#Researchers discover new drugs to combat the root cause of multiple sclerosis At the pathological level,
and effect might lie at the heart of some psychiatric disorders that involve delusional thinking, such as schizophrenia."
However, if cells are exposed to oxidative stress, SIRT1 ubiquitination promotes cell death. These results are important
as it can cause unnecessary psychological stress. The ongoing research will also look at costs. Breast tomosynthesis is a somewhat more expensive technique."
but brain disorders like schizophrenia, and degenerative brain disease. Researchers have completed now 3-D printing a six-layered structure similar to brain tissue, in
but brain disorders like schizophrenia, and degenerative brain disease. ACES Director and research author Professor Gordon Wallace said that the breakthrough is significant progress in the quest to create a bench-top brain that will enable important insights into brain function,
not only for a range of neuropsychiatric disorders such as ADHD, eating disorders and anxiety disorders, but also for more common problems involving maladaptive daily decisions about drug or alcohol use, gambling or credit card binges.
#Missing piece surfaces in the puzzle of autism A study carried out by the Laboratoire Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS/Aix-Marseille Université),
Understanding the mechanisms that underlie autism spectrum disorders (ASD), which affect 7. 6 million people according to the World health organization,
In these different organisms, under-expression of the enzyme induced hypersensitivity to oxidative stress (i e. to the toxicity of free radicals), a smaller number of synapses and abnormal neurotransmission due to a reduction in the number of vesicles carrying neurotransmitters.
The involvement of this enzyme in susceptibility to oxidative stress, which has frequently been observed in autistic children, its association with gastrointestinal diseases
"This expansion and contraction of aluminum particles generates great mechanical stress, which can cause electrical contacts to disconnect.
"Dissolving protein aggregates is a critical step in recycling defective proteins and providing protection against stress-induced cell damage.
But eventually those suppressed memories can cause debilitating psychological problems, such as anxiety, depression, posttraumatic stress disorder or dissociative disorders.
One kind, synaptic GABA receptors, works in tandem with glutamate receptors to balance the excitation of the brain in response to external events such as stress.
Extra-synaptic GABA receptors change the brain's state to make us aroused, sleepy, alert, sedated, inebriated or even psychotic.
The findings imply that in response to traumatic stress, some individuals, instead of activating the glutamate system to store memories,
The drug rerouted the processing of stress-related memories within the brain circuits so that they couldn't be accessed consciously d
Many mental disorders, including depression, schizophrenia and anxiety, affect neurotransmitter systems,"said Axel Brunger, the study's principal investigator.
a hypothesis they supported by testing immunotherapy in a multiple sclerosis model. By shutting down CD4 T cells, immune stimulation prevented an autoimmune response.
or other speech disorders communicate. In an intensive care setting, the technology has the potential to be used to make an early diagnosis of locked-in syndrome (LIS),
Scientists can use the NAPA to determine changes in cellular metabolite level distributions and metabolic noise upon environmental stress
the research group has determined the metabolic response of individual yeast cells to oxidative stress. Additionally, the NAPA platform has shown the capabilities to analyze a wide variety of biomolecules
such as cellular stress and the aging process also are thought to make misfoldings more likely. The new work has its origins in experiments conducted in Prusiner's lab in 2013,
the UCSB researchers collaborated with UC San francisco to study 150 individuals affected with Alzheimer's or dementia.
but a host of other illnesses, including autism and schizophrenia. Researchers can learn a lot by analyzing CNVS in bulk samples--from a tumor biopsy
This new breakthrough suggests that HSD10 reduces oxidative stress, promotes cell repair and prevents cellular death.
and protects the energy-making machinery from oxidative stress. HSD10 is a versatile protein with many known functions
but its role in oxidative stress has remained a mystery. The authors showed that HSD10 preferentially degrades highly toxic cardiolipin peroxides
free radical produced during oxidative stress that would normally initiate apoptosis, or cell death. HSD10 activity is inhibited strongly
"But with rampant oxidative stress leading to uncontrolled cellular death, you end up with diseases such as Alzheimer's and Parkinson's.
"When cardiolipin becomes damaged by oxidative stress, the newly formed cardiolipin peroxides induce apoptosis instead of energy production.
