The comparison involved the normal and tumor genomes from 43 children and adults with brain tumors, leukemia, melanoma and the pediatric eye tumor retinoblastoma."
"In this study of the tumor and normal genomes of 43 patients, CONSERTING identified copy number alterations in children with 100 times greater precision and 10 times greater precision in adults."
and have immediate practical application in associations of farmers and agrifood companies m
#Sensor detects spoilage of food VTT has developed a sensor that detects ethanol in the headspace of a food package.
#3d'organoids'grown from patient tumors could personalize drug screening Three-dimensional cultures (or'organoids')derived from the tumors of cancer patients closely replicate key properties of the original tumors,
These'organoid'cultures are amenable to large-scale drug screens for the detection of genetic changes associated with drug sensitivity
In recent years, scientists have developed organoid cell culture systems as an alternative approach to grow normal and diseased tissue in a dish.
organoids display the hallmarks of the original tissue in terms of its 3d architecture, the cell types present,
whether these cultures could potentially bridge the gap between cancer genetics and patient outcomes. In the new study, the researchers grew 22 organoids derived from tumor tissue from 20 patients with colorectal cancer
and then sequenced genomic DNA isolated from these cultures. The genetic mutations in the organoid cultures closely matched those in the corresponding tumor biopsies and agreed well with previous large-scale analyses of colorectal cancer mutations.
These findings confirm that the cultures faithfully capture the genomic features of the tumors from
which they are derived as well as much of the genomic diversity associated with colorectal cancer. To link drug sensitivity to genetic changes,
In validation of the approach, the researchers identified previously reported associations between specific mutations and resistance to particular drugs.
The organoids also revealed a novel gene-drug association, indicating that the subset of cancer patients with RNF43 mutations would strongly benefit from a drug that inhibits a protein called porcupine."
people at higher risk of developing the disease include those with a family history of pancreatic cancer, heavy smokers, the obese and people over 50 years with new-onset diabetes.
The team discovered that the gene coding for the MOCOS (Molybdenum Cofactor Sulfurase) enzyme was expressed under in stem cells from nine out of eleven of the ASD adults studied.
which has frequently been observed in autistic children, its association with gastrointestinal diseases --which often accompany autistic disorders
"Nusse's lab at Stanford focuses on a family of proteins of called Wnts, which are key regulators of stem cell fate.
lips and eyes--to alter their facial expressions in a variety of social situations. The findings, published in PLOS ONE today (05 august 2015),
and it was seen by some as a black sheep of the transition metal dichalcogenides TMD) family and purposefully ignored.
See fabricated a novel 1mm device (aka Robot Man) made of yellow photonic crystal-enhanced QDS.
"Until our study, we didn't really know how sulfur atoms are incorporated into a natural product--now we have discovered a new family of enzymes
"The study links a family of enzymes--molecules that act as biological catalysts--known as polyketide synthases (PKS) directly to a complex series of chemical reactions that ultimately add sulfur to leinamycin, a member of the polyketide family of natural products."
one of the co-first authors of the study and a member of the Shen lab."Since polyketide synthases are a large family of enzymes that have been proven amenable for polyketide structural diversity and drug discovery,
#Device may detect urinary tract infections faster Sepsis is a major killer and accounts for about half of the hospital deaths in the US by some estimates.
Bukau, the co-chaperones of the so-called J-protein family are key, in that they"lure"the Hsp70 folding helpers to the protein aggregates
A preliminary test of the assay on blood samples and some skin samples from 29 participants from families with inherited heart disease validated the clpp approach
We also find that several of his family members have similar heart conditions. So if we run the new genetic test
and find the man's illness has a genetic cause, such as dilated cardiomyopathy, we now have both a cause and a diagnosis,
and family with whom they live and work and readily distinguish those allies from strangers.
and an impressive collection of odorant receptors--ants have the largest odorant receptor gene family known in insects,
Scripps Family Chair Professor of Chemistry, described such a feat. But Lerner's team reasoned that a selection-based design of these junctions would be a more general approach to making useful protein-in-protein molecules.
exactly what will become of these new families of 2-D materials we've discovered,
and preventing HIV more difficult, leading to sicker patients and more deaths. In turn, once someone is infected with HIV,
The trial, conducted over one year at two Family AIDS Care & Education Services (FACES) health facilities in the Nyanza region in Kenya, enrolled 72 participants at one facility for the intervention
The study found that patients who received the device had significantly lower mortality than heart valve patients who underwent open-heart surgery.
