through the development of telomerase enhancing drugs. At the same time, while telomere damage already occurs in normal aging,
Cheap, lightweight and portable, the advanced nebulizer delivers precise drug doses to patients with life-threatening
Professor Leslie Yeo, Director of RMIT University Micronanophysics Research Laboratory, said the Respite technology had the potential to revolutionize how patients were treated with drugs
Yeo commented that conventional puffers only manage to get 30 percent of the drugs into the lungs,
the rest of the drug gets lost in the mouth. This is a problem when the drug delivered is expensive due to the wastage.
In addition, traditional inhalers also require band-breath coordination to administration, which would require the elderly and very young patients to be taught to avoid misuse. he most important aspect of our device is that it does not require inhalation to generate the aerosols as with the ubiquitous inhalers,
The Respite technology uses sound waves to excite the surface of the fluid or drug. This generates a fine mist capable of delivering much larger molecules directly to the lungs.
The device delivers drugs at rates of up to 3 ml/min, compared to the much smaller doses of 0. 4 ml/min benchmark of current nebulizers.
Yeo believes that Respitetm has a huge potential to deliver drugs for lung cancer patients. he five-year survival rate for lung cancer remains around 15 percent
and scientists a potential drug target to influence the behavior of the circadian clock. This new target may make it possible to counter the effects of jet lag
when drugs should be administered to modify circadian rhythms so that they are most effective. The next step for the team is to test their predictions in an animal model.
"So for clinicians, harnessing microbubble to nanoparticle conversion may be a powerful new tool that enhances drug delivery to tumours,
low-cost method to build DNA NANOTUBES block by block a breakthrough that could help pave the way for scaffolds made from DNA strands to be used in applications such as optical and electronic devices or smart drug-delivery systems.
while Sleiman uses DNA chemistry to design new materials for drug delivery and diagnostic tools.
#Genisphere Reports Successful Treatment of Posterior Capsular Opacification using 3dna Drug Delivery Platform Genisphere LLC,
The targeted 3dna approach is similar to that of an antibody drug conjugate (ADC), but delivers 100 times more of the drug to the targeted cells than an ADC
and has observed no toxicity. Additional studies testing this formulation in rabbits undergoing cataract surgery are ongoing with Drs.
and 3dna nanocarriers can deliver a variety of drug cargoes, we can easily generate targeted drugs for many of these indications."
"He added, "Genisphere's partnership model for development of nanotherapeutics has set the path forward for clinical testing and future commercialization of these and other candidates. t
#Heart-on-a-Chip Device Holds Promise for Drug-Screening When UC Berkeley bioengineers say they are holding their hearts in the palms of their hands,
The system could one day replace animal models for drug safety screening. Photo by Anurag Mathur, Healy Lab) Instead, the research team led by bioengineering professor Kevin Healy is presenting a network of pulsating cardiac muscle cells housed in an inch-long silicone device that effectively models human heart tissue,
and they have demonstrated the viability of this system as a drug-screening tool by testing it with cardiovascular medications.
March 9) in the journal Scientific Reports, represents a major step forward in the development of accurate, faster methods of testing for drug toxicity.
The project is funded through the Tissue Chip for Drug Screening Initiative an interagency collaboration launched by the National institutes of health to develop 3-D human tissue chips that model the structure and function of human organs. ltimately,
these chips could replace the use of animals to screen drugs for safety and efficacy, said Healy.
The study authors noted a high failure rate associated with the use of nonhuman animal models to predict human reactions to new drugs.
and type between humans and other animals. any cardiovascular drugs target those channels, so these differences often result in inefficient and costly experiments that do not provide accurate answers about the toxicity of a drug in humans,
said Healy. t takes about $5 billion on average to develop a drug, and 60 percent of that figure comes from upfront costs in the research and development phase.
Using a well-designed model of a human organ could significantly cut the cost and time of bringing a new drug to market.