They observed whether such mice were resistant to muscle wasting induced by a high level of cortisol--a stress hormone released in your body any time you have a stressful situation such as an illness or a surgery.
a leading journal in the field of developmental biology, open up new avenues for design of drugs for ataxia, a motor coordination disorder.
called BNIP-H, was linked first to Cayman ataxia, a rare genetic disorder affecting a region of the brain involved in motor control and
The study also provides the first experimental data solidifying the link between dysfunctional cholinergic (acetylcholine) secretion and Cayman ataxia.
The researchers showed that a BNIP-H mutant associated with Cayman ataxia caused defects in the transport of the ACL enzyme.
Furthermore, they could also reproduce motor dysfunctions of Cayman ataxia in zebrafish by knocking down BNIP-H, ACL or Chat enzymes.
suggesting that the loss of acetylcholine secretion resulting from BNIP-H mutation could explain some of the symptoms of Cayman ataxia.
"We established the first ACL-based ataxia model in the zebrafish that recapitulates the ataxic phenotype seen in human patients.
cellular and organism levels on how defects in ACL trafficking impairs cholinergic signalling that leads to the development of ataxia."
and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
a journal in the field of developmental biology, open up new avenues for design of drugs for ataxia, a motor coordination disorder.
called BNIP-H, was linked first to Cayman ataxia, a rare genetic disorder affecting a region of the brain involved in motor control and
The study also provides the first experimental data solidifying the link between dysfunctional cholinergic (acetylcholine) secretion and Cayman ataxia.
The researchers showed that a BNIP-H mutant associated with Cayman ataxia caused defects in the transport of the ACL enzyme.
Furthermore, they could also reproduce motor dysfunctions of Cayman ataxia in zebrafish by knocking down BNIP-H, ACL or Chat enzymes.
suggesting that the loss of acetylcholine secretion resulting from BNIP-H mutation could explain some of the symptoms of Cayman ataxia.
"We established the first ACL-based ataxia model in the zebrafish that recapitulates the ataxic phenotype seen in human patients.
cellular and organism levels on how defects in ACL trafficking impairs cholinergic signalling that leads to the development of ataxia."
and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
"Alzheimer's disease, epilepsy, multiple sclerosis and hydrocephalus involve changes in the stiffness of the brain tissues. This new technique allows their detection,
or whether they are under stress. The team has found again by working with people with epilepsy, that stimulating a region called the medial temporal lobe,
#Scientists discover new treatment for dementia Pushing new frontiers in dementia research, Nanyang Technological University,
Singapore (NTU Singapore) scientists have found a new way to treat dementia by sending electrical impulses to specific areas of the brain to enhance the growth of new brain cells.
which mitigates the harmful effects of dementia-related conditions and improves short and long-term memory. Their research has shown that new brain cells,
The increase in brain cells reduces anxiety and depression, and promotes improved learning, and boosts overall memory formation and retention.
The research findings open new opportunities for developing novel treatment solutions for patients suffering from memory loss due to dementia-related conditions such as Alzheimer and even Parkinson disease.
and reduces anxiety. emory loss in older people is not only a serious and widespread problem, but signifies a key symptom of dementia.
At least one in 10 people aged 60 and above in Singapore suffer from dementia and this breakthrough could pave the way towards improved treatments for patients.
Growing new brain cells For decades, scientists have been finding ways to generate brain cells to boost memory and learning,
and age-related diseases such as dementia. As part of a natural cycle, brain cells constantly die and get replaced by new ones.
in part because the underlying causes for different subtypes of autism are diverse and not well-understood. here is no better example than early language development,
professor of neurosciences and co-director of the Autism Center of Excellence at UC San diego. ome individuals are minimally verbal throughout life.
more individualized treatments, said co-author Karen Pierce, Phd, associate professor of neurosciences and co-director of the Autism Center of Excellence.
and underlie later good versus poor language outcome in autism. These findings said researchers, will open new avenues of progress towards identifying the causes and best treatment for these two very different types of autism. or the first time,
our study shows a strong relationship between irregularities in speech-activation in the language-critical superior temporal cortex and actual,
but not all, on the autism spectrum. t
#Graphics in reverse Most recent advances in artificial intelligence such as mobile apps that convert speech to text are the result of machine learning, in
as well as information about stress and perceived discrimination through interviews. Goosby found a strong correlation between perceived discrimination and levels of C reactive-protein protein,
researchers studying a range of conditions from West Nile to multiple sclerosis to diabetes to cancer can generate an unprecedented level of detailed data about cells from relatively small samples.
