However over time many patients become resistant to B-Raf and B-Raf/MEK inhibitor therapy.
meaning patients could stay on therapy for more time, "said Keiran S. Smalley, Ph d.,scientific director of the Donald A. Adam Comprehensive Melanoma Research center of Excellence at Moffitt.
This suggests that drugs that target Epha2 may prevent the development of new disease in patients who receive B-Raf and B-Raf/MEK inhibitor therapy y
or has the right mix of properties to become a safe and effective therapeutic agent,
"For three decades, researchers have sought to find new cancer therapies based on the idea that inhibiting
Our findings suggest therapeutic strategies need to go the other way and target ways to restore PKC activity,
and identify new drug therapies for prevention and treatment.""Still, Goenjian cautioned, PTSD is caused likely by multiple genes
These findings which currently appear inbmc Genomics suggest that future therapies for this disease may need to be individualized.
Mitchell believes the technique will be transformative in providing improved cancer diagnostics that can both predict treatment outcomes and monitor patient responses to therapy.
not only before a patient begins therapy but also following patient responses to therapy,"said Mitchell, the paper's corresponding author and professor of Pathology, Microbiology and Immunology.
The study collected serum from more than 200 patients with prostate cancer and more than 200 controls.
sequencing of cell-free DNA soon after therapy may be used to detect minimal residual disease in solid tumors,
Mitchell further predicted that liquid biopsies will quantify immediate tumor responses to therapy y
#CWRU researchers discover byproducts from bacteria awaken dormant T-cells and HIV viruses Dental and medical researchers from Case Western Reserve University found another reason to treat periodontal disease as soon as possible.
HIV antiviral therapy prevents active HIV cells from replicating and doesn't affect the quiet viruses in sleeping T-cells.
The ultimate goal will be to provide multiple qualified targets for new therapeutic approaches, increasing the potential for the development of new treatments. his collaboration with Biogen,
#Radiation Hormone Therapy Prolong Survival for Older Men With Prostate Cancer Adding radiation treatment to hormone therapy saves more lives among older men with locally advanced prostate therapy than hormone
therapy alone according to a new study in the Journal of Clinical Oncology from Penn Medicine researchers.
The researchers found that hormone therapy plus radiation reduced cancer deaths by nearly 50 percent in men aged 76 to 85 compared to men who only received hormone therapy.
Past studies have shown that 40 percent of men with aggressive prostate cancers are treated with hormone therapy alone exposing a large gap in curative cancer care among baby boomers aging into their 70s.#
#Radiation plus hormone therapy is such a treatment for men with aggressive prostate cancerssaid lead author Justin E. Bekelman MD an assistant professor of Radiation Oncology Medical Ethics and Health policy at Penn
and reduce the use of hormone therapy alone. ocally advanced prostate cancer is cancer that has spread outside but near the prostate gland.
Hormone therapy lowers or blocks the levels of testosterone and other androgens (male hormones) that feed prostate cancer tumors.
Two landmark clinical trials have shown that radiation plus hormone therapy produces a large and significant improvement in survival in younger men relative to hormone therapy alone
Addressing this question for the first time Penn research team compared the combination of radiation plus hormone therapy
versus hormone therapy alone among 31 541 men with prostate cancer ranging in age from 65 years to 85 years.
Among men age 65 to 75 years old radiation plus hormone therapy was associated with a reduction in prostate cancer deaths of 57 percent relative to hormone therapy alone
Similarly among men age 76 to 85 years old radiation plus hormone therapy was associated with a reduction in prostate cancer deaths of 49 percent relative to hormone therapy alone
In both groups radiation plus hormone therapy was associated also with about one-third fewer deaths from any cause.
