Tropes

www.technology.org 2015 11057.txt.txt

#Scientists discover first NA ambulanceu of T researchers have discovered how severely damaged DNA is transported within a cell and how it is repaired. It a discovery that could unlock secrets into how cancer operates a disease that two in five Canadians will develop in their lifetime. cientists knew that severely injured DNA was taken to specialized ospitalsin the cell to be repaired, but the big mystery was how it got there, said Karim Mekhail, a Professor in the Faculty of medicine Department of Laboratory Medicine and Pathobiology. ee now discovered the DNA mbulanceand the road it takes. ekhail discovered this DNA ambulance, which is a motor protein complex, by using yeast cells. His research was published recently in Nature Communications. Mekhail team also found that the DNA hospital, also known as the nuclear pore complex, repairs damaged DNA inaccurately. This inaccurate fix is important because DNA contains the instructions for all our genetic information. While the repaired DNA can still replicate, it has irregular cell instructions a scenario that could cause cancer. his process allows cells to survive an injury, but at a great cost, said Mekhail. he cell has compromised a genome, but it stable and can be replicated, and that usually a recipe for disaster. o-author Daniel Durocher, Senior Investigator at Mount sinai Lunenfeld-Tanenbaum Research Institute, helped the team track the damaged DNA in living cells by using advanced microscopy. The tracking showed that this DNA ambulance is damaged necessary for DNA to efficiently change location within the nucleus. ancer often occurs when our chromosomes break and are said misrepaired Durocher. his work teaches us that the location of the break within the cell nucleus has a big impact on the efficiency of repair. he implications of the research could extend to a large number of developmental and disease settings. he processes wee studying are fundamental to the basic survival of a cell, said graduate student and first author Daniel Chung. lmost every aspect of disease can be linked to problems with DNA. ow Mekhail team is searching for more DNA ambulances and roads while conducting a study to see what role they might play in causing cancer. e expect that this may allow us to identify targets for a new class of anticancer drugs.?Scientists have been searching for this DNA ambulance for a long time and now we suspect there may be said more than one Mekhail. t exciting because it a whole new area of research. ource: Eurekaler i

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