which can be used to develop precisely targeted drug therapies are a current focus in the emerging field of pharmacogenomics.
and elegant nanoprobe for assessing sensitivity to the drug warfarin. To develop the nanoprobe Jackie Ying at the A*STAR Institute of Bioengineering
whether a patient will tolerate the drug or suffer serious side effects. The researchers used gold nanoparticles attached to short sections of DNA that bind to specific complementary sequences of DNA through the base pairing that holds together double-stranded DNA.
but allowing select molecules such as drugs to get through. This critical front line of cellular defence is made up of a layer of fatty lipids just a few nanometres thick.
#Nanoscale biodegradable drug-delivery method could provide a year or more of steady doses About one in four older adults suffers from chronic pain.
and other drugs to be released directly to specific parts of the bodynd in steady doses over a period of up to 14 months.
The method uses biodegradable nanoscale thin films laden with drug molecules that are absorbed into the body in an incremental process.
Now we're looking at a way of creating an extremely thin film or coating that's very dense with a drug and yet releases at a constant rate for very long time periods.
In the paper published today in the Proceedings of the National Academy of Sciences the researchers describe the method used in the new drug-delivery system
and release the drug for more than a year without having to go in and do anything about it says Bryan Hsu Phd'14 who helped develop the project as a doctoral student in Hammond's lab. You don't have to go recover it.
Normally to get long-term drug release you need a reservoir or device something that can hold back the drug.
And it's typically nondegradable. It will release slowly but it will either sit there
The research project tackles a difficult problem in localized drug delivery: Any biodegradable mechanism intended to release a drug over a long time period must be sturdy enough to limit hydrolysis a process by which the body's water breaks down the bonds in a drug molecule.
If too much hydrolysis occurs too quickly the drug will not remain intact for long periods in the body.
Yet the drug-release mechanism needs to be designed such that a drug molecule does in fact decompose in steady increments.
To address this the researchers developed what they call a layer-by-layer technique in
which drug molecules are attached effectively to layers of thin-film coating. In this specific case the researchers used diclofenac a nonsteroidal anti-inflammatory drug that is often prescribed for osteoarthritis and other pain or inflammatory conditions.
We found that it remains active after being released Hsu says meaning that the new method does not damage the efficacy of the drug.
The method also allows the researchers to adjust the quantity of the drug being delivered essentially by adding more layers of the ultrathin coating.
an illness such as tuberculosis for instance requires at least six months of drug therapy. It's not only viable for diclofenac Hsu says.
This strategy can be applied to a number of drugs. Indeed other researchers who have looked at the paper say the potential medical versatility of the thin-film technique is of considerable interest.
To be sure in each case researchers will have to figure out how best to bind the drug molecule in question to a biodegradable thin-film coating.
With graphene droplets now easy to produce, researchers say this opens up possibilities for its use in drug delivery and disease detection.
it could be used for controlled drug release applications.""Drug delivery systems tend to use magnetic particles
which are very effective but they can't always be used because these particles can be toxic in certain physiological conditions,
and deliver drugs to target cells in the human body. Recently researchers created nanoparticles that under the right conditions self-assemble trapping complementary guest molecules within their structure.
and force them to interact exclusively in the intracellular environment can evolve into a valuable strategy to activate drugs inside cells Raymo says.
#Nanoparticles could provide easier route for cell therapy UT Arlington physics researchers may have developed a way to use laser technology to deliver drug and gene therapy at the cellular level without damaging surrounding tissue.
The researchers claim their nanoparticle bar codes could be used with paper metals fluids and even drugs.
explosive derivative drug polymer and ink. This method has high labeling capacity owing to the small sizes of nanoparticles sharp melting peaks
and cost-effective genetic test to determine the correct dosage of blood thinning drugs for the treatment of stroke,
we have developed a new genetic test that can determine the appropriate drug dosage to be administered for each patient."
"Blood thinning drugs or anticoagulant medication prevent clots from forming in the blood. They are used to treat stroke, irregular heartbeat and deep vein thrombosis.
