and treatment of neurological diseases ranging from autism to Alzheimer's disease to multiple sclerosis.""Instead of asking,'How do we study the immune response of the brain?''
''Why do multiple sclerosis patients have the immune attacks?''now we can approach this mechanistically. Because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,
Alzheimer's, Autism, MS and Beyond The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both about the workings of the brain and the diseases that plague it.
And there's an enormous array of other neurological diseases, from autism to multiple sclerosis, that must be reconsidered in light of the presence of something science insisted did not exist t
as well as lifestyle diseases such as obesity, cancer and mental disorders. The circadian rhythm is also related to seasonal reproduction,
cells along the edge experienced greater mechanical stress and tension, and appeared more like fibroblasts,
#Miniature brain'organoids'offer model for autism Scientists have grown miniature brains out of stem cells from people with autism,
Previous studies have looked at the genomes of those with autism to identify the genes that might be responsible,
but 80 percent of autism cases have no clear genetic cause. This is the first study to use brain organoids to investigate the disorder
The researchers took skin cells from four adolescent males with autism and from their fathers who were unaffected by the disorder.
Despite the fact that autism is a complex collection of disorders, the researchers found several clear differences between the brain organoids from the autistic boys and those from their fathers.
'Professor Vaccarino is hopeful that this approach to studying autism, as well as other brain disorders, can offer new insights.'
'This study speaks to the importance of using human cells to bring a better understanding of the pathophysiology of autism and, with that, possibly better treatments. e
it is possible that these blood vessels could be related to a large number of neurological and developmental conditions from autism to attention deficit disorder (ADD TO multiple sclerosis.
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world largest producer of generic drugs,
cells along the edge experienced greater mechanical stress and tension, and appeared more like fibroblasts,
or how sufferers respond to stress, exercise or standard treatment regimens. Stanford's Mcconnell said he also wants to study the effect of giving participants feedback on their progress,
and a drug for multiple sclerosis to control immune response in the brain. Under the two approaches, immune cells from outside the brain were found to travel in greater numbers through the blood into the brain.
an FDA-approved drug used for the treatment of multiple sclerosis; the drug has been shown to foster the migration of white blood cells from the bloodstream to the brain.
or the induction of mechanical stress all of which can change the properties of a particular hydrogel designed to be responsive to those triggers. hese experimental and theoretical results provide a new conceptual framework for liquid motion confined by soft,
For many indications, such as Alzheimer and autism, the need for new treatments is enormous, yet investment in these areas is declining due to recent high profile failures.
In the field of autism, stakeholders such as academic researchers, pharma companies, and patient advocacy groups are coming together to better understand the inner workings of the disease in hopes to increase the development and approval of effective therapeutics.
multi-year collaborative program to develop the infrastructure underpinning new treatments for autism. These are just two instances of industry coming together to achieve a mutually beneficial goal
or how sufferers respond to stress, exercise or standard treatment regimens. Stanford's Mcconnell said he also wants to study the effect of giving participants feedback on their progress,
and post traumatic stress disorder in soldiers returning from combat zones.''We know that high pressure inside the skull resulting from injuries
and public anxiety around having such sensitive data captured, stored, and accessed. We have researched this area by presenting people with potential future scenarios that involved biometrics.
and muscle contractions due to multiple sclerosis. But researchers discovered weak evidence that medical marijuana was associated with improvements in nausea and vomiting due to chemotherapy
And there was very-low quality evidence the drug eased anxiety. In addition, Dr Whiting and her team found weak evidence to support the claim that medicinal cannabis has no effect on psychosis,
and very little evidence in defence of the idea it had no effect on depression.
Notably, cannabinoids were found to cause dizziness, dry mouth, nausea, fatigue, euphoria, vomiting, disorientation, drowsiness, confusion, a loss of balance and hallucination.
'Further large, robust, randomised clinical trials are needed to confirm the effects of cannabinoids, particularly on weight gain in patients with HIV/AIDS, depression, sleep disorders, anxiety disorders, psychosis, glaucoma,
'We're also very interested in addressing stress in working dogs, such as guide dogs for the blind,'sayssean Mealin,
and mitigate stress for the dogs, improving the length and quality of a dog's life,
and trained not to display signs of stress in their behavior.''In addition to disaster response research, the research team has done already work that uses the platform to assist in dog training.
cells along the edge experienced greater mechanical stress and tension, and appeared more like fibroblasts,
Facial recognition software looks for telltale markers of stress or anxiety, while the gas sensors take samples of the user breath looking for compounds that give an indication of how much they drink or smoke.