Similarly, in his lab, Hafler applies Cytof to the study of cellular complexities at the root of diseases such as a multiple sclerosis and cancer.
The accumulation of deposits of a protein fragment termed amyloid ß is thought to be the cause of the development of dementia in AD brains.
put stress on power generators and lead to instabilities in the power system. Grid coordinators have the daily challenge of forecasting the need for
creating an asymmetrical stress that makes the membranes fold. Zhang Jiang and Jin Wang, X-ray staff at the APS,
Garner group has shown that these regions can be informative about diseases ranging from cancer to autism spectrum disorder.
and completed cutting-edge work in understanding the genetics of autism. Building on its strengths in biology
or psychological stress induced epigenomic changes were mediated by ATF7-related transcription factors. After exposure to that stress, changes remained for a long duration of time.
This made researchers think that pathogen infections could induce epigenomic changes in macrophages via ATF7.
this new research provides better understanding about how our immune system remembers appropriate reactions to stress.
or stress levels in soldiers and pilots. In this study, engineers focused on uric acid, which is a marker related to diabetes and to gout.
#Researchers find biomarker for autism that may aid diagnostics By identifying a key signaling defect within a specific membrane structure in all cells, University of California,
they have found both a possible reliable biomarker for diagnosing certain forms of autism and a potential therapeutic target.
Dr. J. Jay Gargus, Ian Parker and colleagues at the UCI Center for Autism Research & Translation examined skin biopsies of patients with three very different genetic types
and possibly digestive and immune problems associated with autism. e believe this finding will be another arrow in the quiver for early and accurate diagnoses of autism spectrum disorders,
said Gargus, director of the Center for Autism Research & Translation and professor of pediatrics and physiology & biophysics. qually exciting,
Autism spectrum disorder is a range of complex neurodevelopmental disorders affecting 2 percent of U s. children.
To see if IP3R function is altered across the autism spectrum, clinical researchers at The Center for Autism & Neurodevelopmental Disorders
which is affiliated with the Center for Autism Research & Translation are currently expanding the study
In the area of drug discovery, scientists at the Center for Autism Research & Translation continue to probe the IP3R channel,
The brains of people who have autism show signs of hyperexcitability, which is seen also in epilepsy,
Cells from individuals who have depressed autism exhibit levels of calcium signaling and this might explain why these patients experience this hyperexcitability.
lack of link to autism New research finds no evidence that thimerosal-containing vaccines cause negative behaviors or result in neuropathology in infant primates,
the administration of vaccines to rhesus macaques did not result in neuropathological abnormalities or aberrant behaviors such as those often observed in autism.
Cellular analysis of the cerebellum, amygdala and hippocampus three brain regions known to be altered in autism was vaccinated similar in
multiple sclerosis and hydrocephalus involve changes in the stiffness of the brain tissues. This new technique allows their detection,
Now University of Pennsylvania researchers have shown at the molecular level how experiencing stress changes a male mouse sperm in such a way that it affects his offspring response to stress.
me that seemingly mild stress to a male mouse would trigger this massive change in microrna response
had offspring with a dampened response to stress. When they compared sperm from the stressed fathers to their unstressed counterparts,
the researchers examined their response to stress, just as they had done in their 2013 study. he results mapped right onto
When subjected to a mild stress, in this case, being restrained briefly, the offspring that arose from the zygotes that received the multi-mir injections had lower cortisone levels compared to offspring in the control groups.
a brain region involved in directing stress regulation, suggesting widespread changes in early neurodevelopment. Finally the researchers aimed to determine how the mirs were carrying out this effect after fertilization.
when a male experiences stress it may trigger the release of mirs contained in exosomes from the epithelial cells that line the epididymis,
such as providing stressed males with enrichment or a reward, might prevent them from passing on an abnormal stress response to the next generation.
and relapsing multiple sclerosis Three phase three clinical studies using the drug ocrelizumab to treat patients with multiple sclerosis (MS) have yielded positive results for treating two forms of the disease and the first ever positive results
#Cell stress response and fat and obesity gene linked In one fell swoop, Cornell researchers have discovered mechanisms that control the function of a fat
and obesity gene while at the same time answering a longstanding question about how cells respond to stress.
without them cells would quickly die under stress, said Shu-Bing Qian, associate professor of nutritional sciences,
Many years ago, researchers observed that obese people have poor cellular stress responses. This may be because their heat shock proteins are reduced,
Identifying with precision the source of that anxiety, and the appropriate focus of action, is rather more challenging.
