Researchers believe the results could lead to new ways of using the hormone to treat psychological problems such as stress and speech disorders.
#Brain training app that could help schizophrenia sufferers live a normal life A new brain training app developed to help improve the memory of people with schizophrenia could save taxpayers thousands of pounds,
which found that schizophrenia patients who played the game regularly for a month were four times better at remembering these kinds of things than non-players.
Schizophrenia is estimated to cost £13. 1billion per year in total in the UK. The long-term mental health condition can cause a range of symptoms including hallucinations and delusions.
But current medications to treat these symptoms cause debilitating side effects including poor memory, which can stop sufferers being able to work or study.
and is aimed at people who suffer with poor episodic memory-one of the main side effects of schizophrenia drugs.
who had been given a diagnosis of schizophrenia, to either the cognitive training group or a control group at random.
which scientists say is important as lack of motivation is another common aspect of schizophrenia.
'We need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
this could help people with schizophrenia minimise the impact of their illness on everyday life.'
but it also meant the they were less likely to feel anxiety or recall fear, researchers found.
They hope the discovery may help the search for treatments for disorders such as Alzheimer's, schizophrenia and post traumatic stress disorder (PTSD.
The experiments also showed that PDE4B-inhibited mice suffered less anxiety, choosing to spend more time in open, brightly lit spaces than normal mice,
whether the findings could have implications for Alzheimer's disease or other dementias.''We'd need to see how this gene could influence memory
'There is currently a lack of effective treatments for dementia and understanding the effect of genes can be a key early step on the road to developing new drugs.'
'With so many people affected by dementia, it is important that there is research into a wide array of treatment approaches to have the best chance of helping people sooner
trapped, frozen or absorbed in some material-from the surface that is triggered by tidal stress on the moon.
and autism, in a dish. With the addition of a blood circulation, which is currently lacking,
and posttraumatic stress disorder. r
#Royal Navy could soon be using remote-controlled warships with'see-through'hulls Sleek and stealthy, it resembles something from Star wars. In fact,
or is caused under stress by road rage or similar. It then responds by offering a suitable massage and blowing air through its ventilation system.
and we derive stress and energy level from that,'Olaf Biedermann, director of innovation at Faurecia said.'
Parents often see their children struggle with swollen lymph nodes, painful enlarged spleens, fatigue and anxiety.
#Three-minute test detects common form of dementia that's hard to diagnose Although Lewy Body disease (LBD) is the second-most-common degenerative disease after Alzheimer's disease,
The late Robin williams had this form of dementia as did legendary NHL coach Alger Joseph"Radar"Arbour,
which also can cause visual hallucinations and make depression worse. Until now, there has been no way to assess or operationalize many of the cognitive and behavioral symptoms of LBD in clinical practice.
and effectively diagnose LBD and Parkinson's disease dementia (PDD) in about three minutes. The LBCRS is a brief rating scale that can be completed by a clinician to assess clinical signs
but are much less commonly found in other forms of dementia. The LBCRS study,"Improving the Clinical Detection of Lewy Body Dementia with the Lewy Body Composite Risk Score,
"recently published in Alzheimer's & Dementia, the journal of the Alzheimer's Association, involved 256 patients who were compared with the clinical dementia rating
and gold standard measures of cognition, motor symptoms, function and behavior. The test was administered in a"real-world"clinic setting with patients who were referred from the community rather than in a research sample.
The clinic sample had a mixture of gender education, comorbidities, behavioral, affective, motor symptoms, and diagnoses.
"Most patients never receive an evaluation by a neurologist skilled in the diagnosis of Lewy body dementia,
"Early detection of Lewy body dementias will be important to enable future interventions at the earliest stages
Galvin has led efforts to develop a number of dementia screening tools, including the Quick Dementia Rating system (QDRS), AD8,
a brief informant interview to translate research findings to community settings. He has done cross-cultural validation of dementia screening methods in comparison with Gold standard clinical evaluations and biomarker assays.
His team also has developed sophisticated statistical models to explore transition points in clinical cognitive, functional, behavioral and biological markers of disease in healthy aging, mild cognitive impairment, Alzheimer disease,
Heat shock proteins are associated also with other nervous system disorders like Parkinson's disease and multiple sclerosis. Although it is still unclear what role these catastrophe aid workers play in the various ailments,
or mechanical stress, can also have undesirable consequences in terms of the material's strength, structure and performance.