Warfarin is the most widely prescribed oral anticoagulant drug. But the dosage for each individual is highly variable,
allowing for'evil twins'of drugs to be identified with much greater sensitivity. Researchers from the University of Cambridge have used this relationship, in combination with powerful lasers and nanopatterned gold surfaces
The drug that was prescribed to patients however, was a mix of both forms, resulting in more than 10,000 children worldwide being born with serious birth defects,
which could be useful in the development of new drugs. The results are published in the journal Advanced Materials.
which would result in very high sensitivity for measuring the chiral purity of drugs. The researchers also used tiny gold structures, known as plasmonic nanostructures, to focus the beams of light.
"Together, these technologies could help ensure that new drugs are safe and pure. r
#Silly Putty material inspires better batteries Using a material found in Silly Putty and surgical tubing, a group of researchers at the University of California,
#To make it happen the team removed parts of skull from three patients experiencing frequent drug-resistant epileptic seizures then attached a packet of electrodes to their exposed brains.
Scientists have looked previously into sewer sensors as a way to examine drug usage on a citywide level.
#Drug Cures Mice Of Down syndrome With A Single Dose Cure Down syndrome with a single injection?
A team of scientists from John Hopkins University and the National institutes of health have cured newborn mice of Down syndrome by injecting them with a drug that stimulates
But the drug is a long way from becoming a human cure. The Hedgehog pathway plays an important role
However if a drug were given in utero it potentially could make a difference as it might alter the genes before they were expressed.
#How To Detect Counterfeit Drugs Growing up in Pakistan in the 1980s, Muhammad Zaman and his family always knew which pharmacy to trust
The crisis of poor quality drugs is worst in the developing world, where regulatory oversight is weak
The bogus-drug trade isn't just a problem for the world's poorest patients:
Last year, the Food and Drug Administration (FDA) warned consumers about fakes of Adderall, the attention-deficit-disorder drug,
and researchers like Zaman are working to make sure that the drugs people take are what they're supposed to be.
Detecting dangerous or substandard drugs is generally difficult. Verifying a medication's manufacturing origin is simple only when it comes from a big
where it combines with a molecule designed to bind solely with the drug in question. Binding sets off a fluorescent probe,
The process reveals how much of the drug is present and how quickly it dissolves, and takes 15 minutes or less."
Some drugs are entirely fakenake oil, sawdust, chalk. But others, particularly those in developing countries, might contain an ineffective amount of medicine or release the right amount in the wrong way;
Pharmacheck is designed to recognize these drugs as well. Too strong a signal right away could mean that the medicine wasn't made properly
Some drugs are entirely fake. Others contain an ineffective amount of medicine. Meanwhile, the FDA is ramping up deployment of its own handheld scanners,
which detect changes in a drug's ingredients and packaging to help determine its provenance.
where counterfeit drugs slip into the country, and more at other points of entry. While not as sophisticated as Zaman's Pharmacheckd-3 can't determine a pill's dose
or how it's released in the bodyda officials say the device is great for screening lots of drugs.
Its convenient and still-unnamed product lab on a piece of paper the size of a business cardirectly detects a drug's ingredients.
Each paper can detect one type of drug. Rub some crushed Tylenol or antimalarial on it, for example, dip it in water,
#Which Drugs Actually Kill Americans Infographic Death reporting in the U s. requires an underlying cause the event or disease that lead to the death.
The subcategories are limited in their detail many drugs are lumped together like MDMA and caffeine which are listed together as psychostimulants.
And while cocaine heroin and alcohol are all responsible for enough deaths to warrant their own stripes on the chart many popular illegal drugs including marijuana
if a person had listed multiple drugs on their death certificate they're being counted twice here.
when its got Marijuana lumped in with all of the truly dangerous drugs. MARIJUANA has caused NEVER a single case of overdose in all of human history.
Tobacco kills more Americans than all of these drugs+pharma=COMBINED!**400000 Americans killed by Tobacco each year.
Drug laws are divorced from reality. They only serve to support the drug trade. We cannot continue to lie to drug users
and expect them to take us seriously. They know better than anyone that all drugs are not bad and all pharmaceuticals are not safe either.
Why would our children listen to us if they think we are fools? Looks like Alcohol overdoses have doubled in the last few years as well.@
Taylorjusher That is because people are believing the lie that legal drugs are safe and illegal ones are dangerous.
while the reckless outlaws using overpriced contaminated incorrectly dosed illegal drugs are still alive and partying.
