Cardiovascular diseases

Aneurysm (6)
Arrhythmia (15)
Cardiovascular disease (72)
Heart attack (88)
Heart disease (98)
Heart failure (48)
Hypertension (31)
Hypoxia (15)
Thrombosis (17)

Synopsis: Health: Illness: Cardiovascular diseases:


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our cultures become more sedentary and rates of obesity and heart disease increase. Cars not only make our cities unhealthy,


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Atherosclerosis is a common human disease associated with heart attack and stroke. Certain bacteria as well as high fat diet are associated with an increased risk for atherosclerosis.

and stability and may ultimately lead to a heart attack she added d


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#Vanderbilt-led team studies blood test for prostate cancer Vanderbilt University researcher William Mitchell, M d.,Ph d,


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The system can identify developing conditions that could lead to hypoxia or G-induced loss of consciousness (GLOC.

We discovered that hypoxia can develop in different conditions. In non-pressurized cockpits, for example, when flying helicopters over high mountain ranges, hypoxia can develop slowly over the course of an hour.

When caused by oxygen supply failures or human condition, blood oxygen levels can drop, from 90 to 60-70 percent.


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#Spotting inherited heart disease before it strikes CM affects one in 2500 adults, with an annual incidence of between 5%and 8%per 100 000, says INHERITANCE coordinator Professor Eloisa Arbustini of the Foundation IRCCS Policlinico San Matteo. t is one of the leading causes

of heart failure due to systolic dysfunction, being responsible for 10 000 deaths per year in Europe, and it is the most common indication for cardiac transplantation in adolescents and adults.

and carries a high risk of ventricular arrhythmias, even in the early phases of the disease. nother major achievement of INHERITANCE has been to provide policy makers with a healthcare model that can be applied across the continent,


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For example, the end-of-line production defect rate for the tiny catheters (flexible tubes) used for treating patients with cardiovascular disease is as high as 80%.


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just as a defibrillator corrects heart arrhythmia. Like its inventor, the prototype device, which is being readied for trials in the US,


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lungs and kidneys and induce diabetes, high blood pressure and cardiovascular disease. Partial solutions exist for the filtering out of arsenic


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after he was victim to several heart attacks. He will now receive a defibrillator implant, which should regulate his heart rate.

north of London, is being used for sufferers of cardiovascular diseases, diabetes or obesity. The device, worn on the waist, can take measurements 24 hours a day,


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Diets rich in fruit and vegetables have been linked to important health outcomes including reductions in cardiovascular disease type 2 diabetes and some forms of cancer.


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#Drug flips cells to limit damage after heart attack University of North carolina at Chapel hill rightoriginal Studyposted by Mark Derewicz-UNC on October 16 2014a new way to generate more blood vessels after a heart attack can reduce damage

and improved heart function after heart attack. The finding published in the journal Nature shows that it is possible to limit the damage wrought by heart attacks which strike nearly one million people in the United states each year.

Heart disease accounts for one in four deaths every year.####Scientists have thought that fibroblasts are differentiated terminally meaning they can t adopt the fate of other kinds of cells;

##After a heart attack fibroblasts replace damaged heart muscle with scar tissue. This scarring can harden the walls of the heart

To explore this idea they induced heart attacks in mice and then studied the fibroblasts to see if the cells expressed markers characteristic of endothelial cells.

Because a heart attack is such a stressful event Ubil created a list of genes that were known to be involved in cellular responses to stress.