The heart cells were derived from human-induced pluripotent stem cells, the adult stem cells that can be coaxed to become many different types of tissue.
mimicking the exchange by diffusion of nutrients and drugs with human tissue. In the future this setup could also allow researchers to monitor the removal of metabolic waste products from the cells. his system is not a simple cell culture where tissue is being bathed in a static bath of liquid,
it replicates how tissue in our bodies actually gets exposed to nutrients and drugs. The heart cells were derived from human-induced pluripotent stem cells,
mimicking the exchange by diffusion of nutrients and drugs with human tissue. In the future, this setup could also allow researchers to monitor the removal of metabolic waste products from the cells. his system is not a simple cell culture where tissue is being bathed in a static bath of liquid,
it replicates how tissue in our bodies actually gets exposed to nutrients and drugs. e
different drugs are used to treat different types of asthma patients. If you know what a person immunophenotype is
The drug paclitaxel has been used for decades to fight breast, ovarian, lung and other cancers. But its effectiveness has been limited by its small molecular size
and insolubility in water--properties that allow the body to clear the drug too quickly,
Many molecular packaging systems have been developed to deliver the drug while counteracting these effects, with a protein-bound version of the drug called Abraxane currently the leading therapy.
But Ashutosh Chilkoti professor and chair of the Department of Biomedical engineering at Duke university, thought his team could do better.
the Duke team doubled tumor exposure to the drug compared to Abraxane while simultaneously reducing its effects on healthy tissue.
In the new packaging system, multiple copies of the drug are bonded chemically to an amino acid polypeptide,
forming a water-soluble nanoparticle with the drug hidden in its core. These nanoparticles are highly soluble in blood
"This delivers the drug directly to the tumor and helps prevent it from randomly absorbing into healthy tissue, reducing side effects."
And since this platform could potentially be used for such a broad array of drugs, it could be a game-changer for cancer therapy."
Understanding how cells release those signals in less than one-thousandth of a second could help launch a new wave of research on drugs for treating brain disorders.
exciting advance that may open up possibilities for targeting new drugs to control neurotransmitter release. Many mental disorders, including depression, schizophrenia and anxiety,
and drug doses could potentially be reduced-helping to alleviate side effects. Revolutionary cell-based therapies, which exploit modified human cells to treat diseases such as cancer,
To overcome this, manufacturers use chemical additives to increase the solubility of Ibuprofen and many other drugs,
The key to making drugs by themselves more soluble is not to give the molecular soldiers time to fall in to their crystalline structures
In addition, it may provide a simple means to make many drugs much more useable. The technique involves first dissolving the substances in good solvents, such as water or alcohol.
The possible applications range from rewritable paper, to water decontamination, to the controlled delivery of drugs or other substances.
and release them later on demand as well as the controlled delivery of tiny amounts of substances, for example, drugs,
The researchers, led by Elena Batrakova, an associate professor at the UNC Eshelman School of Pharmacy's Center for Nanotechnology in Drug Delivery,
#Platelet-Mimicking Nanoparticles Could Effectively Deliver Drugs to Targeted Sites Nanoparticles disguised as human platelets could greatly enhance the healing power of drug treatments for cardiovascular disease and systemic bacterial infections.
San diego, are capable of delivering drugs to targeted sites in the body--particularly injured blood vessels,
Engineers demonstrated that by delivering the drugs just to the areas where the drugs were needed,
targeted drug delivery with nanoparticles, "said Liangfang Zhang, a nanoengineering professor at UC San diego and the senior author of the study."
platelet-mimicking nanoparticles can directly provide a much higher dose of medication specifically to diseased areas without saturating the entire body with drugs."
and release their drug payloads specifically to these sites in the body. Enclosed within the platelet membranes are made nanoparticle cores of a biodegradable polymer that can be metabolized safely by the body.
The nanoparticles can be packed with many small drug molecules that diffuse out of the polymer core and through the platelet membrane onto their targets.
makes platelet membranes extremely useful for targeted drug delivery, researchers said. Platelet copycats at work In one part of this study, researchers packed platelet-mimicking nanoparticles with docetaxel,
a drug used to prevent scar tissue formation in the lining of damaged blood vessels, and administered them to rats afflicted with injured arteries.
because they can focus treatment on the bacteria locally without spreading drugs to healthy tissues
or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments a
#New Nanosheet-Based Photonic crystal Changes Color in Response to Moisture LMU chemists have developed a photonic crystal from ultrathin nanosheets
#Self-Assembled DNA NANOSTRUCTURES Could Be used as Smart Drug-Delivery Vehicles Researchers from Aalto University have published an article in the recent Trends in Biotechnology journal.
Tailored DNA structures could find targeted cells and release their molecular payload (drugs or antibodies) selectively into these cells."
and most importantly, other molecules such as RNA, proteins, peptides and drugs can be anchored to them with the same resolution.
