and we look forward to working with them on other intellectual properties in the future. Diabetes is a chronic disease that occurs either
Police sources spoke of 1000 more deaths in the rural areas of Nepal. 50 more people were killed in northeastern India,
The total death toll for both quakes exceeded 5000. In 1934 Nepal and the neighboring Indian state of Bihar suffered severe damage when an 8. 2 quake struck.
Migration along a gradient, called a taxis, is found all over nature. The daily vertical migration of marine plankton toward sunlight, is one example,
and it the way many microbes find food. f you can design particles that can feel their environment
Professor Thomas said. ut a common end result of this compensatory growth is eventual heart failure, a major cause of death in Australia. uring laboratory tests,
and using this new family of molecules. Furthermore, this discovery opens the way for the development of strategies to eliminate the viral reservoirs of individuals already infected.
the textile could be used in sports and fitness. Joggers could use the integrated sensor stockings to analyze their running style
but the research may potentially uncover several roles theca cells play in female fertility y
and are capable of rapidly penetrating human airway mucus freshly collected from patients visiting the Johns Hopkins Adult Cystic fibrosis Program directed by Michael Boyle,
said Wyss Core Faculty member George Church, Ph d, . who is a pioneer in the converging fields of synthetic biology, metabolic engineering, and genetics.
Church is the Robert Winthrop Professor of Genetics at Harvard Medical school and Professor of Health Sciences and Technology at Harvard and MIT.
Now, Wyss Institute researchers led by Church have developed a new suite of such sensors, reported in Nucleic acids Researchjournal,
said Church. ee trying to control biological processes and we need new ways to get our hands in at the molecular level wee now reaching in deeper than wee previously been able to,
says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
the researchers isolated stem cells from adult skin and coaxed them into Schwann cells by exposing them to small molecules. e observed that the bulge,
CGL4, which usually leads to death in the patient teenage years. Many children presumably also die from this disease during their first week of life,
without any diagnosis other than udden infant death syndrome'says Karl Swärd and Catarina Rippe, researchers at Lund University.
In a recently published study in the journal PLOS ONE (1), the researchers at Lund University reveal that a family of so-called transcription factors called yocardin family coactivatorsregulate the formation of invaginations.
Conference on Artificial intelligence, organized by the Association for the Advancement of Artificial intelligence. A two-year seed grant from the UW-Madison Graduate school currently supports this work.
disability and death in the U s. Smokers who want to quit can turn to various pharmacological aids.
Only about 15 to 30 percent of smokers who try them are able to stop smoking for longer than one year.
members of a family of painkilling drugs sourced from the opium poppy. It can take more than a year to produce a batch of medicine, starting from the farms in Australia,
as such big injuries of an incredibly vascular structure inevitably require a clot in order not to bleed to death,
One-third of patients diagnosed with breast cancer eventually develop metastases in distant organs, with an increased risk of death.
migration and differentiation. Fibronectin is associated with high-risk breast cancer with poor prognosis. The researchers collected images depicting metastases where breast cancer had spread beyond the original tumors.
and diversification of the species. or each robot child, there is a unique enomemade up of a combination of between one and five different genes,
which contains all of the information about the child shape, construction and motor commands. As in nature, evolution in robots takes place through utation where components of one gene are modified
each child was tested on how far it travelled from its starting position in a given amount of time.
each child took the robot about 10 minutes to design, build and test. According to Iida, in future they might use a computer simulation to pre-select the most promising candidates,
Now they report in the journal Advanced Materials that they have discovered a new family of gel-like materials
we were astounded to see exquisite fine-scale fibre architectures, which are completely different from those known in any other contemporary gel materials,
SEM images (false colour) depicting the intricate gel fibre architecture They then discovered that intertwined amongst these microscopic fibres were a profusion of nanoparticles around 100 nanometres in size.
Reversible conversion of a hybrid gel subject to physical and chemical stimuli his makes this family of hybrid gels highly tuneable,
to the best of our knowledge this is the first example of its kind reported in the literature.
Katherine Cohen, Boston Childrengreater precision, greater safetythe life-sized and enlarged 3-D models, based on brain magnetic resonance and magnetic resonance arteriography data from each child
without putting a child at risk. y
#Flexible, biodegradable device can generate power from touch Longstanding concerns about portable electronics include the devicesshort battery life and their contribution to e waste.