Researchers propose to do this by making the plants better at handling stress. Now I know what you might be thinking tress limate changeit sounds like it time to call the plant acupuncturist.
when the plant detects stress. Beneath this superficially crude mechanism lie untold layers of regulatory nuance.
we must remember that obsessive documenting changes the artistic structure of a concert atmosphere. he need to ocumentone life in every detail is a mania that can subtract from one enjoyment of the moment,
The National Science Foundation, the Della Martin Fund for Discoveries in Mental illness, and the Japan Science and Technology Agency, Core Research for Evolutional Science and Technology funded the work
and anxiety to obsessive-compulsive disorder and many others, says Feng. hey will not only allow researchers to study why certain individuals develop a disease
"It's a lot like autism, in that many different CNVS affecting different genes are involved which could possibly explain why the clinical presentations of both these conditions are noted so diverse
or new, CNVS identified in these patients with cerebral palsy is even more significant than some of the major CNV autism research from the last 10 years.
"It's a lot like autism, in that many different CNVS affecting different genes are involved which could possibly explain why the clinical presentations of both these conditions are noted so diverse
or new, CNVS identified in these patients with cerebral palsy is even more significant than some of the major CNV autism research from the last 10 years.
"This research has profound implications for glial disease like Krabbe's, Charcot-Marie-Tooth, peripheral neuropathies or Multiple sclerosis,
we'd expect these machines'performance to hit some roadblocks under stress. Still, with prices starting at just US$169 for the 11-inch model and $199 for the 14-inch, the race to the bottom is alive and well.
The repeated deformation exerts a strong mechanical stress that, over time, damages the electrode contacts
and more When it comes to human phobias, snakes are frequently found toward the top of the list.
or other speech disorders communicate, "says Dr. Atul Gaur, a consultant anesthetist who is collaborating with the Loughborough team."
and can place a great deal of stress on someone who may already be quite ill. The new Tadpole Endoscope (TE
#Our osetta Stonegene Could Unlock The Secrets Of Schizophrenia Schizophrenia affects around 1%of the global population
and can cause paranoia, hallucinations and a breakdown in patients'thought processes, with a huge impact on their ability to carry out everyday tasks.
Around 50%of people who suffer with the condition attempt suicide. There are currently relatively few treatments for the condition
when treatments may be most effective in preventing schizophrenia manifesting in the first place. Mental health conditions are among the most challenging medical problems we face as scientists,
But despite knowing about hundreds of mutations associated with schizophrenia, we are relatively in the dark about
One gene we do have some certainty about is known as isrupted in schizophrenia gene 1 (DISC1.
when mutated, can give rise to a number of mental health conditions including schizophrenia, bipolar disorder, major clinical depression and autism.
While schizophrenia may be inherited, the probability of inheritance from a mutation carried by one parent alone is relatively low.
Targeting Schizophrenia Vulnerable Period Different parts of the brain may mature at different times but most cortical areas go through a similar sequence of development.
So how can studying DISC1 help us decode what is going wrong with other genes in schizophrenia?
or at least many of the genes identified as risk factors in schizophrenia. DISC1 mutations have also been linked to autism
and Asperger syndrome, suggesting that the developmental effects of DISC1 could also be important for understanding these mental health conditions.
what the other genes involved in schizophrenia are doing (or doing wrong) during development to give rise to the debilitating condition of schizophrenia o
#Scientists Control Brain cells Using Sound waves The ability to control brain cells with sound waves sounds like science fiction, right?
The number of years lived with disability have increased in almost every country, attributable to the growth of chronic diseases such as cardiovascular and respiratory diseases, cancer, back pain, mental health disorders, dementia, road injuries, HIV
As society ages, Alzheimer's disease the most common cause for dementia looms ever larger as a prime source of suffering.