A system based on tailored DNA-devices could help to avoid unnecessary drug treatments, since programmed DNA-nanorobots could detect various agents from the blood stream,
this could find uses for example in enhanced drug delivery. In addition, the group has designed a modular DNA-based enzymatic nanoreactor that can be exploited in diagnostics at the molecular scale level v
In this way, the cytoxic drug can be delivered directly to the cells it is intended to eradicate.
"But the relative lack of efficient ways to attach chemotherapeutic drugs to antibodies currently represents a major technological bottleneck,
particularly for patients who take anticoagulant drugs to thin their blood.""It's interesting that you can take something so deadly
It has also been used as a diagnostic tool to determine blood-clotting time in the presence of heparin, an anticoagulant drug."
There also a role for security, for example in drug searches at airports. More fundamentally though, the researcher say it could help them build something that never existed before:
This enzyme activates a harmless drug precursor called CB 1954 which the researchers added to the petri dish where the cells were growing.
and so that they can test the effect of new drugs on inhibiting their growth. But the fibrils that are believed to be most harmful are too tiny to be seen using an optical microscope.
or for drug researchers to put the amyloid proteins in water, inject their drug, and study how the drug influences the growth of the aggregates over time."
"For research in TYPE II DIABETES or Alzheimer's or Parkinson's, having this simple platform to perform these tests at a fraction of the cost of
what's required for fluorescence or neutron scattering would be very useful
#Advances in PET Scanning Technology Helps Reduce Radiation Dosage Researchers in Manchester have used recent advances in PET scanning technology to reduce the radiation dose for both patients
the US Food and Drug Administration has given the go-ahead for a 3d-printed pill to be produced.
The new drug, dubbed Spritam, was developed by Aprecia Pharmaceuticals to control seizures brought on by epilepsy.
Printing the drugs allows layers of medication to be packaged more tightly in precise dosages. A separate technology developed by the firm
Printing the drug meant it could package up to 1, 000 milligrams into individual tablets. The 3d-printed pill dissolves in the same manner as other oral medicines.
Being able to 3d print a tablet offers the potential to create bespoke drugs based on the specific needs of patients,
Beyond their importance to our understanding of basic cell biology, microtubules are a major target for anticancer drugs, such as Taxol,
"A better understanding of how microtubule dynamic instability is regulated could open new opportunities for improving the potency and selectivity of existing anticancer drugs,
The method opens up unexpected possibilities for understanding diseases and drug mechanisms. The study's findings are reported in the September 7 issue of Nature Methods.
when a person stops taking anti-HIV drugs. Further studies in animals and people are needed to determine the viability of this approach.
Early signs are that drugs that increase the activity of IFIT3 may be effective treatments for other viral diseases as well.'
The effects of high drug prices and bad press are said nsustainable he and as recent coverage shows
The effects of high drug prices and bad press are said nsustainable he and as recent coverage shows,
These candidate drugs should have a high potential to pass through clinical trials and could ultimately save lives,
#Researchers Find New Target for Anti-Malaria Drugs A new target for drug development in the fight against the deadly disease malaria has been discovered by researchers at MIT.
the researchers describe how they identified the drug target while studying the way in which the parasites Toxoplasma gondii,
they could be used as a drug target against the diseases they cause, including malaria, he said. his very strongly suggests that you could find small-molecule drugs to target these pores,
That can encourage bacterial drug resistance and, by killing off harmless bacteria in the gut, lead to colonization by pathogenic bacteria, such as Clostridium difficile.
The inability to easily distinguish sepsis from sterile inflammation makes it tough for pharmaceutical companies to conduct clinical trials of drugs aimed at treating sepsis;
MIT researchers used Kamm's microfluidics technology to screen several drugs that aim to prevent tumors from breaking up
Results indicated that the level of drugs needed was often two orders of magnitude higher than predictions based on traditional assaid. o there no way to effectively predict, from the 2-D assaid,
what the efficacy of a particular drug was, Kamm said. If pharmaceutical companies were to winnow potential drugs from,
say, 1, 000 to 100 for testing, Kamm said, e could test those drugs out in a more realistic setting.
#Researchers Uncover New Pathways for Diabetes Research A new Florida State university study is changing how scientists look at diabetes research
and the drugs used to treat the disease. In the Proceedings of the National Academy of Sciences, Associate professor of Chemistry Brian Miller and postdoctoral researcher Carl Whittington report that a key enzyme involved in the body response to glucose can essentially be corrupted by a new mechanism that scientists
researchers uncovered drugs that activate the enzyme, which offered hope for treating type 2 diabetes.
