#SAP and Heidelberg University Hospital Personalize Pregnancy Care This Sunday is International Women's Day,
In partnership with SAP and abcmedien, the University Hospital developed an app to provide pregnant women all information needed along their pregnancy and beyond.
However, unlike the typical pregnancy app, which only pushes consumer product information, the healthcare experts at Heidelberg University Hospital created this app to serve as a dual resource for both mothers and physicians alike.
Because pregnancy doesn't require frequent doctors'appointments, it's difficult to gather feedback from pregnant moms.
To maintain a close relationship with mothers during pregnancy the app asks users discrete and subtle psychological questions purposed to gather information to identify
and prevent health issues like depression. During pregnancy, hormones change and can affect brain chemicals, inducing antepartum depression and/or anxiety.
According to the American Congress of Obstetricians and Gynecologists, roughly 14-23 percent of women will struggle with symptoms of depression at some point during their pregnancy.
Luckily, antepartum depression is 100 percent treatable, but in many cases, the pregnant mother assumes that the mood changes are nothing more than normal hormonal imbalances (similar to PMS).
At Heidelberg University Hospital, doctors can analyze the answers obtained through the app, and proactively identify mothers at risk for such illness
because research suggests that children of women who experienced depression during pregnancy have a higher risk of becoming depressed as adults (JAMA Psychiatry).
By engaging with pregnant women and monitoring their health via this mobile application, Heidelberg University Hospital can reduce immediate and long-term risks for mother and for baby.
and complications arising from those infections lead to nearly 100,000 deaths annually. The health care and liability costs associated with infections are astronomical,
In fact, Carme Ruscalleda, the Catalan chef behind the three Michelin starred restaurant Sant Pau, used it to make an edible model of one of the stained-glass windows of Santa maria del Mar, a gothic church in Barcelona."
"We have to establish a culture of food machine usage. Cooks are keen to do demonstrations
and adults with acute lymphoblastic leukemia (ALL) who had relapsed multiple times or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy CTL019 developed at the Perelman School of medicine at the University of Pennsylvania.
The new data which builds on preliminary findings presented at the American Society of Hematology's annual meeting in December 2013 include results from the first 25 children and young adults (ages 5 to 22
) treated at the Children's Hospital of Philadelphia and first five adults (ages 26 to 60 treated at the Hospital of the University of Pennsylvania.
In July 2014 the U s. Food and Drug Administration granted CTL019 its Breakthrough Therapy designation for the treatment of relapsed and refractory adult and pediatric ALL a step
This is important because the death of photoreceptor cells is known to cause retinal degenerative diseases in humans that lead to blindness.
This adds another member to the family of piezoelectric materials for functional devices says Wenzhuo Wu.
These are part of an even larger family of 2d materials whose piezoelectric materials remain unexplored. Importantly as has been shown by Hone
For this study the research team also worked with Tony Heinz David M. Rickey Professor of Optical Communications at Columbia Engineering and professor of physics at Columbia's Graduate school of Arts and Sciences.
The researchers designed a family of materials that don't include rare earths but instead are made out of copper iodide
and can be collected easily in places where public smoking is allowed it could be part of a low-cost solution for a serious public health issue they say.
One step further along the researchers also determined the molecular architecture of the final double-ring structure left behind after the ORC leaves the system offering a number of key biological insights.
We now have clues to how that double-ring structure stably lingers until the cell enters the DNA-synthesis phase much later on in replication said study coauthor Christian Speck of Imperial College London.
a geobiology graduate student in the lab of Victoria Orphan of Caltech. These assemblages are also found in the Gulf of mexico as well as off Chile New zealand Africa Europe
Furthermore it is applicable to a broad range of documents from school textbooks children's stories and literature.
of a study published Oct 15 2014 in Cancer Research a journal of the American Association of Cancer Research.
Among those they found was disulfiram a drug approved by the FDA to treat alcoholism.
Sprain and Paul Renne director of the Berkeley Geochronology Center and a UC Berkeley professor-in-residence of earth and planetary science are coauthors of the study
or not the new finding spells trouble for modern civilization it likely will help researchers understand how
and treatmentthe scientists assume that an existing metabolic imbalance results in the activation and migration of immune cells to the liver.
