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www.sciencedaily.com 2015 10566.txt.txt

#Cell size regulation mechanism discovered An important mechanism in regulating the size of human cells is controlled via the IGF/Akt/mtor cascade. It has often been suggested that the mtor-dependent activity of S6 kinase might be relevant for this process. However, recent data from the research group led by Markus Hengstschläger of the Institute for Medical Genetics of the Medical University of Vienna now suggest that another protein complex, known as eif3, is an important cell size regulator. Firstly eif3 is responsible for the interaction between mtor and S6 kinase and secondly it is an important initiator of general protein synthesis (the new formation/translation of proteins) in the cell. Arrayarrayin the human body cell division and cell growth are linked not necessarily. For example, nerve cells can grow without multiplying and there is no cell growth during the initial cell divisions of the oocyte following fertilisation. Whilst, in recent years, a lot of research has been carried out into the mechanisms underlying cell division, very little attention has been given to the questions of how the different sizes of cells are regulated or why muscle cells, skin cells or blood cells need to be of different sizes. However, one thing is clear: if the control of cell growth goes awry, not only are the different types of cells no longer able to fulfil their various functions, tumours also start to form in most cases.""These findings are an important further step in our understanding of the molecular control of cell size and may also be relevant for developing new tumour therapies in the future, "explains Markus Hengstschläger g

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