Sixty healthy adults had scanned their brains using diffusion spectrum imaging which provided a picture of the orientation of moving water molecules.
And, multi-shell imaging was used on 78 healthy adults to get similar images using different imaging parameters.
The device is expected to make a difference in medical treatments, preventive health care and sports p
because once you have that architecture, then you can ask fundamental biological questions. Kilian said these questions range from the basic how macrophages signal to the breast cells to the more long-term:
using them to measure activity in the larger culture population, which can include as many as a million cells. ecause we have all those electrodes,
and then compare the amount of activity being expressed by the culture to a target rate,
The optoclamp can be used to control cell cultures grown atop electrode arrays as well as in living animal models in
allowing experiments to focus stimulation on specific areas of the brain or brain cell cultures. The light signals now affect an entire culture
or brain region. e want to precisely control where photons are being sent to activate different cells, Newman said. ptogenetics allows genetic specification
Each silicon stump, or pillar has an elliptical cross section, and by carefully varying the diameters of each pillar
and rotating them around their axes, the scientists were able to simultaneously manipulate the phase and polarization of passing light.
or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize,
assistant professor of mechanical engineering and a faculty member in the Penn State Materials Research Institute. ur surfaces combine the unique surface architectures of lotus leaves
the researchers etched micrometer scale pillars into a silicon surface using photolithography and deep reactive-ion etching,
and then created nanoscale textures on the pillars by wet etching. They then infused the nanotextures with a layer of lubricant that completely coated the nanostructures,
Mooney who is also the Robert P. Pinkas Family Professor of Bioengineering at the Harvard John A. Paulson School of engineering
As of now, transplanted cell death remains a major challenge. To improve the therapeutic ability of transplanted stem cells,
but hotspots are regions of volcanic activity at Earth surface that show no obvious association with plate boundaries.
but have extensive association with microglia (mobile cells that surround and protect neurons) instead. Scientists found a different application for Scales too.
this 3d analysis showed that association with active microglial cells occurs early in plaque development,
which has proven to be extremely safe for health monitoring, even during various stages of pregnancy.
The paper outlines the overall architecture and server-side deployment model the design of Safepay, prototype implementation and security analysis. Here how it works:
given our previous finding in PLOS Pathogens where we found that this family of proteins generally affects the lipid property of cell membrane
The application of the CRISPR-Cas9 system for mammalian genome editing was reported first in 2013, by Zhang and separately by George Church at Harvard university.
and the Chikungunya virus in a man who was asymptomatic at the time, but eventually reported having a fever and joint pains a
looked at the health records of 4. 1 million adults in the UK who were initially free of diabetes and cardiovascular disease and found:
overweight and obese individuals The relative association between blood pressure and diabetes decreased as body mass index (BMI)
RAS PROTEINS control the chemical pathways responsible for growth, migration and survival within a cell. Basically, theye got a big job.
Last flu season, H3n2 contributed to some 36,000 deaths in the United states. And in some patients particularly young children
older adults and people with weakened immune systems knowing that the H3n2 strain is present may alter treatment.
Kristine Wylie investigates the viruses that set up residence in and on the human body, collectively known as the virome.
due to apparent activation of blind pores within the carbon architectures as the cell charges and discharges over time,
Nanocarbon architectures derived from biological materials such as mushrooms can be considered a green and sustainable alternative to graphite-based anodes,
The nanoribbon-like architectures transform upon heat treatment into an interconnected porous network architecture which is important for battery electrodes
because such architectures possess a very large surface area for the storage of energy, a critical component to improving battery performance.
that will be eventually be able to treat countless patients. he findings are particularly significant in the light of improving life expectancies and the associated increase in cases of ARMD.
Approximately 610,000 people die from heart disease every year in the United states oughly one of every four deaths
These risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
There is also a website available for calculating a child metabolic syndrome severity score using clinical measures e
or the size and position of the foetus in a pregnant woman, to mention a few examples.