The elderly obese man had drugs in his system as he stepped in front of the bus that squished him running away from his angry wife with that machete.
More proof that the war on drugs is a wasteful fallacy. Absolute BS. I don't know where they got these statistics but
Alcohol and opioids like heroin have got to be the drugs causing the most death..The graph is anything but clear.
Auroria I agree that sugar is a drug and that is extremely unhealthy (I avoid it).
In that same time green pharma related drug deaths increased from 2. 7 to 9. 9 per 100000 per year (1. 8cm by ruler to 6. 6cm where 25%=16. 6cm
Something like Deaths by Drug Overdose Group by Drug would have been a billion times better. Please be more responsible.
1. This chart shows deaths caused by drug overdose. It does not show deaths from chronic health problems caused by drug use nor accidents (car crashes falls) nor suicides while intoxicated.
If all these other deaths were shown the death count for alcohol would be much much greater. 2. Overdose deaths from cannabis LSD magic mushrooms
People concentrate on illegal drugs when legal drugs kill many times more. In France Alcool is third biggest killer.
Here government encourage to drink wine
#Something Is Killing Up to Half Of America's Bees There's some kind of environmental issue/plague/apocalypse killing America's honeybees
which#chews up these drugs essentially#rendering them ineffective. These new special powers all lie in the bacteria s genes
By removing the bacteria s genes that make them antibiotic-resistant CRISPR can boost the effectiveness of existing drugs.
The World health organization has declared that it is ethical to use experimental drugs in this outbreak? allowing some potential treatments to skip clinical trials that would validate the drug's safety and efficacy?
and U s. federal agencies want to fast-track human trials of a promising vaccine. If all goes well,
Scientists have been conducting research on micrometre-sized actuators that one day may make it possible to transport drugs or chemical sensor molecules to specific locations throughout the human body.
We want controllers to steer them to do useful tasks such as targeted drug delivery and mobile sensing.
paves way for personalized drug treatments Panasonic, together with the Belgium-based research institution IMEC, has developed a DNA TESTING chip that automates all stages of obtaining genetic information,
we can determine that this drug will work for this person, or this drug will have severe side-effects on that person.
Investigating SNPS enables tailor-made therapy. But with the current method, it has to be done in a specialized lab,
announced that the RP-VITA Remote Presence Robot has received 510 (k) clearance by the U s. Food and Drug Administration (FDA) for use in hospitals.
Drug delivery was via an intraperitoneal injection i e. an injection into the body cavity. While the results were outstanding more work needed to be done before this solution could be taken out of a lab situation and into a real world one.
but that is also capable of electrical stimulation and local drug delivery and this over several weeks in vivo was no small task
New research gives the first evidence of how this might be possible by treating mice with a new drug that made cancer cells less likely to grow in other parts of the body.
The team then used a drug in the mice with cancer that fools this oxygen sensor into behaving
They found that the cancer was then less likely to spread in those mice that had been treated with the drug than in those that hadn.
The new guidelines also call for offering the drugs to prevent HIV infectiono-called pre-exposure prophylaxis,
#Designer antibodies may rid body of AIDS virus Anti-HIV drugs have extended life for millions of people,
whether drugs can shock cells that are infected with latent HIV to make new viruses, setting them up for the kill by the natural immune response.
#Researchers identify new target for anti-malaria drugs A new target for drug development in the fight against the deadly disease malaria has been discovered by researchers at MIT.
the researchers describe how they identified the drug target while studying the way in which the parasites Toxoplasma gondii,
they could be used as a drug target against the diseases they cause, including malaria, he says. his very strongly suggests that you could find small-molecule drugs to target these pores,
Customizable viruses The Food and Drug Administration has approved a handful of bacteriophages for treating food products,
"Conventionally, cells cultured on the surface of plastic dishes have been used to identify new drug targets, test chemical toxicity,
including tumor metastasis and drug/toxin sensitivity.""This is important as pharmaceutical companies and regulatory agencies look for new,
including regenerative medicine strategies involving therapeutic cells, multifunctional drug delivery, surgical implants, and tissue engineered medical products.