Seniors living in highly automobile dependent suburbs who lose their licenses can suffer a decreased quality of life as a result.
because that's where the infrastructure is already in place for a better quality of life for people with limited mobility options says Patterson who holds a Canada Research Chair Transportation and Land use Linkages for Regional Sustainability.
The issue is important for planning future transportation systems as well as for its implications on the future welfare of the large baby-boom generation now starting to enter retirement.
#Defective gene renders diarrhea vaccine ineffective Acute diarrheal illnesses cause nearly one-fifth of all child deaths in developing countries.
Today vaccination is considered the most important method for reducing mortality. Unfortunately several studies have shown that the two available living vaccines Rotarix and Rotateq
This marriage of materials science and biology could give birth to a flexible sensitive coating that is easy and cheap to manufacture in large quantities.
Shutting off vital tumour growth processes can lead to the death of human brain tumour-initiating cells.
and their families says Weiss leader of the university's Brain and Mental health strategic research priority.
Glioblastoma is the most common and deadly form of brain cancer among adults. The progression and complexity of the tumours are often difficult to treat.
and eliminate the stem cells that give rise to these new neurons in adults while leaving other olfactory bulb cells intact.
To further explore this idea his team also eliminated the formation of adult-born neurons in mice that did not experience sensory deprivation.
Dr Burton's work could point to the potential development of new drugs as well as new approaches to preventing brain damage and death.
The study Self-association of an Insect Beta-13-Glucan Recognition Protein Upon Binding Laminarin Stimulates Prophenoloxidase Activation as an Innate Immune response was published recently in the Journal of Biological Chemistry.
just as effective as invasive neck surgery for long-term prevention of fatal and disabling strokes reports an international trial led by UCL (University college London) funded by the Medical Research Council and Stroke Association.
and no impact on long-term quality of life. At the moment stenting is used not widely in the UK due to historical uncertainty over its long-term effectiveness says study leader Professor Martin Brown from the UCL Institute of Neurology.
Dr Shamim Quadir Research Communications Manager at the Stroke Association said: A transient ischaemic attack also known as a mini-stroke can be a warning sign that someone has carotid artery stenosis
#Slow enteral feeding protocol can reduce instances of death in extreme preterm infants A standardized slow enteral feeding (SSEF) protocol significantly reduces the incidence of necrotizing enterocoltis (NEC)
or death of intestinal tissue and death in infants with extremely low birth weight according to a new study.
and accompanying death in infants with a birth weight below 750 grams or 1. 65 pounds.
While NEC continues to be a significant cause of mortality and morbidity in extreme preterm infants the increased use of human breast milk
and implementation of standardized feeding protocols have helped to reduce its incidence. However this new study has shown a way to further reduce NEC with the use of SSEF particularly in infants with extremely low birth weight.
and death and demonstrated comparable weight gain and head growth at discharge from the neonatal intensive care-unit unit (NICU) without prolonging the NICU stay.
Very easily says Alex Greenwood from the German Leibniz Institute for Zoo and Wildlife Research.
The Capflank-method is suited even for heavily fragmented ancient DNA extracted from animal bones from museum collections.
Greenwood's colleagues successfully applied Capflank to samples from koalas kept in museums. Capflank is at its most efficient though with fresh DNA.
In their latest study Christian Seiser and his team at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna addressed this question.
The hallmark of stressed genes is a start signal for transcriptionstudy leader Christian Seiser says:
While Anna Sawicka now works as a Postdoc at the Max Planck Institute in Goettingen Christian Seiser and his team work to understand the function of the histone mark for long term activation of genes during the stress response.
Interleukin-33 (IL-33) discovered in 2003 by Jean-Philippe Girard's team is a protein in the family of interleukins soluble messengers that enable communication between cells in the immune system and play a crucial
whether maternal age is important in the accumulation of MITOCHONDRIAL DNA (mtdna) mutations both in the mother and in the child as a result of transmission.
Collaborating with Ian Paul a pediatrician at the Penn State Milton S. Hershey Medical center they took samples of blood and of cells inside the cheek from 39 healthy mother-child pairs.
--if there is a severe decrease in mitochondrial molecules during the egg-cell development--then the genetic makeup of the child might differ dramatically from that of the mother.
Knowing the size of the bottleneck allows us to predict within a range the percentage of disease-carrying molecules that will be passed on to the child.