But now, in a landmark study by George Church and his team at the Wyss Institute for Biologically Inspired Engineering at Harvard university and Harvard Medical school, the gene editing system known as CRISPRAS9 has been used to genetically engineer pig DNA
Church is the Robert Winthrop Professor of Genetics at Harvard Medical school and a Wyss core faculty member.
The advance, reported by Church and his team, including the study lead author, Luhan Yang, a research fellow at HMS and the Wyss, was published in the October 11 issue of Science.
or PERVSROUGHT more than a billion dollarsworth of pharmaceutical industry investments in developing xenotransplant methods to a standstill by the early 2000s, said Church.
Church and his team have inactivated all 62 repetitive genes containing a PERV in pig DNA,
and is currently collaborating with Church on further genetic modifications of his pigs. f Church and his team are able to produce pigs from genetically engineered embryos lacking PERVS by the use of CRISPR-Cas9,
When the offspring became adults, the researchers examined their response to stress, just as they had done in their 2013 study. he results mapped right onto
and help us better understand the functions and interactions of genes, the origin and spread of diseases, the co-evolution of hosts and parasites and migration of human populations.
Then scientists placed the cells into culture conditions containing certain cytokines and soon saw that their efforts were continued successful cells to divide as stem cells instead of undergoing differentiation into B-cells.
In a culture without these cytokines the cells differentiated into various immune cells. Team wanted to test
The team also established that concurrently silencing both receptors had a strong inhibitory effect on the proliferation, migration and invasion of the cancer cells.
First, the receptors are not usually present in normal adult tissues which means that any drug therapy will likely have few side effects.
which is the leading cause of serious long-term disability in adults. The five-year study, performed in an animal model,
The carbonic anhydrase would be immobilized with solvent inside a reactor vessel that serves as a large purification column.
Their sensors have been used to monitor premature babies, pregnant women, patients in Intensive care units and patients suffering from sleep disorders.
The disease affects more than four million Americans and causes over 750,000 hospitalizations and 130,000 deaths per year in the United states alone.
disease and cell death. eat shock genes and their heat shock proteins are expressed highly during stress and are very critical to protect cells;
and assess male fertility at low cost Scientists have developed a new paper device that analyzes DNA
It also could determine the DNA integrity of sperm a predictor of fertility from semen samples as accurately as current clinical methods t
He used his research to launch three biotech companies centered on forensic science, fertility assessment and contraception methods.
Each company was formed around the discovery of unique identifying protein features within the cellular architecture of sperm and egg cells.
The difference is that Ovastasis plans to use those protein biomarkers as targets for a novel female birth control medication. he identification of drug targets that are selective to the egg
or to the sperm gives you opportunities to create small-molecule drugs for female and male contraception, contraceptive vaccines,
Currently approved female birth control medications work by manipulating the female body estrogen and progesterone levels. While effective, these drugs are steroids
Ovastasis is developing a new form of birth control that will interact only with a woman reproductive cells to arrest their development.
and release the drug payload, triggering changes that result in cell death within a few days.
The same biomarkers that will help limit the area of impact for Ovastasis birth control will also help Neoantigenics confine the toxic effects of cancer treatment to growing egg and tumor cells.
and want to preserve fertility, Herr said. While Neoantigenicsmedication would have to attack growing egg cells in order to kill similar cancer cells,
it would leave a woman reserve of dormant primordial eggs untouched. Only egg cells that are growing in the ovary in preparation for ovulation carry the SAS1B protein.
he CPM+LPCS that we have derived from human ipscs can be transferred from one medium to another for continuous culture
or death, can take as little as two weeks. That may not leave enough time for the immune system to mount an effective response.
and smuggle cancer signals their neighbors New research in The FASEB Journal suggests that an in vitro co-culture system robustly quantifies the transfer of fluorescent proteins between cells
#Study reveals the architecture of the molecular machine that copies DNA DNA replication is essential to all life,
and Stony Brook University has revealed that vital complex molecular architecture. And to their surprise, it does not look as they had expected. ur finding goes against decades of textbook drawings of
they have to survive on their own without family protection. To ensure successful colonization by these vulnerable creatures,
Frommer and his lab have worked extensively on the family of SWEET sugar transporters, which play several key roles in plants,
A Los angeles woman who got a pig liver in 1992 died within 34 hours. The last time a doctor transplanted a pig heart into a person, in India in 1996,
Harvard university scientist George Church and his former student, Farren Isaacs, of Yale, held a press conference to announce a breakthrough of their own.