including progressive supranuclear palsy and frontotemporal dementia (FTD). The same mouse model is used to study Alzheimer's and FTD,
#'Brain training'game helps people with schizophrenia live a normal life Patients who played the game regularly for a month were four times better than non-players at remembering the kind of things that are critical for normal, day-to-day life,
People recovering from schizophrenia suffer serious lapses in episodic memory which prevent them from returning to work
Schizophrenia affects about one in every hundred people and results in hallucinations and delusions (Rex) his kind of memory is essential for everyday learning
and everything we do really both at home and at work. We have formulated an ipad game that could drive the neural circuitry behind episodic memory by stimulating the ability to remember where things were on the screen,
Schizophrenia affects about one in every hundred people and results in hallucinations and delusions it is estimated to cost the NHS about £2bn a year in treatment alone,
with wider costs for society such as lost work. Although the main symptoms can be treated with antipsychotic drugs,
which has led scientists to find ways of training the brain through computer-based games. e need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
The study, published in the Philosophical Transactions of the Royal Society B, involved 22 schizophrenia patients who played the game for eight hours over a period of four weeks
Importantly, the patients with schizophrenia enjoyed playing the game and were motivated to continue. The group that played the game was approximately four times better in terms of their memory than the group that did not,
this could help people with schizophrenia minimise the impact of their illness on everyday life. i
Dr John Coates, a fellow in neuroscience and finance at the University of Cambridge who specialises in the biology of risk taking and stress, said he is now getting bout one call a weekfrom financial institutions,
A firm called Equivital makes a chest-mounted wearable sensor that measures heart rate, stress, breathing, skin temperature and body position.
what it takes to cope with stress in much the same way that a sports star medical information might be handed over
which is implicated in animal models of depression and anxiety.""This will open the door to a range of new experiments to better understand
it will allow experiments with multiple animals in the same space to better understand social interaction in the treatment of chronic pain and mental disorders, for example."
The finding demonstrates that the stress of crystal deformation can impart a newfound degree of control over magnetic and electrical behavior in spintronic devices and sensors.
however, apply stress in all directions equally. he biggest challenge we faced was accurately controlling uniaxial stress at temperatures as low as 3 kelvin,
The team constructed a unique cell that clamps a multiferroic barium cobalt germanium oxide (Ba2coge2o7) crystal between a pair of zirconium oxide pistons (Fig. 1). They then investigated how the sample electric polarization changed under uniaxial stress.
In contrast, by deforming the Ba2coge2o7 crystal with varying levels of uniaxial stress, the researchers could tune the polarization output in unprecedented ways, from fully on to fully off,
because they show we can control the spin-driven ferroelectricity in this compound by applying uniaxial stress at the low megapascal level,
particularly for crystals with high levels of symmetry. any multiferroic materials have the potential to show stress-induced effects,
This expansion and contraction of aluminum particles generates great mechanical stress, which can cause electrical contacts to disconnect.
Limiting it to a single point allows us to control the parameters, like contact stress and geometry,
This"stress activated"process meant that, the harder the tip squeezed and sheared the ZDDP-containing oil between the tip and sample,
you get a high stress due to the concentration of force. When you push on a less stiff surface,
so the stress is lower. The thicker the film, the more it acts as a cushion to reduce the stress that is needed to cause the chemical reactions needed to keep growing.
It's self-limiting, or in other words, it has a way of cutting off its own growth".
Without being able to control the stress and geometry of a single point of contact
Being able to pinpoint the level of stress at which they begin to break down and form tribofilms allows researchers to compare various properties in a more rigorous fashion."
In elastocaloric materials a change in mechanical stress can create a change in temperature. In the Journal of Applied Physics("Elastocaloric effect of Ni-Ti wire for application in a cooling device"),a team of researchers from Technical University of Denmark report that the elastocaloric effect opens the door to alternative forms
or by applying an external stress. This is responsible for the temperature-induced"shape memory effect "and stress-induced"superelasticity."
"After the stress is removed, the crystal structure reverts back to its austenitic phase, which causes the material to cool down
effectively acting as a 2-D liquid("Interactions and Stress Relaxation in Monolayers of Soft Nanoparticles at Fluid-Fluid Interfaces".
function, or react to damage or stress, all of these things you could observe at an organ level,
creating an asymmetrical stress that makes the membranes fold. Argonne researchers are able to fold gold nanoparticle membranes in a specific direction using an electron beam
and maintain excellent focusing properties under high stress, lead author of the research, Phd candidate Xiaorui Zheng said. hey have the potential to revolutionise the next-generation integrated optical systems by making miniaturised and fully flexible photonics devices.
and deform plastically under application of stress.""That means that a metal thin film lateral spring structure cannot be used as a stretchable antenna,
but brain disorders like schizophrenia, and degenerative brain disease. ACES Director and research author Professor Gordon Wallace said that the breakthrough is significant progress in the quest to create a bench-top brain that will enable important insights into brain function,
Many types of dementia are linked to sleep disturbances, including difficulties in falling asleep. It is increasing acknowledged that these sleep disturbances may accelerate memory loss in Alzheimer disease.
eating disorders and anxiety disorders, but also for more common problems involving maladaptive daily decisions about drug or alcohol use, gambling or credit card binges.
or other speech disorders communicate. In an intensive care setting, the technology has the potential to be used to make an early diagnosis of locked-in syndrome (LIS),
#Oxytocin Delivering Nasal Device to Treat Mental illness Researchers at the University of Oslo have tested a new device for delivering hormone treatments for mental illness through the nose.