Aortic stenosis can lead to heart failure and death. About 100,000 people in the United states have aortic stenosis a
because once you have that architecture, then you can ask fundamental biological questions.""Kilian said these questions range from the basic--how macrophages signal to the breast cells--to the more long-term:
"Our surfaces combine the unique surface architectures of lotus leaves and pitcher plants, in such a way that these surfaces possess both high surface area
the researchers etched micrometer scale pillars into a silicon surface using photolithography and deep reactive-ion etching,
and then created nanoscale textures on the pillars by wet etching. They then infused the nanotextures with a layer of lubricant that completely coated the nanostructures,
or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize,
Chemical analysis of these insoluble deposits reveals that they are made up of a family of short protein fragments,
An international team of researchers led by Christian Haass (Professor of Metabolic Biochemistry at LMU and Speaker for the German Center for Neurodegenerative Diseases in Munich) and Dr. Michael Willem (LMU) has made now a discovery
and an international team of colleagues report that a misfolded version of a protein called alpha-synuclein seems to act in a similar way to transmit MSA from diseased human brain tissue to mice and to human cell cultures.
Both MSA and PD can arise sporadically in families with no history of the disease,
Woerman led a research team in the development of a rapid new method to test prion transmission using human cell cultures.
Arrayin 2004, professor Petter Strømme examined a child with congenital cataract, growth delay and symptoms from the brain, the peripheral nervous system,
#Completely paralyzed man voluntarily moves his legs, scientists report A 39-year-old man who had had been paralyzed completely for four years was able to voluntarily control his leg muscles
In addition to the robotic device, the man was aided by a novel noninvasive spinal stimulation technique that does not require surgery.
me, having spent my whole adult life before breaking my back as an athlete.""Even in the years since he lost his sight,
and quality of life,"said V. Reggie Edgerton, senior author of the research and a UCLA distinguished professor of integrative biology and physiology, neurobiology and neurosurgery.
he now believes it is possible to significantly improve quality of life for patients with severe spinal cord injuries,
a disease that the World health organization estimates was responsible for 584,000 deaths in 2013, along with an estimated 198 million new cases in that span of time.
sequenced the genomes of more than 100 members of a Colombian family affected with early-onset Alzheimer's.
when the mutation so powerfully determines the early age at onset in most of the family members?
Human culture stems from knowledge acquired through society's shared experience. Cultural transmission enables new members of society to quickly learn from this accumulated experience.
which infects 50 million people and causes 40,000-110,000 deaths via severe diarrhea worldwide.""Chelsea is a fearless experimenter.
Then they challenged these cultures with the parasite E. histolytica.""We do this all the time in cancer research,
E. histolytica decimated many thousands of these independent cell cultures. However, a small number of cells seemed to resist the parasite.
Over these generations of selection, we saw the cultures becoming more and more enriched for cells lacking specific genes."
A follow-up experiment showed that new intestinal cells treated with E. histolytica showed potassium efflux--the flow of potassium from inside a cell out through the cell wall--directly before cell death."
"The parasite was causing potassium efflux right before cell death and cells that happened to be unable to transport potassium didn't die."
"This is a major finding with translational implications for this infection that causes so many deaths worldwide, but also proof that this cancer-science approach can be used to explore genetic mechanisms of resistance in the field of infectious disease,
mortality due to disease can be prevented by manipulating characteristics of the host t
#Super-stretchable metallic conductors for flexible electronics Washington state University researchers have discovered how to stretch metal films used in flexible electronics to twice their size without breaking.