##By increasing the number of blood vessels in the injury region we were able to greatly reduce the effects of the heart attack.##

##Ubil says his study shows that this could be a novel strategy for treating heart attacks.

and this could potentially benefit people who have heart attacks.####Deb adds:####We are also currently investigating


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##The free insurance covered specific high-impact medical conditionsâ##such as heart disease and cancerâ ##which poor residents often die from

##Rates of early death and illness from chronic conditionsâ##such as heart disease and cancerâ##have increased dramatically in India in the past few decades putting the poor at high risk of not having access to services they need


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With nowhere else to go much of the excess glucose remains in the bloodstream where in high concentrations it can damage tissues throughout the bodyâ##potentially leading to blindness kidney damage cardiovascular diseases and other severe health problems.##


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which are prescribed to millions to reduce the risk of heart attack or stroke. The team was able to separate physical and biochemical effects on platelet behavior by forming polymer gels with different degrees of stiffness


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#Heart disease could be written on your face University of Rochester rightoriginal Studyposted by Mark Michaud-Rochester on September 2 2014new technology that uses software algorithms


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The blood levels of certain fats that are predictors of heart disease risk also improved more in the low-carb group.

##Yet we found those on a low-carb diet had significantly greater decreases in estimated 10-year risk for heart disease after six and 12 months than the low-fat group.##


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when they detect a heart murmur and conduct further diagnostic tests such as chest X-rays, an echocardiogram,


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and hypertension by picking up airborne biomarkers exhaled or released through the skin. ach of these diseases has its own biomarkers that the device would be able to sense,


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and chronic diseases such as hypertension and diabetes. The researchers conducted experiments to gauge the effect of insufficient sleep on memory.


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As millions more people are diagnosed with hypertension and diabeteshich often go hand-in-hand with obesityhey will face increased risk for stroke,


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which has long been associated with inflammation, cell migration, proliferation, hypertension, and other processes. COX inhibitors block production of inflammatory and pain-inducing lipids,


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#Depression can be deadly for older Americans Older adults in the US who suffer from major depression face a 43 percent increased risk of death, especially from cardiovascular disease or cancer, according to a new study. here a major link

This includes findings that major depression was associated with 2. 68 times the risk of cardiovascular disease mortality among those who did not have cardiovascular disease at the baseline.

He says related research has suggested major depression may have a physiological effect on blood pressure or arterial tightening that can cause cardiovascular disease. t physiologically important


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and rheumatic heart disease. Previous efforts to develop a strep throat vaccine had resulted in immune system reactions that caused other diseases such as rheumatic fever

The group A carbohydrate was thought previously to play a largely structural role in the bacteria cell walls. e have confirmed now that it actually plays a critical role in how the bacteria resist the immune response. his may trigger diseases such as rheumatic heart disease,


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Diets rich in fruit and vegetables have been linked to important health outcomes including reductions in cardiovascular disease type 2 diabetes and some forms of cancer.


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and hypertension by picking up airborne biomarkers exhaled or released through the skin. ach of these diseases has its own biomarkers that the device would be able to sensesays Sherman Fan professor of biomedical engineering at University of Michigan


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#Freedom Driver allows man with artificial heart to await transplant at home Heart failure patients awaiting organ transplants normally find themselves anchored to the hospital bed by a washing machine-sized device that keeps blood pumping through their veins.

This organ shortage means that sufferers of advanced heart failure are implanted with devices to aid in survival.


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But a team of scientists are urging caution with a study conducted at the Technion-Israel Institute of technology suggesting that exposure to silicon-based nanoparticles may play a role in the development of cardiovascular disease.

The team was seeking to explore the effects that the nanoparticles have on the development of atherosclerosis a condition that leads to the hardening of the arteries and cardiovascular events such as heart attack and stroke.


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These mice also had higher levels of a protein produced by the nucleus called hypoxia inducible factor (HIF-1a.


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I'll need solid coverage for my impending heart attack. Via Fast Company Shar r


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#Bionic pancreas shows promise in managing diabetes The bionic pancreas In 2000, Ed Damiano s son was diagnosed with type 1 diabetes.#


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#The Living Heart Project will use 3d simulation of the human heart to combat heart disease The World health organization recent research has revealed that 17.3 million people died from cardiovascular diseases worldwide in 2008,

A report by the American Heart Association, Forecasting the Future of Cardiovascular disease in the United states, believes the total direct medical costs of cardiovascular disease will reach $818. 1 billion over the next three decades.

The project is breaking new ground in the study of heart disease and personalized treatment, since researchers are limited currently at being able to predict a pacemaker effect on a patient before surgery, for example.