About one out of every hundred Norwegians develop schizophrenia or autism in the course of their lifetime.
Many psychiatric disorders such as autism, schizophrenia and bipolar disorder are characterised by poor social functioning. Oxytocin is a hormone that influences social behaviour
and has shown promise for the treatment of mental illness. Researchers at Uio have discovered now that low doses of oxytocin may help patients with mental illness to better perceive social signals.
Medicine through the nose Because of oxytocin role in social behaviour, researchers have explored the possibility of administering the hormone for the treatment of mental illness.
May yield new treatments The next step in the research is to carry out the same tests on people with mental illness. e are now running tests in volunteers diagnosed with autism spectrum disorders,
says Dr Quintana. e hope that this research project is the first step in the development of a series of new medicines that may be of great help to more people with mental illness,
It is the most common age-related dementia, and the number of people with the disease in the U s. is expected to increase to 15 million in 2050,
and other dementias is expected to be $226 billion in 2015 alone, and could reach $1. 1 trillion in 2050 h
#Possible Biomarker for Autism Discovered Study also points to potential new drug discovery advances. By identifying a key signaling defect within a specific membrane structure in all cells, University of California,
they have found both a possible reliable biomarker for diagnosing certain forms of autism and a potential therapeutic target.
Dr. J. Jay Gargus, Ian Parker and colleagues at the UCI Center for Autism Research & Translation examined skin biopsies of patients with three very different genetic types
and possibly digestive and immune problems associated with autism. e believe this finding will be another arrow in the quiver for early and accurate diagnoses of autism spectrum disorders,
said Gargus, director of the Center for Autism Research & Translation and professor of pediatrics and physiology & biophysics. qually exciting,
Autism spectrum disorder is a range of complex neurodevelopmental disorders affecting 2 percent of U s. children.
To see if IP3R function is altered across the autism spectrum, clinical researchers at The Center for Autism & Neurodevelopmental Disorders
which is affiliated with the Center for Autism Research & Translation are currently expanding the study
In the area of drug discovery, scientists at the Center for Autism Research & Translation continue to probe the IP3R channel,
The brains of people who have autism show signs of hyperexcitability, which is seen also in epilepsy,
Cells from individuals who have depressed autism exhibit levels of calcium signaling and this might explain why these patients experience this hyperexcitability.
multiple sclerosis and hydrocephalus involve changes in the stiffness of the brain tissues. This new technique allows their detection,
#Single Drop of Blood in Brain Can Trigger Immune response Akin to Multiple sclerosis Disruption of the blood-brain barrier triggers a cascade of events that results in autoimmunity and brain damage characteristic of multiple sclerosis.
A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS). This is the first demonstration that introduction of blood in the healthy brain
and other dementias e
#Blood test to Detect Alzheimer Disease Close to Development Early detection presents new opportunities to slow or perhaps even halt disease progression.
including Parkinsons, multiple sclerosis and breast cancer. Image is for illustration purposes only. Credit: Tannim101. here are significant benefits to early disease detection
including Parkinsons, multiple sclerosis and breast cancer. His team research on the role of autoantibodies explains that:
Dogs wagging their tails to the left were found to be expressing negative emotions such as fear, anxiety and aggression,
The plaques found in some forms of dementia, for example, have more elasticity than normal brain tissue the new technique might be able to detect those differences.
or too much stress but their underlying cause has remained a mystery. Now researchers have found that a migraine may be triggered by a protein deep in the brain that stimulates the neurons controlling facial sensations.
#Brain training app could help people with schizophrenia Scientists at Cambridge university said tests on a small number of patients who played the game over four weeks found they had improvements in memory and learning.
Schizophrenia is a long-term mental health condition that causes a range of psychological symptoms, ranging from changes in behavior through to hallucinations and delusions.