#New technology could speed up lifesaving drug discoveries A team of researchers from our University has developed a revolutionary new biochip device that will lead to a faster
and more cost effective way of discovering new lifesaving drugs. Preventing kinase over-activity The'Phosphosense'technology screens compounds for use in drugs
and select which one can be developed into drugs to fight against diseases. The device was developed at Bath by researchers Dr Pedro Estrela and Phd student Nikhil Bhalla in the Department of Electronic & Electrical engineering, Dr Mirella Di Lorenzo in the Department of Chemical engineering,
Revolutionising drug discovery Dr Giordano Pula, Lecturer in the Department of Pharmacy & Pharmacology said:"
"This technology has the potential to change the drug discovery process as we know it
and facilitate the development of new drugs for diseases like cancer, stroke and dementia.""The simplicity is the strength of this technology.
"The work, published in the Nature Group journal Scientific Reports, explains how this technology identifies potential new drugs by combining semiconductor devices that measure protein kinase activity by calculating ph change,
which signifies the effectiveness of a potential drug compound in blocking kinase activity y
#Getting the perfect fit for artificial hips When a patient receives a new hip, it is adjusted usually only approximately to leg length.
can also be tested for drug discovery using our strategy.""The research team evaluated about 6,
000 compounds from both the KU Chemical Methodologies and Library Development Center and the Food and Drug Administration in a process known as"High Throughput Screening,"hunting for compounds that obstruct Hur's interface with healthy
Thus, the combined treatment with inhibitors of fork reversal and currently used chemotherapeutics could improve the specificity of these drugs toward cancer cells."
"For some drugs, having the correct'handedness'is essential as you need the right key in the lock to make the drugs work.
Stealing oil has become a lucrative activity among drug cartels, forcing Pemex to stop shipping finished fuel through its pipelines after discovering 3, 674 illegal taps last year.
#New Polymer Gel Could Create Edible Devices for Ultra-Long Drug Delivery A team of scientists has developed a polymer gel that could allow for the development of long-acting devices that reside in the stomach,
including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
or extended-release drug-delivery systems that could last for weeks or months after a single administration. his delivery system provides a flexible and smooth external covering that slowly disintegrates,
which could release drugs or small devices for monitoring and imaging the GI TRACT, says Edith Mathiowitz,
In particular, the authors say they are excited for the drug-delivery applications of this technology. With further work in adjusting the polymer composition or the design of the system
they say that they could tailor devices to release drugs over a specific timeframe of up to weeks or months at a time.
MIT is negotiating an exclusive license agreement with Lyndra, an early-stage biotechnology company developing novel oral drug-delivery systems,
In a March 2015 commentary piece in Nature, Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.
The findings open the door to new possibilities for developing drugs to fight asthma as well as other diseases
This enzyme activates a harmless drug precursor called CB 1954 which the researchers added to the petri dish where the cells were growing.
Its development could usher in a new generation of portable sensors that can use polarized light for applications ranging from drug screening to quantum computing.
Chirality is critically important in drugs because whether they are left handed or right handed determines their biological activity.
Having a portable sensor capable of detecting a drug chirality could be a game changer. nexpensive CPL detectors could be integrated into the drug production process to provide real time sensing of drugs
in a press release. ortable detectors could be used to determine drug chirality in hospitals and in the field. n research published in the journal Nature Communications,
The team is currently using the tool to etect the presence of malaria-related drug resistance. g
which will inform the drug discovery process. And hemophilia is just the first chronic disease that the company will tackle.
#Hack Helps Patients Prevent Adverse Drug Reactions For anyone who ever Googled hat happens when you take prescription drug with other prescription drug,
to learn about adverse reactions to prescription drugs. his allows you to put in the drugs youe taking,
or post it work that scientists are doing to tie that drug to an adverse event.
idodrugs. club first identifies the chemical ingredient in the drug you enter. italin, for instance, is the brand name that most people probably recognize,
Unfortunately, lcoholdoes not count as a drug on this platform, at least from my own (brief) research.
For the results, a team of researchers used different types of an analytical chemistry technique to analyse the fingerprints of patients attending drug treatment services.
and not whether they have taken actually the drug. When someone has taken cocaine, they excrete traces of benzoylecgonine
and methylecgonine as they metabolise the drug and these chemical indicators are present in fingerprint residue.
