Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through"virtual biopsies
"Our nanodrug can be engineered to carry a variety of drugs, proteins and genetic materials to attack tumors on several fronts from within the brain,"said Julia Ljubimova, MD, Phd,
The drug delivery system and its component parts together called a nanobioconjugate or nanodrug, is in an emerging class of molecular drugs designed to slow
or stop cancers by blocking them in multiple ways within the brain. The drug is about 20 to 30 nanometers in size-a fraction of a human hair,
which is 80,000 to 100,000 nanometers wide. Cedars-Sinai scientists began developing the"platform"of the drug delivery system about a decade ago.
The nanodrug can have a variety of chemical and biological"modules"attached.""Each component serves a specialized function,
"Several drugs are quite effective in treating different types of breast cancers, lung cancer, lymphoma and other cancers at their original sites,
May 27th, 2015fine-tuned molecular orientation is key to more efficient solar cells May 26th, 2015cancer Iranian Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th,
Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th, 2015discoveries Who needs water to assemble DNA?
chemicals and drugs-any substance that someone wants to track closely -and then detected using an optical readout device e
scientists assemble promising antimicrobial compounds June 1st, 2015govt. -Legislation/Regulation/Funding/Policy Next-generation illumination using silicon quantum dot-based white-blue LED June 7th,
2015laboratories NIST's'nano-raspberries'could bear fruit in fuel cells June 9th, 2015mesoporous Particles for the Development of Drug Delivery System Safe to Human bodies June 9th,
Advanced method opens up new opportunities for investigation of dynamic processes June 9th, 2015mesoporous Particles for the Development of Drug Delivery System Safe to Human bodies June 9th, 2015mems MEMS Industry
2015stable Perovskite Solar cells Developed through Structural Simplification June 9th, 2015materials/Metamaterials Mesoporous Particles for the Development of Drug Delivery System Safe to Human bodies June 9th,
#New Sensors Measure Blood Anticoagulation Drug Iranian researchers from Isfahan University of Technology produced a highly sensitive and accurate sensor
which can measure a type of blood anticoagulation drug. The sensor was produced through a simple
Protamine is an important drug that is used as an anti-heparin agent to prevent blood coagulation during cardiovascular surgeries.
a simple but very sensitive sensor based on fluorescence spectroscopy was presented by using cadmium telluride quantum dots to quickly measure protamine drug.
it is able to prevent excess consumption of the drug without wasting time. Therefore, the required medical actions can be taken before it gets too late.
-Legislation/Regulation/Funding/Policy Toward nanorobots that swim through blood to deliver drugs (video) June 17th,
2015discoveries Toward nanorobots that swim through blood to deliver drugs (video) June 17th, 2015high-tech nanofibres could help nutrients in food hit the spot June 17th,
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Toward nanorobots that swim through blood to deliver drugs (video) June 17th,
and carry payloads of pharmaceutical drugs to targeted tissues. Unlike other methods of making carbon nanoparticles-which require expensive equipment
We use spectroscopy to confirm the formulation as well as visualize the delivery of the particles and drug molecules."
"The team found that the nanoparticles did not release the drug payload at room temperature, but at body temperature began to release the anticancer drug.
The researchers also determined which topical applications penetrated the skin to a desired depth. In further experiments, the researchers found they could alter the infusion of the particles into melanoma cells by adjusting the polymer coatings.
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,
You can load it with two drugs, or three, or four, so you can do multidrug therapy with the same particles.""
and also we can tune them to release the drugs in the presence of the cellular environment.