#New molecule found to prevent preterm birth Premature births are linked intimately with inflammation of the uterine tissue, a biological response
which is the world's leading cause of infant death and the origin of potentially severe,
The research team is looking forward for tests to be able in a near future that will be able to predict the preterm delivery risk of a woman,
937 deaths in the U s. Although current infection rates are declining, the majority of these deaths, about 8,
but showed extensive association with microglia--mobile cells that surround and protect neurons. Another example of Scales's practical application came from examining the 3d positions of active microglial cells and amyloid beta plaques.
a detailed 3d reconstruction and analysis using Scales clearing showed that association with active microglial cells occurs early in plaque development,
and seriously improve the quality of life by reducing carbon emissions from fossil fuels and encourage efficient use of resources."
and prevents cellular death. The authors first discovered that an enzyme related to HSD10, Csga, produces energy during sporulation in the bacterium Myxococcus xanthus.
or cell death. HSD10 activity is inhibited strongly when bound to the amyloid beta peptide so prevalent in Alzheimer's disease."
a postdoctoral research associate in the Franklin College of Arts and Sciences.""But with rampant oxidative stress leading to uncontrolled cellular death,
you end up with diseases such as Alzheimer's and Parkinson's. HSD10 potentially prevents this by removing these damaged lipids before they have a chance to act."
Mooney--who is also the Robert P. Pinkas Family Professor of Bioengineering at the Harvard John A. Paulson School of engineering
As of now, transplanted cell death remains a major challenge. To improve the therapeutic ability of transplanted stem cells,
Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients.
Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the Mcgill University Health Centre (RI-MUHC) and University of Alberta could be a game changer for patients, improving both quality of life and longevity.
The research team discovered a new gene involved in muscle wasting that could be a good target for drug development.
In all of these chronic conditions, muscle wasting predicts earlier death.""Cancer patients often present with muscle wasting even prior to their initial cancer diagnosis,
not only can we potentially improve the quality of life of patients, but also allow them to better tolerate their oncological treatments, to stay at home for a longer period of time,
The quantum lab on tour through Austria Currrently, a light version of the virtual lab can be experienced as an interactive exhibit in the special exhibition"Das Wissen der Dinge"in the Natural history Museum Vienna.
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
#Novel role of mitochondria identified in immune function Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
Patricia A. Martin-Deleon, a reproductive biologist at the University of Delaware, has witnessed this behavior many times in her studies of fertility in mice, the closest genetic model to humans (and with a much faster reproductive cycle.
The research, supported by the National institutes of health-National Institute of Child Health and Human Development and the Delaware INBRE program, is published in the Journal of Biological Chemistry.
disappointing reality that they can't have a child of their own. Even when the process works, a high sperm-to-egg ratio is required, the opposite of
"That gives us hope they can be used as vehicles for improving fertility and the chances of producing healthy embryos and offspring."
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
The paper outlines the overall architecture and server-side deployment model the design of Safepay, prototype implementation and security analysis. Here's how it works:
and then trigger a specific response, such as cell death. This system can be customized to detect any DNA sequence in a mammalian cell
Cells that did not receive the new gene could be induced to undergo cell death creating a pure population of the desired cells.
They showed that silicone elastomers can be printed seamlessly into gradient architectures composed of soft and rigid regions.
The Canadian Diabetes Association reports that more than 20 Canadians are diagnosed newly with the disease every hour of every day.
It is also the seventh leading cause of death in Canada, with associated health-care costs estimated at nearly $9 billion a year.
"Without access to this critical tissue through the Alberta Diabetes Institute Isletcore and the generosity of organ donors and their families, we would not have been able to carry out this study,
an aging population and heightened awareness of the disease stemming from the 2011 death of Apple Inc. cofounder Steve jobs. Zajac-Kaye's group discovered that a single protein is behind the process that allows pancreatic neuroendocrine tumors to thrive.
and induced the death of pancreatic cancer cells. Researchers then tested its effectiveness on human pancreatic cells that had been implanted in mouse models.
Metastases cause the vast majority of cancer deaths, but their tiny seeds are so difficult to track that few researchers have managed to study them.
despite the fact that it causes virtually all breast cancer deaths. Previous work by Werb's group had found a subset of cells at the edges of breast cancer tumors that seemed primed to metastasize.
undifferentiated state and relatively immune to cell death, which the researchers surmised might help metastatic colonies survive in new and hostile environments.
Also, each family of bacteriophages can have a different genome organization and life cycle, making it difficult to engineer them
The MIT team began with a phage from the T7 family that naturally kills Escherichia coli.
and characterization of atomically thin 2d hybrid perovskites and introduces a new family of 2d solution-processed semiconductors for nanoscale optoelectronic devices, such as field effect transistors and photodetectors."