It is the marketplace of human knowledge, queries, anxieties, ideas, journeys, hopes, sorrows and dreams.
#Brain-training game helps'minimise impact of schizophrenia on life'A rain traininggame improves the cognitive function of people with schizophrenia
was tested for four weeks by 22 participants with a schizophrenia diagnosis. Schizophrenia is a long-term mental health condition
which can contribute to behavioural changes, confused thinking, apathy and, in some cases, delusions or hallucinations.
People with schizophrenia may experience cognitive impairments, including poor episodic memory, which affects remembering things such as times and dates,
Wizard aims to improve the cognitive functionality and episodic memory of people with schizophrenia, with in-game tasks including users moving through rooms and identifying items in boxes and character locations.
e need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
n conjunction with medication and current psychological therapies, Wizard could help people with schizophrenia minimise the impact of their illness on everyday life. eople with schizophrenia often find studying
The employment rate for people with schizophrenia was recorded at 8%,according to a 2013 paper. The Wizard game will be included as a mode within the popular brain-training app, Peak,
and can affect brain chemicals, inducing antepartum depression and/or anxiety. According to the American Congress of Obstetricians and Gynecologists, roughly 14-23 percent of women will struggle with symptoms of depression at some point during their pregnancy.
#Tool enhances social inclusion for people with autism The University of Alicante has developed together with centres in the UK Spain
and Bulgaria a tool designed to assist people with autism spectrum disorders by adapting written documents into a format that is easier for them to read
Although in principle the tool has been designed for people with autism spectrum disorders who generally have difficulties in areas such as communication social interaction
when it's under stress said Chia-Hong Tsai doctoral candidate with MSU's Department of energy Plant Research Laboratory
#Personalized treatment for stress-related diabetes Researchers at Lund University in Sweden are testing a treatment for type 2 diabetes
and described the molecular mechanism through which it starts the transcription of stress-activated genes.
Their results could help to develop therapeutics to treat stress-related disease and have been published in the journal Genome Research.
Triggers for stress so called stress factors include not only emotional strain but also physical factors such as heat cold too much sun infections injuries and toxic substances--for example in cigarette smoke.
Stressed genes share a hallmark on histone H3we all know some of the body's reactions to stress from first hand experience:
It came as a big surprise that we found the same mark at fifty percent of the stress-activated genes.
The stress signal causes the addition of a phosphate mark to the H3 proteins at the promoter the regulatory region of a gene.
which blocked transcription up to this point and stress-regulated genes are activated explains Anna Sawicka the findings.
The study has identified not only histone phosphorylation as a hallmark of stress-activated genes but also the mechanism by
Stress can make you sick. A detailed understanding of the stress reaction on a molecular level could help to develop therapeutics to treat stress-related disease.
While Anna Sawicka now works as a Postdoc at the Max Planck Institute in Goettingen Christian Seiser and his team work to understand the function of the histone mark for long term activation of genes during the stress response.
Their first cues hint to a function of the phosphate mark in combination with another histone mark as part of the so-called histone code.
and the immune and stress response systems was discovered to be overactive in many types of cancer and responsible for switching off the normal cellular mechanisms that naturally lead to cell death.
and autism-spectrum disorder can have profound lifelong effects on learning and memory but relatively little is known about the molecular pathways affected by these diseases.
and his team used human fetal brain cells to study the molecular effects of reducing the activity of genes that are mutated in two distinct autism-spectrum disorders.
That's because stress makes Atg9 undergo a modification that enables 14-3-3 zeta to bind with it
and diabetes, partly because they promote oxidative stress and inflammation. Moreover, intervention studies with a diet low in AGES have shown significantly improved insulin sensitivity, reduced oxidant stress, and alleviated inflammation."
"When analysed separately, the authors found that there was a statistically significant association of GDM with fried food consumption away from home,
#Anorexia/bulimia: Bacterial protein implicated Eating disorders (ED) such as anorexia nervosa bulimia and binge eating disorder affect approximately 5-10%of the general population
Anorexia nervosa bulimia and binge eating disorder are all eating disorders (ED) . If the less well defined and atypical forms are included ED affect 15-20%of the population particularly adolescents and young adults.