This means (cue maniacal laughter) attorneysfees accountantsfees and compliance costs. Raising $50 million under Regulation A is going to require your company to invest money in the process.
Champalimaud Foundation. here are some very important diseases of the spinal cord, like multiple sclerosis. So when the diseases begin,
At the same time, however, the mechanical stress on the products needs to be kept as low as possible,
and stress signals that is otherwise invisible to the human eye. The crop health monitoring imagery utilized by Farmlogs shows information that is actionable
such as mental disability, autism, and cancer. Sticky-flares have the potential to help scientists understand the complexities of RNA better than any analytical technique to date
anxiety, and impulsive behavior. Typical physical symptoms include enlarged heads, flat feet and distinctive facial features.
Almost one-third of patients with fragile X also show symptoms of autism spectrum disorders.
#High-res MRI links cerebellum to bipolar disorder A different type of MRI has given researchers an unprecedented look at previously unrecognized differences in the brains of people with bipolar disorder, a new study reports.
The cerebellar differences were not present in patients taking lithium, the most commonly used treatment for bipolar disorder.
Despite being relatively commonipolar disorder affects about one percent of the populationcientists don have a good understanding of what causes bipolar disorder,
Researchers examined 15 patients with bipolar disorder and 25 control subjects matched for age and gender.
ELEVATED MRI SIGNAL Compared to the brains of people without bipolar disorder, the MRI signal was elevated in the cerebral white matter
and the cerebellar region of patients affected by bipolar disorder. The elevated signal may be due to either a reduction in ph or a reduction in glucose concentrationoth factors influenced by cell metabolism.
Previous research has suggested that abnormal cell metabolism may play a role in bipolar disorder. However, investigating metabolic abnormalities in the brain has been hindered by lack of a good imaging tools.
One reason researchers didn know that the cerebellum might be important in bipolar disorder, is because no one chose to look there, says Casey Johnson,
The majority of bipolar disorder research has found differences in the frontal region of the brain.
the researchers conducted an extensive search of the scientific literature on bipolar disorder and began to find pieces of evidence that suggested that the cerebellum may function abnormally in bipolar disorder
and that lithium might potentially target the cerebellum and alter glucose levels in this brain region. ur paper,
While lithium can be an effective mood stabilizer for people with bipolar disorder, it causes numerous unpleasant side effects for patients. f lithium effect on the cerebellum is the key to its effectiveness as a mood stabilizer,
then a more targeted treatment that causes the same change in the cerebellum without affecting other systems might be a better treatment for patients with bipolar disorder,
and the National Alliance for Research on Schizophrenia and Depression provided funding for the study.
a Marker of Neuroinflammation in the Brain During Major depressive episodes showed that there was a 30%increase in inflammation among patients experiencing a major clinical episode."
Multiple sclerosis (MS) was second, and inflammatory conditions such as rheumatoid arthritis (RA), the priciest. However, cancer accounts for 32%of drugs costing more than $100, 000 a year,
One common way that our genetic material can be harmed is from a phenomenon called oxidative stress.
When they exposed these quadruplex-forming sequences to oxidative stress in vitro, a series of different tests indicated that the extra G allowed the damages to fold out from the quadruplex structure,
Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress:
which the G4 sequences act as sensors of oxidative stress e
#New Cell Structure Finding Might Lead to Novel Cancer Therapies University of Warwick scientists in the U k. say they have discovered a cell structure
so as to reduce the stress on the couple. About 13%of couples of reproductive age experience fertility problems.
In plants as in animals and humans, intricate molecular networks regulate important biological functions, such as development and stress responses.
and an earlier Science paper, both of which describe how plants respond to drought and temperature stress.
"False-positive alarms cause anxiety for care teams, patients and families, and can lead to clinicians becoming desensitized to true patient emergencies
Scientists add that it could become a significant step towards slowing the spread of brain diseases like Alzheimer, multiple sclerosis and Parkinson.