It is anticipated that this technology could see the introduction of portable drug tests for law enforcement agencies to use within the next decade.
For the results, a team of researchers used different types of an analytical chemistry technique to analyse the fingerprints of patients attending drug treatment services.
and not whether they have taken actually the drug. When someone has taken cocaine, they excrete traces of benzoylecgonine
and methylecgonine as they metabolise the drug and these chemical indicators are present in fingerprint residue.
It is anticipated that this technology could see the introduction of portable drug tests for law enforcement agencies to use within the next decade.
new effective drugs are increasingly available to treat the disease and prevent deformed joints. To conduct the research, scientists from University college Dublin and the University of Sheffield,
#More effective drugs for diabetes in the offing Scientists have found a new way to lower blood sugar levels by reducing glucose production in the liver,
paving the way for more effective drugs for type 2 diabetes. Some treatments for type 2 diabetes make the body more sensitive to insulin,
"We think this strategy could lead to more effective drugs for type 2 diabetes, "said principal investigator Brian N Finck, associate professor of medicine in the Division of Geriatrics and Nutritional Science."
"A drug that shuts down glucose production has the potential to help millions of people affected by the most common form of diabetes,
and the biopharmaceutical company Metabolic Solutions Development Co. The company is involved in clinical trials that are evaluating the drug compound MSDC-0602 as a treatment for diabetes.
#New drug approach could overcome antibiotic resistance WASHINGTON: Researchers have discovered a new group of antibiotics that may provide relief to those affected by antibiotic resistance.
and their metabolism in animals,"said Joseph Falkinham, a professor of microbiology in the College of Science and an affiliate of the Virginia Tech Centre for Drug Discovery.
This enzyme activates a harmless drug precursor called CB 1954, which the researchers added to the petri dish where the cells were growing.
which is also a clinically used drug, "said co-author Hongtao Zhang, from the Perelman School of medicine at the University of Pennsylvania in US.
"A drug that interferes with these initial metabolic changes could make very effective treatment for myeloma,
What more, Aprecia have just been awarded FDA approval for the first of 3d printed drug of its kind, the epilepsy drug Spritam.
and claims to be the world only company to utilize 3d printing technology to develop drugs.
Spritam is only the first of the 3d printed drugs they are planning to develop.
their new drug could play a key role in treating a variety of seizure afflictions.
This new drug is set to be released in the first quarter of 2016. But why, you can rightly ask,
does a drug like this need to be printed 3d? Surely epilepsy drugs already exist? Well you would be absolutely right,
He further stated that this same approach will be used on other drugs in the near future as well. his is the first in a line of central nervous system products Aprecia plans to introduce as part of our commitment to transform the way patients experience taking medication,
this 3d printed approach to drugs does open up a wide range of options for more customized drugs.
Tao Levy, an analyst at Wedbush Securities, has speculated already that this could be used to develop custom drugs featuring a dosage perfect for a single patient,
and 3d printed drugs could be a welcome addition to that system. In short, Spritam is definitely paving the way for a new generation of 3d printed drugs.
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as China's Food and Drug Administration announced that China's self-developed 3d printed hip replacement (joint) has been certified commercially,
adding that he hopes that these 3d printed hip parts will act as promotional pieces within the drug administration system. t is said that at the end of year,
If a Makerbot Replicator 3d printer can be used in pharmacological research labs for advances studies on how to administer cancer fighting drugs,
as a drug delivery system, as well. Chen and Wang have conducted demonstrations to show the great potential of combining 3d printing with nanoengineering, installing polydiacetylene (PDA) nanoparticles within the microfish.
"or manipulating drug delivery in the human body. Co-author Bruce Drinkwater, Professor of Ultrasonics at the University of Bristol, said
similar to an ultrasound scanner but for manipulating particles (that is, drug capsules, kidney stones or microsurgical instruments),
However he was excited most about the technology's potential in treating diseases such as cancer by delivering drugs more efficiently."
"If we could hold drugs (or more likely microcapsules with drugs inside) in the place where they are needed
and then slowly release them we could use much smaller doses, which would result in less side effects,
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