The application of the CRISPR-Cas9 system for mammalian genome editing was reported first in 2013, by Zhang and separately by George Church at Harvard.
or death in the cabozantinib arm as compared with the everolimus arm. Regaining tumour control after prior targeted therapy may reduce symptoms related to kidney cancer
Virginia--a liquid-cooled FPGA was operated using a custom processor architecture provided by Altera. With a water inlet temperature of approximately 20 degrees Celsius and an inlet flow rate of 147 milliliters per minute
Bakir's group has demonstrated the fabrication of copper vias that would run through the silicon columns that are part of the cooling structure fabricated on the FPGAS.
fabricated high aspect ratio copper vias through the silicon columns, reducing the capacitance of the connections that would carry signals between chips in an array."
"The findings are particularly significant in the light of improving life expectancies and the associated increase in cases of ARMD.
Risk Factors for Cardiovascular disease Approximately 610,000 people die from heart disease every year in the United states--that's one of every four deaths.
These modifiable risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
or the size and position of the fetus in a pregnant woman, to mention a few examples.
Trib1 is part of the protein family Tribbles which play diverse roles in cell signalling and development.
From River Besòs sediments, after three years'research, the researchers have obtained a stable bacterial culture
"The metamaterial consists of silicon pillar arrays embedded in a polymer matrix and clad in gold film.
"The chemical marriage between URMC-099 and antiretroviral drug nanoformulations could increase drug longevity, improve patient compliance,
Dr Fernández-Espejo added,"The ultimate aim is to use this information in targeted therapies that can drastically improve the quality of life of patients.
'Understanding how subtle changes in our genes may trigger brain cell death is one of the most promising avenues for the development of new treatments for Parkinson's.'
or damaged by routine manual work or sports such as rock climbing. Additionally people attempting to escape identification might deliberately thwart the sensors by rubbing out their fingerprints,
a man in the prime years of his life suffering from debilitating heart failure and a former NFL athlete crippled by end-stage heart failure were treated all successfully with a surgical approach pioneered by cardiac experts at University of California, San diego School of medicine.
and death for a person waiting for a transplant or suffering from advanced heart failure.""An LVAD relieves symptoms,
and increases mortality.""Pretorius said biventricular support is required for up to 30 percent of LVAD recipients.
If any of these associations are disrupted, the transcription factor is inhibited. In this study, Tsigelny and team aimed to disrupt the OLIG2 buddy system as a potential treatment for glioblastoma.
Cancer is a leading cause of death worldwide, accounting for over 8 million deaths per year,
and 70%of the world's cancer deaths occur in Africa, Asia and Central and South america.
The number of new cancer cases is expected to rise by 70%over the next two decades 1. With the help of his Research Associate Ana Isabel Barbosa,
which operates in a similar way to a pregnancy test, has already been used successfully by Dr Reis in a separate study that detected prostate cancer with the help of a smartphone camera.
"It's as simple as pregnancy tests, where the specific marker shows in a few seconds,"explains project coordinator Dr. Marco Antonio Rite Palomares, director of the Biotechnology Center of the Tec de Monterrey FEMSA.
natural cell death no longer functioned properly. According to the researchers, the apoptotic process is to be seen as completely independent of the uptake mechanism.
if you're crafting devices with complex architectures, such as customized miniature biomedical devices. Within a single patient-specific device, the corners, the curves,
"These are the sorts of architectures that we are now producing synthetically, "says Erb, who has received a $225,
With this technology, we're finally scratching the surface where we can theoretically determine that a particular fiber architecture leads to improved mechanical properties
and we can also produce those complicated architectures
#3-D printed'building blocks'of Life scientists have developed a 3-D printing method capable of producing highly uniform'blocks'of embryonic stem cells.
Previous work in this realm relied on"growing the cell cultures in a Petri dish, which tends to deform the structure,
"And, borrowing from previous cell culture work done by our group, our high-frequency ultrasound method detects changes within the stiffness of cells with high accuracy.
but can lead to severe adverse reactions. 150 deaths between 2004 and 2008 in the US were thought to be a result of drug manufacturers deliberately cutting heparin with OSCS to save money.