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they have largely been used to target life-threatening problems such as heart failure. Stanford Helen Blau, director of the Baxter Laboratory for Stem Cell biology, studies a more banal


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and metabolic diseases, says Sheng Ding, a stem-cell biologist at the Gladstone Institute of Cardiovascular disease in San francisco, California.


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while shifting focus to prevention in patients at risk of a heart attack.""We can t just assume that modifying the risk factor is modifying risk,

ATP III reflected a growing consensus among physicians that sharply lowering cholesterol would lessen the likelihood of heart attacks

Clinical trials have shown repeatedly that statins reduce the risk of heart attack and stroke, but lowering LDL with other medications does not work as well.

including fighting inflammation, another risk factor for heart disease. Krumholz s scepticism is rooted in experience. In 2008 and 2010, the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial challenged dogma

or blood sugar to prespecified targets did not reduce the risk of heart attack or stroke. In the case of blood sugar, the risks were worsened.

"Short people have a higher risk of heart disease, he says.""But wearing high heels does not lower your risk.

Most of those who have a heart attack do not have high LDL, he notes. Cohn advocates treating patients with statins based on the state of health of their arteries,

but has not yet been shown to reduce heart attacks or strokes. Francis expects the new guidelines to relax the targets.


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Dr. Bruce Conklin, a stem cell biologist at the Gladstone Institute of Cardiovascular disease in San francisco, along with colleagues developed these tiny hearts using stem cells derived from skin tissue.


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Broad investigators have led international consortia that have found thousands of genetic variants responsible for common diseases such as diabetes heart disease


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Currently a patient who has experienced a heart attack or weakening of the heart has wires running from the implant to a charger


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including cancer and cardiovascular disease, the researchers say. here been a growing amount of excitement about delivery to the liver in particular,


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and cause a stroke or heart attack. However new technology from MIT may soon change that:

If a patient is at risk for thrombosis you could send them home with a 10-pack of these sticks

High levels of activation markers have been related to recurrent thrombosis but they don t have good sensitivity or specificity.


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and other microbes to its surface, causing infections and thrombosis (blood clotting) that lead to hundreds of thousands of deaths annually.

and heart disease and a lack of permanent oatingsfor medical implants that might help these patients.


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but now a team of Israeli scientists has for the first time found that exposure nanoparticles (NPS) of silicon dioxide (Sio2) can play a major role in the development of cardiovascular diseases

and have significant adverse effects on macrophages a type of white blood cell that take up lipids leading to atherosclerotic lesion development and its consequent cardiovascular events such as heart attack or stroke.

We also wanted to use nanoparticles as a model for ultrafine particle (UFP) exposure as cardiovascular disease risk factors.

A recent update from the American Heart Association also suggested that fine particles in air pollution leads to elevated risk for cardiovascular diseases.


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heart tissue is unable to repair itself after a heart attack. Now Tel aviv University researchers are literally setting a new gold standard in cardiac tissue engineering.

"We now have to prove that these autologous hybrid cardiac patches improve heart function after heart attacks with minimal immune response,


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That temporary loss of signal transduction results in arrhythmias. Nanotubes can fix that and Jacot who has a joint appointment at Rice


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heart problems and deep vein thrombosis has been developed by researchers at the Institute of Bioengineering and Nanotechnology (IBN).

They are used to treat stroke, irregular heartbeat and deep vein thrombosis. Warfarin is the most widely prescribed oral anticoagulant drug.


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the second-largest killer in the U s. after heart disease.""Trained as medical doctor and Ph d.,with both a grandfather and an uncle who died of cancer,


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when we are working out treatment for a child with congenital heart disease we can create a 3d dissection model of the patient

According to experts from Materialise, a majority of the 3d printing applications for the pediatric unit will focus on complex diseases including congenital heart disease, premature skull formations and congenital bronchial softening.