To examine just how some inhaled anesthetic drugs affect viral and bacterial infections, Krishnan Chakravarthy, M d.,Ph d.,a faculty member at the Johns Hopkins Institute of Nanobiotechnology and a resident physician in the department of anesthesiology and critical
"Given that these drugs are the most common anesthetics used in the operating room, "there is a serious need to understand how they work
"A therapy based on these inhaled drugs may help deal with new viral and bacterial strains that are resistant to conventional vaccines
"We hope our study opens the door to the development of new drugs and therapies that could change the infectious disease landscape."
The discovery and exploitation of this new drug target was made possible by an earlier discovery by Ball lab. That finding enabled researchers to identify, on a molecular level,
the target of action for drug molecules by using rhodium-based inorganic complexes that recognize specific folds in a protein chain
There a large surface area with weak interactions for which we have failed typically to find good drugs, he said.
with limited success. here no evidence people have tried to go after the coiled coil as a drug target,
Such knowledge could pave the way for new drugs for a myriad of diseases, including cancer.
therefore, of particular interest. he ability to produce kinases for study should be useful in learning how these proteins function and in developing new types of drugs,
and the University of Michigan claiming novel reagents used for screening small-molecule chemical libraries for new drug leads.
and neurodegenerative diseases, validating histone methyltransferases (HMTS) as an important class of drug targets among biomedical researchers.
Director of Drug Discovery Chemistry at Cayman Chemical. e are going after drug compounds that have a specific mechanism of action
#3d Barcode May Prevent Drug Counterfeiting A specialized barcode unveiled at The british Science Festival on Wednesday may play an important role in combating the global proliferation of fake medications.
Packing and labeling may look similar to real brand-name drugs, but these false pills could cause serious harm.
it safe for the patient to take the drug. Sofmat managing director Dr. Phil Harrison told The Guardian this system
while they were initially designing photosensitive polymers for drug delivery applications. Once they came up with a polymer that responded to UV light,
meaning more absorption occurs on small nanoparticles. his is an important consideration for drug delivery
because it could explain what happens with nanoparticles with high drug encapsulation and extensive burst release.
or drugs inside a man-made biodegradable nanoparticle rapperthat patients inhale could penetrate the mucus barrier
we can develop insights into how Alzheimer disease naturally progresses and potential drug targets, said principal investigator Michael Rafii, M d.,Ph d.,assistant professor of neurosciences and interim co-director of the Alzheimer Disease Cooperative Study (ADCS) at UC San diego. The 3-year study
M d.,a world leader in Alzheimer research, to promote the discovery, development and testing of new drugs for the treatment of AD.
The discovery provides a new platform for drug delivery systems and an entirely different view of cellular functions.
Chilkoti lab has designed self-assembling proteins for drug delivery systems for several years. Simply by adding heat,
and when drugs are released inside the body through non-temperature-related mechanisms such as changes in acidity levels.
however, drugs could be encapsulated in protein cages that accumulate inside of a tumor and dissolve once heated.
Not only would this provide a more accurate way of delivering drugs, but the cages themselves could be used therapeutically. hese packaging systems have always been inert,
This enzyme activates a harmless drug precursor called CB 1954 which the researchers added to the petri dish where the cells were growing.
and not the type that the drug Herceptin targets. Each year, more than 100,000 women in the United states alone are diagnosed with this.
The usual treatment is followed surgery by years of a hormone-blocking drug. But many women also are urged to have chemo,
and hormone-blocking drugs. Women in the middle group were assigned randomly to get hormone therapy alone or to add chemo.
#Pseudo-platelet Drug Delivery System Targets Cancer Researchers are using patients own platelet membranes to coat drugs and use as nanovehicles for anticancer treatments.
Corresponding author Zhen Gu, an assistant professor in the joint biomedical engineering program at North carolina State university and the University of North carolina Chapel hill, said there are two significant benefits in using platelet membranes to coat anticancer drugs.
comparted to about six hours for nanoscale vehicles without the coating. his combination of features means that the drugs can
which are placed then in a solution with a nanoscale gel containing the anticancer drug doxorubicin (Dox).
The surface of the spheres are coated then with the anticancer drug TRAIL, which attacks the cell membrane of cancer cells.