2015nanomedicine Toward nanorobots that swim through blood to deliver drugs (video) June 17th, 2015arrowhead Receives Regulatory Clearance to Begin Additional Phase 2b Studies of Hepatitis b Candidate ARC-520 June 17th,
2015cellulose from wood can be printed in 3-D June 17th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th, 2015discoveries Scientists film shock waves in diamond:
Method could be useful in developing green energy and a better understanding of rust June 18th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th,
Method could be useful in developing green energy and a better understanding of rust June 18th, 2015new Sensors Measure Blood Anticoagulation Drug June 17th,
#Nanowire implants offer remote-controlled drug delivery Abstract: Remote-controlled Eradication of Astrogliosis in Spinal cord Injury via Electromagnetically-induced Dexamethasone Release from"Smart"Nanowireswen Gao and Richard Borgenswe describe a system to deliver drugs to selected tissues continuously,
if required, for weeks. Drugs can be released remotely inside the small animals using pre-implanted,
novel vertically aligned electromagnetically-sensitive Polypyrrole Nanowires (Ppynws). Approximately 1-2mm 2 Dexamethasone (DEX) doped Ppynws was lifted on a single drop of sterile water by surface tension,
We conclude that the administrations of drugs can be controlled locally and non-invasively, opening the door to many other known therapies,
A team of researchers has created a new implantable drug-delivery system using nanowires that can be controlled wirelessly.
which can be used to control the release of a preloaded drug. The system eliminates tubes
"This tool allows us to apply drugs as needed directly to the site of injury, which could have broad medical applications,
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
"The team tested the drug-delivery system in mice with compression injuries to their spinal cords
The nanowires can be loaded with a drug and, when the correct electromagnetic field is applied, the nanowires release small amounts of the payload.
The magnitude and wave form of the electromagnetic field must be tuned to obtain the optimum release of the drug,
and the precise mechanisms that release the drug are understood not yet well, she said. The team is investigating the release process.
The electromagnetic field is likely affecting the interaction between the nanomaterial and the drug molecules, Borgens said."
and release drugs, "he said.""It is a reversible process. Once the electromagnetic field is removed, the polymer snaps back to the initial architecture
and retains the remaining drug molecules.""For each different drug the team would need to find the corresponding optimal electromagnetic field for its release,
Gao said. This study builds on previous work by Borgens and Gao. Gao first had to figure out how to grow polypyrrole in a long vertical architecture,
which allows it to hold larger amounts of a drug and extends the potential treatment period.
Functional Drug Delivery Using Electromagnetic field-Responsive Polypyrrole Nanowires, "was published in the journal Langmuir. Other team members involved in the research include John Cirillo,
In addition, the concentration of drug maintained during treatment is known not because it is below the limits of systemic detection,
very small dose of a drug to effectively serve as a big dose right where you need it,
"By the time the drug diffuses from the site out into the rest of the body it is in amounts that are undetectable in the usual tests to monitor the concentration of drugs in the bloodstream."
which the drug delivery device will work. The current system appears to be limited to a depth in tissue of less than 3 centimeters,
#New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment Iranian researchers designed a biosensor with application in assessment of effectiveness of drugs on the stability of the four-strand structure of DNA to prevent the growth
and to create a simple method to investigate their interactions with a number of drugs and compounds.
The studies can be used in the diagnosis, designing and production of anticancer drugs. The research team presented an effective method to detect the four-strand structure of DNA by using biosensors.
Electrochemical studies showed that the designed biosensor creates an appropriate environment for the evaluation of the drug abilities to stabilize the structure.
and to study its interaction with a number of drugs s
#Miniature Technology, Large-scale Impact: Winner of the 2015 Lindros Award for translational medicine, Kjeld Janssen is pushing the boundaries of the emerging lab-on-a-chip technology The postage stamp-sized square of fused silica Kjeld Janssen is holding
#UK study reveals new method to develop more efficient drugs A new study led by University of Kentucky researchers suggests a new approach to develop highly-potent drugs
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
thus reducing or possibly even eliminating their resistance to targeted drugs. The study was led by Peixuan Guo
"Efficacy is the key in drug development, "Guo said.""Inhibiting multisubunit targets works similar to the series-circuit Christmas decorating light chains;
multiple drugs are needed not, as well). Using this method, a single subunit targeting to the target RNA or protein subunits that is unique and assenting for the organism,
"One of the vexing problems in the development of drugs is drug resistance, "said Tim Tracy, former Dean of the UK College of Pharmacy and current UK provost."