Tough yet flexible, these spongy devices can withstand both shock and stress, a feature that many stretchable electronics do not possess.
and have anxiety (even) with getting gas, said Sandoval. ow we can have confidence to charge our electric vehicles and drive them from place to place (in Nevada).
#Scientists grow human mini-brains that are giving big insights into autism Scientists first grew mini-hearts in a lab. Then they 3d printed skin.
In a study published last week in Cell, a team from Yale School of medicine used the technique to glean insight into why autism occurs in some people without a clear genetic cause.
Within a month, it was apparent that organoids created from people with autism overproduced one type of neuron that acts to dampen the chatter of normal neural activity.
and may in part cause the faulty wiring behind autism behavioral symptoms. Further sleuthing led the scientists to a single gene responsible for the glitch.
Before mini-brains, scientists had to shift through gobs of genomic data to fish out gene variants associated with autism.
From strings of lights adding holiday cheer to artificial sunlamps alleviating seasonal affective disorder, they brighten our days.
Thus, rtms treatment could be potentially improve aphasia, hemispatial neglect or pain perception resulting from stroke or brain injury.
while deformed and under stress on knee and wrist joints. It is lightweight, breathable and generates heat over the entire surface area of the material.
The Bruchas lab studies circuits that control a variety of disorders including stress, depression, addiction, and pain.
foam-like battery material that can withstand shock and stress.""It is possible to make incredible materials from trees
but buckled due to changes of the internal stress in the layer during the etching process.
Cancer Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015news and information Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
New technique creates multilayered, self-assembled grids with fully customizable shapes and compositions June 23rd,
2015nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd,
2015discoveries Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
2015announcements Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
2015nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,201 0
4-D printing to advance chemistry, materials sciences and defense capabilities June 18th, 2015discoveries Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together
#New composite protects from corrosion at high mechanical stress (Nanowerk News) Material researchers at the INM Leibniz Institute for New Materials will be presenting a composite material
New composite protects from corrosion at high mechanical stress. This patented composite exhibits its action by spray application,
As a result, it can withstand high mechanical stress. The coating passes the falling ball test with a steel hemispherical ball weighing 1. 5 kg from a height of one meter without chipping
but at substantial stress levels, the bonds can open up and provide fracture energy dissipation by stick/slip interactions and frictional sliding of the platelets against each other."
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Michael Cima (left) and Robert Langer Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the worlds largest producer of generic drugs,
such as mental disability, autism and cancer. A new technology--called"Sticky-flares"--developed by nanomedicine experts at Northwestern University offers the first real-time method to track
or the induction of mechanical stress-all of which can change the properties of a particular hydrogel designed to be responsive to those triggers."
Since the realignment of the atoms causes stress and eventually fractures in the material, the atomic lattice of a substance cannot be rearranged infinitely often.
and someone with schizophrenia would be a leap in our understanding of how our brains shape who we are (or vice versa).
and epinephrine (stress hormones) Insulin production Calcium metabolism Fights free radicals The majority of people suffer from Vitamin c deficiency
SCHIZOPHRENIA BIPOLAR OR MANIACO-DEPRESSION, HOW PLASMA PROTEINS PRODUCE THE CONDITION AT THE BRAIN CELLS'LEVEL OF CHEMICAL IMBALANCE,
but also allow the car to monitor driver stress levels. This would then allow the car to help reduce stress, for example by changing mood lighting, audio settings and climate control.
JLR also has a redictive Infotainment Screenprototype that uses cameras embedded in the car to track the driver hand movements
that involve paralysis such as stroke, brain injury, ALS and even multiple sclerosis. The Rehabilitation Sixteen days after his implant surgery, Sorto began his training sessions at Rancho Los Amigos National Rehabilitation Center,
and treatment of neurological diseases ranging from autism to Alzheimer disease to multiple sclerosis. nstead of asking,
hy do multiple sclerosis patients have the immune attacks? now we can approach this mechanistically. Because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,
Alzheimer, Autism, MS and Beyond The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both about the workings of the brain and the diseases that plague it.