Knowledge about both the maternal age effect and the bottleneck size is useful in family planning. We have some predictive power now
which accounts for nearly two per cent of all cancer deaths. Professor Guido Franzoso from the Department of Medicine at Imperial College London who led the research said:
and the immune and stress response systems was discovered to be overactive in many types of cancer and responsible for switching off the normal cellular mechanisms that naturally lead to cell death.
and animals FGF21 levels are elevated in association with obesity insulin resistance and nonalcoholic fatty liver disease.
The antibiotic a member of the thiopeptide family of antibiotics is not in widespread use partly due to its complex structure
By turning a woman over onto her stomach we can treat the breast underneath the board
These modifications ease concerns of patients like Kim Doran of New Albany OH who have a family history of heart disease.
When other scientific workgroups discovered that further benign tumors--in this case meningeal tumors--occur more often in ARMC5-Cushing families the group of Patrick May
#Suicide and gender roles: Reporting distorts reality Men angry and rejected women sociable and mentally ill--a current study by the Meduni Vienna demonstrates that these gender stereotypes prevail when Austrian daily newspapers report on suicide.
This has far-reaching consequences. When it comes to suicidal behaviour there is a clear gender paradox:
the ratio of men to women who actually commit suicide is three to one but with attempted suicides it is exactly the opposite--three women for every one man.
A study by the Meduni Vienna which has recently been published in the highly journal Sex Roles demonstrates that the cultural script that bears partial responsibility for this is also found in the reports by Austrian daily newspapers.
These gender-specific differences are made visible by the formulation the nature and frequency of reported suicide motives.
Articles about suicide in women focus more on sociability relationships with other people and motives that are anchored in the family environment.
Psychiatric illnesses are cited also as a motive and are described in a stigmatizing manner. More complex language and cautious expressions are also the hallmarks of articles about female suicide.
In contrast the articles about male suicide use more words that relate to anger and rejection.
This conservative role image that pervades Austria anyway is reinforced by this style of reporting.
Suicide risk could be reduced by changing the style of reportingbut that's not all. A very specific problem arises from this
The suicide risk can be reduced as a result. Journalists should therefore take care to present as correct a view as possible of suicidal tendencies
Spotlight on eleven Austrian daily newspapers507 articles containing the word'suicide'from eleven Austrian daily newspapers from between 1997 and 2005 were investigated.
The study is one of the first investigations to look comprehensively at the subject of gender-specific patterns in the reporting of suicide.
For the water to reach the households in a clean state via the distribution network a team headed by microbiologist Ursula Obst who directs the partial project for water processing and water quality assurance developed methods for the central semi
In the region of Pucanganom we installed a system that processes toilet sewage of 15 families and the dung of their animals in three biogas facilities.
and child care centers to report illnesses to local public health departments could improve the detection of disease outbreaks
if certain child care centers are reporting the beginning of stomach flu (vomiting and diarrhea), other centers can start taking steps to thoroughly clean to kill any viruses before symptoms occur
In addition, if child care providers see that larger centers in their community are reporting flu-like illness,
and more frequently than school-aged children and adults because their immune systems are underdeveloped. Young children often are responsible for spreading viruses to the rest of the community.
"However, child care or preschool absences are typically more likely to be associated with illness and most young children continue to need child care for most of the year,
"says Hashikawa, a member of the U-M Institute for Healthcare Policy and Innovation. Most public health departments do not electronically track influenza
or stomach illnesses in preschools and child care centers settings.""Most illness reporting methods used by many public health departments are based slow,
Staff were trained to use the system daily to report any ill child. No confidential or identifying information was collected.
They also entered the age range of the ill child (infant, 0-12 months),(toddler, 13-35 months) or (preschooler, 36-59 months), daily attendance at their center,
child brought to a physician. Researchers sent data electronically to the public health department weekly or more frequently if spikes in illness cases were seen.
"Preliminary data suggest that using the online biosurveillance in child care centers and preschools gives us an earlier detection
Scientific literature on Bre1 had been mixed. Some studies indicated that Bre1 had a role as a tumor suppressor Strahl said.
but is losing brilliant ideas in the Valley of Death between the lab and the market.