He is well-known for his pioneering work of constructing RNA nanoparticles as drug carriers. Guo's research team also includes Dan Shu, Farzin Haque, Mario Vieweger, Fengmei Pi, Hui Zhang, Yi Shu, Chi Wang, Peng Zhang, Ashwani
2015uk study reveals new method to develop more efficient drugs July 8th, 2015superconductor could be realized in a broken Lorenz invariant theory July 7th, 201 0
Researchers at EPFL and ICFO have developed a reconfigurable sensor made from graphene to detect nanomolecules such as proteins and drugs;
2015new Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015discoveries Super graphene can help treat cancer July 10th,
2015nanobiotechnology UK study reveals new method to develop more efficient drugs July 8th, 2015bonelike 3-D silicon synthesized for potential use with medical devices:
2015uk study reveals new method to develop more efficient drugs July 8th, 201 0
#Researchers find nanowires have pronounced unusually'anelastic'properties Anelastic materials exhibit gradual full recovery of deformation once a load is removed, leading to efficient dissipation of internal mechanical energy.
Silver nanoparticles have antibacterial properties, but their use has been a cause for concern because they persist in the environment.
Our results demonstrate that the application of green chemistry principles may allow the synthesis of nanoparticles with biodegradable cores that have higher antimicrobial activity and smaller environmental impact than metallic silver nanoparticles.
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
"People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores.""The researchers used the nanoparticles to attack E coli, a bacterium that causes food poisoning;
"We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
#Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize.
That is, they have engineered a drug delivery system so that the very enzymes that make cancers dangerous could
and deliver a payload of drug, "said Cassandra Callmann, a graduate student in chemistry and biochemistry at the University of California, San diego,
Callmann created tiny spheres packed with the anticancer drug paclitaxel (also known by the trade names Taxol and Onxal) and coated with a peptide shell.
MMPS tear up that shell releasing the drug. The shell fragments form a ragged mesh that holds the drug molecules near the tumor.
The work, led by Nathan Gianneschi a professor of chemistry and biochemisty at UC San diego, builds on his group's earlier sucess using a similar strategy to mark tumors for both diagnosis and precise surgical removal.
To package the drug into the spheres, Callmann had to add chemical handles. As it turns out, a group of atoms essential to the drug molecule's effectiveness,
and also toxicity, made for a good attachment point. That means the drug was inactivated as it flowed through the circulatory system until it reached the tumor.
The protection allowed the researchers to safely give a dose 16 times higher than they could with the formulation now used in cancer clinics,
using a single lower dose of the drug. In mice treated with the nanoparticles coated with peptides that are impervious to MMPS or given saline,
We'll test this in other models-with other classes of drug and in mice with a cancer that mimics metastatic breast cancer, for example."
2015nanocrystalline Thin-film Solar cells July 15th, 2015better memory with faster lasers July 14th, 2015cancer Nanospheres shield chemo drugs,
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
Researchers from Polytechnique Montral and Imperial College London demonstrate the wavelike quantum behavior of a polariton condensate on a macroscopic scale and at room temperature July 14th, 2015nanospheres shield chemo drugs,
2015nanomedicine Agilent technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies July 15th, 2015nanospheres shield chemo drugs,
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
2015patents/IP/Tech Transfer/Licensing Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions July 14th,
including increasing the self-cleaning, antibacterial, antifungal, acidic and alkaline resistance. This objective was achieved by creating a homogenous coating made of a nanocomposite of zinc oxide/nitrogen silver (N-Ag/Zno) on the fabrics.
and only one therapy has been approved by the Food and Drug Administration. While most of these vaccines are created with dendritic cells,
showed applying small quantities of antibiotic to the surface of medical devices, from small dental implants to hip replacements, could protect patients from serious infection.
the risk of deep bone infection is reduced substantially. ur research shows that applying small quantities of antibiotic to a surface between the polymer layers
The study, funded by the European commission and the UK Engineering and Physical sciences Research Council, is published in Acta Biomaterialia("Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide
Since the advent of biotechnology, researchers have modified bacteria to produce therapeutic drugs or antibiotics. In this novel study
chemicals and drugs any substance that someone wants to track closely and then detected using an optical readout device e
and to measure changes in those signals as they administered cardio-or neuro-stimulating drugs."