While some psychotic symptoms can be treated reasonably well with medication patients often still have debilitating problems with memory
and cognitive function, meaning they struggle to get back to work or stay in education. There is increasing evidence that computer-assisted training can help people with schizophrenia overcome some of their symptoms, with better outcomes in their daily lives.
This study, published in the journal Philosophical Transactions of the Royal Society B, found that 22 patients who played the memory game made significantly fewer errors
since lack of motivation is a common feature of schizophrenia.""We need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
but slow progress is being made toward developing a drug treatment, "said Barbara Sahakian from the department of psychiatry at Cambridge university."
#Spontaneous Rare Mutations Cause Half Of Autism Researchers are saying a new analysis of data on the genetics of autism spectrum disorder disputes a commonly held belief that autism results from the chance combinations
instead, further evidence to suggest that devastating"ultra-rare"mutations of genes that they classify as"vulnerable"play a causal role in roughly half of all autism spectrum disorder cases.
a Cold Spring Harbotr Laboratory assistant professor and on faculty at the New york Genome Center, finds that"autism genes"-i e.,
and give rise to autism, usually don't remain in the gene pool for more than one generation before they are,
This is because those born with severe autism rarely reproduce. The team's data helps the research community prioritize which genes with LGDS are most likely to play a causal role in ASD.
The team pares down a list of about 500 likely causal genes to slightly more than 200 best"candidate"autism genes.
that sort of'range anxiety'could be gone for good-the roads actually charge your car as you drive.
it could lead to the creation of MRI machines that don't require people to lie inside the claustrophobic machine,
which triggers the production of pro-inflammatory proteins in response to infection, tissue damage, or stress.
Almost two thirds of the sites suggested that vaccines cause autism, and more than 40 percent claim theye responsible for rain injury The majority present information as scientific when it doesn actually qualify for that distinction.
These noteworthy results were achieved by the non-destructive stress-relaxation ability of the unique electrodes as well as the good piezoelectricity of the device components.
both in normal conditions and in situations of stress--like the body experiences following a bone marrow transplant.
Late-onset AD is the most common form of dementia affecting an estimated 30 million persons worldwide--a number that is expected to quadruple over the next 40 years.
"Delaying dementia onset by even just two years could potentially lower the worldwide prevalence of AD by more than 22 million cases over the next four decades,
#Drugs stimulate body's own stem cells to replace the brain cells lost in multiple sclerosis Led by researchers at Case Western Reserve,
when administered systemically to animal models of multiple sclerosis. The results are published online Monday, April 20, in the scientific journal Nature."
"We know that there are stem cells throughout the adult nervous system that are capable of repairing the damage caused by multiple sclerosis,
"Our approach was to find drugs that could catalyze the body's own stem cells to replace the cells lost in multiple sclerosis."
"The findings mark the most promising developments to date in efforts to help the millions of people around the world who suffer from multiple sclerosis.
Current multiple sclerosis therapies aim to slow further myelin destruction by the immune system, but the Case Western Reserve team used a new approach to create new myelin within the nervous system.
Their work offers great promise of developing therapies that reverse disabilities caused by multiple sclerosis or similar neurological disorders."
"Tesar emphasized that much work remains before multiple sclerosis patients might benefit from the promising approach. Scientists still must find ways to transform the topical medications for internal use
Neither had been considered previously as a therapeutic for multiple sclerosis, but testing revealed each had an ability to stimulate OPCS to form new myelinating cells.
When administered systemically to lab mice afflicted with a multiple sclerosis-like disease, both drugs prompted native OPCS to regenerate new myelin."
This truly represents a paradigm shift in how we think about restoring function to multiple sclerosis patients."
The team is optimized enthusiastic that versions of these two drugs can be advanced to clinical testing for multiple sclerosis in the future,
"but off-label use of the current forms of these drugs is more likely to increase other health concerns than alleviate multiple sclerosis symptoms.
"While multiple sclerosis is the initial focus for translating this research into the clinic, a number of other disorders involve myelin loss
or dysfunction including cerebral palsy, age-related dementia, optic neuritis and schizophrenia. Any drugs developed that enhance myelination in multiple sclerosis also hold promise for benefiting these other disorders."
"The approach from Case Western Reserve University combines cutting-edge stem cell and drug screening technologies to develop new chemical therapeutics for myelin disorders,
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