--but they have become the poster child for the larger problem of drug discovery and development in part because they underpin every part of modern medical practice from surgery to cancer treatment and pretty much everything in between.
#Detecting depressive states in elderly with on-line monitoring devices Specialists at the Autonomous Metropolitan University (UAM) of Mexico developed a system that achieved detecting depression in older adults,
such as family abandonment of or a chronic condition, tend to fall into a depressed state. According to Edwin Almeida Calderón, researcher in the area of Industrial Design at UAM and head of the project, elderly people (over 70 years) tend to have well-defined behavior patterns."
and rest in very specific places at the household.""Using a device that can be placed on the forearm of the older person and a webcam that records movement patterns,
suggests reduced mortality An automated early warning and response system for sepsis developed by Penn Medicine experts has resulted in a marked increase in sepsis identification
and care transfer to the ICU and an indication of fewer deaths due to sepsis. A study assessing the tool is published online in the Journal of Hospital Medicine.
There are as many as three million cases of severe sepsis and 750000 resulting deaths in the United states annually.
and practice cultures across our health system increases the generalizability of our findings to other health care settings.
The results challenge previous assumptions about population growth. Researchers in 40 countries correlated birth rates with economic data and concluded that a moderately low birth rate--a little below two children per woman--can actually boost a country's overall standard of living.
While governments generally favor higher birth rates to maintain the workforce and tax base needed to fund pensions health care
and other benefits for the elderly it is typically families that bear the brunt of the cost of having children the study found.
Higher fertility imposes large costs on families because it is they rather than governments that bear most of the costs of raising children.
Also a growing labor force has to be provided with costly capital such as factories office buildings transportation and housing said UC Berkeley demographer Ronald Lee an author of the far-reaching study to be published Oct 10 in the journal Science.
Instead of trying to get people to have more children governments should adjust their policies to accommodate inevitable population aging added Lee who co-authored the report Is low fertility really a problem?
The study also highlighted the role of smoking in the development of lung cancer. Many of the early genetic faults are caused by smoking.
"Conventional techniques, like genome-wide association studies, must test all possible genetic mutations and variants in a disease cell, compared with a normal cell,
Of the 25 genes previously identified in the literature 19 (76 percent) were identified by DIGGIT,
"It's important to stress that this constitutes an important improvement over traditional gene-association studies.
The latter can identify statistical associations between mutations and disease, but cannot explain how the mutation drives that effect,
Similar but more powerful transformers are used in electricity substations to convert the high voltages of the transmission grid into the standard AC power supply delivered to households.
and the second-leading cause of cancer death in men (after lung cancer. In 2014, more than 230,000 new cases of prostate cancer will be diagnosed.
With the biofilm signature in hand, the two scientists then invented a technology that reacts to the presence of NTHI proteins by changing color, much like a rapid strep or pregnancy test.
when exposed to peanut proteins through breast milk or in house dust but this current study adds skin exposure to the list of culprits that make a child allergic by the first time they taste a peanut.
In a collaboration among the Jaffe Food Allergy Institute The Mindich Child Health and Development Institute Immunology Institute and Tisch Cancer Institute at The Mount sinai Hospital researchers exposed mice
#Community justice court associated with lower rearrest rates The opening of a community court in a high-crime area of San francisco was associated with a lower chance that offenders would be arrested for another crime within a year, according to a new RAND Corporation study.
all sharing traditional court goals of reducing crime, ensuring safety and protecting due process rights. The programs seek to address problems often linked to criminal behavior
At community courts, the criminal case management process itself involves providing access to treatment and social services.
Kilmer and co-author Jesse Sussell examined one-year rearrest rates among those arrested for eligible offenses--such as theft, vandalism, drug offenses, assault and disorderly conduct--inside and outside the catchment area both before and after the Community Justice Center opened.
#Women who eat fried food regularly before conceiving at increased risk of developing gestational diabetes during pregnancy Women who eat fried food regularly before conceiving are increased at risk of developing gestational diabetes during pregnancy,
Gestational diabetes (GDM) is a complication that can arise during pregnancy, and is characterised by abnormally high blood glucose during the pregnancy (especially in the final 3 months).
It can lead to increased birthweight of the child, as well jaundice and other complications. When left untreated, it can cause complications or stillbirth.
New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that women who eat fried food regularly before conceiving are increased at risk of developing gestational diabetes during pregnancy.