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and patients often die of heart failure by their teenage years. One in four million children suffer from HGPS,


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As a result of this project, a commercial portable cost-effective photoacoustic flow cytometer will be developed for broad application with cancers as well as infection and cardiovascular diseases by detection of bacteria, viruses,


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#Platelet-Mimicking Nanoparticles Could Effectively Deliver Drugs to Targeted Sites Nanoparticles disguised as human platelets could greatly enhance the healing power of drug treatments for cardiovascular disease and systemic bacterial infections.

"While this proof of principle study demonstrates specific delivery of therapeutic agents to treat cardiovascular disease and bacterial infections,

"We hope to develop platelet-mimicking nanoparticles into new treatments for systemic bacterial infections and cardiovascular disease


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It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.


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an associate professor of neurology and a researcher in the Ahmanson-Lovelace Brain Mapping Center at UCLA. ascular compliance is a useful marker for a number of cardiovascular diseases,

such as hypertension and diabetes, Wang said. rowing evidence suggests intracranial vascular pathology also may be associated with the origin and progression of cerebrovascular disorders and neurodegenerative diseases, such as Alzheimer disease,


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such as those targeting cardiovascular diseases, in which the platelet membrane could help us target relevant sites in the body. i


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#Artificial blood Vessels Become Resistant To Thrombosis, Study Scientists from ITMO University developed artificial blood vessels that are not susceptible to blood clot formation.

Surgery, associated with cardiovascular diseases, such as ischemia, often require the implantation of vascular grafts-artificial blood vessels,


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could let you see how hypoxia was changing in the tumor, so you could adjust the radiation accordingly.


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the result is a potentially fatal arrhythmia. Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves-using light.


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if someone will have a heart attack. Nguyen's concern for his mother's heart condition inspired him to create the device.


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and whether someone is having a heart attack. The idea is that if higher than usual heart activity is detected,

Research has shown that drivers suffering from cardiovascular disease are 23 per cent more likely to be involved in a road accident

rising to 52 per cent for drivers suffering from angina-chest pains caused by the heart.

Ford's car seat may in some cases detect increased heart activity before the driver notices they are having a heart attack,


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the result is a potentially fatal arrhythmia. Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves-using light.


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or high risk atherosclerotic plaques--inflamed fatty deposits in the artery wall and a main contributor to cardiovascular disease (CVD).

and causing a heart attack or stroke. CVD remains the leading cause of morbidity and mortality in developed nations,

although few focus on the important clinical endpoint of thrombosis.""Our results showed that the fluorescence ACPP probes were able to distinguish high risk plaques with high sensitivity


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Dilated cardiomyopathy is a leading cause of death for those with DMD. Other researchers have started investigating the possibility that phosphodiesterase inhibitors,


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e-muscularizingthe area and fixing the characteristic damage of a heart attack. The hydrogel worked like a charm;

The team did not invent a treatment for this heart disease, but a booster pack that lets a preexisting treatment really kick into high gear.


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a pacemakers use in heart arrhythmias, efficacy (or side effects) of prescribed medications, and dosing compliance,


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#New blood clot-busting nanocapsule promises immediate care for heart attacks When blood clots form in the aftermath of a heart attack or stroke,

medications can be deployed to break them apart, but delivery is tricky. Getting the medicine to the clot takes some guesswork

It could be given in a heart attack straight away, in the ambulance as soon as there are symptoms.""Tissue plasminogen activator (tpa) is another common form of blood-clot medication.


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and function after a heart attack Though sufferers of heart attacks may survive the initial event, they cause permanent damage to the organ in the form of scar tissue,

which affects its ability to pump blood. Scientists around the world are working on this problem, with hydrogels,

In pigs that had suffered from a heart attack, blood pumped out of the left ventricle was reduced from the normal 50 percent to 30 percent.


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points out that while the teeth could prevent oral infections, such as endocarditis, and preserve dental implants, it could also wipe out helpful bacteria that help protect a person from harmful pathogens.


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Indeed, the so-called"patient-centered medication safeguard"could be a valuable tool for providers who deal with the millions of patients who take multiple medications each day to manage conditions such as high blood pressure, asthma, COPD, heart disease and diabetes.