) USC biomedical engineer Dong Song, a member of the team, says that the group has tried the stimulation on a woman with epilepsy,
#This Robotic Hand Wired to a Brain Implant Restored a Paralyzed Man Sense of touch In the last few years,
In 2012, a man with one leg took the stairs all the way to the top of Chicago Willis Tower on a thought-controlled prosthetic limb.
Meanwhile, a paralyzed woman directed a robotic arm with her thoughts to bring a straw to her lips for a sip of soda.
The astronomers created a video explaining the slow death of the universe to illustrate the discovery.
390 gram (0. 9-pound) Robohon sports a 2-inch touchscreen, a quad-core CPU, and can connect to 3g, LTE,
Robohon was designed by renowned Japanese roboticist Tomotaka Takahashi, the man behind the similarly-styled Kirobo humanoid robot and several others.
Everyone who ever tried to listen to music, whether in tiny earphones or big expensive cans, knows that
the music leaking out in the room around him. urn down the volume or youl go deaf!
he realized the danger of hearing loss by listening to music too loudly isn just something parents say
because they can stand your music. According to data by the World health organization and the American Academy of Audiology
Most devices we use today to listen to music, however, can crank the volume up to more than 100db.
Along with serial entrepreneur Anthony Lye, the startup they co-founded, Aegis Acoustics, is on a mission to prevent further hearing loss among kids who love consuming their music with headphones.
The sound of music At first glance the Aegis Pro headphones don look like a particularly revolutionary product.
That a useful feature for parents until the child figures out how to deactivate or hide it, presumably.
Hsieh specializes in male fertility and men health. He treats sexual dysfunction, including low testosterone, erectile dysfunction and Peyronie disease.
the senior author of the new study, Trever Bivona, MD, Phd, assistant professor of medicine and member of the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC).
they could turn on a gener even families of genesy targeting enhancers at distant locations in the genomeomething that their previous gene activators could not do.
and fulfil their regular (adult) lifespan of around 22 months. The research was funded by the Lee kuan yew Research Fellowship
Studies have shown that perceived discrimination among minority adolescents leads to smoking, anger, alcohol use and abuse, depression or psychological distress,
According to the American Heart Association, African americans are at a higher risk than whites to die of heart disease.
but most of this research has been in adults. Goosby study is one of the first to examine the effects of discrimination in youth. e haven seen any studies that have been done in people this young before,
because there is a growing literature that shows discrimination is actually harmful for people health, particularly among African american adults,
#New transitional stem cells discovered Preeclampsia is a disease that affects 5 to 8 percent of pregnancies in America.
Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers.
meaning that all the cells in the culture are quite similar to each other in the way they express their genetic information. reviously,
During anti-angiogenic therapy, said Bergers, the Neill H. and Linda S. Brownstein Endowed Chair in Brain tumor Research and a member of the UCSF Helen Diller Family Comprehensive Cancer Center,
The innate neuronal property might be utilized to protect neurons from degeneration or cell death in the future.
we might be able to protect neurons from degeneration or cell death. Recent studies have suggested that changes in a region at the presynaptic membrane
Now that they have a reliable human beige fat cell culture system, Kajimura said, his team will be able to use the system as a screening platform to identify
and characterization methods together with our previous knowledge to create this thin films architecture. The use of thin film technology for Bi oxide is not trivial and required long and hard studies.
what theye touching while gaming. The Hands Omni glove developed at Rice Oshman Engineering Design Kitchen will provide a way for gamers
and developed with sponsor Virtuix, a Houston gaming technology company, is intended to provide force feedback to the fingertips as players touch,
while pain treatment options are limited to opioid-family pharmaceuticals such as morphine. It was while conducting clinical research at the University of California San francisco
Lam and his fellow researchers followed up this observation by looking at different types of cancers with known pain associations for instance, certain breast and melanoma cell lines.
and amount of TMPRSS2 in these cancer cell cultures stood in exact correlation with the known level of pain each cancer causes. t was exactly
what we know clinically about pain association, adds Lam. A New Direction for Drug Research The startling discovery of TMPRSS2 role in triggering cancer pain may lead to the creation of targeted cancer pain therapies that effectively shut down the expression of this gene
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