Importantly the clinical trials have shown that the side effects of radiation plus hormone therapy are very acceptable relative to hormone therapy alone. lder men with aggressive prostate cancers should know that the combination of radiation plus
hormone therapy is both tolerable and effective in curing prostate cancersaid Bekelman. In addition to offering new evidence for older men Bekelman research also demonstrates that the prior clinical trial findings for younger men apply in the eal-worldof routine clinical practice.#
The Penn-led study examined radiation treatment and hormone therapy in the Surveillance Epidemiology and End Results (SEER) Medicare database.
and provide clinicians with currently unavailable information about the risk of metastatic relapse and the best therapy.
able to closely follow the rapid evolution of targeted therapies. Having created the system and established its effectiveness,
control the release of therapeutic compounds and enhance the efficiency of the treatment. he decorating of nanoparticles very tiny particles with cyclodextrins allows us to play with the functionality,
she explains. hey can even incorporate molecules with a capability for photo-stimulated killing for combined chemo-and photo-therapy as well as imaging.
The next step is a number of preliminary safety experiments to test its therapeutic potential in humans.
This could potentially lead to new therapeutic treatments to effectively combat the condition. The fellow, Diego Gómez-Nicola, from the CNS Inflammation group at the University of Southampton in the United kingdom, examined how a specific cell protein receptor called CSF1R controls the spread and inflammation in neurodegenerative diseases.
Game developers, psychologists and therapists worked together on tailoring the right scenarios for both pain rehabilitation and mental health treatments.
so we thought they can provide effective complimentary therapies in different diseases. This videogame is like a bonding factor between patients and their therapists and doctors."
"The search for videogame treatments to some psychological disorders proved to be specially challenging.""At first I found it bizarre that my addiction to gambling could be treated with a videogame.
The research proves therapeutical videogames can be useful for certain patients. Now scientists say it is up to policymakers to play the game.
"There is no problem with acceptability by patients and therapists. There is also no problem with existing technology.
"In the meantime researchers are already searching for new therapeutical applications of this-and other-serious games m
Studies show that as few as 56 percent of glaucoma patients follow the therapy protocol.
The first study shows that the microneedle therapy would inject drugs into space between two layers of the eye near the ciliary body
The researchers hope to produce a time-release version of the drug that could be injected to provide therapy that lasts for months.##
We can t study how it replicates we can t test therapeutics and we can t generate live virus vaccines.##
and affect disease development is absolutely critical to creating much needed therapeutic interventions.####says William Fischer an assistant professor of medicine who has treated Ebola patients in Africa.##
#How to coax doctors out of their comfort zones Hearing about a new therapy from an influential colleague increases a doctor s odds of trying it out.
It s difficult to get doctors to adopt new therapies because you are invading people s comfort zones
The current belief is physicians catch a new therapy in what is known as a contagion model.
if you don t see a patient with that condition for six months you may have forgotten the therapy.
and emphasize using the new therapy (or best practice) closer to the point at which they would actually use it.
In regard to potential future therapies the ability to convert adult human cells presents the possibility of using a patient s own skin cells
#Therapy cures hearing loss from loud noises University of Michigan rightoriginal Studyposted by Kara Gavin-U. Michigan on October 21 2014scientists restoredâ#hearing to mice that were deafened partly by noise.
Preventing the nutrient exchange for example may offer a new therapeutic strategy against these antibiotic-resistant organisms The National institutes of health supported the research.
or delivering therapeutic jolts of electricity right where a patient feels pain. Finally the"smart chip"contains a radio antenna to beam back sensor readings or signal the completion of its therapeutic task.
The current prototype is the size of the head of a ballpoint pen. Researchers hope to design a next-generation implant one-tenth that size.
#Stop cancer from spreading without chemo Stanford university rightoriginal Studyposted by Tom Abate-Stanford on October 6 2014 Researchers are testing a protein therapy that stops breast
The new therapy doesn't have side effects. It works by preventing two proteins Axl and Gas6 rom interacting to initiate the spread of cancer.