The research is led by Drs Cuilin Zhang and Wei Bao, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, part of the US National institutes of health) Rockville
, MD, USA, and colleagues. Gestational diabetes (GDM) is a complication that can arise during pregnancy
and is characterised by abnormally high blood glucose during the pregnancy (especially in the final 3 months.
It can lead to increased birthweight of the child, as well jaundice and other complications. When left untreated, it can cause complications or stillbirth.
Women who have GDM are more likely to later develop full blown type 2 diabetes.
However, there are few prospective epidemiological studies examining the association of fried food consumption with other health outcomes,
Thus in this new study, the authors examined the association between prepregnancy fried food consumption, both at home and away from home
The authors included 21,079 singleton pregnancies from 15,027 women in the Nurses'Health Study II (NHS II) cohort.
The authors documented 847 incident GDM pregnancies during 10 years of follow-up. After adjustment for age, parity, dietary and non-dietary factors, the risk ratios for developing GDM among women who consumed total fried foods 1-3, 4-6,
The association persisted after further adjustments were made for varying body-mass index (BMI. After this, the risk ratios of GDM among women who consumed total fried foods 1-3, 4-6,
"When analysed separately, the authors found that there was a statistically significant association of GDM with fried food consumption away from home,
This may partly explain why we observed a stronger association of GDM risk with fried foods consumed away from home than fried foods consumed at home."
Igor Spetic had family open his medicine bottles. Cotton balls give him goose bumps. Now, blindfolded during an experiment,
"We have used osseointegration to create a long-term stable fusion between man and machine, where we have integrated them at different levels.
Dry powder inhaler formulation Despite advances in vaccination and antimicrobial therapy, community-acquired pneumonia remains a leading cause of morbidity and mortality, even in highly developed countries.
The tread may show individual wear marks from a bicycle pedal for example a type of detail that could link a specific shoe to a crime scene.
#Small molecule jams the switch to prevent inflammatory cell death Walter and Eliza Hall Institute scientists have discovered a small molecule that blocks a form of cell death that triggers inflammation opening the door for potential new treatments for inflammatory disease such as rheumatoid arthritis Crohn's disease
and psoriasis. The researchers made the discovery while investigating how a protein called MLKL kills cells in a process known as necroptosis.
Necroptosis is discovered a recently cell death pathway linked to immune disorders. It is a vital process in
which cells undergo programmed death while warning the immune system that something has gone wrong such as during viral infection.
Dr Joanne Hildebrand Ms Maria Tanzer Dr James Murphy Associate professor John Silke and colleagues studied how MLKL changes shape to trigger cell death.
MLKL is the final protein in the cell death pathway but it needs to be activated before it can kill the cell Dr Hildebrand said.
'when activated allowing it to attach to the cell membrane and trigger cell death. It's like flicking a molecular switch she said.
If the less well defined and atypical forms are included ED affect 15-20%of the population particularly adolescents and young adults.
quality of life, study shows A new implantable device to control heart failure is showing promising results in the first trial to determine safety and effectiveness in patients according to lead researcher Dr. William Abraham of The Ohio State university Wexner
In the pilot study 20 patients with New york Heart Association (NYHA) functional class III or ambulatory functional class IV heart failure were implanted with the device.
and average quality of life scores improved nearly 30 points. Drug and device therapies that are currently available for heart failure improve that same quality of life score by only five or 10 points.
So this is truly a significant improvement Abraham said. The most common adverse effect during the trial was infection of the exit site experienced by 8 out of 20 participants.
Alpha-helix rods and folded beta-sheet constructions were clearly visible within the 20 subunits of the APC/C defining the overall architecture of the complex.
They present their findings in six articles published in the current issue of Neurosurgical Focus an online peer-reviewed journal published by the American Association of Neurological Surgeons.
and death--food and water tainted with pathogens from fecal matter results in the deaths of roughly 700000 children each year.
While the current toilet has been created to serve four to six people a day a larger facility that could serve several households simultaneously is under design with the target of meeting a cost level of five cents a day per user set by the Gates Foundation.
Linden who called the 16 teams a family of researchers said the foundation has funded trips for CU-Boulder team members to collaborate with the other institutions in places like Switzerland South africa and North carolina.
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