Isaacs and Church described how, in separate experiments, they created what they called a enomically reordered organism, or GRO.
Church and Isaacs recently announced they had formed a Boston-based company, enevolv, to supply such GROS for use by industry to,
Church declared that e are aiming at modifying plant and animal cells, and maybe plants and animals. potential objection to the technology is already apparent:
Church likewise argues that his GROS are safe because they depend upon unnatural amino acids that are supplied only in the lab. Withhold these and the bacteria die.
Both Romesberg and Church reported a tiny fraction of the bacteria managed to slip the genetic handcuffs via mutation.
#Transplant Surgeons Revive Hearts After Death Transplant surgeons have started using a device that allows them to eanimatehearts from people who have died recently,
Transplant surgeons recognize two major categories of death. People can be brain dead, or they die
what they now call irculatory death. But by the time it stops on its own, a person heart is starved of oxygen
Eventually he thinks it might be possible to recover livers as much as an hour after death.
unlike in the U s. There are more than twice as many heart donors per capita in the U s as in the U k. Large believes taking hearts from circulatory-death donors could expand the supply in the U k. by almost a third,
Donors at the Papworth hospital have included victims of car accidents and failed suicide attempts by hanging.
though not all, die shortly after their family chooses to remove life support. If their hearts do stop,
and family members have given consent. hey are dying and it permissible to use their organs.
This way the team effectively turns a circulatory death into a brain dead eating heartdonor. With the heart pumping,
used to improve coverage in busy locations such as stadiums. Small cells usually link back to a carrier network using cable.
#Paralyzed Man Arm Wired to Receive Brain signals Scientists at Case Western Reserve University in Ohio say theye used electronics to get around a paralyzed man spinal injury,
Last year, a different Ohio man with partial arm paralysis received a brain implant and was able to mentally open
To complete the bridge of the man spinal cord injury, doctors then inserted more than 16 fine wires into the volunteer right arm and hand.
He said the man has been paralyzed for so long that his muscles are atrophied weak and. Efforts to combine brain-computer interfaces with FES systems began 20 years ago.
Spritam is an epilepsy medication used to treat seizures in children and adults. It's porous thanks to the 3d printing process,
"In nature, a great number of microorganisms, like diatoms, can assemble biominerals into intricate hierarchical three-dimensional architectures with great structural control,
Available treatments for quitting smoking fail in the vast majority of those who try them,
according to a study published last week (August 6) in the Journal of the American Chemical Society. he bacterium is like a little Pac-Man.
whiskers play a key role for animals in exploring, hunting or even just living undergroundsays electrical engineer Cagdas Tuna,
Spritam (levetiracetam) is an oral adjunctive therapy to treat a range of seizures in adults and children with epilepsy.
Cancers in this system the oesophagus, stomach, intestines and rectum are major causes of death and difficult to investigate,
Black silicon consists of clusters of microscopic vertical pillars or nanowires. Incoming light bouncing between individual silicon nanowires cannot escape the complex structure,
They then seeped a polymer between the silicon nanowire pillars. After the plastic support solidified, they etched away the silicon backing, leaving bull-eye patterned black silicon embedded in supple plastic.
digital music has matched and will likely soon surpass physical formats in the money it generates,
The drops contributed to the overall picture for the global music industry revenue of $14. 97bn in 2014, down a modest 0. 4%from a year earlier.
CDS are still far more popular than digital music in Japan which nonetheless saw revenue decline by 5. 5%in 2014,
and other sites to license music consistently. Youtube, owned by search engine giant Google, enjoys so-called afe harbourstatus under US law that lets it avoid liability for copyright infringement as it is considered an internet service provider.
The IFPI, in data released in the report, said that more than half of all internet users accessed music through video sites such as Youtube in the past six months.
and hate speech, using the aftermath of the Paris terrorist attacks to tighten the law on hate crime
and crack down on racism online. acism, antisemitism, hatred of Muslims, hatred of foreigners and homophobia are all rising in an unbearable way in our country, the prime minister,
There will also be tougher penalties for crimes deemed to have been fuelled by racism and antisemitism.