This is a very promising therapy that appears to be effective and nontoxic in preclinical experiments Giaccia says.
whether this therapy is safe and effective in humans. Source: Stanford Universityyou are free to share this article under the Creative Commons Attribution-Noderivs 3. 0 Unported license e
The team s findings are published online in Clinical Pharmacology and Therapeutics. The simulation we used was able to predict the effects that were seen in patients who actually took troglitazone
Kim Brouwer is chair of the Division of Pharmacotherapy and Experimental Therapeutics at the UNC Eshelman School of Pharmacy.
and the Proceedings of the National Academy of Sciences (PNAS) provide a promising new target for antiviral therapies.
Such a therapy could be generalizable across all types of Herpes viruses and wouldn't be prone to developing resistance The exciting part of this is that the physical properties of packaged DNA play a very important role in the spread of a viral infection
This could lead to a therapy that isn't linked to the virus gene sequence or protein structure
which would make developing resistance to the therapy highly unlikely. Most viruses whether they infect bacteria plants
He believes that the latest discovery opens the door to exploring therapeutics through this channel.
or using rib perichondrium-like cells for regenerative therapy. The lab received support for this study and future work from the NIH the Merck Investigator Studies Program and the USC Regenerative medicine Initiative Award.
By answering these questions we are accelerating the discovery of new regenerative therapies for the patients who need them the most.
Focusing on just the wound healing##side effect##the scientists launched the rodent study to determine what the mechanism behind its therapeutic effects might be.
##HSCS are one of the best therapeutic tools at our disposal because they can make any blood cell in the body.
and help us target therapies.####Warner says she and her colleagues don t yet know the significance of the three bacterial classes that dominated the preemies gut microbiota.
we can move forward to consider novel therapies that may help treat this devastating condition.
by the time they turn four years old, even with therapeutic drugs. Researchers are now beginning to study why SAS is less severe in some dogs while causing severe symptoms in others.
Montclare explains that in addition to therapeutic formulations which could prevent nerve damage in the event of a gas attack
Plans are under way to begin developing therapeutic applications. Michelle Zhang a coauthor of the paper and, at the time, a high school intern in Bonneau lab, first broached the idea.
COLLATERAL DAMAGE or breast cancer prevention and DCIS therapy effective drug concentrations are required in the breast.
Tamoxifen is an anti-estrogen therapy for a type of breast cancer that requires estrogen to grow.
People who have persistent difficulties sleeping after a divorce may address the issue by seeking out cognitive behavioral therapy,
and is typically aggressive. here is an urgent and ongoing need for the development of novel therapies
They report their results in Cancer Biology & Therapy. The AAV2 killed 100 percent of the cells in the laboratory by activating proteins called caspases,
since tumor necrosisr deathn response to therapy is used also as the measure of an effective chemotherapeutic,
and could ultimately aid in finding a potential probiotic therapy. Grow the needle without the hay
Haller treated 17 adult Type 1 diabetes patients for two weeks with the cocktail therapy and then followed them for a year.
and two years. he model has mostly been to test therapies aimed at beta cell preservation in people who have just been diagnosed,
COMBINATION THERAPIES Atkinson began considering Thymoglobulin as a treatment for diabetes nearly a decade ago.
Based on Schatz belief in combination therapies, the group began shepherding a cocktail of Thymoglobulin and Neulasta through early studies done with mouse models. espite tremendous strides in our understanding of the natural history of Type
the study could potentially be paradigm-shifting for our field in that it documents we should really be looking at combination therapies in treating Type 1 diabetes,
says principal investigator and senior author Edward Damiano of the Boston University department of biomedical engineering. here no current standard-of-care therapy that could match the results we saw. ne of the key virtues of this device is its ability to start controlling the blood sugar instantly,
He says perhaps there will be a way to combine behavioral therapy and stem cell treatments after a brain injury to rebuild some of the damage.