The sensation of satiety is reached (anorexia) or not reached (bulimia or overeating). Moreover the bacterial protein itself seems to have anorexigenic properties.
Furthermore their immunological response determined the development of eating disorders in the direction of anorexia or bulimia.
which can result in diseases such as multiple sclerosis type 1 diabetes lupus or rheumatoid arthritis. There are currently no existing cures for these diseases.
The scientists performed preclinical trials using experimental autoimmune encephalomyelitis a preclinical model for human multiple sclerosis.
#How rabies hijacks neurons to attack brain Rabies causes acute inflammation of the brain, producing psychosis and violent aggression.
releasing a bit of stress, and making it easier for a second atom to climb out of a trough
While conventional lithium-ion batteries are composed of brittle electrodes that can crack under stress the new formulation produces battery cells that can be bent,
and trees when under stress and detectors to identify concentrations in air samples could be used to monitor our changing ecology.
The robot body transitions from soft to hard, reducing the stress where the rigid electronic components join the body
and Dr. Howard Shane who leads the Autism Language Program and the Center for Communication Enhancement at Boston Children Hospital.
After graduating from university with a degree in computer science Izak created an ipad app that was inspired by his younger brother Oriel who has autism.
and by lowering the energy costs of walking reduce joint stress and fatigue. But bringing bionic devices into the clinic is not easy.
#More than A hundred Genetic Variants Tied to Schizophrenia To a large extent, schizophrenia and other psychiatric disorders are caused illnesses by genes.
Now teams of scientists from research centers around the world, looking at the genetics of nearly 80,000 people, have worked together to identify 108 genetic loci associated with the disorder.
including schizophrenia. The lack of such understanding to date has meant there hasn been a true new breakthrough drug to treat these disorders in 50 years.
and even stress. And companies like Apple are hoping to become repositories for all this information,
That increasingly important as researchers begin to see connections between Phelan-Mcdermid, autism, and other conditions.
but some researchers argue that the rate of false positives causes patients undue anxiety and creates a burden on the health system.
and the stress this can put on the power grid. But Solar City believes that if building huge factories to produce advanced solar panels can bring down costs,
First Emotion-Reading Apps for Kids with Autism The first mobile apps that use emotion-reading software to help kids with autism are nearing release,
Though the early academic research focused on applications such as helping people with autism, so far the technology has been used commercially to help marketers understand
We started out with research on autism, and we went out and did this commercial stuff.
and apply it back to autism again. The advertising work helped make the software more accurate by rainingit
and borderline personality disorder. The project builds on expanding knowledge about how the brain works; the development of microlectronic systems that can fit in the body;
The U s. faces an epidemic of mental illness among veterans, including suicide rates three or four times that of the general public.
says one aim could be to extinguish fear in veterans with posttraumatic stress disorder, or PTSD. Fear is generated in the amygdala part of the brain involved in emotional memories.
like relaxation or anxiety, using implants he called timoceivers. But Delgado, also funded by the military,
Dougherty says a brain implant would only be considered for patients truly debilitated by mental illness, and who can be helped with drugs
She not being paranoid. Documents leaked last June by former U s. intelligence contractor Edward Snowden revealed a global surveillance operation coördinated by the U s. National security agency and its counterpart in Britain
foam-like battery material that can withstand shock and stress.""It is possible to make incredible materials from trees
foam-like battery material that can withstand shock and stress.""It is possible to make incredible materials from trees
The product uses"low levels of pulsed electrical energy to signal specific neural pathways, allowing users to dial up or dial down their stress responses and energy levels."
Among others, these include people with nonverbal autism, people with nonverbal learning disorders, people with ALS, people with Rett Syndrome,
one atom may move down a peak providing a little stress for another atom to move up a trough,
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world largest producer of generic drugs,
The method released the stress in the laminate layer and avoided stress to build up between the two stacked layers.
Yet, more traditional approaches to thermocompression bonding come with long cycle times(>1 minute per die),
and someone with schizophrenia would be a leap in our understanding of how our brains shape who we are (or vice versa).
and stress would be too great. In a project funded by The swiss National Science Foundation (SNSF) Empa
The Saturas sensor provides accurate information for optimized irrigation to reduce water consumption with no stress to the plants and increases fruit production and quality.
Yoon said one population that could stand to benefit from the smart mouth guard is combat veterans with posttraumatic stress,
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