Studies on mice found that using the combination drug delivery system in the form of a pseudo-platelet was significantly more effective against large tumors
and circulating tumor cells than using the drugs in a nanogel delivery system without the platelet membrane. e like to do additional preclinical testing on this technique,
Gu said. nd we think it could be used to deliver other drugs, such as those targeting cardiovascular diseases, in
#An Accessible Approach to Making a Mini-brain If you need a working miniature brain say for drug testing, to test neural tissue transplants,
and that could eventually lead to the development of a drug to enhance recovery from strokes.
#Scientists Work on the Drug Building Process One Block at a time, University of Illinois Reveals Molecule-Making Machine Simplifies Complex Chemistrychampaign, Ill.
and enable new drug development and other technologies that rely on small molecules. We wanted to take a very complex process, chemical synthesis,
Drug Application for alectinib, which has been granted Breakthrough Therapy Designation--2015 ASCO Annual Meeting SOUTH SAN FRANCISCO, Calif.--BUSINESS WIRE)--Genentech,
Alectinib was granted Breakthrough Therapy Designation by the U s. Food and Drug Administration (FDA) in June 2013 for people with ALK-positive NSCLC
#New Test Detects Drug Use From A Single Fingerprint, University of Surrey Study Research published today in the journal Analyst has demonstrated a new,
used different types of an analytical chemistry technique known as mass spectrometry to analyse the fingerprints of patients attending drug treatment services.
a drug often used to treat anxiety disorders. Researchers placed electrodes at strategic points on the skin
The achievement was made possible by a new generation of drug-containing coating applied to the inner surface of the vessel.
The lifetime of such grafts is determined often by the amount of drug stored within the graft,
The system, developed by the researchers, is based on the entrapment of the drug inside a porous protective shell,
You just need to take the right kind of drug. For example, after the implantation of an artificial ureter, urease crystals often start to grow inside
It is possible to apply a similar drug-containing coating that dissolves urease. The same approach may be used for kidney or liver surgery,
members of a family of painkilling drugs sourced from the opium poppy. It can take more than a year to produce a batch of medicine, starting from the farms in Australia,
where the active drug molecules are extracted and refined into medicines. hen we started work a decade ago,
Current drug treatments have to be taken for a lifetime, which causes side effects and many other issues,
Some promising experimental Alzheimer drugs require early determination of how the disease is likely to progress,
electrical devices (pacemakers or defibrillators) or drugs (eg beta blockers. However, these methods are relatively crude: they can stop
"says research supervisor Dr James St john, from Griffith's Eskitis Institute for Drug Discovery. The technique was developed
"In light of the overwhelming impact of spinal cord injury, new therapeutic interventions for drug discovery and cell therapy are needed urgently."
and drug responses and personalizing treatments in a rapid, cost-effective manner. The findings are reported currently in the Advance Online issue of the journal Nature Medicine."
and validation of new drugs and targets and modeling resistance to therapy,"says Muthuswamy.""By using a cohort of patient samples from
which we can screen for drugs and mutations, we can begin to understand why some patients respond to a treatment
and for drug screening to identify precision therapy strategies
#New lab-on-chip device promises faster TB diagnosis Singapore: US researchers have developed a new low-cost lab-on-a-chip device to aid analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Jay z has admitted also dealing drugs as a teenager. Here's what he told Vanity fair magazine in 2013:
I was a drug dealer. To be in a drug deal, you need to know what you can spend,
what you need to re-up. Or if you want to start some sort of barbershop or car wash those were the businesses back then.
and Drug Administration in the United states to market this therapy. The company says it will look to receive approval from Health Canada once Dig Rush has been approved by the FDA g
and didn't involve drugs or ear-plugs.''EEG or Electroencephalography measures electrical activity in the brain using pads on the scalp,
and is aimed at people who suffer with poor episodic memory-one of the main side effects of schizophrenia drugs.
but slow progress is being made towards developing a drug treatment.''So this proof-of-concept study is important
because it demonstrates that the memory game can help where drugs have failed so far.''Because the game is interesting,
He said his team is now working on developing drugs that will specifically inhibit PDE4B. The drugs will be tested first in animals to see
whether any of them might be suitable to go forward into clinical trials in humans. In the experiments, published on today in the journal Neuropsychopharmacology,
and understanding the effect of genes can be a key early step on the road to developing new drugs.'
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