and monitor brain disease and therapy. Portable scans Another commonly used method for mapping brain function is positron emission tomography (PET),
The work creates the potential to develop lectroceuticaltreatments as alternatives to drug therapies, says William Newsome, professor of neurobiology and director of the Stanford Neurosciences Institute.
and can be targeted by therapeutics. A few rare cells, however, remain dormant, biding their time and avoiding destruction before activating
when selecting the most effective therapy and appropriate dosage. The investigators are currently designing a study to correlate pharmacokineticshe time course of drug metabolismith genotype.
and potentially provide therapies for diseases such as amyotrophic lateral sclerosis (Lou Gehrig disease), Huntington, or Alzheimer. In the specially engineered growth systemhe arpetsfu
discoveries like this provide tools for modeling disease in the laboratory and for developing cell-replacement therapies.
pave the way for an urgently needed therapy that is highly effective against the flu virus
a Mcgill Phd student and the study first author. nderstanding their individual role is crucial in developing a new therapy.
and that specific inhibition of PGE2 will be an effective therapy against influenza viral infection by boosting immune responses. i
and would aid clinical trials that aim to develop anti-RSV therapeutics. TOO SICK TO SEND HOME?
Published in the Journal of Pharmacology and Experimental Therapeutics, the new research could significantly change the quality of life for scleroderma patients
The findings in adolescent mice are an especially promising step in efforts to develop better therapies for schizophrenia in humans,
the greater understanding of the biology of vision gained from such studies also informs the search for new forms of therapy,
Inglehearn says. ince new therapies are often specific to particular forms of inherited blindness, it is essential for each patient to know which condition they have,
helping to test the new therapies and potentially benefiting from them themselves. A grant from the National Eye Research Centre, together with funding from other sources, supported the research s
then this could be a potential target for new therapies, Canaan says. The immune system response that produces inflammation is crucial in warding off infections. hus it has short-term beneficial effects on survival
as well as the new 3d method, to compare the radiologistsanalyses with pathologic review of tumor samples after therapy and surgical removal.
and each received pre-and post-chemoembolization MRI scans to assess the effects of therapy on the tumors.
and whether these therapy choices help people live longer. The software used in the MRI scans was developed at Johns Hopkins and at Philips Research North america.
and social behaviors nd if you don t understand the circuitry you are never going to understand how the gene mutation affects the behavior. oing forward he says such a complete understanding will be necessary for the development of future therapies.
which is refined further by chemical processes to create higher-value therapeutics such as oxycodone and hydrocodone better known by brand names such as Oxycontin and Vicodin respectively.
And that has held back certain medical therapies. MAGIS: The new method Unlike the calutron, which requires huge amounts of energy to maintain a magnetic field with electromagnets,
cancer therapies, and nutritional diagnostics. The new method also has the potential to enhance our national security.
which have a wide range of application from membranesâ##for instance for the purification of waterâ##to therapeutic uses including the development of new drug systems. ource:
scanning medical therapy and imaging and research in biology and materials science. ecause it employs commercial lasers
and coordination difficulties one of the major challenges teachers and occupational therapists come up against time and again is limited the time they have to work one-to-one with each childhill says. n this respect haptic robotic technologies have huge potential efficiency benefits. hey provide a means by which children can receive supported practice at a level
which adjusts to their growing abilities without the need for one-to-one interaction with a therapist. anks of these systems could be used simultaneously by multiple children in a clinic
also called mitochondrial gene replacement therapy, is not to tweak the physical characteristics or personality traits of a child those reside in the nucleus,
and therapies we validate in animal models often fail to be tested effective when in humans,
He works with therapists to sustain his mobility with the Freedom Driver onboard is on a number of blood-thinning medications and eats low sodium meals.