Muslims and Jews and often the government words have been lacking. He said action must be taken to specifically combat the high level of inequality,
the woman was raped and the attackers ransacked the flat, saying: ou Jews, you have money
#Can the internet of things save us from traffic jams? Traffic is getting worse. It doesn just feel that way,
but rather theye in the back seat with the windows dark, doing a crossword puzzle or reading the newspaper, talking to family or whatever,
could be applied to protective clothing in sports, for making bulletproof vests and in constructing buildings. Sosanya is in the early states of developing the new weaving method, an idea
and cut down on the number of materials used. retty much everyone sports companies has a neoprene on the inside a nice soft stretchy material on the inside then layers of foam
and Canadian police are investigating links between the hack and two suicides. The company said that Biderman resignation was n the best interest of the company
with police tying multiple blackmail attempts and at least two suicides to the leak. e are actively adjusting to the attack on our business and membersprivacy by criminals,
when more and more families are struggling to survive in the city. like the food and love the price,
so this is obviously not something that is going to be used to draw the Millennium Falcon into the Death Star any time soon.
It hovered thanks to"Magnetic field Architecture"(MFA), a fancy name for what the company's founder,
As a result, one type of resistant staph bacteria called MRSA causes over 80,000 infections and 11,285 deaths occur every year.
#Dr dre's new album streamed 25 million times on Apple Music in its first week Compton,
the new album from hip-hop mogul and Apple employee Dr dre, was streamed 25 million times in its first week on Apple Music.
only available for stream on Apple Music and digitally through itunes. Beats cofounder Jimmy Iovine was positive about the results,
saying that it constituted a good start for Apple Music.""We're beginning to show what we can do in terms of communicating music to a worldwide audience and helping artists at the same time,
"he told The New york times . But where Iovine says Apple is started just getting getting music to the world,
hip-hop's current kings are already old hands at disseminating their music to a huge and internet-literate fanbase.
and it's getting an upgrade to version 3. 0 with the 2016 family, headlined by the Snapdragon 820.
That means that at least one woman and one person of color is interviewed for each executive position"just so someone (else) can get in the door,
if you are a woman or an underrepresented minority.""Also on Tuesday, start-up backing firm Hackers/Founders said it was committing $20 million to Women 2. 0, a San francisco-based media company and resource that assists female entrepreneurs."
The article also touches upon the misogyny that possibly exists within the modern dating culture.
"but rather in the midst of reviving the dating culture by building something that is changing the world"and leading to"meaningful relationships."
"While reading the recent Vanity fair article about today's dating culture, we were saddened to see that the article didn't touch upon the positive experiences that the majority of our users encounter daily,
Virtual reality is a huge buzzword in the Hollywood and gaming communities, as folks look to eye-popping photography directly to your eyes to as the next big thing,
Virtual reality is a huge buzzword in the Hollywood and gaming communities, as folks look to eye-popping, immersive photography as the next big thing,
what most average U s. households get today. Fiber-optic cables work by sending data that's been encoded as packets of light.
The idea is that every household item that needs to be replenished frequently will get its own dedicated Dash button.
The standalone DRS buttons are meant for items in the household for which no machine is associated-such as shaving blades, creams, paper towels,
and sports drinks. Brands would be able to supply consumers with their own-brand Dash buttons,
She said as this type of crime-stealing sensitive information or trade secrets-is often profit-motivated,
Turkey's journey towards a new startup culture While far from the levels of Greece, Spain,
from gaming to software development and mobile applications.""Most common companies we see are based internet ones that do need not to much initial funding to thrive.
such as the low tolerance to failure and a strong"family effect",by which children are encouraged to choose safer careers.
And the"Woman Entrepreneur of the Year"award which began in 2007, has seen increased participation in the last editions, with up to 7,
and service oriented architecture, the lines between software providers and software consumers have blurred, almost to the point in
That's one death every seven seconds. 52 million Europeans are living with diabetes, and in Germany alone, there are 6 to 8 million documented cases.
because the app will red-flag the issue, the doctor can intervene, and the doctor and patient can work on solutions together.
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