And there an enormous array of other neurological diseases, from autism to multiple sclerosis, that must be reconsidered in light of the presence of something science insisted did not exist u
#Disruption of Delicate Chemical Balance Implicated as a Cause of Schizophrenia Scientists produce strongest evidence yet of schizophrenia causes.
what causes schizophrenia a condition that affects around 1%of the global population. Published today in the journal Neuron,
published last year in the journal Nature. ee finally starting to understand what goes wrong in schizophrenia,
and Genomics. ur study marks a significant step towards understanding the biology underpinning schizophrenia, which is an incredibly complex condition
his work builds on our understanding of the genetic causes of schizophrenia unravelling how a combination of genetic faults can disrupt the chemical balance of the brain. cientists in the UK,
as part of an international consortium, are uncovering the genetic causes of a range of mental health issues, such as schizophrenia. n the future,
this work could lead to new ways of predicting an individual risk of developing schizophrenia
Researchers studying psychiatric disorders have suspected previously that disruption of this balance contributes to schizophrenia. The first evidence that schizophrenia mutations interfere with excitatory signalling was uncovered in 2011 by the same team,
based at Cardiff University MRC Centre for Neuropsychiatric Genetics and Genomics. This paper not only confirms their previous findings,
To reach their conclusions scientists compared the genetic data of 11,355 patients with schizophrenia against a control group of 16,416 people without the condition.
Comparing the CNVS found in people with schizophrenia to those found in unaffected people the team was able to show that the mutations in individuals with the disorder tended to disrupt genes involved in specific aspects of brain function.
The disease-causing effects of CNVS are suspected also to be involved in other neurodevelopmental disorders such as intellectual disability, Autism Spectrum Disorder and ADHD.
Around 635,000 people in the UK will at some stage in their lives be affected by schizophrenia.
The estimated cost of schizophrenia and psychosis to society is around £11. 8 billion a year.
The symptoms of schizophrenia can be extremely disruptive, and have a large impact on a person ability to carry out everyday tasks,
Alzheimer is the most common type of dementia characterized by the loss of memory and other mental abilities linked to an accumulation of amyloid-beta and other toxic compounds in the brain.
and schizophrenia resist complete reprogramming. A team of researchers led by the University of Cambridge has described for the first time in humans how the epigenome the suite of molecules attached to our DNA that switch our genes on
and schizophrenia resist complete reprogramming. Although our genetic information the ode of lifeis written in our DNA,
However, data analysis of human diseases suggests that such genes are associated with conditions such as schizophrenia, metabolic disorders and obesity.
this knowledge can be helpful in the development of therapeutic interventions for neurological diseases underlined by altered dendritic spine density, such as autism spectrum disorder, Schizophrenia or Alzheimer's disease.
and reacts to changes in the environment can help us to find new ways to treat neurodegenerative diseases and mental illness. ource:
to see if they might have been infected with any of the same viruses."Multiple sclerosis is wheeled usually out as being linked to a virus,
Facial recognition software looks for telltale markers of stress or anxiety, while the gas sensors take samples of the user breath looking for compounds that give an indication of how much they drink or smoke.
But the process is accelerated in those likely to develop Alzheimer's or other forms of dementia.
or prevent Alzheimer's and other forms of dementia.""This study gives patients and families hope for the future,
hope that detecting leaky blood vessels early will provide the opportunity to stop dementia before it starts,
There are probably several different paths to dementia, Corriveau says, including one that involves leaky blood vessels.
imagined for people with late-stage dementia who are unable to speak but require constant physical touch.
A do-at home kit can remove the stress and the threat of discrimination a trip to the clinic can bring.
and reduce anxiety. They recently launched a Kickstarter campaign to turn their prototypes in to consumer-ready models,
could lead to the development of more minimally invasive probes to treat neurological disorders including stress, depression, addiction,
which is not only responsible for the high associated with the drug-plus hallucinations, delusions, memory loss, and feelings of anxiety or calm-it also been shown to slow tumour growth in mice.
And now, scientists have figured out that the mechanisms by which the drug delivers its desired medical effects
the researchers figured out that negative psychological side-effects of the drug, such as memory defects, mood swings, anxiety,
and paranoia, were triggered by a single pathway in the brain that was separate from the pathway that triggers the drug cancer-killing properties.
along with a physician's finger according to Dr. Samadani who also serves as co-director of the Steven & Alexandra Cohen Veterans Center for the Study of Posttraumatic Stress and Traumatic Brain injury at NYU Langone.
and neurodegenerative disorders, including depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS dementia complex, asphyxia in newborns and epilepsy.
and have been suggested as a possible cause of neurodevelopmental disorders such as autism, epilepsy or intellectual disability (see this review article for further background).