Products that use silica-based nanoparticles for biomedical uses such as various chips drug or gene delivery and tracking imaging ultrasound therapy and diagnostics may also pose an increased cardiovascular
#Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most neurological disorders#said Choi.#
#Gelatin nanoparticles are a delivery vehicle that could be used to deliver many therapeutics to the brain#Choi said.#
supporting the idea that we could develop A3ar agonists as possible new therapeutics to treat chronic pain,
These include rooftop garden loral therapy, art classes making realistic representations of everyday objects, music therapy with bongos sounding ike a heartbeat.
doing art therapy and attempting physical therapy with dances and alloon badminton (the racket is stretched pantyhose on a frame).
and the project is expected to be completed 2018.20 years from now there will be therapies, instead of chemo, that will be a much more targeted approach to treatment,
One example of such a therapy that already exists is Herceptin, a drug specifically designed for women with a type of breast cancer characterised by over-activity of the Her2 gene..
whichassuming robo-therapy is much, much cheaper than human-therapywill also vanish from the economy.)
when an AI can train up an robo-therapist better than a human canagain, no great stretch because all we re really talking about is access to a huge database of psychological data combined with ultra-accurate pattern recognition, two already possible developments.
and the growth of new neurons or neurogenesis is an important step in developing therapies to address impaired learning
The therapy has been tricky to administer, because it requires placing ultrasound leads on the skin directly over the bone injury.
and control of the nanobots is equivalent to a computer system. his is the first time that biological therapy has been able to match how a computer processor works,
But because stem cell therapies remain cutting edge, they have largely been used to target life-threatening problems such as heart failure.
The lab most recent findings suggest that stem cell therapy could be used to help older patients recover from muscular injuries, for example from falls,
Our data pave the way for such a stem cell therapy, Blau said. Other recent work in stem cell therapy has looked similarly for ways the cells could improve functioning of existing organs, rather than building replacements through regenerative medicine.
For instance one recent study suggested that the cells may be able to kick-start insulin-making in pancreas in Type-1 diabetics by replacing Beta cells.
and that it could lead to personalized reprogrammed cell therapies to treat a variety of conditions.
Nature News In a milestone for a politically charged field, the US Food and Drug Administration (FDA) has approved the world's first clinical trial of a therapy generated by human embryonic stem cells.
phase I safety study of a stem cellerived therapy for spinal cord injury. The publicly traded company has an extensive patent portfolio relating to embryonic stem cell research,
Politics and approval In a conference call with analysts and reporters, Geron's president and CEO Thomas Okarma said that the trial"marks the dawn of a new era in medical therapeutics.
and may soon try out the therapy on stronger fearful memories. To discover whether drug treatment would change this,
and may soon try out the therapy on stronger fearful memories r
#The genomics of the sniffles: Nature News Genome sequences of the cold virus could reveal new secrets behind its prowess.
could be used to design new therapies against colds or to determine, for example, why one strain can cause more severe symptoms than another."
The risks involved with a bone-marrow transplant far outweigh those that come with years of antiretroviral drug therapy
whether a patient is responding to therapy. Whereas Magnetic resonance imaging (MRI) is a useful tool, tumors only show up on imaging scans once they are at least one millimeter in diameter
but reproducing it could lead to new stem-cell-based therapeutic strategies. The initial target of the leprosy bacterium#Mycobacterium leprae#is Schwann cells,
say#for cell therapy. Although the number of published papers from ips-cell research has not yet caught up with that of ES-cell work (see Inducing a juggernaut),
the spinal-cord trial would double the number of companies sponsoring human clinical trials for ES-cell therapies.
and Japan is setting up a stem-cell bank of some 75 ips-cell lines intended for future therapies.
saying that work on embryonic-stem-cell lines could lead to therapies for Parkinson s disease, diabetes and other ailments."
Jay Cohn, a cardiologist at the University of Minnesota Medical school in Minneapolis, also worries that the focus on LDL levels offers up the wrong patients for statin therapy.
and motivated many patients to get the statin therapy that he believes they need.""Just to throw that out the window doesn t seem like the ideal scenario.
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