Gutruf said the research used zinc oxide-present in most sunscreens as a fine powder mixed into a lotion-as the UV sensing material.
#Mimicking the body on a chip for new drug testing Scientists in an EU-supported project have developed a microfluidic chip that simultaneously analyses the reactions of several human organ tissues
when they come into contact with candidates for new drugs. The ground-breaking device could save millions of euros in drug development costs.
One of the biggest challenges for pharmaceutical companies is reducing the multi-million-euro cost of drug development
and shortening the time to market of medicines in order to fully exploit them before patents run out.
called Body-on-a-Chip (BOC), replacing the 2d cell culture conventionally used for drugs testing with a multi-tissue device that better mimics real-life conditions in the body, by combining several organ
and their effectiveness prior to formal clinical testing. he pharma industry loses a lot of money by keeping drug candidates in the development process for too long,
only to find out at a late stage that the drug is not working, explained BOC coordinator, Dr Jan Lichtenberg,
They want to know the drug toxic liability as soon as possible to eliminate failures from their programme,
Understanding the long-term toxicity of drugs Traditionally the potential harmfulness of drugs has been tested on cells grown on plates in a 2d format.
The drug being tested passes in a nutrient solution across these various compartmentalised rgansand the plate is connected with analytical methods such as mass spectroscopy to analyse the drug metabolites produced.
The BOC allows these drug metabolites to be identified and their effect on other tissues studied.
and more commonly used drugs known to be toxic to the liver such as paracetamol, were passed over these tissues to test the device worked correctly.
as well as screening and translation of new classes of drugs, Singh said g
#3d potential through laser annihilation (Nanowerk News) Whether in the pages of H g wells, the serial adventures of Flash gordon,
By contrast, the team's previous research showed the drug was effective in preventing atherosclerosis
the nano-packaged drug improved physiologic outcomes among animals with heart muscle thickening and pumping dysfunction, the hallmarks of advanced disease."
or break a drug, "says lead investigator Subroto Chatterjee, Ph d.,a professor of medicine and pediatrics at the Johns hopkins university School of medicine and a metabolism expert at its Heart and Vascular Institute."
"In our study, the right packaging vastly improved the drug's performance and its ability not merely to prevent disease
stems from fast uptake by various tissues and organs and from the slow clearance of the encapsulated form of the drug.
Next, to observe how quickly the body broke down the nano-wrapped and the original forms of the drug,
The kidneys are the final stop on most drugs'journey inside the body just before they are cleared through urine.
and cholesterol levels as did treated animals with free-floating forms of the drug. However, animals treated with the free-floating form of D-PDMP required 10 times higher doses to achieve GSL
and cholesterol levels observed in mice given the nano-encapsulated form of the drug. When scientists measured the thickness of the animals'aortas--the body's largest vessel responsible for carrying oxygen-rich blood from the heart to the rest of the body--they observed stark differences among the groups they say.
Mice treated with either version of the drug fared better, but animals that got the encapsulated form of the drug had aortas nearly indistinguishable from the aortas of healthy mice fed a regular diet, according to researchers.
Most strikingly, they reported, D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
and pumping ability improved in animals that received treatment with the encapsulated form of the drug,
However, mice given non-encapsulated drug required 10 times higher doses to achieve similar benefits.
Researchers say their next step is to test how the drug performs in larger mammals.
or proteins that could be targeted by drugs, eventually leading to new medicines to fight cancer r
and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
and osteoporosis. Michael Cima (left) and Robert Langer Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the worlds largest producer of generic drugs,
Wouldnt this be a great way to make a drug-delivery system? Langer says. He brought this idea to Cima,
and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents.