#Study pinpoints autism-linked protein for sculpting brain connections A new study by Duke researchers provides a close up of synapse refinement
Disruptions in the protein called hevin have previously been linked to autism depression and suicide but the molecule's role in the developing brain was mostly unknown until now.
The balance of those two types of types of connections in the cortex could go awry in neurological diseases such as autism
and neuroscientists to use to address questions ranging from fundamental mechanisms in cell biology to the underlying causes of mental illness to the discovery of novel therapeutics.
and to understanding the basis of neurodevelopmental and neurodegenerative disorders such as schizophrenia Alzheimer's disease and epilepsy.
of which has previously been implicated in risk for schizophrenia. The article published in Nature today is'Common genetic variants influence human subcortical brain structures
The discovery could lead to targeted therapies and interventions for Alzheimer's disease, autism and other neurological conditions.
The discovery will guide research into more personalized medical treatments for Alzheimer's, autism, depression and other disorders."
some of the genes are implicated in cancer and mental illness. In October 2014, the NIH invested nearly $32 million in its Big data Initiative,
and stress would be too great. In a project funded by The swiss National Science Foundation (SNSF),
and no prior work has examined the relationship of MITOCHONDRIAL DNA to psychosocial stress. We are interested in these relationships
because there is now clear evidence that stress exposure and psychiatric conditions are associated with inflammation and health conditions like diabetes and heart disease.
or absence of childhood adversity and the presence or absence of lifetime depressive anxiety or substance use disorders.
These effects were seen in individuals with major depression depressive disorders and anxiety disorders as well as those with parental loss and childhood maltreatment.
These findings indicate that childhood stress and some psychiatric disorders are linked to important cellular changes that may represent advanced cellular aging.
and prevention options for stress-related psychiatric and medical conditions and may shed light on the aging process itself. said Dr. Tyrka also the director of research for Butler Hospital l
''Why do multiple sclerosis patients have the immune attacks?''now we can approach this mechanistically. Because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,
And there's an enormous array of other neurological diseases, from autism to multiple sclerosis, that must be reconsidered in light of the presence of something science insisted did not exist t
Patients with G1d have seizures, movement disorders, speech disorders, and developmental delays as infants because insufficient glucose is transported to the brain.'
and dementia with Lewy bodies (DLB), this protein forms aggregates that cause neurodegeneration.""When alpha-synuclein aggregates accumulate within a brain cell,
you have a place that has higher stress, "Minsky said.""The reason the gecko's fibers stick so well is because the mushroom-shaped tip forces the high stressed region from edge to the center,
you concentrate the stress in the center when you're pulling straight up.""To detach the posts,
which shifts the stress back to the edge and allows the crack to easily start from there.
Mesencephalic dopaminergic (mda) neurons and their connections to other neurons in the brain are believed to be related to disorders including drug abuse, schizophrenia, Parkinson's disease,
and the stress it may place on gut integrity.""Nearly all of the participants in our study had blood markers identical to patients admitted to hospital with sepsis.
and heat stress s
#Comprehensive know-how and the full value chain, from technology development to complete systems Arraythe FBH develops the LED TECHNOLOGY in the UV-B and UV-C spectral range from the chip to the final
While conventional lithium-ion batteries are composed of brittle electrodes that can crack under stress, the new formulation produces battery cells that can be bent,
while deformed and under stress on knee and wrist joints. It is lightweight, breathable and generates heat over the entire surface area of the material.
The discovery could eventually benefit millions of patients with chronic pain from trauma, diabetes, shingles, multiple sclerosis or other conditions that cause nerve damage."
"We can now specifically search for agents to control ER stress and its downstream pathways,
and diabetic pain were linked to ER stress. Neuropathic pain is a common consequence of both Type 1
The team was able to show that blocking soluble epoxide hydrolase blocks ER stress and associated neuropathic pain.
The researchers tested the compounds in rats that were subjected to chronic mild stress that caused the animals to act in ways that resemble human depression.
"said Dr. Tom Mosley, director of the Memory Impairment and Neurodegenerative Dementia (MIND) Center at UMMC and senior scientist on the study."
It is of interest that the gene has also been suggested in other studies to be involved in autism and personality traits."
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