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Salsalate, a nonsteroidal anti-inflammatory, does carry risks, particularly an increased danger of heart attacks and strokes. However, these have been assessed as low enough to justify the drug's use against pain from both osteoarthritis and rheumatoid arthritis


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while theye losing weight or reducing their risk or diabetes or heart disease. ealth is not only a physical condition,


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With diabetes or hypertension, it important to look at the total medical care costs of treating those conditions,


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It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.


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As a result, these subjects were increased at risk of developing high blood pressure and suffering heart attacks and strokes.

taking a daily 300-mg Vitamin c supplement was associated significantly with an increased risk of cardiovascular disease mortality.


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#Nanotechnology developed to help treat heart attack and stroke Australian researchers funded by the National Heart Foundation are a step closer to a safer

and more effective way to treat heart attack and stroke via nanotechnology. The research jointly lead by Professor Christoph Hagemeyer, Head of the Vascular Biotechnology Laboratory at Baker IDI Heart and Diabetes Institute and Professor Frank Caruso,

Professor Frank Caruso from the Melbourne School of engineering said the targeted drug with its novel delivery method can potentially offer a safer alternative with fewer side effects for people suffering a heart attack

or stroke. p to 55,000 Australians experience a heart attack or suffer a stroke every year. bout half of the people who need a clot-busting drug can use the current treatments


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#Artificial blood vessels become resistant to thrombosis Abstract: Scientists from ITMO University developed artificial blood vessels that are not susceptible to blood clot formation.

Surgery, associated with cardiovascular diseases, such as ischemia, often require the implantation of vascular grafts-artificial blood vessels,


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"While this proof of principle study demonstrates specific delivery of therapeutic agents to treat cardiovascular disease and bacterial infections,

"We hope to develop platelet-mimicking nanoparticles into new treatments for systemic bacterial infections and cardiovascular disease."


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#Artificial blood vessels become resistant to thrombosis Scientists from ITMO University developed artificial blood vessels that are not susceptible to blood clot formation.

"Surgery, associated with cardiovascular diseases, such as ischemia, often require the implantation of vascular grafts-artificial blood vessels,


R_www.nanowerk.com 2015 05157.txt.txt

#Nanotechnology developed to help treat heart attack and stroke Australian researchers funded by the National Heart Foundation are a step closer to a safer

and more effective way to treat heart attack and stroke via nanotechnology. The research jointly lead by Professor Christoph Hagemeyer, Head of the Vascular Biotechnology Laboratory at Baker IDI Heart and Diabetes Institute and Professor Frank Caruso,

Professor Frank Caruso from the Melbourne School of engineering said the targeted drug with its novel delivery method can potentially offer a safer alternative with fewer side effects for people suffering a heart attack

or stroke. p to 55,000 Australians experience a heart attack or suffer a stroke every year. bout half of the people who need a clot-busting drug can use the current treatments


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#Researchers Identify Protein That Opens the Door to Cell Death Findings could aid development of novel therapeutics for conditions ranging from heart failure and stroke to cancer and neurodegeneration.

The new study, appearing online September 17 in the journal Molecular Cell, suggests that blocking the door with a small molecule inhibitor could be key to the treatment of cardiovascular diseases such as heart attack and stroke

In pathological states, particularly those involving hypoxia (oxygen deficiency), calcium and ROS accumulate within mitochondria,

Dr. Madesh also explained that the new findings could aid the development of novel therapeutics for conditions ranging from heart failure and stroke to cancer and neurodegeneration all of

which involve hypoxia and mitochondrial dysfunction to varying degrees. In these diseases if the PTP could be prevented from opening,


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#New uper-Tomatocan Fight Cancer, Heart disease, Diabetes and Alzheimer Scientists said that they have invented a uper-tomatowhich can fight cancer, heart disease, diabetes and Alzheimer.


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It our single biggest health problem, affecting the lives of 100 million adults--more than heart disease, cancer,


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It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.