Any intense heat during final assembly, with hermetic sealing, could destroy the drugs already loaded into the reservoirs
yet carry the same volume of drugs. This means making the drugs take up more volume than the electrical and other components
he says. Thats the next major challenge e
#Researchers introduce new layered semiconducting materials as silicon alternative (Nanowerk News) When the new iphone came out,
for the first time revealing details about how deactivation of a key protein may lead to metastasis. The new findings also are providing evidence for the mechanisms involved in a cell's response to anticancer drugs,
and our previous findings that there might be a mechanical signature to drug resistance. Advanced models allow researchers to convert AFM data into properties about the cells internal scaffolding,
#Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells (Nanowerk News) Nanoparticles packed with a clinically used chemotherapy drug
and encapsulating the chemotherapy drug doxorubicin can target and kill cancer stem-like cells six times more effectively than free doxorubicin.
break open, and release the anticancer drug under the acidic conditions of the tumor microenvironment and in tumor-cell endosomes and lysosomes,
although the drug-carrying nanoparticles could bind to the variant CD44 receptors on cancerous mammosphere cells,
This achievement will also contribute to accelerating the research applications of RNAI such as to the development of RNA-based next-generation drugs,
#A new approach to develop highly-potent drugs A new study led by University of Kentucky researchers suggests a new approach to develop highly-potent drugs
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
Published in Nanomedicine("New approach to develop ultra-high inhibitory drug using the power function of the stoichiometry of the targeted nanomachine or biocomplex),
thus reducing or possibly even eliminating their resistance to targeted drugs. The study was led by Peixuan Guo, director of UK's Nanobiotechnology Center and one of the top nanobiotechnology experts in the world.
"Efficacy is the key in drug development, Guo said.""Inhibiting multisubunit targets works similar to the series-circuit Christmas decorating light chains;
multiple drugs are needed not, as well). Using this method, a single subunit targeting to the target RNA or protein subunits that is unique and assenting for the organism,
or die and thus, no longer able to cause disease. ne of the vexing problems in the development of drugs is drug resistance,
He is well-known for his pioneering work of constructing RNA nanoparticles as drug carriers u
the antimalarial garment can be worn during the day to provide extra protection and does not dissipate like skin-based repellants.
biomedical scientists have developed drugs with nanogold to target malignant tumours. The nanogold attracts light emitted from laser therapies
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
In a study published in Nature Nanotechnology("An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core),
People have been interested in using silver nanoparticles for antimicrobial purposes, but there are lingering concerns about their environmental impact due to the long-term effects of the used metal nanoparticles released in the environment,
and environmentally responsible method to make effective antimicrobials with biomaterial cores. The researchers used the nanoparticles to attack E coli
We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.
They initially sought to develop nanoparticles that could be used to deliver drugs to cancer cells. Brandl had synthesized previously polymers that could be cleaved apart by exposure to UV light.
But he and Bertrand came to question their suitability for drug delivery, since UV light can be damaging to tissue and cells,
and approved by the Food and Drug Administration as a food additive, and polylactic acid, a biodegradable plastic used in compostable cups and glassware.
The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
"More specifically, it is a drug delivery system (DDS) whereby a nano-level contrast agent (Gd)- DTPA is prepared,
which can reduce the amount of drugs needed d
#Magnetic material unnecessary to create spin current (Nanowerk News) It doesn't happen often that a young scientist makes a significant and unexpected discovery,
#New material opens possibilities for super-long-acting pills (Nanowerk News) Medical devices designed to reside in the stomach have a variety of applications,
including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
or extended-release drug-delivery systems that could last for weeks or months after a single administration.
which could release drugs or small devices for monitoring and imaging the GI TRACT, says Edith Mathiowitz,
In particular, the authors say they are excited for the drug-delivery applications of this technology. With further work in adjusting the polymer composition or the design of the system
they say that they could tailor devices to release drugs over a specific timeframe of up to weeks or months at a time.
MIT is negotiating an exclusive license agreement with Lyndra, an early-stage biotechnology company developing novel oral drug-delivery systems, for this and other related technologies.
Im delighted to see these new oral systems provide an opportunity that Ive not seen previously enabling patients to swallow a single pill that can then act for whatever length of time is desired,
Special delivery for the gut"),Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.
which can be used to create extended-release systems via swallowable pills, they envision an emerging field of orally delivered devices that can maximize adherence and therapeutic efficacy y
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