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and potentially treating human diseases such as cancer, cardiovascular disease, neurodegenerative conditions and diabetes, which can be driven by mutations in control regions of the genome.


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#Normalization Of Testosterone Level After Testosterone Replacement Therapy Patients with low testosterone levels who have gone then on to have testosterone replacement therapy (TRT) could be at lower risk of cardiovascular events such as heart attack or stroke,

In the study, researchers from Kansas city VA Medical centre in Kansas city, USA, examined the effect of TRT on cardiovascular outcomes by comparing incidences of heart attack, stroke,


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and break down the blot clots that cause heart attacks and strokes. No only does the minuscule device start working within minutes, it portable,

If this formation of blood clots, known as thrombosis, happens to block blood flow to the heart,

a heart attack can follow. The longer the brain or heart are oxygenated without blood the greater the risk that vital tissues will begin to die,

it set to make a huge difference to the many heart attack and stoke patients who don actually respond to current treatments.

around half of the 55,000 Australians who experience heart attack or stroke every year cannot use the clot-busting treatments administered by paramedics due to the severe side effects that can cause excessive internal bleeding."


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and a 13 percent increased risk of developing coronary heart disease, while a separate study found that working 49-hour weeks was associated with lower mental health, particularly in women.


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"But many diseases, like cancer, cardiovascular disease or neurodegenerative conditions, have a much more complex genetic component.


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the second-largest killer in the U s. after heart disease.""Trained as medical doctor and Ph d.,with both a grandfather and an uncle who died of cancer,


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"said study co-author Paul M Ridker, MD, MPH, the Eugene Braunwald Professor of Medicine at Harvard Medical school and director of the Center for Cardiovascular disease Prevention at Brigham and Women's Hospital."

and therapeutically target individuals at increased risk for developing cardiovascular disease who are also at risk for developing Alzheimer's disease,


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and another saw major improvement in vasculitis of the lower limbs and was able to return to normal physical activity without a wheelchair.


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The paper goes on to describe functional gene disruptions for diseases such as hypertension, diabetes and obesity.


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"We did not find any aneurysms, thromboses or inflammation. Endogenous cells had colonized the vascular prostheses


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because they often have latent ischaemic heart disease which reduces blood flow to the heart. Latent means they don't have any clinical signs

or symptoms, making it very difficult to predict a future heart attack.""He continued:""Ischaemic heart disease should be diagnosed at an early stage

so that preventive therapies can be given. But exercise stress testing is inappropriate for diagnosis in hemodialysis patients who have multiple complications including muscle weakness, osteoporosis and peripheral arterial disease."

which could be caused by latent ischaemic heart disease and may lead to fatal cardiac events.""He added:"

"An abnormal Q wave indicates the presence of previous myocardial infarction or serious myocardial injury responsible for low cardiac output, heart failure and/or potentially fatal arrhythmias.

Cardiac function assessment for heart failure, coronary angiography for ischaemic heart disease and Holter ECG monitoring for lethal arrhythmias can identify the type of myocardial injury

It detects scar tissue formed after the heart muscle is damaged by a heart attack. 3. C reactive-protein protein is a nonspecific test used to detect inflammation in the body.


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because they often have latent ischaemic heart disease which reduces blood flow to the heart. Latent means they don't have any clinical signs

or symptoms, making it very difficult to predict a future heart attack.""He continued:""Ischaemic heart disease should be diagnosed at an early stage

so that preventive therapies can be given. But exercise stress testing is inappropriate for diagnosis in hemodialysis patients who have multiple complications including muscle weakness, osteoporosis and peripheral arterial disease."

which could be caused by latent ischaemic heart disease and may lead to fatal cardiac events.""He added:"

"An abnormal Q wave indicates the presence of previous myocardial infarction or serious myocardial injury responsible for low cardiac output, heart failure and/or potentially fatal arrhythmias.

Cardiac function assessment for heart failure, coronary angiography for ischaemic heart disease and Holter ECG monitoring for lethal arrhythmias can identify the type of myocardial injury


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